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The map label for this gene is fdh [H]

Identifier: 53723253

GI number: 53723253

Start: 3008389

End: 3009564

Strand: Reverse

Name: fdh [H]

Synonym: BPSS2235

Alternate gene names: 53723253

Gene position: 3009564-3008389 (Counterclockwise)

Preceding gene: 53723254

Following gene: 53723249

Centisome position: 94.85

GC content: 73.3

Gene sequence:

>1176_bases
ATGAAGGCACTTTGCTGGCACGGCAAGCATACGGTCCGATACGAGACTGTCGCGGACCCGGCCGTCGAGGACCCGCGCGA
CGCGATCGTCGAGGTTCGCGCGTGCTCGATCGGCGGCGCGGACCTGCATCTGTACGACGCGGTGATCCCCGGCCTGAAGG
ATGGCGACGTGCTCGGCCGCGAATGCGTCGGCGAGGTCGTCGAGATCGGCGCGGGCGTATCGCGGCGGCGCGTCGGCGAG
CGCGTCGTCGTGCCGTTCGCGATCGCGTGCGGCGAGTGCGACCAGTGCCGGCGCGGCAACTGGTCGGTATGCGAGACGAC
GAACCCGCACCGCGCGCTGGCCGACAAGGTGTTTGGCCACGCCACCGGCGGCCTGCTCGGCTGCGGCCATCTGGCGGGCG
GCTATCCGGGCGGGCAGGCGCAATACGTGCGCGTGCCGCACGCGGACGTCGCGCCCGCGACGATACCGGACGGCGTCGAC
GACGAGCGCGCGCTGTTCGTCGGCGACAGCCTCGCGACCGGCTGGCAGGCGGCCGCGCAGTGCGAGATCGAGCCGGGCAA
CGTCGTCGCGGTGTGGGGCGCGGGGGCGGTGGGGCTGTTCGCGGCGATGAGCGCGCGCCTGCTCGGCGCGGCCGAGGTGA
TCGCGATCGACCGCGTGCCGGAGCGGCTCGCGCTCGCGCAGAAGCTCGGCGCGACGCCGCTCGATTTCGAGCGGCTCGGC
GTGGCCGATACGCTTGCCGAGCGCACGCGCGGCAAGGGTCCGGACAAATGCATCGACGCGGTCGGGCTGGAGGCGCAGGC
GGGCGAGGCGCTCGACGCGGTGACCGACCGCTTCAGGCCGACCGTGGCCGCGGGCGCCGATCAGCCGCACGTGCTGCGCG
AGATGATCTACGCGTGCCGGCCGGGCGGCGTGCTATCGGTGCCGGGCGTCTACGGCGGGCTCGTCGACAAGCTGCCGATG
GGCGCGCTGATGCACAAGGGCCTCACGCTGCGCGCGGGGCAGACGCACGTCTGCCGCTGGACGGCCGGGCTGCTCGAGCG
GATCGCCGACGGGCGGCTCGATCCGTCGTGCGTCATCACGCATCGCGCGACGCTCGAAGAGGGGCCTGCGATGTATGAAA
CCTTCGGCGCGCGGCGCGACGGCTGCATTCGGCCGGTGCTGCGGCCCCGGCATTGA

Upstream 100 bases:

>100_bases
CGGCCCGCACGCGGTACGCGGCCCCCGGCCGGGCCCGATCCGGTTCGCCCCCACCGCCACGCATGCGGCGCGCGCGCCGT
CCCACCCGGAGGAACTCGCG

Downstream 100 bases:

>100_bases
GCGTGCGGCGGGCGCGCGCCGACGGCGCGATCCGGCCCGCGCCTGCCGCGCGCCGCGCGGGGTTCGTCCGCGTGCGCCGG
AGATACGCGCGGCGCGCCGG

Product: Zinc-binding dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKALCWHGKHTVRYETVADPAVEDPRDAIVEVRACSIGGADLHLYDAVIPGLKDGDVLGRECVGEVVEIGAGVSRRRVGE
RVVVPFAIACGECDQCRRGNWSVCETTNPHRALADKVFGHATGGLLGCGHLAGGYPGGQAQYVRVPHADVAPATIPDGVD
DERALFVGDSLATGWQAAAQCEIEPGNVVAVWGAGAVGLFAAMSARLLGAAEVIAIDRVPERLALAQKLGATPLDFERLG
VADTLAERTRGKGPDKCIDAVGLEAQAGEALDAVTDRFRPTVAAGADQPHVLREMIYACRPGGVLSVPGVYGGLVDKLPM
GALMHKGLTLRAGQTHVCRWTAGLLERIADGRLDPSCVITHRATLEEGPAMYETFGARRDGCIRPVLRPRH

Sequences:

>Translated_391_residues
MKALCWHGKHTVRYETVADPAVEDPRDAIVEVRACSIGGADLHLYDAVIPGLKDGDVLGRECVGEVVEIGAGVSRRRVGE
RVVVPFAIACGECDQCRRGNWSVCETTNPHRALADKVFGHATGGLLGCGHLAGGYPGGQAQYVRVPHADVAPATIPDGVD
DERALFVGDSLATGWQAAAQCEIEPGNVVAVWGAGAVGLFAAMSARLLGAAEVIAIDRVPERLALAQKLGATPLDFERLG
VADTLAERTRGKGPDKCIDAVGLEAQAGEALDAVTDRFRPTVAAGADQPHVLREMIYACRPGGVLSVPGVYGGLVDKLPM
GALMHKGLTLRAGQTHVCRWTAGLLERIADGRLDPSCVITHRATLEEGPAMYETFGARRDGCIRPVLRPRH
>Mature_391_residues
MKALCWHGKHTVRYETVADPAVEDPRDAIVEVRACSIGGADLHLYDAVIPGLKDGDVLGRECVGEVVEIGAGVSRRRVGE
RVVVPFAIACGECDQCRRGNWSVCETTNPHRALADKVFGHATGGLLGCGHLAGGYPGGQAQYVRVPHADVAPATIPDGVD
DERALFVGDSLATGWQAAAQCEIEPGNVVAVWGAGAVGLFAAMSARLLGAAEVIAIDRVPERLALAQKLGATPLDFERLG
VADTLAERTRGKGPDKCIDAVGLEAQAGEALDAVTDRFRPTVAAGADQPHVLREMIYACRPGGVLSVPGVYGGLVDKLPM
GALMHKGLTLRAGQTHVCRWTAGLLERIADGRLDPSCVITHRATLEEGPAMYETFGARRDGCIRPVLRPRH

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=340, Percent_Identity=27.9411764705882, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI156523966, Length=386, Percent_Identity=25.3886010362694, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI34577061, Length=374, Percent_Identity=27.807486631016, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4501939, Length=276, Percent_Identity=27.1739130434783, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4501929, Length=272, Percent_Identity=30.5147058823529, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI71565154, Length=278, Percent_Identity=26.6187050359712, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4501933, Length=214, Percent_Identity=30.3738317757009, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI71743840, Length=256, Percent_Identity=27.734375, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI262073058, Length=256, Percent_Identity=27.734375, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI156627571, Length=380, Percent_Identity=22.8947368421053, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786825, Length=393, Percent_Identity=43.765903307888, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI1788073, Length=371, Percent_Identity=23.7196765498652, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790045, Length=365, Percent_Identity=26.8493150684932, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI87082125, Length=284, Percent_Identity=28.8732394366197, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788075, Length=245, Percent_Identity=30.2040816326531, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI226510992, Length=348, Percent_Identity=24.4252873563218, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787863, Length=360, Percent_Identity=23.3333333333333, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87081918, Length=229, Percent_Identity=30.1310043668122, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786552, Length=197, Percent_Identity=28.9340101522843, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790718, Length=231, Percent_Identity=26.8398268398268, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=241, Percent_Identity=27.8008298755187, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=241, Percent_Identity=26.9709543568465, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=177, Percent_Identity=28.8135593220339, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319257, Length=310, Percent_Identity=26.1290322580645, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319955, Length=216, Percent_Identity=31.0185185185185, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=307, Percent_Identity=25.7328990228013, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=216, Percent_Identity=31.0185185185185, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=356, Percent_Identity=25.561797752809, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17137530, Length=397, Percent_Identity=26.7002518891688, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17737897, Length=397, Percent_Identity=26.7002518891688, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI17737895, Length=298, Percent_Identity=27.8523489932886, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 41290; Mature: 41290

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS01098 LIPASE_GDSL_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALCWHGKHTVRYETVADPAVEDPRDAIVEVRACSIGGADLHLYDAVIPGLKDGDVLGR
CCCEEECCCCEEEEEECCCCCCCCCHHHHEEEEEEECCCCCEEEHHHHCCCCCCCCHHHH
ECVGEVVEIGAGVSRRRVGERVVVPFAIACGECDQCRRGNWSVCETTNPHRALADKVFGH
HHHHHHHHHCCCHHHHHCCCEEEEEEEEECCCCHHHHCCCCCEECCCCHHHHHHHHHHHH
ATGGLLGCGHLAGGYPGGQAQYVRVPHADVAPATIPDGVDDERALFVGDSLATGWQAAAQ
CCCCCEECHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEECCCHHCCCHHHEE
CEIEPGNVVAVWGAGAVGLFAAMSARLLGAAEVIAIDRVPERLALAQKLGATPLDFERLG
EEECCCCEEEEECCCHHHHHHHHHHHHHCHHHEEEEHHCHHHHHHHHHHCCCCCCHHHHC
VADTLAERTRGKGPDKCIDAVGLEAQAGEALDAVTDRFRPTVAAGADQPHVLREMIYACR
HHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCEECCCCCHHHHHHHHHHCC
PGGVLSVPGVYGGLVDKLPMGALMHKGLTLRAGQTHVCRWTAGLLERIADGRLDPSCVIT
CCCEEECCCHHHHHHHHCCHHHHHHCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEE
HRATLEEGPAMYETFGARRDGCIRPVLRPRH
ECCHHHCCCHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKALCWHGKHTVRYETVADPAVEDPRDAIVEVRACSIGGADLHLYDAVIPGLKDGDVLGR
CCCEEECCCCEEEEEECCCCCCCCCHHHHEEEEEEECCCCCEEEHHHHCCCCCCCCHHHH
ECVGEVVEIGAGVSRRRVGERVVVPFAIACGECDQCRRGNWSVCETTNPHRALADKVFGH
HHHHHHHHHCCCHHHHHCCCEEEEEEEEECCCCHHHHCCCCCEECCCCHHHHHHHHHHHH
ATGGLLGCGHLAGGYPGGQAQYVRVPHADVAPATIPDGVDDERALFVGDSLATGWQAAAQ
CCCCCEECHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEECCCHHCCCHHHEE
CEIEPGNVVAVWGAGAVGLFAAMSARLLGAAEVIAIDRVPERLALAQKLGATPLDFERLG
EEECCCCEEEEECCCHHHHHHHHHHHHHCHHHEEEEHHCHHHHHHHHHHCCCCCCHHHHC
VADTLAERTRGKGPDKCIDAVGLEAQAGEALDAVTDRFRPTVAAGADQPHVLREMIYACR
HHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCEECCCCCHHHHHHHHHHCC
PGGVLSVPGVYGGLVDKLPMGALMHKGLTLRAGQTHVCRWTAGLLERIADGRLDPSCVIT
CCCEEECCCHHHHHHHHCCHHHHHHCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEE
HRATLEEGPAMYETFGARRDGCIRPVLRPRH
ECCHHHCCCHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]