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The map label for this gene is bioA [C]

Identifier: 53721343

GI number: 53721343

Start: 424731

End: 426152

Strand: Reverse

Name: bioA [C]

Synonym: BPSS0308

Alternate gene names: 53721343

Gene position: 426152-424731 (Counterclockwise)

Preceding gene: 53721344

Following gene: 53721342

Centisome position: 13.43

GC content: 69.62

Gene sequence:

>1422_bases
ATGGCATACCGAAACGATTCCCTTCTCACGAGCGCGCAGCAGGACACGCGGCATCTGCTGCACCCGTGGGCCGACCTGTC
CGCGCTCGGCCGCGAGACGCCGACCGTCATCGTCGAGGCGCAGGGCACGCGCGTGACCGACGCCGAAGGCCGTACCTATC
TCGACGCGATCGGCGGCATGTGGTGCGTGACGCTCGGCTACGGCCGGCGCGAGATCGCCGACGCGATCCGCGATCAGGCG
CTGCGCATGCCGTTCTACACGCCGTTCGGCGCGATGACGAACGAGCCCGCCGCCGCGCTCGGCGCGCGGCTCGCCGCGCT
CGCGCCCGGCGATCTGAAGCGCGTGCACCTGACCACCTGCGGCTCGACAGCGGTCGAATCGGCGCTGCGTTTCGCGCACT
ACTACTTCGGCGCGACGGGCCGCCCGCACAAGCGCCACATCGTCACGCGCGGCGACGCGTACCACGGCAGCACATATCTC
GCCGCATCGATATCCGGCAAGGCGTGGGACCGCACGTGCTTTCACTACGACAGCACGATCGTCCATCACCTGTCGTCGCC
GAACCCGTACCGGCGGCCGGCCGGCATGAGCGTCGACGCGTTCTGCGCGTCGCTCGTCGACGAATTCGACGCGCTGATCG
CGAAGCTCGGCGCGGAGCAGATCGCATGCTTCATCGCCGAGCCGATCCTCGCGTCGGGCGGCGTGATCGTGCCGCCGCCC
GGCTATCTCGCCGCGATGCGCGAGCGCTGCCGCCGGCACGACATCCTGTACATCAGCGACGAAGTCGTCACGGGCTTCGG
CCGCGTCGGCCACTTCTTCGCGTCGCACGCGCACTTCGGCATCGAGCCCGACATGATCGTCGTCGCGAAGGGGCTCACCT
CCGGCTACCAGCCGCTCGGCGCGGTGCTGATCTCGGAGCGGCTCGTCGATGCGGTATCCGGCGAGCACGCGTACGGCAAC
GGCGTGTTCACGAACGGTTTCACCTACTCGGGCCATCCGGTCGCCTGCGCGGCCGCGCTCGCCAACATCGAGCTGATGGA
GCGCGAGCGGATCTGCGAGCACGTGCGCGACGTCGGCCCGTACTTCATTCGCCGGCTCGATGCGCTGCGGCGCCTGCCGA
TCGTCGGCGACGTGCGCGGCGATCATCTGATGGCGTGCATCGAATGCACGAGCGGCGCGGGCGCGACGGGCGCGTTGCCG
ACGCCCGCGGACATCGCGATCGCGCAGCGCGTCGATCGCCACTGCGAGGAGATGGGCCTGCTCGTGCGGCCCTACGAGAG
CATGTGCATCCTGTCGCCGCCCCTCACCGTGACGCGCGCCGACATCGACGAAATCTGCGCGATTCTCGCGGCCGCGCTCG
AGCGCGCGCAGCGCGAGCTCGCGCAACATGCCCCCGTTCGCGAGGAAAACGAAACATGCTGA

Upstream 100 bases:

>100_bases
GCGACGTGCTCGTGCTCGACAACGTCTACGTGCAGCACGGCCGCTTCGCGTTCTCCGGGCCGCGCCTGCATCTCGTCAGC
CTGACCGACTGAGGCAACAC

Downstream 100 bases:

>100_bases
TCAACGGCCTTTGCATCGAAGGGGGCGGCGAGCCGCTGCCGATCGTCGATCCGGCGACGGGCGAGCCGCTCGCGGCGCCC
GCCGCCGCGAGCGCGGCCGA

Product: hypothetical protein

Products: S-Adenosyl-4-methylthio-2-oxobutanoate; 7,8-Diaminononanoate [C]

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MAYRNDSLLTSAQQDTRHLLHPWADLSALGRETPTVIVEAQGTRVTDAEGRTYLDAIGGMWCVTLGYGRREIADAIRDQA
LRMPFYTPFGAMTNEPAAALGARLAALAPGDLKRVHLTTCGSTAVESALRFAHYYFGATGRPHKRHIVTRGDAYHGSTYL
AASISGKAWDRTCFHYDSTIVHHLSSPNPYRRPAGMSVDAFCASLVDEFDALIAKLGAEQIACFIAEPILASGGVIVPPP
GYLAAMRERCRRHDILYISDEVVTGFGRVGHFFASHAHFGIEPDMIVVAKGLTSGYQPLGAVLISERLVDAVSGEHAYGN
GVFTNGFTYSGHPVACAAALANIELMERERICEHVRDVGPYFIRRLDALRRLPIVGDVRGDHLMACIECTSGAGATGALP
TPADIAIAQRVDRHCEEMGLLVRPYESMCILSPPLTVTRADIDEICAILAAALERAQRELAQHAPVREENETC

Sequences:

>Translated_473_residues
MAYRNDSLLTSAQQDTRHLLHPWADLSALGRETPTVIVEAQGTRVTDAEGRTYLDAIGGMWCVTLGYGRREIADAIRDQA
LRMPFYTPFGAMTNEPAAALGARLAALAPGDLKRVHLTTCGSTAVESALRFAHYYFGATGRPHKRHIVTRGDAYHGSTYL
AASISGKAWDRTCFHYDSTIVHHLSSPNPYRRPAGMSVDAFCASLVDEFDALIAKLGAEQIACFIAEPILASGGVIVPPP
GYLAAMRERCRRHDILYISDEVVTGFGRVGHFFASHAHFGIEPDMIVVAKGLTSGYQPLGAVLISERLVDAVSGEHAYGN
GVFTNGFTYSGHPVACAAALANIELMERERICEHVRDVGPYFIRRLDALRRLPIVGDVRGDHLMACIECTSGAGATGALP
TPADIAIAQRVDRHCEEMGLLVRPYESMCILSPPLTVTRADIDEICAILAAALERAQRELAQHAPVREENETC
>Mature_472_residues
AYRNDSLLTSAQQDTRHLLHPWADLSALGRETPTVIVEAQGTRVTDAEGRTYLDAIGGMWCVTLGYGRREIADAIRDQAL
RMPFYTPFGAMTNEPAAALGARLAALAPGDLKRVHLTTCGSTAVESALRFAHYYFGATGRPHKRHIVTRGDAYHGSTYLA
ASISGKAWDRTCFHYDSTIVHHLSSPNPYRRPAGMSVDAFCASLVDEFDALIAKLGAEQIACFIAEPILASGGVIVPPPG
YLAAMRERCRRHDILYISDEVVTGFGRVGHFFASHAHFGIEPDMIVVAKGLTSGYQPLGAVLISERLVDAVSGEHAYGNG
VFTNGFTYSGHPVACAAALANIELMERERICEHVRDVGPYFIRRLDALRRLPIVGDVRGDHLMACIECTSGAGATGALPT
PADIAIAQRVDRHCEEMGLLVRPYESMCILSPPLTVTRADIDEICAILAAALERAQRELAQHAPVREENETC

Specific function: Biotin biosynthesis. [C]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=456, Percent_Identity=26.7543859649123, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI37574042, Length=435, Percent_Identity=27.816091954023, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI226442705, Length=436, Percent_Identity=27.5229357798165, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI24119277, Length=436, Percent_Identity=27.0642201834862, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI4557809, Length=424, Percent_Identity=26.8867924528302, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI226442709, Length=366, Percent_Identity=28.6885245901639, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI284507298, Length=293, Percent_Identity=29.6928327645051, Blast_Score=118, Evalue=2e-26,
Organism=Escherichia coli, GI1786991, Length=446, Percent_Identity=30.0448430493274, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1788044, Length=428, Percent_Identity=28.9719626168224, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI145693181, Length=349, Percent_Identity=30.0859598853868, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1789016, Length=436, Percent_Identity=29.8165137614679, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1787560, Length=425, Percent_Identity=30.3529411764706, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1789759, Length=412, Percent_Identity=28.1553398058252, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI1786349, Length=316, Percent_Identity=27.8481012658228, Blast_Score=83, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI32564660, Length=447, Percent_Identity=28.4116331096197, Blast_Score=151, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI25144271, Length=423, Percent_Identity=25.0591016548463, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI25144274, Length=267, Percent_Identity=28.8389513108614, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71992977, Length=444, Percent_Identity=25.2252252252252, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17541228, Length=459, Percent_Identity=23.7472766884532, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324386, Length=485, Percent_Identity=25.1546391752577, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323470, Length=418, Percent_Identity=27.0334928229665, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324432, Length=421, Percent_Identity=26.3657957244656, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321456, Length=359, Percent_Identity=23.6768802228412, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28574759, Length=449, Percent_Identity=28.2850779510022, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI161085790, Length=450, Percent_Identity=27.7777777777778, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI21356575, Length=426, Percent_Identity=28.169014084507, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI21357415, Length=430, Percent_Identity=25.1162790697674, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.62 [C]

Molecular weight: Translated: 51355; Mature: 51224

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYRNDSLLTSAQQDTRHLLHPWADLSALGRETPTVIVEAQGTRVTDAEGRTYLDAIGGM
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCEEECCCCCCHHHHHCCE
WCVTLGYGRREIADAIRDQALRMPFYTPFGAMTNEPAAALGARLAALAPGDLKRVHLTTC
EEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEC
GSTAVESALRFAHYYFGATGRPHKRHIVTRGDAYHGSTYLAASISGKAWDRTCFHYDSTI
CHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCHHHHHCHHH
VHHLSSPNPYRRPAGMSVDAFCASLVDEFDALIAKLGAEQIACFIAEPILASGGVIVPPP
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEECCC
GYLAAMRERCRRHDILYISDEVVTGFGRVGHFFASHAHFGIEPDMIVVAKGLTSGYQPLG
HHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHH
AVLISERLVDAVSGEHAYGNGVFTNGFTYSGHPVACAAALANIELMERERICEHVRDVGP
HHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
YFIRRLDALRRLPIVGDVRGDHLMACIECTSGAGATGALPTPADIAIAQRVDRHCEEMGL
HHHHHHHHHHHCCCEECCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
LVRPYESMCILSPPLTVTRADIDEICAILAAALERAQRELAQHAPVREENETC
EECCCCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AYRNDSLLTSAQQDTRHLLHPWADLSALGRETPTVIVEAQGTRVTDAEGRTYLDAIGGM
CCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEECCCEEECCCCCCHHHHHCCE
WCVTLGYGRREIADAIRDQALRMPFYTPFGAMTNEPAAALGARLAALAPGDLKRVHLTTC
EEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEC
GSTAVESALRFAHYYFGATGRPHKRHIVTRGDAYHGSTYLAASISGKAWDRTCFHYDSTI
CHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCHHHHHCHHH
VHHLSSPNPYRRPAGMSVDAFCASLVDEFDALIAKLGAEQIACFIAEPILASGGVIVPPP
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEECCC
GYLAAMRERCRRHDILYISDEVVTGFGRVGHFFASHAHFGIEPDMIVVAKGLTSGYQPLG
HHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHH
AVLISERLVDAVSGEHAYGNGVFTNGFTYSGHPVACAAALANIELMERERICEHVRDVGP
HHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
YFIRRLDALRRLPIVGDVRGDHLMACIECTSGAGATGALPTPADIAIAQRVDRHCEEMGL
HHHHHHHHHHHCCCEECCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
LVRPYESMCILSPPLTVTRADIDEICAILAAALERAQRELAQHAPVREENETC
EECCCCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Amino-7-oxononanoate; S-Adenosyl-L-methionine [C]

Specific reaction: 8-Amino-7-oxononanoate + S-Adenosyl-L-methionine <==> S-Adenosyl-4-methylthio-2-oxobutanoate + 7,8-Diaminononanoate [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]