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The map label for this gene is pksE [H]

Identifier: 53722025

GI number: 53722025

Start: 1324682

End: 1325866

Strand: Reverse

Name: pksE [H]

Synonym: BPSS1004

Alternate gene names: 53722025

Gene position: 1325866-1324682 (Counterclockwise)

Preceding gene: 53722026

Following gene: 53722024

Centisome position: 41.79

GC content: 68.69

Gene sequence:

>1185_bases
ATGCTGAATACTTTCATGTTTCCGGGCCAAGGTTCGCAAGCGAAGGGAATGGGCGGCGCCCTGTTCGATCGCTTCGCCGA
TCTCACCGCGCAGGCCGACGCCGTGCTCGGTTATTCGATCCGCGCGCTGTGCGTCGACGATCCGCGCGACGAGCTCGGCC
GCACGCAATTCACGCAGCCGGCGCTATACGTCGTCAATGCCTTGACGTACTACGCGAAATGCGAGGACAGCGGCGAGACG
CCCGATTTTCTCGCCGGCCACAGCCTGGGCGAATTCAACGCGCTGCTCGCGGCGGGCTGCTTCGACTTCGAGACCGGCCT
GAAGCTCGTCGCCCGGCGCGCAGAGTTGATGAGCCAGGCCCGCGACGGCGCGATGGCCGCGATCGTCAACGCGAGCCGCG
AGCAGATCGAGCGCACGCTCGACGAGCACGGCCTCGTCGATACCGCGATCGCGAACGACAACACGCCGTCGCAACTCGTC
ATCTCCGGCCCCGCCCACGAAATCGCGCGGGCCGAGGCGCTGTTCCAGCACGATCGGGTGCGGTATCTGCGGCTCAATAC
CAGCGGCGCGTTCCACTCGAAATTCATGCGGCCCGCGCAGCAGGCATTCGCCGCGCATCTACAGTCGTTCCGGCTCGCGG
ACCCGGCGATCCCGGTGATCTCGAACGTATCGGCGCGCCCTTACGAGAACGGCCGCGTGAGCGAAGGGCTCGCGCAGCAG
ATCGCAAGCCCGGTGCGATGGTGCGAGAGCATTCGCTATCTGCTCGCGCTGGCCGCCGAGCGCGGAGAAGCGATCGAATT
CACCGAGCTCGGACACGGCGACGTACTGACACGGCTCGTCCATACGATCCGGCGGCAGACACCGGCCCCGGCAGCGGCCC
CGGCGGCGGCCGCGACGCCGGCGCGCGCTCGCCCGACGCCGCCCGGCGAGCCCGAGCGGCCCGCGCAGCAGACGGCGGCC
GCGCCGCGCGCATCCGACTCCGCATCCGCATCGATCGGCGCGGCCGAACGGGTCGCCGCGTGGAATCGGGACTACCCCGT
CGGCACCCGCGTTCGCTCGTCGCTGATACACGACGACGTTCTCGAAACGCGGACCCCGGCAACCGTGCTGTTCGGCCACC
GCGCCGCGGTGTACATGAAGGGCTACAACGGCTACTTCGATCTCGCCGAAGTGACGCCCGCCTGA

Upstream 100 bases:

>100_bases
CGTCGACCGACGCGGGCAATCGACGCGGGAACGGTCCGCTTCGCACGGCGCGCCGCCGGCTGGGCCCGCATTGACCGATG
CGCGACGCGCGGGAGGCGAG

Downstream 100 bases:

>100_bases
GCGCGCGACGCGCGCCCGAAGCCGGCGCGCCTCGACGTCGCCGCCCCGCCGGTCGCGCCGCGCCCTCGGAAACGGGCGCG
GCCGTTGGCGCGCGCGGCAG

Product: acyl transferase

Products: NA

Alternate protein names: Malonyl CoA-acyl carrier protein transacylase; MCT [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MLNTFMFPGQGSQAKGMGGALFDRFADLTAQADAVLGYSIRALCVDDPRDELGRTQFTQPALYVVNALTYYAKCEDSGET
PDFLAGHSLGEFNALLAAGCFDFETGLKLVARRAELMSQARDGAMAAIVNASREQIERTLDEHGLVDTAIANDNTPSQLV
ISGPAHEIARAEALFQHDRVRYLRLNTSGAFHSKFMRPAQQAFAAHLQSFRLADPAIPVISNVSARPYENGRVSEGLAQQ
IASPVRWCESIRYLLALAAERGEAIEFTELGHGDVLTRLVHTIRRQTPAPAAAPAAAATPARARPTPPGEPERPAQQTAA
APRASDSASASIGAAERVAAWNRDYPVGTRVRSSLIHDDVLETRTPATVLFGHRAAVYMKGYNGYFDLAEVTPA

Sequences:

>Translated_394_residues
MLNTFMFPGQGSQAKGMGGALFDRFADLTAQADAVLGYSIRALCVDDPRDELGRTQFTQPALYVVNALTYYAKCEDSGET
PDFLAGHSLGEFNALLAAGCFDFETGLKLVARRAELMSQARDGAMAAIVNASREQIERTLDEHGLVDTAIANDNTPSQLV
ISGPAHEIARAEALFQHDRVRYLRLNTSGAFHSKFMRPAQQAFAAHLQSFRLADPAIPVISNVSARPYENGRVSEGLAQQ
IASPVRWCESIRYLLALAAERGEAIEFTELGHGDVLTRLVHTIRRQTPAPAAAPAAAATPARARPTPPGEPERPAQQTAA
APRASDSASASIGAAERVAAWNRDYPVGTRVRSSLIHDDVLETRTPATVLFGHRAAVYMKGYNGYFDLAEVTPA
>Mature_394_residues
MLNTFMFPGQGSQAKGMGGALFDRFADLTAQADAVLGYSIRALCVDDPRDELGRTQFTQPALYVVNALTYYAKCEDSGET
PDFLAGHSLGEFNALLAAGCFDFETGLKLVARRAELMSQARDGAMAAIVNASREQIERTLDEHGLVDTAIANDNTPSQLV
ISGPAHEIARAEALFQHDRVRYLRLNTSGAFHSKFMRPAQQAFAAHLQSFRLADPAIPVISNVSARPYENGRVSEGLAQQ
IASPVRWCESIRYLLALAAERGEAIEFTELGHGDVLTRLVHTIRRQTPAPAAAPAAAATPARARPTPPGEPERPAQQTAA
APRASDSASASIGAAERVAAWNRDYPVGTRVRSSLIHDDVLETRTPATVLFGHRAAVYMKGYNGYFDLAEVTPA

Specific function: Probably involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. Probably has an acyl transferase activity and could also have a flavin mononucleotide-dependent oxidoreductas

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=309, Percent_Identity=31.3915857605178, Blast_Score=119, Evalue=6e-27,
Organism=Escherichia coli, GI1787334, Length=289, Percent_Identity=34.9480968858132, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71984332, Length=298, Percent_Identity=30.2013422818792, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=171, Percent_Identity=30.4093567251462, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24665753, Length=306, Percent_Identity=31.3725490196078, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004136
- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR013785
- InterPro:   IPR004410
- InterPro:   IPR016036
- InterPro:   IPR014179 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF03060 NPD [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 42492; Mature: 42492

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNTFMFPGQGSQAKGMGGALFDRFADLTAQADAVLGYSIRALCVDDPRDELGRTQFTQP
CCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHCCCCCCCH
ALYVVNALTYYAKCEDSGETPDFLAGHSLGEFNALLAAGCFDFETGLKLVARRAELMSQA
HHHHHHHHHHHHCCCCCCCCCCHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RDGAMAAIVNASREQIERTLDEHGLVDTAIANDNTPSQLVISGPAHEIARAEALFQHDRV
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHCCE
RYLRLNTSGAFHSKFMRPAQQAFAAHLQSFRLADPAIPVISNVSARPYENGRVSEGLAQQ
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHHH
IASPVRWCESIRYLLALAAERGEAIEFTELGHGDVLTRLVHTIRRQTPAPAAAPAAAATP
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
ARARPTPPGEPERPAQQTAAAPRASDSASASIGAAERVAAWNRDYPVGTRVRSSLIHDDV
CCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHH
LETRTPATVLFGHRAAVYMKGYNGYFDLAEVTPA
HHCCCCCEEEECCCEEEEEECCCCEEECCCCCCC
>Mature Secondary Structure
MLNTFMFPGQGSQAKGMGGALFDRFADLTAQADAVLGYSIRALCVDDPRDELGRTQFTQP
CCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHCCCCCCCH
ALYVVNALTYYAKCEDSGETPDFLAGHSLGEFNALLAAGCFDFETGLKLVARRAELMSQA
HHHHHHHHHHHHCCCCCCCCCCHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RDGAMAAIVNASREQIERTLDEHGLVDTAIANDNTPSQLVISGPAHEIARAEALFQHDRV
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHCCE
RYLRLNTSGAFHSKFMRPAQQAFAAHLQSFRLADPAIPVISNVSARPYENGRVSEGLAQQ
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHHH
IASPVRWCESIRYLLALAAERGEAIEFTELGHGDVLTRLVHTIRRQTPAPAAAPAAAATP
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
ARARPTPPGEPERPAQQTAAAPRASDSASASIGAAERVAAWNRDYPVGTRVRSSLIHDDV
CCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHH
LETRTPATVLFGHRAAVYMKGYNGYFDLAEVTPA
HHCCCCCEEEECCCEEEEEECCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]