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The map label for this gene is fba [H]

Identifier: 54020605

GI number: 54020605

Start: 739818

End: 740648

Strand: Reverse

Name: fba [H]

Synonym: mhp589

Alternate gene names: 54020605

Gene position: 740648-739818 (Counterclockwise)

Preceding gene: 54020606

Following gene: 54020604

Centisome position: 82.96

GC content: 28.88

Gene sequence:

>831_bases
ATGGTTTTTATCGATCCAAAAGAAACATTTTCAAAACTAAATGCAGAGAATAAACCAATTTTTGCTTTTAATGTTATAAA
TTTAGAAACACTTTTTGCTGTAATTAAAGCAGGTGAAATTTCTAAAAAACCCTTAATAATTCAGTTAAGTTTGGGAGGAA
TTAGATATTCCCGTATTGAATTTCTAGCGCCAATGATTGTTTCGGCGATTAAAAATTCACCAGGAAAATTTATTTTTCAC
CTTGATCACTGTGATGATTTAGAACTTTTTGAAAAATATCTTGAATTAGGTTTTAATTCTGCTATGTTTGATGGCTCAAA
ATTTGATGTTGCTAAAAATATCGAAAAATCTTTAAAAGCAAAGGAACTTGCCAAGGAAAAAAATATTTTCCTTGAGTTAG
AAATTGGCCAAATCGGCGGGAAAGAAATTGGTCATCAAGCAGAAAATCAGCAAATTCTTGACCTAGAAATTATAAAAGAT
TTTTATAAAAAAACTCAACCTGATCTTTTGGCAATTGCTTTTGGAACTGCTCATGGAATTTACAAGAAAAAGGCAAATCT
TAACTGAGAATTAATCCAAAATTTCAAAAAAGCATATAGAATTCCGCTTGTTATGCATGGAACAAGTGGTCTTTCGATTC
AAGAAATTCAAAAAGCAATTAGTTGTGGAATTAACAAAATCAATATTTTTACAGACCTTTTAGTTAGTTTTTCCGAACAG
GTGAAACTATATTTTCAAGAAAATCCAAATGCCTTTGATATTCGGAAAATTAATGAAAAAGGAATTGAAAAGATGACAGA
AAAAATTCTTTCTTATCTTAAAATAGCATAA

Upstream 100 bases:

>100_bases
GCCGTGGAGTTGTCCGTGTTGGAAATAAAGGATATCAAATTATTATTGGAACCGATGTTGAATTTGTAGCTGATTATCTT
AAAAAAATGATAGGAAAATA

Downstream 100 bases:

>100_bases
GAATCTAACATTTTATTTTTCTTCTCTGGTTTAAAAAAGCTTTAAATTCATAGACTATTTTGCAAATTCGCGGTAAATTT
GGCCAAAAATGATTGACATT

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MVFIDPKETFSKLNAENKPIFAFNVINLETLFAVIKAGEISKKPLIIQLSLGGIRYSRIEFLAPMIVSAIKNSPGKFIFH
LDHCDDLELFEKYLELGFNSAMFDGSKFDVAKNIEKSLKAKELAKEKNIFLELEIGQIGGKEIGHQAENQQILDLEIIKD
FYKKTQPDLLAIAFGTAHGIYKKKANLNWELIQNFKKAYRIPLVMHGTSGLSIQEIQKAISCGINKINIFTDLLVSFSEQ
VKLYFQENPNAFDIRKINEKGIEKMTEKILSYLKIA

Sequences:

>Translated_276_residues
MVFIDPKETFSKLNAENKPIFAFNVINLETLFAVIKAGEISKKPLIIQLSLGGIRYSRIEFLAPMIVSAIKNSPGKFIFH
LDHCDDLELFEKYLELGFNSAMFDGSKFDVAKNIEKSLKAKELAKEKNIFLELEIGQIGGKEIGHQAENQQILDLEIIKD
FYKKTQPDLLAIAFGTAHGIYKKKANLN*ELIQNFKKAYRIPLVMHGTSGLSIQEIQKAISCGINKINIFTDLLVSFSEQ
VKLYFQENPNAFDIRKINEKGIEKMTEKILSYLKIA
>Mature_276_residues
MVFIDPKETFSKLNAENKPIFAFNVINLETLFAVIKAGEISKKPLIIQLSLGGIRYSRIEFLAPMIVSAIKNSPGKFIFH
LDHCDDLELFEKYLELGFNSAMFDGSKFDVAKNIEKSLKAKELAKEKNIFLELEIGQIGGKEIGHQAENQQILDLEIIKD
FYKKTQPDLLAIAFGTAHGIYKKKANLN*ELIQNFKKAYRIPLVMHGTSGLSIQEIQKAISCGINKINIFTDLLVSFSEQ
VKLYFQENPNAFDIRKINEKGIEKMTEKILSYLKIA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=257, Percent_Identity=31.1284046692607, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1788072, Length=259, Percent_Identity=34.3629343629344, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1789526, Length=280, Percent_Identity=28.5714285714286, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1789293, Length=311, Percent_Identity=26.3665594855305, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322790, Length=320, Percent_Identity=27.5, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 31163; Mature: 31163

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFIDPKETFSKLNAENKPIFAFNVINLETLFAVIKAGEISKKPLIIQLSLGGIRYSRIE
CEEECCHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHCCCCCCCCEEEEEECCCEEHHHHH
FLAPMIVSAIKNSPGKFIFHLDHCDDLELFEKYLELGFNSAMFDGSKFDVAKNIEKSLKA
HHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
KELAKEKNIFLELEIGQIGGKEIGHQAENQQILDLEIIKDFYKKTQPDLLAIAFGTAHGI
HHHHHHCCEEEEEEECCCCCHHHCCCCCCCEEEHHHHHHHHHHCCCCCEEEEEEHHHHHH
YKKKANLNELIQNFKKAYRIPLVMHGTSGLSIQEIQKAISCGINKINIFTDLLVSFSEQV
HHHCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHE
KLYFQENPNAFDIRKINEKGIEKMTEKILSYLKIA
EEEEECCCCEEEEEECCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVFIDPKETFSKLNAENKPIFAFNVINLETLFAVIKAGEISKKPLIIQLSLGGIRYSRIE
CEEECCHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHCCCCCCCCEEEEEECCCEEHHHHH
FLAPMIVSAIKNSPGKFIFHLDHCDDLELFEKYLELGFNSAMFDGSKFDVAKNIEKSLKA
HHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
KELAKEKNIFLELEIGQIGGKEIGHQAENQQILDLEIIKDFYKKTQPDLLAIAFGTAHGI
HHHHHHCCEEEEEEECCCCCHHHCCCCCCCEEEHHHHHHHHHHCCCCCEEEEEEHHHHHH
YKKKANLNELIQNFKKAYRIPLVMHGTSGLSIQEIQKAISCGINKINIFTDLLVSFSEQV
HHHCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHE
KLYFQENPNAFDIRKINEKGIEKMTEKILSYLKIA
EEEEECCCCEEEEEECCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]