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The map label for this gene is kynU [H]

Identifier: 53718486

GI number: 53718486

Start: 986413

End: 987663

Strand: Reverse

Name: kynU [H]

Synonym: BPSL0847

Alternate gene names: 53718486

Gene position: 987663-986413 (Counterclockwise)

Preceding gene: 53718487

Following gene: 53718485

Centisome position: 24.24

GC content: 70.42

Gene sequence:

>1251_bases
ATGAAAACACGTGAAGAAGCGCTCGCGCTCGACCGCGACGACCCGCTCGCGCCGCTGCGCGAGCAGTTCGCGCTGCCCGC
CGGCGTGATCTATCTCGACGGCAATTCGCTCGGCGCGCAGCCGCGCGCGGCGGCCGCCCGCGCGCAACAGGTGATCGGCG
CCGAATGGGGCGAAGGCCTCATCCGCAGCTGGAACACGGCCGGCTGGTTCGCGCTGCCGCGCCGGCTCGGCGACAGGCTC
GCGCCGCTCATCGGCGCGGCCGACGGCGAGGTCGCGATCACCGATACGATCTCGATCAACCTGTTCAAGCTGCTGGCCGC
GATGCTGCGGCACCAGGCGCGGCACGCGCCGAAGCGCCGCGTGATCGTGTCGGAGCGCTCGAACTTCCCGACCGACCTGT
ACATCGCGCAGGGCCTGATCGCGCAGTTCGACCGCGACTACGAACTGCGCCTCATCGACGATCCCGCCGATCTGCCCGAC
GCGCTCGACGACGAGACCGCCGTCGCGATGATCACCCACGTGAACTACCGCACGGGCTACATGCACGACATGCCGTCCGT
CACGCAGACGGTTCGCCAGGCCGGCGCGCTGATGCTGTGGGATCTCGCGCATTCGGCGGGCGCCGTGCCCGTCGATCTGA
ACGGCGCGCTCGCCGACGGCGCGGTGGGTTGCACGTACAAGTACCTGAACGGCGGCCCCGGCTCGCCCGCGTTCGTCTGG
GTGCCCAAGCGCCATCAGCGGGCGTTCGAGCAGCCGCTGTCCGGCTGGTGGGGCCATCGCGCGCCGTTCGCGATGCAGCC
CGCGTTCGAGCCCGATCCGGGCATCGCGCGCTTTCTGTGCGGCACGCAGCCGATCGTGTCGATGTCGATGGTCGAATGCG
GGCTCGACGTGTTCGCGCAGACCGACATGCACGCGATCCGCCGCAAATCGCTCGCGCTCACCGACGCGTTCGTCGCGCTC
GTCGAATCGCGCTGCGCGGGCCAGCCGCTCAAGCTCGTCACGCCGCGCGCGCATCATCAGCGCGGCTCGCAGGCGAGCTT
CGAGCATCCGCACGGCTACGAGGTGATGCAGGCGCTGATCGCGCGCGGCGTGATCGGCGACTACCGCGAGCCGCGCATCC
TGCGCTTCGGCTTCACGCCGCTCTACACGCGCTTCGTCGACGTGTGGGACGCGGTCGAGACGCTGCGCGACATTCTCGAC
ACCGAGGCATGGCGCGCGCCCGAGTTCGCCACGCGCGCCGCGGTGACCTGA

Upstream 100 bases:

>100_bases
CGCTCGACGCGAGCCCCGTGCGCGCGGTGCTGCGCGCGCTGCCCGCCGCGCCGCGCTGAAGACGCATGCGCGTGCCCCCT
CCCCAACCAGGTTCGACATC

Downstream 100 bases:

>100_bases
GCCCGCGCGAGCGCCGCGCGAAGCGTGCGGCCATCGGCCGGATCGGCCGCCCGCACCGCCCCATCTATTCCATGGAGACA
AACGTGAATTCAGGTCACAT

Product: hypothetical protein

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKTREEALALDRDDPLAPLREQFALPAGVIYLDGNSLGAQPRAAAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGDRL
APLIGAADGEVAITDTISINLFKLLAAMLRHQARHAPKRRVIVSERSNFPTDLYIAQGLIAQFDRDYELRLIDDPADLPD
ALDDETAVAMITHVNYRTGYMHDMPSVTQTVRQAGALMLWDLAHSAGAVPVDLNGALADGAVGCTYKYLNGGPGSPAFVW
VPKRHQRAFEQPLSGWWGHRAPFAMQPAFEPDPGIARFLCGTQPIVSMSMVECGLDVFAQTDMHAIRRKSLALTDAFVAL
VESRCAGQPLKLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPRILRFGFTPLYTRFVDVWDAVETLRDILD
TEAWRAPEFATRAAVT

Sequences:

>Translated_416_residues
MKTREEALALDRDDPLAPLREQFALPAGVIYLDGNSLGAQPRAAAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGDRL
APLIGAADGEVAITDTISINLFKLLAAMLRHQARHAPKRRVIVSERSNFPTDLYIAQGLIAQFDRDYELRLIDDPADLPD
ALDDETAVAMITHVNYRTGYMHDMPSVTQTVRQAGALMLWDLAHSAGAVPVDLNGALADGAVGCTYKYLNGGPGSPAFVW
VPKRHQRAFEQPLSGWWGHRAPFAMQPAFEPDPGIARFLCGTQPIVSMSMVECGLDVFAQTDMHAIRRKSLALTDAFVAL
VESRCAGQPLKLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPRILRFGFTPLYTRFVDVWDAVETLRDILD
TEAWRAPEFATRAAVT
>Mature_416_residues
MKTREEALALDRDDPLAPLREQFALPAGVIYLDGNSLGAQPRAAAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGDRL
APLIGAADGEVAITDTISINLFKLLAAMLRHQARHAPKRRVIVSERSNFPTDLYIAQGLIAQFDRDYELRLIDDPADLPD
ALDDETAVAMITHVNYRTGYMHDMPSVTQTVRQAGALMLWDLAHSAGAVPVDLNGALADGAVGCTYKYLNGGPGSPAFVW
VPKRHQRAFEQPLSGWWGHRAPFAMQPAFEPDPGIARFLCGTQPIVSMSMVECGLDVFAQTDMHAIRRKSLALTDAFVAL
VESRCAGQPLKLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPRILRFGFTPLYTRFVDVWDAVETLRDILD
TEAWRAPEFATRAAVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=444, Percent_Identity=27.9279279279279, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI74101437, Length=277, Percent_Identity=26.3537906137184, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17550466, Length=395, Percent_Identity=26.0759493670886, Blast_Score=145, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323261, Length=456, Percent_Identity=30.0438596491228, Blast_Score=166, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 45899; Mature: 45899

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTREEALALDRDDPLAPLREQFALPAGVIYLDGNSLGAQPRAAAARAQQVIGAEWGEGL
CCCHHHHHCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCHH
IRSWNTAGWFALPRRLGDRLAPLIGAADGEVAITDTISINLFKLLAAMLRHQARHAPKRR
HHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCE
VIVSERSNFPTDLYIAQGLIAQFDRDYELRLIDDPADLPDALDDETAVAMITHVNYRTGY
EEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCC
MHDMPSVTQTVRQAGALMLWDLAHSAGAVPVDLNGALADGAVGCTYKYLNGGPGSPAFVW
CCCCHHHHHHHHHCCCEEEEEHHHCCCCCEEECCCCCCCCCCCEEEEECCCCCCCCEEEE
VPKRHQRAFEQPLSGWWGHRAPFAMQPAFEPDPGIARFLCGTQPIVSMSMVECGLDVFAQ
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHH
TDMHAIRRKSLALTDAFVALVESRCAGQPLKLVTPRAHHQRGSQASFEHPHGYEVMQALI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCCCCCCCCCCHHHHHHHH
ARGVIGDYREPRILRFGFTPLYTRFVDVWDAVETLRDILDTEAWRAPEFATRAAVT
HHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC
>Mature Secondary Structure
MKTREEALALDRDDPLAPLREQFALPAGVIYLDGNSLGAQPRAAAARAQQVIGAEWGEGL
CCCHHHHHCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCHH
IRSWNTAGWFALPRRLGDRLAPLIGAADGEVAITDTISINLFKLLAAMLRHQARHAPKRR
HHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCE
VIVSERSNFPTDLYIAQGLIAQFDRDYELRLIDDPADLPDALDDETAVAMITHVNYRTGY
EEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCC
MHDMPSVTQTVRQAGALMLWDLAHSAGAVPVDLNGALADGAVGCTYKYLNGGPGSPAFVW
CCCCHHHHHHHHHCCCEEEEEHHHCCCCCEEECCCCCCCCCCCEEEEECCCCCCCCEEEE
VPKRHQRAFEQPLSGWWGHRAPFAMQPAFEPDPGIARFLCGTQPIVSMSMVECGLDVFAQ
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHH
TDMHAIRRKSLALTDAFVALVESRCAGQPLKLVTPRAHHQRGSQASFEHPHGYEVMQALI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCCCCCCCCCCHHHHHHHH
ARGVIGDYREPRILRFGFTPLYTRFVDVWDAVETLRDILDTEAWRAPEFATRAAVT
HHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA