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The map label for this gene is pth [H]

Identifier: 53718159

GI number: 53718159

Start: 572627

End: 573232

Strand: Reverse

Name: pth [H]

Synonym: BPSL0519

Alternate gene names: 53718159

Gene position: 573232-572627 (Counterclockwise)

Preceding gene: 161723210

Following gene: 53718158

Centisome position: 14.07

GC content: 67.49

Gene sequence:

>606_bases
ATGATCAAACTGATCGTCGGCCTCGGCAATCCCGGGGCGGAATACACGGCGACGCGCCACAACGCGGGTTTCTGGCTCGT
CGACCAGCTCGCGCGCGAAGCCGGTGCGACGCTGCGCGACGAACGGCGCTTCCACGGCTTCTATGCGAAGGCGCGCCTGT
TCGGCGAGGAAGTGCACCTGCTCGAGCCGCAGACGTACATGAATCGCTCCGGCCAAGCGGTCGTCGCGCTCGCGCATTTC
TTCAAGATCCTGCCGACCGAGATACTCGTCGCGCACGACGAGCTGGACCTGCCGCCCGGCGCGGCAAAGCTCAAGCTCGG
CGGCGGCAGCGGCGGCCACAACGGCCTGAAGGACATCTCCGCACATCTGTCCTCGCAGCAGTACTGGCGGCTGCGGATCG
GCATCGGCCATCCGCGCGACCTGATTCCCGAAAGCGCGCGCGCGGGCGCGAAGCCCGACGTCGCGAACTTCGTGCTGAAG
CCGCCGCGCAAGGACGAGCAGGACCTGATCAACGCCGCGATCGAGCGCGCGCTCGCCGTGATGCCGACCGCCATCAAGGG
CGAGACCGAGCGCGCGATGATGCAGTTGCATCGCAACGGCGCGTAA

Upstream 100 bases:

>100_bases
CGTTTCGCACGACGGTCGACGAGACCCGCCGCGGCTTGCCCGGCGGGTTTTTTCATTTTTGCCGCCCGCGAGGGCGAGCC
CTGACGGGCAAGCGTTCATC

Downstream 100 bases:

>100_bases
GCCGCCGCGGGTGCCGCCCGCGCCTGCCGTGCGCGCCCGCCGCGCGCATCGGTTAAGCTCGTCGTTTTAACGCATCAGGA
GCCACGTGGTGAGCCGTTAC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLFGEEVHLLEPQTYMNRSGQAVVALAHF
FKILPTEILVAHDELDLPPGAAKLKLGGGSGGHNGLKDISAHLSSQQYWRLRIGIGHPRDLIPESARAGAKPDVANFVLK
PPRKDEQDLINAAIERALAVMPTAIKGETERAMMQLHRNGA

Sequences:

>Translated_201_residues
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLFGEEVHLLEPQTYMNRSGQAVVALAHF
FKILPTEILVAHDELDLPPGAAKLKLGGGSGGHNGLKDISAHLSSQQYWRLRIGIGHPRDLIPESARAGAKPDVANFVLK
PPRKDEQDLINAAIERALAVMPTAIKGETERAMMQLHRNGA
>Mature_201_residues
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLFGEEVHLLEPQTYMNRSGQAVVALAHF
FKILPTEILVAHDELDLPPGAAKLKLGGGSGGHNGLKDISAHLSSQQYWRLRIGIGHPRDLIPESARAGAKPDVANFVLK
PPRKDEQDLINAAIERALAVMPTAIKGETERAMMQLHRNGA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=189, Percent_Identity=34.3915343915344, Blast_Score=93, Evalue=2e-19,
Organism=Escherichia coli, GI1787455, Length=197, Percent_Identity=54.8223350253807, Blast_Score=174, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 22026; Mature: 22026

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLFGEEVHL
CEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHEE
LEPQTYMNRSGQAVVALAHFFKILPTEILVAHDELDLPPGAAKLKLGGGSGGHNGLKDIS
ECCHHHHCCCCCHHHHHHHHHHHCCHHHEEECCCCCCCCCCEEEEECCCCCCCCHHHHHH
AHLSSQQYWRLRIGIGHPRDLIPESARAGAKPDVANFVLKPPRKDEQDLINAAIERALAV
HHCCCCCEEEEEEECCCCHHHCCCCCCCCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHH
MPTAIKGETERAMMQLHRNGA
CCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLFGEEVHL
CEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHEE
LEPQTYMNRSGQAVVALAHFFKILPTEILVAHDELDLPPGAAKLKLGGGSGGHNGLKDIS
ECCHHHHCCCCCHHHHHHHHHHHCCHHHEEECCCCCCCCCCEEEEECCCCCCCCHHHHHH
AHLSSQQYWRLRIGIGHPRDLIPESARAGAKPDVANFVLKPPRKDEQDLINAAIERALAV
HHCCCCCEEEEEEECCCCHHHCCCCCCCCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHH
MPTAIKGETERAMMQLHRNGA
CCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA