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The map label for this gene is ispD

Identifier: 53719710

GI number: 53719710

Start: 2518595

End: 2519305

Strand: Reverse

Name: ispD

Synonym: BPSL2099

Alternate gene names: 53719710

Gene position: 2519305-2518595 (Counterclockwise)

Preceding gene: 53719715

Following gene: 53719709

Centisome position: 61.83

GC content: 71.59

Gene sequence:

>711_bases
GTGACCTCCCGACTTTTTGCCCTGATTCCGTGCGCCGGCACCGGCAGCCGTTCCGGCTCGGCATTGCCGAAGCAATACCG
CACGCTCGCCGGACGCGCGCTGCTGCACTACACGCTTGCCGCGTTCGACGCATGCAGCGAGTTCGCGCAGACGCTCGTCG
TGATCTCTCCCGACGACGCCCACTTCGACGCGCGCCGCTTCGCCGGCCTGCGCTTCGCGGTGCGGCGCTGCGGCGGCGCG
TCGCGGCAGGCGTCGGTGATGAACGGGCTGATCCAGCTCGCCGAATTCGGCGCGACGGACGCCGACTGGGTGCTCGTGCA
CGACGCCGCGCGCCCCGGCATCACGCCGGCGCTGATCCGCACGCTGATCGGCGCGCTGAAGGACGACCCCGTCGGCGGCA
TCGTCGCGCTGCCGGTCGCCGACACGCTCAAGCGCGTGCCGGCGGGCGGCGACGCGATCGAGCGCACCGAATCGCGCAAC
GGCCTCTGGCAGGCGCAGACGCCGCAGATGTTCCGCATCGGCATGCTGCGCGACGCGATCCGGCGCGCGCAGCTCGATGG
CCACGACCTGACCGACGAGGCGAGCGCGATCGAATGGGCGGGCCACACGCCGCGCGTCGTGCAGGGCAGCCTGCGCAACT
TCAAGGTCACGTATCCGGAGGATTTCGACCTCGCGGAGGCGATCCTCGCGCAACCGGCGCGCGCTTCCTGA

Upstream 100 bases:

>100_bases
GCGAACGCCGGATGGCGGACGAGCTCGGCGCGGCGCATCGCGGCGAAAGACGTATTATAAAATCCGTCCTTCGATTTCAT
CTTCCCGGCGTTCCCTTTCC

Downstream 100 bases:

>100_bases
ACCGCATCTTCACCATCGCATCACACTCGGATCGAATCACATGGATTTCAGAATCGGACAAGGCTACGACGTGCACCAGC
TCGTTCCCGGACGCCCGCTC

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTSRLFALIPCAGTGSRSGSALPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVISPDDAHFDARRFAGLRFAVRRCGGA
SRQASVMNGLIQLAEFGATDADWVLVHDAARPGITPALIRTLIGALKDDPVGGIVALPVADTLKRVPAGGDAIERTESRN
GLWQAQTPQMFRIGMLRDAIRRAQLDGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFDLAEAILAQPARAS

Sequences:

>Translated_236_residues
MTSRLFALIPCAGTGSRSGSALPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVISPDDAHFDARRFAGLRFAVRRCGGA
SRQASVMNGLIQLAEFGATDADWVLVHDAARPGITPALIRTLIGALKDDPVGGIVALPVADTLKRVPAGGDAIERTESRN
GLWQAQTPQMFRIGMLRDAIRRAQLDGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFDLAEAILAQPARAS
>Mature_235_residues
TSRLFALIPCAGTGSRSGSALPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVISPDDAHFDARRFAGLRFAVRRCGGAS
RQASVMNGLIQLAEFGATDADWVLVHDAARPGITPALIRTLIGALKDDPVGGIVALPVADTLKRVPAGGDAIERTESRNG
LWQAQTPQMFRIGMLRDAIRRAQLDGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFDLAEAILAQPARAS

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family

Homologues:

Organism=Homo sapiens, GI157412259, Length=236, Percent_Identity=24.5762711864407, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1789104, Length=225, Percent_Identity=40.4444444444444, Blast_Score=153, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPD_BURM7 (A3MKM4)

Other databases:

- EMBL:   CP000548
- RefSeq:   YP_001080810.1
- ProteinModelPortal:   A3MKM4
- SMR:   A3MKM4
- GeneID:   4894670
- GenomeReviews:   CP000548_GR
- KEGG:   bmn:BMA10247_1259
- TIGR:   BMA10247_1259
- HOGENOM:   HBG672839
- OMA:   FPQGAIL
- ProtClustDB:   PRK00155
- BioCyc:   BMAL320389:BMA10247_1259-MONOMER
- HAMAP:   MF_00108
- InterPro:   IPR001228
- InterPro:   IPR018294
- TIGRFAMs:   TIGR00453

Pfam domain/function: PF01128 IspD

EC number: =2.7.7.60

Molecular weight: Translated: 25379; Mature: 25248

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRLFALIPCAGTGSRSGSALPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVISPDDA
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
HFDARRFAGLRFAVRRCGGASRQASVMNGLIQLAEFGATDADWVLVHDAARPGITPALIR
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHH
TLIGALKDDPVGGIVALPVADTLKRVPAGGDAIERTESRNGLWQAQTPQMFRIGMLRDAI
HHHHHHCCCCCCCEEEECHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
RRAQLDGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFDLAEAILAQPARAS
HHHHCCCCCCCCCHHHHHCCCCCCHHHHCCCCCEEEECCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
TSRLFALIPCAGTGSRSGSALPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVISPDDA
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
HFDARRFAGLRFAVRRCGGASRQASVMNGLIQLAEFGATDADWVLVHDAARPGITPALIR
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHH
TLIGALKDDPVGGIVALPVADTLKRVPAGGDAIERTESRNGLWQAQTPQMFRIGMLRDAI
HHHHHHCCCCCCCEEEECHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
RRAQLDGHDLTDEASAIEWAGHTPRVVQGSLRNFKVTYPEDFDLAEAILAQPARAS
HHHHCCCCCCCCCHHHHHCCCCCCHHHHCCCCCEEEECCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA