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The map label for this gene is ptxR [H]

Identifier: 53721202

GI number: 53721202

Start: 219213

End: 220175

Strand: Reverse

Name: ptxR [H]

Synonym: BPSS0166

Alternate gene names: 53721202

Gene position: 220175-219213 (Counterclockwise)

Preceding gene: 53721203

Following gene: 53721192

Centisome position: 6.94

GC content: 65.42

Gene sequence:

>963_bases
ATGACCGTTCTTGAGGTGGGAAATATGTCCGAGGTGGGGATAAGAAATTTGAATCACCTGCGCGTTTTCATGGCGATCGT
CGAGAAGGGCAGCTTCACTGCGGCGGCCGAATGCCTGAGCATGTCGAAATCACTGGTCAGCGAATACCTGAGCCGCCTCG
AAGCCGAGATCGACACGCAGCTCGTGATGCGCAGCACCCGCCGGATCGCGCCGACCGACGCCGGCAACAAGCTGTATTGC
GCGTCGCAGGCGTTCGTGAGCGGCCTGTACGACGTGATCGGCAGCATCCGCTGCCTGCGCCACGAATCGACCGGCCTGTT
GCGCGTCGCGGCGCCGAGCGGCTTTTCCACCACGCATCTGAGCTCGATCGCCGCGACCTTCATTCATCAGCATCCGCAGA
TCGAGCTCGAGATCGTCTGCAACGACGACGAGATCGATCTGGTGGGCGAGCGCGTCGATCTCGCGTTCGAAACCGGATGG
CCCAAGAAGAAGGGCTTCCGGATGAAGATGCTCGGCGCGTTCGATCAGGTGCTCGTCGCGTCGCCCGAGTATTCGCGCAG
GCACGCGGTGCCGCGGCATCCGGACGATCTGCCCGGCTCGCACTGGATCGGGCACGGCGGGCTCGCCAATCTCAGCTATT
CGGTGTTCGGCAACGAGGGGCGATCGGTCCGGATTCAGACCCCCGGGCGCCTGAAGGTGAAGAGCGTGCTGCTCGCGCAT
CAGATGGCGCTCGCCGGCGCGGGCATCAGTGCGTTTCCCGATTATCTGGTCGCCGAGGATCTGCGCGAAGGGCGCCTGCA
TCGGCTGCTGCCGACGTGGACGATGCCGAAGGGCGGCATCTACGCGTTTCGCACGGCGCCGCGGCAGGCGTCGGTTCGCG
AGCGCCTGTTTCTCGCCGCGGTCCAGGCGTATCTGGCCGGCCTGTGCGGCGAGCACGCGCGCGCGGGCGCGGTCCCGACC
TAG

Upstream 100 bases:

>100_bases
TATCCAGCACCGGGCTCATGTCGCCGAATCGCGATGCAGCGCCCGCGCGACATCGGCGCCTCGCCCGCGAACGGGCGAGC
GCCACTCGGTATTTCGAAAC

Downstream 100 bases:

>100_bases
CCGCGCGCGGCGCGGTGGGTCGCGACGCGGCATGGCTCGGCTCGGTGCGCACCGGGTGCCCGCGTCGATGCCCCGAGTCA
ACGGGACGCCGATTGCATCC

Product: LysR family regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MTVLEVGNMSEVGIRNLNHLRVFMAIVEKGSFTAAAECLSMSKSLVSEYLSRLEAEIDTQLVMRSTRRIAPTDAGNKLYC
ASQAFVSGLYDVIGSIRCLRHESTGLLRVAAPSGFSTTHLSSIAATFIHQHPQIELEIVCNDDEIDLVGERVDLAFETGW
PKKKGFRMKMLGAFDQVLVASPEYSRRHAVPRHPDDLPGSHWIGHGGLANLSYSVFGNEGRSVRIQTPGRLKVKSVLLAH
QMALAGAGISAFPDYLVAEDLREGRLHRLLPTWTMPKGGIYAFRTAPRQASVRERLFLAAVQAYLAGLCGEHARAGAVPT

Sequences:

>Translated_320_residues
MTVLEVGNMSEVGIRNLNHLRVFMAIVEKGSFTAAAECLSMSKSLVSEYLSRLEAEIDTQLVMRSTRRIAPTDAGNKLYC
ASQAFVSGLYDVIGSIRCLRHESTGLLRVAAPSGFSTTHLSSIAATFIHQHPQIELEIVCNDDEIDLVGERVDLAFETGW
PKKKGFRMKMLGAFDQVLVASPEYSRRHAVPRHPDDLPGSHWIGHGGLANLSYSVFGNEGRSVRIQTPGRLKVKSVLLAH
QMALAGAGISAFPDYLVAEDLREGRLHRLLPTWTMPKGGIYAFRTAPRQASVRERLFLAAVQAYLAGLCGEHARAGAVPT
>Mature_319_residues
TVLEVGNMSEVGIRNLNHLRVFMAIVEKGSFTAAAECLSMSKSLVSEYLSRLEAEIDTQLVMRSTRRIAPTDAGNKLYCA
SQAFVSGLYDVIGSIRCLRHESTGLLRVAAPSGFSTTHLSSIAATFIHQHPQIELEIVCNDDEIDLVGERVDLAFETGWP
KKKGFRMKMLGAFDQVLVASPEYSRRHAVPRHPDDLPGSHWIGHGGLANLSYSVFGNEGRSVRIQTPGRLKVKSVLLAHQ
MALAGAGISAFPDYLVAEDLREGRLHRLLPTWTMPKGGIYAFRTAPRQASVRERLFLAAVQAYLAGLCGEHARAGAVPT

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=292, Percent_Identity=26.7123287671233, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI145693193, Length=301, Percent_Identity=30.2325581395349, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI87081978, Length=299, Percent_Identity=27.7591973244147, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1786401, Length=297, Percent_Identity=25.2525252525253, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787589, Length=284, Percent_Identity=27.112676056338, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1789440, Length=288, Percent_Identity=25.3472222222222, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787128, Length=293, Percent_Identity=25.2559726962457, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788706, Length=175, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=8e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35011; Mature: 34880

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLEVGNMSEVGIRNLNHLRVFMAIVEKGSFTAAAECLSMSKSLVSEYLSRLEAEIDTQ
CEEEECCCCCHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVMRSTRRIAPTDAGNKLYCASQAFVSGLYDVIGSIRCLRHESTGLLRVAAPSGFSTTHL
HHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCHHHH
SSIAATFIHQHPQIELEIVCNDDEIDLVGERVDLAFETGWPKKKGFRMKMLGAFDQVLVA
HHHHHHHHHCCCCEEEEEEECCCCEEEECCEEEEEEECCCCCCCCCEEHHHHHHHHHHCC
SPEYSRRHAVPRHPDDLPGSHWIGHGGLANLSYSVFGNEGRSVRIQTPGRLKVKSVLLAH
CCCHHHHCCCCCCCCCCCCCCEECCCCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHH
QMALAGAGISAFPDYLVAEDLREGRLHRLLPTWTMPKGGIYAFRTAPRQASVRERLFLAA
HHHHHCCCHHHCCHHHHHHHHHHCCHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
VQAYLAGLCGEHARAGAVPT
HHHHHHHHHCCHHCCCCCCC
>Mature Secondary Structure 
TVLEVGNMSEVGIRNLNHLRVFMAIVEKGSFTAAAECLSMSKSLVSEYLSRLEAEIDTQ
EEEECCCCCHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVMRSTRRIAPTDAGNKLYCASQAFVSGLYDVIGSIRCLRHESTGLLRVAAPSGFSTTHL
HHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCHHHH
SSIAATFIHQHPQIELEIVCNDDEIDLVGERVDLAFETGWPKKKGFRMKMLGAFDQVLVA
HHHHHHHHHCCCCEEEEEEECCCCEEEECCEEEEEEECCCCCCCCCEEHHHHHHHHHHCC
SPEYSRRHAVPRHPDDLPGSHWIGHGGLANLSYSVFGNEGRSVRIQTPGRLKVKSVLLAH
CCCHHHHCCCCCCCCCCCCCCEECCCCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHH
QMALAGAGISAFPDYLVAEDLREGRLHRLLPTWTMPKGGIYAFRTAPRQASVRERLFLAA
HHHHHCCCHHHCCHHHHHHHHHHCCHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
VQAYLAGLCGEHARAGAVPT
HHHHHHHHHCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]