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The map label for this gene is thrS [H]

Identifier: 53719558

GI number: 53719558

Start: 2314737

End: 2316644

Strand: Reverse

Name: thrS [H]

Synonym: BPSL1945

Alternate gene names: 53719558

Gene position: 2316644-2314737 (Counterclockwise)

Preceding gene: 53719559

Following gene: 53719556

Centisome position: 56.86

GC content: 62.26

Gene sequence:

>1908_bases
ATGGTTTCGATACGATTGCCCGACGGCTCGGTTCGCCAATACGAGCATCCGGTGACGGTCGCCGAAGTGGCGGCGTCGAT
CGGCCCCGGTCTGGCGAAGGCCGCGCTCGGCGGCAAGCTCGACGGCGAACTCGTCGATACGTCCGCGCTGATCGATCGCG
ACGCGTCGCTCGCGATCGTCACCGACAAGGATGCCGACGGGCTCGACATCATTCGCCATTCGACCGCCCACTTGCTCGCC
TACGCGGTGAAGGAGTTGCATCCGGACGCGCAGGTGACGATCGGCCCCGTGATCGACAACGGCTTCTACTACGATTTCTC
GTATCACCGCCCGTTTACGCCCGAGGATCTGGAGGCGATCGAAAAGCGCATGCAGGAACTCGCGAAGCGGGACGAGCCCG
TCACGCGCCGCGTCGTGTCGCGCGACGAGGCCGTGTCGTACTTCCGCAGCATCGGCGAGAAATACAAGGCGGAGATCATC
GAATCGATTCCCGCGAGCGACGAGATCAAGCTGTATTCGCACGGCAGCTTCACCGATCTGTGCCGCGGCCCGCACGTGCC
GTCGACGGGCAAGCTGAAGGTTTTCAAGCTGATGAAGGTCGCGGGCGCGTACTGGCGCGGCGATTCGAAGAACGAGCAAC
TGCAGCGGATCTACGGCACAGCCTGGACGAGGAAGGAAGACCAGGACGCGTACCTGCACATGCTCGAAGAGGCGGAAAAG
CGCGATCACCGCAAGCTCGGCAAGCAACTCGACCTGTTCCACATCCAGGAAGAGGCGCCCGGCATGGTGTTCTGGCATCC
GAAGGGCTGGACGCTGTGGCAGCAGGTCGAGCAGTACATGCGCCGTCGCCTCGACGCGGCCGGCTATCTCGAGATCAAGA
CGCCGATGATCATGGATCGTTCGCTGTGGGAGGCGTCCGGCCACTGGCAGAACTATCGCGAGAACATGTTCACGACGGAA
TCGGAGAAGCGCGACTACGCGATCAAGCCGATGAATTGTCCGGGCCACGTGCAGGTGTTCAAGCACGGGCTGCGCTCGTA
TCGCGATCTGCCGCTGCGGTACGCCGAGTTCGGTTCGTGCCACCGTAACGAGGCGTCGGGCGCGCTGCACGGGCTGATGC
GCGTGCGCGGCTTCGTGCAGGACGATGCGCATATTTTCTGTACCGAGGACCAGATCAACTCCGAGGCGATCGCGTTCAAC
AAGCTCGCGATGAGCGTCTACGAGGATTTCGGCTTCGATCGGATCGACATCAAGCTGTCGCTGCGTCCCGAGCAGCGGAT
GGGTTCGGACGAGACGTGGGACCACGCGGAAGAGGGCCTGCGCAACGCGCTGAAGGCATGCGGCCTCGAGTGGGAGGAAC
TGCCGGGCGAGGGCGCGTTCTACGGCCCGAAGATCGAGTACCACATCAAGGACGCGCTCGGCCGCTCGTGGCAATGCGGC
ACGCTGCAACTCGACATGATGCTGCCCGAGCGGCTCGGCGCCGAGTACGTGGCCGAGGACAACAGTCGCCGCCGGCCGGT
GATGCTTCACCGGGCGATTGTCGGCTCGATGGAGCGTTTCCTCGGGATTCTGATCGAGCACCATGCTGGTGCAATGCCGG
TCTGGCTCGCGCCTGCCCACGCGGTTGTGCTGAATATTGCCGAAAGTCAGGCGGAATATGCTCGGACTGTTGCTCAATCG
TTGCAAAAACAAGGGCTTAGAGTGTCGGCCGATTTGCGCAACGAGAAAATTAGCTATAAAATACGCGAGCACACGCTCGA
AAAAGTTCCCTACCTGCTCGTCGTAGGCGACAAGGAGCGTGAAGCACAAACGGTAGCCGTGCGTGCCCGTGGCGGCGTCG
ATCTGGGTGTCATGCCCGTCGAAGCCTTCGTTGAGCGTCTGCGTGAGGACATCCAGGCGTTCAAGTAA

Upstream 100 bases:

>100_bases
AGCGGGGCCGCATTTTTTTTGTTGCGCGTTTTCATTGTTCATTGCCGCGTTCGCGCGTTGATAGTCTGCCGATCACTGAC
GGCATCACGGAGATTGCTAT

Downstream 100 bases:

>100_bases
CCGCCCTGGCAGCGCGGCTCGTTTTTTTAATTTTTAGAGGAAACGTAACATCGCTACTGATAAGTCGTCGCATCGCATCA
ACGGTGAAATCACTGCGCCG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MVSIRLPDGSVRQYEHPVTVAEVAASIGPGLAKAALGGKLDGELVDTSALIDRDASLAIVTDKDADGLDIIRHSTAHLLA
YAVKELHPDAQVTIGPVIDNGFYYDFSYHRPFTPEDLEAIEKRMQELAKRDEPVTRRVVSRDEAVSYFRSIGEKYKAEII
ESIPASDEIKLYSHGSFTDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDSKNEQLQRIYGTAWTRKEDQDAYLHMLEEAEK
RDHRKLGKQLDLFHIQEEAPGMVFWHPKGWTLWQQVEQYMRRRLDAAGYLEIKTPMIMDRSLWEASGHWQNYRENMFTTE
SEKRDYAIKPMNCPGHVQVFKHGLRSYRDLPLRYAEFGSCHRNEASGALHGLMRVRGFVQDDAHIFCTEDQINSEAIAFN
KLAMSVYEDFGFDRIDIKLSLRPEQRMGSDETWDHAEEGLRNALKACGLEWEELPGEGAFYGPKIEYHIKDALGRSWQCG
TLQLDMMLPERLGAEYVAEDNSRRRPVMLHRAIVGSMERFLGILIEHHAGAMPVWLAPAHAVVLNIAESQAEYARTVAQS
LQKQGLRVSADLRNEKISYKIREHTLEKVPYLLVVGDKEREAQTVAVRARGGVDLGVMPVEAFVERLREDIQAFK

Sequences:

>Translated_635_residues
MVSIRLPDGSVRQYEHPVTVAEVAASIGPGLAKAALGGKLDGELVDTSALIDRDASLAIVTDKDADGLDIIRHSTAHLLA
YAVKELHPDAQVTIGPVIDNGFYYDFSYHRPFTPEDLEAIEKRMQELAKRDEPVTRRVVSRDEAVSYFRSIGEKYKAEII
ESIPASDEIKLYSHGSFTDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDSKNEQLQRIYGTAWTRKEDQDAYLHMLEEAEK
RDHRKLGKQLDLFHIQEEAPGMVFWHPKGWTLWQQVEQYMRRRLDAAGYLEIKTPMIMDRSLWEASGHWQNYRENMFTTE
SEKRDYAIKPMNCPGHVQVFKHGLRSYRDLPLRYAEFGSCHRNEASGALHGLMRVRGFVQDDAHIFCTEDQINSEAIAFN
KLAMSVYEDFGFDRIDIKLSLRPEQRMGSDETWDHAEEGLRNALKACGLEWEELPGEGAFYGPKIEYHIKDALGRSWQCG
TLQLDMMLPERLGAEYVAEDNSRRRPVMLHRAIVGSMERFLGILIEHHAGAMPVWLAPAHAVVLNIAESQAEYARTVAQS
LQKQGLRVSADLRNEKISYKIREHTLEKVPYLLVVGDKEREAQTVAVRARGGVDLGVMPVEAFVERLREDIQAFK
>Mature_635_residues
MVSIRLPDGSVRQYEHPVTVAEVAASIGPGLAKAALGGKLDGELVDTSALIDRDASLAIVTDKDADGLDIIRHSTAHLLA
YAVKELHPDAQVTIGPVIDNGFYYDFSYHRPFTPEDLEAIEKRMQELAKRDEPVTRRVVSRDEAVSYFRSIGEKYKAEII
ESIPASDEIKLYSHGSFTDLCRGPHVPSTGKLKVFKLMKVAGAYWRGDSKNEQLQRIYGTAWTRKEDQDAYLHMLEEAEK
RDHRKLGKQLDLFHIQEEAPGMVFWHPKGWTLWQQVEQYMRRRLDAAGYLEIKTPMIMDRSLWEASGHWQNYRENMFTTE
SEKRDYAIKPMNCPGHVQVFKHGLRSYRDLPLRYAEFGSCHRNEASGALHGLMRVRGFVQDDAHIFCTEDQINSEAIAFN
KLAMSVYEDFGFDRIDIKLSLRPEQRMGSDETWDHAEEGLRNALKACGLEWEELPGEGAFYGPKIEYHIKDALGRSWQCG
TLQLDMMLPERLGAEYVAEDNSRRRPVMLHRAIVGSMERFLGILIEHHAGAMPVWLAPAHAVVLNIAESQAEYARTVAQS
LQKQGLRVSADLRNEKISYKIREHTLEKVPYLLVVGDKEREAQTVAVRARGGVDLGVMPVEAFVERLREDIQAFK

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=632, Percent_Identity=39.7151898734177, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI38202255, Length=632, Percent_Identity=38.4493670886076, Blast_Score=457, Evalue=1e-128,
Organism=Homo sapiens, GI20070344, Length=649, Percent_Identity=37.1340523882897, Blast_Score=412, Evalue=1e-115,
Organism=Escherichia coli, GI1788013, Length=634, Percent_Identity=59.3059936908517, Blast_Score=794, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=138, Percent_Identity=27.536231884058, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71984184, Length=631, Percent_Identity=38.5103011093502, Blast_Score=473, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI71984192, Length=631, Percent_Identity=38.5103011093502, Blast_Score=473, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322112, Length=651, Percent_Identity=39.1705069124424, Blast_Score=469, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322654, Length=396, Percent_Identity=38.8888888888889, Blast_Score=305, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24583839, Length=631, Percent_Identity=38.8272583201268, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24583842, Length=631, Percent_Identity=38.8272583201268, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI28574141, Length=631, Percent_Identity=38.8272583201268, Blast_Score=476, Evalue=1e-134,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 72266; Mature: 72266

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSIRLPDGSVRQYEHPVTVAEVAASIGPGLAKAALGGKLDGELVDTSALIDRDASLAIV
CEEEECCCCCCHHHCCCCHHHHHHHHHCCCHHHHHHCCCCCCCEECHHHHHCCCCCEEEE
TDKDADGLDIIRHSTAHLLAYAVKELHPDAQVTIGPVIDNGFYYDFSYHRPFTPEDLEAI
ECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCCCCCHHHHHHH
EKRMQELAKRDEPVTRRVVSRDEAVSYFRSIGEKYKAEIIESIPASDEIKLYSHGSFTDL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHH
CRGPHVPSTGKLKVFKLMKVAGAYWRGDSKNEQLQRIYGTAWTRKEDQDAYLHMLEEAEK
HCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RDHRKLGKQLDLFHIQEEAPGMVFWHPKGWTLWQQVEQYMRRRLDAAGYLEIKTPMIMDR
HHHHHHCCCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHCH
SLWEASGHWQNYRENMFTTESEKRDYAIKPMNCPGHVQVFKHGLRSYRDLPLRYAEFGSC
HHHHCCCCHHHHHHHCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCC
HRNEASGALHGLMRVRGFVQDDAHIFCTEDQINSEAIAFNKLAMSVYEDFGFDRIDIKLS
CCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEE
LRPEQRMGSDETWDHAEEGLRNALKACGLEWEELPGEGAFYGPKIEYHIKDALGRSWQCG
ECCHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCEECCEEEEEEHHHCCCCCCCC
TLQLDMMLPERLGAEYVAEDNSRRRPVMLHRAIVGSMERFLGILIEHHAGAMPVWLAPAH
EEEEEECCHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHH
AVVLNIAESQAEYARTVAQSLQKQGLRVSADLRNEKISYKIREHTLEKVPYLLVVGDKER
HHEEHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEHHHHHHHHHCCEEEEECCCCC
EAQTVAVRARGGVDLGVMPVEAFVERLREDIQAFK
CCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVSIRLPDGSVRQYEHPVTVAEVAASIGPGLAKAALGGKLDGELVDTSALIDRDASLAIV
CEEEECCCCCCHHHCCCCHHHHHHHHHCCCHHHHHHCCCCCCCEECHHHHHCCCCCEEEE
TDKDADGLDIIRHSTAHLLAYAVKELHPDAQVTIGPVIDNGFYYDFSYHRPFTPEDLEAI
ECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCCCCCHHHHHHH
EKRMQELAKRDEPVTRRVVSRDEAVSYFRSIGEKYKAEIIESIPASDEIKLYSHGSFTDL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHH
CRGPHVPSTGKLKVFKLMKVAGAYWRGDSKNEQLQRIYGTAWTRKEDQDAYLHMLEEAEK
HCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RDHRKLGKQLDLFHIQEEAPGMVFWHPKGWTLWQQVEQYMRRRLDAAGYLEIKTPMIMDR
HHHHHHCCCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHCH
SLWEASGHWQNYRENMFTTESEKRDYAIKPMNCPGHVQVFKHGLRSYRDLPLRYAEFGSC
HHHHCCCCHHHHHHHCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCC
HRNEASGALHGLMRVRGFVQDDAHIFCTEDQINSEAIAFNKLAMSVYEDFGFDRIDIKLS
CCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEE
LRPEQRMGSDETWDHAEEGLRNALKACGLEWEELPGEGAFYGPKIEYHIKDALGRSWQCG
ECCHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCEECCEEEEEEHHHCCCCCCCC
TLQLDMMLPERLGAEYVAEDNSRRRPVMLHRAIVGSMERFLGILIEHHAGAMPVWLAPAH
EEEEEECCHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHH
AVVLNIAESQAEYARTVAQSLQKQGLRVSADLRNEKISYKIREHTLEKVPYLLVVGDKER
HHEEHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEHHHHHHHHHCCEEEEECCCCC
EAQTVAVRARGGVDLGVMPVEAFVERLREDIQAFK
CCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA