Click here to switch to the map view.

The map label for this gene is ggt [H]

Identifier: 53722312

GI number: 53722312

Start: 1760116

End: 1761837

Strand: Reverse

Name: ggt [H]

Synonym: BPSS1288

Alternate gene names: 53722312

Gene position: 1761837-1760116 (Counterclockwise)

Preceding gene: 53722318

Following gene: 53722310

Centisome position: 55.53

GC content: 66.67

Gene sequence:

>1722_bases
ATGAATGCAACGAATCGTTTCAAGTCGACGGTGCTCGCCGCGCTCGTGAGCTCGGCGCTCGCCGGTTTTCTGCCGAGCGC
GCCCGCCCATGCGAAGGGCCCGCAGCAGCGCGTCGTGCTGGACGGCTCGGCCGTCGCGGTCGCCGACAAGTACAGCGCCG
ACGCGGCCGAGGAGATCTTCAGGCAGGGCGGCAACGCGGTCGACGCCGCGGTCGCGATCGCCTTCACGCTCGCCGTCACC
TATCCGGAGGCGGGCAACATCGGCGGCGGCGGCTTCATGACCGTCTACATGGGCGGCAAGCCGTACTTTCTCGACTATCG
CGAGCGCGCGCCGCTCGCCGCGACGAAGGACATGTATCTCGACAAGGACGGCAACGTCGTCAAGGGCATGAGCCTGTACG
GCGATCGCGCGGTCGGCGTGCCCGGCACGGTGGCCGGGATGTGGGAGGCGCAGAAGCGCTTCGGCAAGCTGAAGTGGAAG
CAGGTGATCGCGCCCGCGATCCGTTACGCGCGCGACGGCTTCGTCGTCGACGAGCAGCTCGCGCAACGCGGCGTCGACGC
GTCGAAGGAGTTCGGCGGCAAGACGAACTTCGATCAATACTTCAGCGGCCTGAAGGCGGGCGCGACCTTCAAGCAGCCGG
AGCTCGCGGCGGTGCTCGCGCGCATCGCGAACGACGGCGCGAAGGATTTCTACGACGGCAAGACGGCCGACCTGATCGCC
GCATCGATGAAGAAGGGCGGCGGCCTGATCACGAAGCAGGATCTCGTCCAGTACAAGGCGGTGTGGCGCCAGCCGATCCA
GGCGAACTGGAACGGCTATCGCGTGATCACCGCGCCGCCGCCGAGCTCGGGCGGCATCGGCCTCGTGCAGTTGCTGACGA
TGAAGGCGGACCGCAAGGCCGATTTCGACGGCGTCGCGCTCAATTCGCCGCAATACGTGCATCTGATCGCCGAGATCGAG
AAGCGCGTGTTCGCCGATCGCGCGCAGTACCTCGGCGATCCGGATTTCTACAAGGTGCCCGTCGCGCAGTTGACCGACGC
CGCGTACATCGCCAAGCGCGCGGCCGAGGTGAATCCCGAGAAGCCGTCCGACACGAAGAGCGTGCTGCCGGGCCTCGGCA
CGTCGATGCCGGAGAAGGCCGAGACGACGCATTTCTCCGTCGTCGACAAGTGGGGCAACGCGGTGTCGAACACGTACACG
ATCAACGGCTACTTCGGCTCGGGCGTCGTCGCCGAAGGCACGGGCATCGTGCTCAACGACGAGATGGACGATTTCTCCGC
GAAGCCGGGCGTCGCCAACATGTTCGGCGTCGTCGGCAGCGACGCGAACGCGATCGAGCCGAAGAAGCGGCCGCTGTCGT
CGATGTCGCCGACGGTCCTCACGAAGGACGGCAAGGTCGCGCTCGTGATCGGCACGCCGGGCGGCTCGCGGATCTTCACG
TCGATCTTCCAGGTGATCACGAACCTGTACGACTTCAAGATGCCGCTGAAGGACGCGGTCGGCGCGATGCGCTTTCACCA
CCAGCTGCTGCCGCCGAACACGATCTTCTGGGAGCCGTACCACCCGATCGACGGCGAGCTGGCGAAGGGCATCGAGGCGA
AGGGCTACACGCTCAAGGGCCAGGATTTCAGCGGCGACATCCAGGCGATCCGGATCGACGGCAAGACGCCCGAGGCGGTG
TCCGATCCGCGCGGCCGCGGCGTGTCGCGCGTGATCCGGTAA

Upstream 100 bases:

>100_bases
ACGAAACCCCATTTTTGTATACGCGCGCAGCCATGCTATAAGCCTATTCGTCGGACTTTCGTGCCCCAATTAGCAAGGAG
ATCGAAATGGGAGACATCCA

Downstream 100 bases:

>100_bases
GCGCGGCGCGCCGGCGTGCCGAAGCCGCGGCGCGCCGGCGCGAGCACGAACGGGCCGGCGAAAGCGCGGCGCGCCGACCG
TCGCGCGCCGCGCTTTCGCG

Product: gamma-glutamyltransferase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MNATNRFKSTVLAALVSSALAGFLPSAPAHAKGPQQRVVLDGSAVAVADKYSADAAEEIFRQGGNAVDAAVAIAFTLAVT
YPEAGNIGGGGFMTVYMGGKPYFLDYRERAPLAATKDMYLDKDGNVVKGMSLYGDRAVGVPGTVAGMWEAQKRFGKLKWK
QVIAPAIRYARDGFVVDEQLAQRGVDASKEFGGKTNFDQYFSGLKAGATFKQPELAAVLARIANDGAKDFYDGKTADLIA
ASMKKGGGLITKQDLVQYKAVWRQPIQANWNGYRVITAPPPSSGGIGLVQLLTMKADRKADFDGVALNSPQYVHLIAEIE
KRVFADRAQYLGDPDFYKVPVAQLTDAAYIAKRAAEVNPEKPSDTKSVLPGLGTSMPEKAETTHFSVVDKWGNAVSNTYT
INGYFGSGVVAEGTGIVLNDEMDDFSAKPGVANMFGVVGSDANAIEPKKRPLSSMSPTVLTKDGKVALVIGTPGGSRIFT
SIFQVITNLYDFKMPLKDAVGAMRFHHQLLPPNTIFWEPYHPIDGELAKGIEAKGYTLKGQDFSGDIQAIRIDGKTPEAV
SDPRGRGVSRVIR

Sequences:

>Translated_573_residues
MNATNRFKSTVLAALVSSALAGFLPSAPAHAKGPQQRVVLDGSAVAVADKYSADAAEEIFRQGGNAVDAAVAIAFTLAVT
YPEAGNIGGGGFMTVYMGGKPYFLDYRERAPLAATKDMYLDKDGNVVKGMSLYGDRAVGVPGTVAGMWEAQKRFGKLKWK
QVIAPAIRYARDGFVVDEQLAQRGVDASKEFGGKTNFDQYFSGLKAGATFKQPELAAVLARIANDGAKDFYDGKTADLIA
ASMKKGGGLITKQDLVQYKAVWRQPIQANWNGYRVITAPPPSSGGIGLVQLLTMKADRKADFDGVALNSPQYVHLIAEIE
KRVFADRAQYLGDPDFYKVPVAQLTDAAYIAKRAAEVNPEKPSDTKSVLPGLGTSMPEKAETTHFSVVDKWGNAVSNTYT
INGYFGSGVVAEGTGIVLNDEMDDFSAKPGVANMFGVVGSDANAIEPKKRPLSSMSPTVLTKDGKVALVIGTPGGSRIFT
SIFQVITNLYDFKMPLKDAVGAMRFHHQLLPPNTIFWEPYHPIDGELAKGIEAKGYTLKGQDFSGDIQAIRIDGKTPEAV
SDPRGRGVSRVIR
>Mature_573_residues
MNATNRFKSTVLAALVSSALAGFLPSAPAHAKGPQQRVVLDGSAVAVADKYSADAAEEIFRQGGNAVDAAVAIAFTLAVT
YPEAGNIGGGGFMTVYMGGKPYFLDYRERAPLAATKDMYLDKDGNVVKGMSLYGDRAVGVPGTVAGMWEAQKRFGKLKWK
QVIAPAIRYARDGFVVDEQLAQRGVDASKEFGGKTNFDQYFSGLKAGATFKQPELAAVLARIANDGAKDFYDGKTADLIA
ASMKKGGGLITKQDLVQYKAVWRQPIQANWNGYRVITAPPPSSGGIGLVQLLTMKADRKADFDGVALNSPQYVHLIAEIE
KRVFADRAQYLGDPDFYKVPVAQLTDAAYIAKRAAEVNPEKPSDTKSVLPGLGTSMPEKAETTHFSVVDKWGNAVSNTYT
INGYFGSGVVAEGTGIVLNDEMDDFSAKPGVANMFGVVGSDANAIEPKKRPLSSMSPTVLTKDGKVALVIGTPGGSRIFT
SIFQVITNLYDFKMPLKDAVGAMRFHHQLLPPNTIFWEPYHPIDGELAKGIEAKGYTLKGQDFSGDIQAIRIDGKTPEAV
SDPRGRGVSRVIR

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=561, Percent_Identity=32.620320855615, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI73915090, Length=561, Percent_Identity=32.620320855615, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI73915096, Length=561, Percent_Identity=32.620320855615, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI73915094, Length=561, Percent_Identity=32.620320855615, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI113429324, Length=562, Percent_Identity=31.3167259786477, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI113429326, Length=566, Percent_Identity=30.9187279151943, Blast_Score=192, Evalue=9e-49,
Organism=Homo sapiens, GI109148539, Length=523, Percent_Identity=29.6367112810707, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI153266885, Length=548, Percent_Identity=26.4598540145985, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI153266901, Length=549, Percent_Identity=26.5938069216758, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI153266907, Length=545, Percent_Identity=25.3211009174312, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI30581157, Length=195, Percent_Identity=42.5641025641026, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI30581155, Length=195, Percent_Identity=42.5641025641026, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI218505805, Length=189, Percent_Identity=40.7407407407407, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI310124095, Length=194, Percent_Identity=36.5979381443299, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1789856, Length=532, Percent_Identity=45.4887218045113, Blast_Score=426, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI212646519, Length=536, Percent_Identity=35.4477611940299, Blast_Score=259, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI72000294, Length=536, Percent_Identity=35.4477611940299, Blast_Score=259, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17506189, Length=525, Percent_Identity=33.5238095238095, Blast_Score=220, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17542894, Length=505, Percent_Identity=33.8613861386139, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI193208247, Length=496, Percent_Identity=32.258064516129, Blast_Score=218, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI193208245, Length=496, Percent_Identity=32.258064516129, Blast_Score=218, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI72001495, Length=226, Percent_Identity=28.7610619469027, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI72001497, Length=245, Percent_Identity=28.9795918367347, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17564448, Length=417, Percent_Identity=26.378896882494, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323330, Length=588, Percent_Identity=31.2925170068027, Blast_Score=167, Evalue=3e-42,
Organism=Drosophila melanogaster, GI18859893, Length=535, Percent_Identity=35.5140186915888, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI161077496, Length=541, Percent_Identity=31.2384473197782, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI45551474, Length=475, Percent_Identity=32, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI161077880, Length=536, Percent_Identity=30.9701492537313, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24642670, Length=475, Percent_Identity=32, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24642666, Length=475, Percent_Identity=32, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI161077878, Length=475, Percent_Identity=32, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI18859741, Length=543, Percent_Identity=28.3609576427256, Blast_Score=187, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61416; Mature: 61416

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNATNRFKSTVLAALVSSALAGFLPSAPAHAKGPQQRVVLDGSAVAVADKYSADAAEEIF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEEEECCCCCHHHHHHH
RQGGNAVDAAVAIAFTLAVTYPEAGNIGGGGFMTVYMGGKPYFLDYRERAPLAATKDMYL
HCCCCHHHHHHHHHHHHEEECCCCCCCCCCCEEEEEECCCEEEECHHCCCCCCCCCCEEE
DKDGNVVKGMSLYGDRAVGVPGTVAGMWEAQKRFGKLKWKQVIAPAIRYARDGFVVDEQL
CCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEECHHH
AQRGVDASKEFGGKTNFDQYFSGLKAGATFKQPELAAVLARIANDGAKDFYDGKTADLIA
HHCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHCCCCHHHHHH
ASMKKGGGLITKQDLVQYKAVWRQPIQANWNGYRVITAPPPSSGGIGLVQLLTMKADRKA
HHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCC
DFDGVALNSPQYVHLIAEIEKRVFADRAQYLGDPDFYKVPVAQLTDAAYIAKRAAEVNPE
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHCCCCC
KPSDTKSVLPGLGTSMPEKAETTHFSVVDKWGNAVSNTYTINGYFGSGVVAEGTGIVLND
CCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCEEECCCCEEECC
EMDDFSAKPGVANMFGVVGSDANAIEPKKRPLSSMSPTVLTKDGKVALVIGTPGGSRIFT
CCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCHHHHH
SIFQVITNLYDFKMPLKDAVGAMRFHHQLLPPNTIFWEPYHPIDGELAKGIEAKGYTLKG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHCCCCCCCEEECC
QDFSGDIQAIRIDGKTPEAVSDPRGRGVSRVIR
CCCCCCEEEEEECCCCCCCCCCCCCCCHHHHCC
>Mature Secondary Structure
MNATNRFKSTVLAALVSSALAGFLPSAPAHAKGPQQRVVLDGSAVAVADKYSADAAEEIF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEEEECCCCCHHHHHHH
RQGGNAVDAAVAIAFTLAVTYPEAGNIGGGGFMTVYMGGKPYFLDYRERAPLAATKDMYL
HCCCCHHHHHHHHHHHHEEECCCCCCCCCCCEEEEEECCCEEEECHHCCCCCCCCCCEEE
DKDGNVVKGMSLYGDRAVGVPGTVAGMWEAQKRFGKLKWKQVIAPAIRYARDGFVVDEQL
CCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEECHHH
AQRGVDASKEFGGKTNFDQYFSGLKAGATFKQPELAAVLARIANDGAKDFYDGKTADLIA
HHCCCCCHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHCCCCHHHHHH
ASMKKGGGLITKQDLVQYKAVWRQPIQANWNGYRVITAPPPSSGGIGLVQLLTMKADRKA
HHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCC
DFDGVALNSPQYVHLIAEIEKRVFADRAQYLGDPDFYKVPVAQLTDAAYIAKRAAEVNPE
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHCCCCC
KPSDTKSVLPGLGTSMPEKAETTHFSVVDKWGNAVSNTYTINGYFGSGVVAEGTGIVLND
CCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCEEECCCCEEECC
EMDDFSAKPGVANMFGVVGSDANAIEPKKRPLSSMSPTVLTKDGKVALVIGTPGGSRIFT
CCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCHHHHH
SIFQVITNLYDFKMPLKDAVGAMRFHHQLLPPNTIFWEPYHPIDGELAKGIEAKGYTLKG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHCCCCCCCEEECC
QDFSGDIQAIRIDGKTPEAVSDPRGRGVSRVIR
CCCCCCEEEEEECCCCCCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]