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The map label for this gene is kynA [H]

Identifier: 53718485

GI number: 53718485

Start: 985394

End: 986314

Strand: Reverse

Name: kynA [H]

Synonym: BPSL0846

Alternate gene names: 53718485

Gene position: 986314-985394 (Counterclockwise)

Preceding gene: 53718486

Following gene: 53718479

Centisome position: 24.21

GC content: 68.95

Gene sequence:

>921_bases
ATGCAGCCGCCCGGCGACGACGCCGCGCCCCGCTGCCCGTTCGCCGGCGCGCACGCGCCCGACGCGCCGCACGTGCCCGA
GGCCGCCGGCGACGACGCGCAGGCCGGCTGGCATCGCGCGCAGCTCGACTTCTCGCAATCGATGAGCTACGGCGATTACC
TGTCGCTCGACCCGATCCTCGATGCGCAGCATCCGCGCTCGCCCGATCACAACGAGATGCTGTTCATCATCCAGCATCAG
ACGAGCGAGCTGTGGATGAAGCTCGCGCTCTACGAACTGCGCGCGGCGCTCGCGTCGATCCGCGACGACGCGCTGCCGCC
CGCGTTCAAGATGCTCGCGCGCGTGTCGCGCGTGCTCGAGCAGCTCGTGCAGGCGTGGAACGTGCTCGCGACGATGACGC
CGTCCGAATACTCGGCGATGCGGCCGTATCTCGGCGCGTCGTCGGGCTTCCAGTCGTACCAGTATCGGGAGCTGGAGTTC
ATCCTCGGCAACAAGAACGCGCAGATGCTGCGCCCGCACGCGCACCGGCCGGCGATTCATGCGCATCTGGAAGCGTCGCT
GCAGGCGCCGTCGCTATACGATGAAGTGATTCGCCTGCTCGCGCGGCGCGGCTTTCCGATCGCGCCCGAGCGGCTCGACG
CCGACTGGACGCAGCCGACGCGCCACGATCGCACCGTCGAGGCCGCGTGGCTCGCGGTGTACCGCGAGCCGAACGCGCAC
TGGGAGCTGTACGAGATGGCCGAAGAGCTCGTCGATCTCGAGGACGCGTTCCGCCAATGGCGCTTCCGCCACGTGACGAC
GGTCGAGCGGATCATCGGCTTCAAGCAGGGCACGGGCGGCACGAGCGGCGCGCCGTATCTGCGCAAGATGCTCGACGTCG
TGCTGTTCCCCGAACTCTGGCACGTGCGCACGACGCTGTAG

Upstream 100 bases:

>100_bases
GAGCCCGCGCGAGCGCCGCGCGAAGCGTGCGGCCATCGGCCGGATCGGCCGCCCGCACCGCCCCATCTATTCCATGGAGA
CAAACGTGAATTCAGGTCAC

Downstream 100 bases:

>100_bases
CGCCGCGCGCACGCGCGGCGAAGCGTCAGGGCGCGGTGCGCGCGAGCTCGTCGGCCGCCGGCAGCCCGCCGCGGCGCAGC
CGCGGAATGTGCCGGCGCAG

Product: putative tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MQPPGDDAAPRCPFAGAHAPDAPHVPEAAGDDAQAGWHRAQLDFSQSMSYGDYLSLDPILDAQHPRSPDHNEMLFIIQHQ
TSELWMKLALYELRAALASIRDDALPPAFKMLARVSRVLEQLVQAWNVLATMTPSEYSAMRPYLGASSGFQSYQYRELEF
ILGNKNAQMLRPHAHRPAIHAHLEASLQAPSLYDEVIRLLARRGFPIAPERLDADWTQPTRHDRTVEAAWLAVYREPNAH
WELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL

Sequences:

>Translated_306_residues
MQPPGDDAAPRCPFAGAHAPDAPHVPEAAGDDAQAGWHRAQLDFSQSMSYGDYLSLDPILDAQHPRSPDHNEMLFIIQHQ
TSELWMKLALYELRAALASIRDDALPPAFKMLARVSRVLEQLVQAWNVLATMTPSEYSAMRPYLGASSGFQSYQYRELEF
ILGNKNAQMLRPHAHRPAIHAHLEASLQAPSLYDEVIRLLARRGFPIAPERLDADWTQPTRHDRTVEAAWLAVYREPNAH
WELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL
>Mature_306_residues
MQPPGDDAAPRCPFAGAHAPDAPHVPEAAGDDAQAGWHRAQLDFSQSMSYGDYLSLDPILDAQHPRSPDHNEMLFIIQHQ
TSELWMKLALYELRAALASIRDDALPPAFKMLARVSRVLEQLVQAWNVLATMTPSEYSAMRPYLGASSGFQSYQYRELEF
ILGNKNAQMLRPHAHRPAIHAHLEASLQAPSLYDEVIRLLARRGFPIAPERLDADWTQPTRHDRTVEAAWLAVYREPNAH
WELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=166, Percent_Identity=36.144578313253, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32564651, Length=174, Percent_Identity=29.8850574712644, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17552370, Length=174, Percent_Identity=29.8850574712644, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17530891, Length=370, Percent_Identity=29.1891891891892, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017485
- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 34814; Mature: 34814

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPPGDDAAPRCPFAGAHAPDAPHVPEAAGDDAQAGWHRAQLDFSQSMSYGDYLSLDPIL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHCCCCCCCCCCCCCC
DAQHPRSPDHNEMLFIIQHQTSELWMKLALYELRAALASIRDDALPPAFKMLARVSRVLE
CCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
QLVQAWNVLATMTPSEYSAMRPYLGASSGFQSYQYRELEFILGNKNAQMLRPHAHRPAIH
HHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHEEEEEEECCCCHHHCCCCCCCCHHH
AHLEASLQAPSLYDEVIRLLARRGFPIAPERLDADWTQPTRHDRTVEAAWLAVYREPNAH
HHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHEEECCCCC
WELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
HVRTTL
HHHHCC
>Mature Secondary Structure
MQPPGDDAAPRCPFAGAHAPDAPHVPEAAGDDAQAGWHRAQLDFSQSMSYGDYLSLDPIL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHCCCCCCCCCCCCCC
DAQHPRSPDHNEMLFIIQHQTSELWMKLALYELRAALASIRDDALPPAFKMLARVSRVLE
CCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
QLVQAWNVLATMTPSEYSAMRPYLGASSGFQSYQYRELEFILGNKNAQMLRPHAHRPAIH
HHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHEEEEEEECCCCHHHCCCCCCCCHHH
AHLEASLQAPSLYDEVIRLLARRGFPIAPERLDADWTQPTRHDRTVEAAWLAVYREPNAH
HHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHEEECCCCC
WELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
HVRTTL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA