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The map label for this gene is galK [H]

Identifier: 52787959

GI number: 52787959

Start: 4127074

End: 4128243

Strand: Direct

Name: galK [H]

Synonym: BLi04282

Alternate gene names: 52787959

Gene position: 4127074-4128243 (Clockwise)

Preceding gene: 52787952

Following gene: 52787960

Centisome position: 97.74

GC content: 49.57

Gene sequence:

>1170_bases
ATGAATACTGCAGCCGCTTTATCAAACGACTTTCGTTCTATTTTTAAGACAGAAAAGACACCGCGAACCTTTTTTGCTCC
GGGAAGGATCAACTTAATCGGCGAACACACGGATTATAATGGAGGGCATGTTTTCCCCGCCTCGATTTCATTTGGCACCT
ATGCCCTTGGCGTGAAGCGCGATGATCAAATGATCCGCTTCTATTCAAAGAACTTCCCTGACAAAGGAATAATTGAATGC
AGCTTGAGCGATTTAGCCTTTGACCAGTCCGACGGCTGGGCCAATTATCCGAAGGGAATGTTCCTTTTGACGAAAGCGGC
AGGCCATCAAATCGTTCACGGCGCCGATATTTTGTATTACGGAAATATTCCGCACGGAGCGGGCCTCTCTTCTTCCGCAT
CGATTGAGCTTGCGACAGGCGTTTTGTTAAAAGGGCTTTATGATTTGCAGACAGACACGATCTCCATGGTGAAGCTCGGA
CAAAAAGTCGAAAACGAATACATTGGCGTGGGGAGCGGCATTATGGATCAATTCGCGATCGGCATGGGGAAAAAGGATCA
CGCGATTTTGCTAGACTGCCGTACACTTGATTACACATACGCTCCCTTCGTGTTGAAAGAACACGATGTGATCATCATCA
ATACAAACAAACAGCGGACGCTGGCCGGGTCTAAATATAATGAAAGGCGCACCCAATGTGAAGAGGCGCTCGGCGATCTG
CAACAGGAGTTGTCGATCGCAAGCCTGGGCGAATTGACGATGGAAGGATTTGAAGCCCATCAGCACCTCATCAGAAATGA
AATCAATCAAAAACGCGCCAAACATGCTGTCTACGAAAATGCCCGGACGCTGAAGGCGCTTGAAAAACTTCGCGAAGGCG
ACCTCGCCGGATTTGGCAAGCTGATGAATGAATCCCATTTGTCATTAAGGGATGATTATGAAGTGACGGGGCTGGAGCTT
GATGCCATTGTCCAGGCGGCCTGGGAACAAGACGGTGTCCTTGGCGCCCGCATGACCGGCGCCGGGTTCGGCGGCTGTGC
GATTGCGATTGTAGAAAAAGACCGGACAGACAGCTTTAAAGAACGCGTGAATGCCGTCTACCGCGAAACGGTTGGCTATG
ATGCCGCTTTTTATACTGCGGCAATAGGCGACGGCGCCAAAGAAATATAG

Upstream 100 bases:

>100_bases
ACACTTTTTATTGCACCAATCGAAAACCCGTAGTAAACTGGGGTTGAACTTAATTAAATTAATTTATTAAGTCTGGTACG
TCAAACGAATAGGAGGATAT

Downstream 100 bases:

>100_bases
AAAGGGGAATGGATATGAGCGTGTTGGTTTTGGGCGGTGCCGGCTATATCGGTTCACACGCCGTGTACCAATTAATAGAC
AGAGGCGAAAACGTCGTTGT

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MNTAAALSNDFRSIFKTEKTPRTFFAPGRINLIGEHTDYNGGHVFPASISFGTYALGVKRDDQMIRFYSKNFPDKGIIEC
SLSDLAFDQSDGWANYPKGMFLLTKAAGHQIVHGADILYYGNIPHGAGLSSSASIELATGVLLKGLYDLQTDTISMVKLG
QKVENEYIGVGSGIMDQFAIGMGKKDHAILLDCRTLDYTYAPFVLKEHDVIIINTNKQRTLAGSKYNERRTQCEEALGDL
QQELSIASLGELTMEGFEAHQHLIRNEINQKRAKHAVYENARTLKALEKLREGDLAGFGKLMNESHLSLRDDYEVTGLEL
DAIVQAAWEQDGVLGARMTGAGFGGCAIAIVEKDRTDSFKERVNAVYRETVGYDAAFYTAAIGDGAKEI

Sequences:

>Translated_389_residues
MNTAAALSNDFRSIFKTEKTPRTFFAPGRINLIGEHTDYNGGHVFPASISFGTYALGVKRDDQMIRFYSKNFPDKGIIEC
SLSDLAFDQSDGWANYPKGMFLLTKAAGHQIVHGADILYYGNIPHGAGLSSSASIELATGVLLKGLYDLQTDTISMVKLG
QKVENEYIGVGSGIMDQFAIGMGKKDHAILLDCRTLDYTYAPFVLKEHDVIIINTNKQRTLAGSKYNERRTQCEEALGDL
QQELSIASLGELTMEGFEAHQHLIRNEINQKRAKHAVYENARTLKALEKLREGDLAGFGKLMNESHLSLRDDYEVTGLEL
DAIVQAAWEQDGVLGARMTGAGFGGCAIAIVEKDRTDSFKERVNAVYRETVGYDAAFYTAAIGDGAKEI
>Mature_389_residues
MNTAAALSNDFRSIFKTEKTPRTFFAPGRINLIGEHTDYNGGHVFPASISFGTYALGVKRDDQMIRFYSKNFPDKGIIEC
SLSDLAFDQSDGWANYPKGMFLLTKAAGHQIVHGADILYYGNIPHGAGLSSSASIELATGVLLKGLYDLQTDTISMVKLG
QKVENEYIGVGSGIMDQFAIGMGKKDHAILLDCRTLDYTYAPFVLKEHDVIIINTNKQRTLAGSKYNERRTQCEEALGDL
QQELSIASLGELTMEGFEAHQHLIRNEINQKRAKHAVYENARTLKALEKLREGDLAGFGKLMNESHLSLRDDYEVTGLEL
DAIVQAAWEQDGVLGARMTGAGFGGCAIAIVEKDRTDSFKERVNAVYRETVGYDAAFYTAAIGDGAKEI

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=382, Percent_Identity=38.7434554973822, Blast_Score=245, Evalue=4e-65,
Organism=Homo sapiens, GI4503897, Length=402, Percent_Identity=27.8606965174129, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI48527957, Length=402, Percent_Identity=27.8606965174129, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1786972, Length=368, Percent_Identity=41.304347826087, Blast_Score=268, Evalue=7e-73,
Organism=Caenorhabditis elegans, GI71989053, Length=410, Percent_Identity=27.5609756097561, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319494, Length=287, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320212, Length=271, Percent_Identity=29.8892988929889, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 42791; Mature: 42791

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTAAALSNDFRSIFKTEKTPRTFFAPGRINLIGEHTDYNGGHVFPASISFGTYALGVKR
CCCHHHHHHHHHHHHHCCCCCCEEECCCEEEEEECCCCCCCCEEEEEEECCCEEEEEECC
DDQMIRFYSKNFPDKGIIECSLSDLAFDQSDGWANYPKGMFLLTKAAGHQIVHGADILYY
CHHHHHHHHCCCCCCCEEEEEHHHHEECCCCCCCCCCCCEEEEEECCCCEEEECCEEEEE
GNIPHGAGLSSSASIELATGVLLKGLYDLQTDTISMVKLGQKVENEYIGVGSGIMDQFAI
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCEECCCCCHHHHHHH
GMGKKDHAILLDCRTLDYTYAPFVLKEHDVIIINTNKQRTLAGSKYNERRTQCEEALGDL
CCCCCCCEEEEEEEECCCCCCCEEEECCCEEEEECCCCEEECCCCCHHHHHHHHHHHHHH
QQELSIASLGELTMEGFEAHQHLIRNEINQKRAKHAVYENARTLKALEKLREGDLAGFGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LMNESHLSLRDDYEVTGLELDAIVQAAWEQDGVLGARMTGAGFGGCAIAIVEKDRTDSFK
HHCCCCCCCCCCCEECCEEHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCHHHH
ERVNAVYRETVGYDAAFYTAAIGDGAKEI
HHHHHHHHHHCCCCHHHHEEECCCCCCCC
>Mature Secondary Structure
MNTAAALSNDFRSIFKTEKTPRTFFAPGRINLIGEHTDYNGGHVFPASISFGTYALGVKR
CCCHHHHHHHHHHHHHCCCCCCEEECCCEEEEEECCCCCCCCEEEEEEECCCEEEEEECC
DDQMIRFYSKNFPDKGIIECSLSDLAFDQSDGWANYPKGMFLLTKAAGHQIVHGADILYY
CHHHHHHHHCCCCCCCEEEEEHHHHEECCCCCCCCCCCCEEEEEECCCCEEEECCEEEEE
GNIPHGAGLSSSASIELATGVLLKGLYDLQTDTISMVKLGQKVENEYIGVGSGIMDQFAI
CCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCEECCCCCHHHHHHH
GMGKKDHAILLDCRTLDYTYAPFVLKEHDVIIINTNKQRTLAGSKYNERRTQCEEALGDL
CCCCCCCEEEEEEEECCCCCCCEEEECCCEEEEECCCCEEECCCCCHHHHHHHHHHHHHH
QQELSIASLGELTMEGFEAHQHLIRNEINQKRAKHAVYENARTLKALEKLREGDLAGFGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LMNESHLSLRDDYEVTGLELDAIVQAAWEQDGVLGARMTGAGFGGCAIAIVEKDRTDSFK
HHCCCCCCCCCCCEECCEEHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCHHHH
ERVNAVYRETVGYDAAFYTAAIGDGAKEI
HHHHHHHHHHCCCCHHHHEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]