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The map label for this gene is cynR [H]

Identifier: 53721944

GI number: 53721944

Start: 1214231

End: 1215166

Strand: Reverse

Name: cynR [H]

Synonym: BPSS0920

Alternate gene names: 53721944

Gene position: 1215166-1214231 (Counterclockwise)

Preceding gene: 53721947

Following gene: 53721942

Centisome position: 38.3

GC content: 63.46

Gene sequence:

>936_bases
GTGCTGCATGGCATCGGGCTCAAATACTTCGTGGAAGTCGCGCGCACTGGCTCGCTCGCAGCGGCATCGCAACAGCTTCA
CGTCGCGGTGTCGGCGATCAGCCGGCAAATCGCAAAGCTCGAGGAGCAGGTGGGCACGCCACTGTTCGAGCGCATGCCGC
GCGGCATGATCCTGACCGAAGCGGGCGAATTGCTCGTGCAGCATGCGCGCCGCGCGCTGATGGATGGTGACGCGGTGCTT
GCCGAGATATCGGAAATACATGCGCTCGGGCTTGGGATCGTGCGCATCGGCTCCACGGAGGGTTTCACGCGCTGTTTTCT
GCCGAGCGTCATGGCGACGCACTATCGCCAGCATCCGCGCACGCGCTTCGTGATGCGTTCAGGTACGCCCGCGCAGGTCG
AGCATTGGGTGGCAAGCGGCGAAGTCGATATGGGCCTCGCATTTTCGACGTCGACATCGACGGCGTTGAGCGTCGAATAC
AGCGTCAAGGCGCCCGTCTGTGCGCTGCTGCCGCCGACACATCCTTTGGCGGGAAGAACGAGCGTCACGCTCGACGACAT
TCTTCAGTACCCCACCGCCGTGCTAGATCGGGGCACCACCGTGCGCCAGTTGATCGACTTGTGCTGTTCGGCACGCGGCG
TGCATCTGGAGCCCATTCTGACGAGCAACAACTCGAGCGCGATGCACCATTTCGCCGCGCTCACCGGCACGATCACCCTC
GGCAGCCAGGTCGCGCTCGAAGGCAATCCCGGGCCCCCGACACTCGTCGCCATGCCCATCGACGAGCCATTGCTCAATGA
GCGCCTTTTGCAGGTCACGGTGATGCGTGAGCGCCGCCTTCCGCCAGCGGTCGTTCAGTTTCTGAAAACGCTGTCGAATG
CGTTGCGCGAGAGTCAGGGCGCATCCGCGGCGCGCGCCAGGAGAAAAAAACGCTAA

Upstream 100 bases:

>100_bases
GTGACTGCAATTAAGCCCAGTCTAGGAACACCAAAAATTCGCGACAATTTCAAAATTTGCGACTAGCATTGCCAAAAAGA
CAATGCTCAAGGAAAGCGTC

Downstream 100 bases:

>100_bases
CCGGCTGCAGCAGGCAGCTCCACCGAGTATGACTGTGTGGCCGCTCAGGCGGCGTGGCCGGCTGGGGCCGTCGGCGAACC
TCCGGGTTGGACCACAAACC

Product: LysR family regulatory protein

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MLHGIGLKYFVEVARTGSLAAASQQLHVAVSAISRQIAKLEEQVGTPLFERMPRGMILTEAGELLVQHARRALMDGDAVL
AEISEIHALGLGIVRIGSTEGFTRCFLPSVMATHYRQHPRTRFVMRSGTPAQVEHWVASGEVDMGLAFSTSTSTALSVEY
SVKAPVCALLPPTHPLAGRTSVTLDDILQYPTAVLDRGTTVRQLIDLCCSARGVHLEPILTSNNSSAMHHFAALTGTITL
GSQVALEGNPGPPTLVAMPIDEPLLNERLLQVTVMRERRLPPAVVQFLKTLSNALRESQGASAARARRKKR

Sequences:

>Translated_311_residues
MLHGIGLKYFVEVARTGSLAAASQQLHVAVSAISRQIAKLEEQVGTPLFERMPRGMILTEAGELLVQHARRALMDGDAVL
AEISEIHALGLGIVRIGSTEGFTRCFLPSVMATHYRQHPRTRFVMRSGTPAQVEHWVASGEVDMGLAFSTSTSTALSVEY
SVKAPVCALLPPTHPLAGRTSVTLDDILQYPTAVLDRGTTVRQLIDLCCSARGVHLEPILTSNNSSAMHHFAALTGTITL
GSQVALEGNPGPPTLVAMPIDEPLLNERLLQVTVMRERRLPPAVVQFLKTLSNALRESQGASAARARRKKR
>Mature_311_residues
MLHGIGLKYFVEVARTGSLAAASQQLHVAVSAISRQIAKLEEQVGTPLFERMPRGMILTEAGELLVQHARRALMDGDAVL
AEISEIHALGLGIVRIGSTEGFTRCFLPSVMATHYRQHPRTRFVMRSGTPAQVEHWVASGEVDMGLAFSTSTSTALSVEY
SVKAPVCALLPPTHPLAGRTSVTLDDILQYPTAVLDRGTTVRQLIDLCCSARGVHLEPILTSNNSSAMHHFAALTGTITL
GSQVALEGNPGPPTLVAMPIDEPLLNERLLQVTVMRERRLPPAVVQFLKTLSNALRESQGASAARARRKKR

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=222, Percent_Identity=31.981981981982, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787879, Length=242, Percent_Identity=28.099173553719, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788481, Length=283, Percent_Identity=26.8551236749117, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787530, Length=235, Percent_Identity=25.9574468085106, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI145693105, Length=300, Percent_Identity=24.3333333333333, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1787601, Length=205, Percent_Identity=28.780487804878, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87081904, Length=215, Percent_Identity=29.3023255813954, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788296, Length=231, Percent_Identity=26.4069264069264, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789204, Length=222, Percent_Identity=23.8738738738739, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790208, Length=294, Percent_Identity=27.5510204081633, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788748, Length=274, Percent_Identity=24.0875912408759, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788887, Length=183, Percent_Identity=30.0546448087432, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI2367136, Length=180, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789639, Length=122, Percent_Identity=31.1475409836066, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1790399, Length=206, Percent_Identity=25.7281553398058, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790262, Length=187, Percent_Identity=27.2727272727273, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788297, Length=245, Percent_Identity=26.9387755102041, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI87081978, Length=98, Percent_Identity=34.6938775510204, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33620; Mature: 33620

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHGIGLKYFVEVARTGSLAAASQQLHVAVSAISRQIAKLEEQVGTPLFERMPRGMILTE
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEHH
AGELLVQHARRALMDGDAVLAEISEIHALGLGIVRIGSTEGFTRCFLPSVMATHYRQHPR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHCCC
TRFVMRSGTPAQVEHWVASGEVDMGLAFSTSTSTALSVEYSVKAPVCALLPPTHPLAGRT
CEEEEECCCHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEECCCCEEEECCCCCCCCCCC
SVTLDDILQYPTAVLDRGTTVRQLIDLCCSARGVHLEPILTSNNSSAMHHFAALTGTITL
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHEEEE
GSQVALEGNPGPPTLVAMPIDEPLLNERLLQVTVMRERRLPPAVVQFLKTLSNALRESQG
CCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
ASAARARRKKR
CHHHHHHHCCC
>Mature Secondary Structure
MLHGIGLKYFVEVARTGSLAAASQQLHVAVSAISRQIAKLEEQVGTPLFERMPRGMILTE
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEHH
AGELLVQHARRALMDGDAVLAEISEIHALGLGIVRIGSTEGFTRCFLPSVMATHYRQHPR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHCCC
TRFVMRSGTPAQVEHWVASGEVDMGLAFSTSTSTALSVEYSVKAPVCALLPPTHPLAGRT
CEEEEECCCHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEECCCCEEEECCCCCCCCCCC
SVTLDDILQYPTAVLDRGTTVRQLIDLCCSARGVHLEPILTSNNSSAMHHFAALTGTITL
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHEEEE
GSQVALEGNPGPPTLVAMPIDEPLLNERLLQVTVMRERRLPPAVVQFLKTLSNALRESQG
CCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
ASAARARRKKR
CHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]