Click here to switch to the map view.

The map label for this gene is hisC1

Identifier: 53718158

GI number: 53718158

Start: 571468

End: 572538

Strand: Reverse

Name: hisC1

Synonym: BPSL0518

Alternate gene names: 53718158

Gene position: 572538-571468 (Counterclockwise)

Preceding gene: 53718159

Following gene: 53718154

Centisome position: 14.05

GC content: 68.35

Gene sequence:

>1071_bases
GTGAGCCGTTACTGGAGCGACATCGTCCGTCAACTCGAGCCGTATGTGCCGGGCGAGCAGCCGGCGCTCGCGCATCCCGT
CAAGCTGAACACGAACGAGAATCCGTATCCGCCGTCGCCGCGCGCGCTCGACGCGATCCGGCGCGAGCTCGGCGACACGG
GCGAAGCGCTGCGCCGCTATCCGGACCCGGTCGCGCGCAGGCTGCGCGAGACGGTGGCGGCCTATCACGGCATCGCGCCC
GAGCAGGTGTTCGCCGGCAACGGCTCCGACGAAGTGCTCGCGCACGCGTTCCAGGCGCTCCTGCAACACGACAGGCCGCT
GCGCTTCCCGGACATCACGTACAGCTTCTACCCGACCTATGCGCGGCTCTATCGCGTCGCATACGAGACGGTACCGCTCG
CCGACGATTTCTCGATCGTCGTCGACGACTATCTCGACGACGCCGGCTGCGTGCTGTTCCCGAACCCGAACGCGCCGACG
GGCCGCGCGCTGCCGCTTGCCGACATCGAGCGGATCGTCGCCGCCAACCCGAGCTCGGTTGTCGTGATCGACGAGGCCTA
TGTCGATTTCGGCGCGGAATCGGCCGTCTCGCTGATCGCGCGCTATCCGAATCTGCTCGTCGTGCATACCGTGTCGAAGG
CGCGCTCGCTCGCCGGCATGCGCGTCGGCTTCGCGTTCGGCGACGCCGCGCTGATCGACGCGCTCACGCGCGTGAAGGAC
AGCTTCAACTCGTATCCGCTCGACCGTCTCGCGCAAGTCGCGACGCAAGCGTCGTACGAGGACGAGGCGTGGTTCCAGGC
GACGCGCAAGCAGGTGATCGCGAGCCGCGAGCGGCTCGTCGGCGCGCTGGCGGCGCTCGGCTTCGACGTCGTGCCGTCGG
CGGCGAATTTCGTGTTCGCGCGCCCTCGTAGCCACGATGCGGCGACGCTCGCCGCGCAACTGAAACAGCGGGAAATTTTC
GTGCGGCACTTCAAGCTGCCGCGGATCGACCAGCACTTGCGCATCACGGTCGGCTCGGACGCCGAATGCGACGCGCTCGT
CGCGGCGCTGCGGGAGCTGCTCGCCGCTTAA

Upstream 100 bases:

>100_bases
AACGGCGCGTAAGCCGCCGCGGGTGCCGCCCGCGCCTGCCGTGCGCGCCCGCCGCGCGCATCGGTTAAGCTCGTCGTTTT
AACGCATCAGGAGCCACGTG

Downstream 100 bases:

>100_bases
CGTACGACGGGGCACGGGGCGGGCTGGACGACAGGAACGGGCCGACCCGCGCGGTCGGCCGGCGGGCCGCAGCGATATCG
GAACGACGTCGGAACAATAC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSRYWSDIVRQLEPYVPGEQPALAHPVKLNTNENPYPPSPRALDAIRRELGDTGEALRRYPDPVARRLRETVAAYHGIAP
EQVFAGNGSDEVLAHAFQALLQHDRPLRFPDITYSFYPTYARLYRVAYETVPLADDFSIVVDDYLDDAGCVLFPNPNAPT
GRALPLADIERIVAANPSSVVVIDEAYVDFGAESAVSLIARYPNLLVVHTVSKARSLAGMRVGFAFGDAALIDALTRVKD
SFNSYPLDRLAQVATQASYEDEAWFQATRKQVIASRERLVGALAALGFDVVPSAANFVFARPRSHDAATLAAQLKQREIF
VRHFKLPRIDQHLRITVGSDAECDALVAALRELLAA

Sequences:

>Translated_356_residues
MSRYWSDIVRQLEPYVPGEQPALAHPVKLNTNENPYPPSPRALDAIRRELGDTGEALRRYPDPVARRLRETVAAYHGIAP
EQVFAGNGSDEVLAHAFQALLQHDRPLRFPDITYSFYPTYARLYRVAYETVPLADDFSIVVDDYLDDAGCVLFPNPNAPT
GRALPLADIERIVAANPSSVVVIDEAYVDFGAESAVSLIARYPNLLVVHTVSKARSLAGMRVGFAFGDAALIDALTRVKD
SFNSYPLDRLAQVATQASYEDEAWFQATRKQVIASRERLVGALAALGFDVVPSAANFVFARPRSHDAATLAAQLKQREIF
VRHFKLPRIDQHLRITVGSDAECDALVAALRELLAA
>Mature_355_residues
SRYWSDIVRQLEPYVPGEQPALAHPVKLNTNENPYPPSPRALDAIRRELGDTGEALRRYPDPVARRLRETVAAYHGIAPE
QVFAGNGSDEVLAHAFQALLQHDRPLRFPDITYSFYPTYARLYRVAYETVPLADDFSIVVDDYLDDAGCVLFPNPNAPTG
RALPLADIERIVAANPSSVVVIDEAYVDFGAESAVSLIARYPNLLVVHTVSKARSLAGMRVGFAFGDAALIDALTRVKDS
FNSYPLDRLAQVATQASYEDEAWFQATRKQVIASRERLVGALAALGFDVVPSAANFVFARPRSHDAATLAAQLKQREIFV
RHFKLPRIDQHLRITVGSDAECDALVAALRELLAA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=354, Percent_Identity=31.638418079096, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1788722, Length=257, Percent_Identity=28.0155642023346, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=382, Percent_Identity=28.0104712041885, Blast_Score=107, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS81_BURP1 (Q3JW89)

Other databases:

- EMBL:   CP000124
- RefSeq:   YP_332164.1
- ProteinModelPortal:   Q3JW89
- STRING:   Q3JW89
- GeneID:   3690866
- GenomeReviews:   CP000124_GR
- KEGG:   bpm:BURPS1710b_0750
- TIGR:   BURPS1710b_0750
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   MRGELND
- ProtClustDB:   PRK05387
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39286; Mature: 39155

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRYWSDIVRQLEPYVPGEQPALAHPVKLNTNENPYPPSPRALDAIRRELGDTGEALRRY
CCHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHC
PDPVARRLRETVAAYHGIAPEQVFAGNGSDEVLAHAFQALLQHDRPLRFPDITYSFYPTY
CCHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
ARLYRVAYETVPLADDFSIVVDDYLDDAGCVLFPNPNAPTGRALPLADIERIVAANPSSV
HHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCCCCE
VVIDEAYVDFGAESAVSLIARYPNLLVVHTVSKARSLAGMRVGFAFGDAALIDALTRVKD
EEEEHHHHCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHEEHHHCHHHHHHHHHHHHH
SFNSYPLDRLAQVATQASYEDEAWFQATRKQVIASRERLVGALAALGFDVVPSAANFVFA
HHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
RPRSHDAATLAAQLKQREIFVRHFKLPRIDQHLRITVGSDAECDALVAALRELLAA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRYWSDIVRQLEPYVPGEQPALAHPVKLNTNENPYPPSPRALDAIRRELGDTGEALRRY
CHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHC
PDPVARRLRETVAAYHGIAPEQVFAGNGSDEVLAHAFQALLQHDRPLRFPDITYSFYPTY
CCHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
ARLYRVAYETVPLADDFSIVVDDYLDDAGCVLFPNPNAPTGRALPLADIERIVAANPSSV
HHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCCCCE
VVIDEAYVDFGAESAVSLIARYPNLLVVHTVSKARSLAGMRVGFAFGDAALIDALTRVKD
EEEEHHHHCCCHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHEEHHHCHHHHHHHHHHHHH
SFNSYPLDRLAQVATQASYEDEAWFQATRKQVIASRERLVGALAALGFDVVPSAANFVFA
HHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
RPRSHDAATLAAQLKQREIFVRHFKLPRIDQHLRITVGSDAECDALVAALRELLAA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA