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The map label for this gene is arcB

Identifier: 52787841

GI number: 52787841

Start: 3991058

End: 3992065

Strand: Direct

Name: arcB

Synonym: BLi04164

Alternate gene names: 52787841

Gene position: 3991058-3992065 (Clockwise)

Preceding gene: 52787840

Following gene: 52787842

Centisome position: 94.52

GC content: 48.31

Gene sequence:

>1008_bases
ATGAACCAAACGATTAATTTAAAAGGCAGAAGCTACTTAGCTGAAAAAGATTTTTCAGAAGAAGAAATCCTCTATTTGCT
CGATCTGGCCCAGAAACTAAAAGAAAAAAAAGCACAAGGCATCAGGCATCGCTATTTGGAAGGCAAAAACATCGCTTTGC
TGTTTGAAAAGCCTTCTACAAGAACGCGCTGCGCTTTTACGACAGCCTGTATCGACCTCGGTGCGCATCCCGAATATTTG
GGCAAAGACGACATTCAGCTCGGCAAAAAAGAGTCGATCGAAGACACGGCCAAAGTTCTCGGCCGCATGTTCGACGGAAT
TGAATTCCGCGGATTTGAACACGAAAAAGTGATCTCACTGGCAGAGCATTCCGGTGTGCCGGTATGGAACGGGCTGACCG
ATTTATGGCATCCGACGCAGATGCTTGCGGACTTTATGACTGTGAAAGAACATACGGGACGCGTAAAAGGCGTCAAGCTC
ACCTATATCGGCGACGGCCGGAACAATGTCGCCAACAGCCTGCTCATCGGCGGCGCAAAAGTCGGCATGGACGTAAGAAT
CTGTTCGCCTCAAGAGCTTTTCCCTGATCAGGACATAGTTAAAATGGCGGAAGCGTTCGCTGAAGAATCCGGCGGAAAAA
TCACCGTTACAAGCGATACAGATAAAGCCGTGTCCGGAGCCGACGTTCTGTATACGGACGTCTGGGTATCCATGGGGGAA
GAAGACAAGTTTGCAGAAAGAATCAAACTGCTCAAGCCTTATCAAGTGAATATGGATCTCGTCAAGAAAACAGGCAACGA
CAACGTCATCTTCCTGCACTGTCTGCCTGCCTTCCACGACCTTCATACAACCTACGGACAAAATGTTTACGAACAGCACG
GCCTTAAAGAAATGGAAGTGACGGACGAAGTGTTCCGCAGCAAACACTCTAAAGTGTTCGATGAAGCTGAAAACCGCATG
CACACGATTAAAGCTGTCATGGCAGCGACGCTCGGCGATCTTGACTGA

Upstream 100 bases:

>100_bases
GGGGAGCTTTCAAGAGGACGCGGCGGCCCGCGCTGCATGAGCATGCCGCTCTACCGAGAAGATGTGAAATAACCAACCTA
AAGAAAAAGGAGAGAGATCC

Downstream 100 bases:

>100_bases
CAGGAAAAGGGACTCATTCCCTTTTCCATTCTAAACCGAATGAGGTGACAAAAATGGCGGAAGAAAAAAAACTTGGGCTG
TTTGCGCTCATCGCGCTTGT

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MNQTINLKGRSYLAEKDFSEEEILYLLDLAQKLKEKKAQGIRHRYLEGKNIALLFEKPSTRTRCAFTTACIDLGAHPEYL
GKDDIQLGKKESIEDTAKVLGRMFDGIEFRGFEHEKVISLAEHSGVPVWNGLTDLWHPTQMLADFMTVKEHTGRVKGVKL
TYIGDGRNNVANSLLIGGAKVGMDVRICSPQELFPDQDIVKMAEAFAEESGGKITVTSDTDKAVSGADVLYTDVWVSMGE
EDKFAERIKLLKPYQVNMDLVKKTGNDNVIFLHCLPAFHDLHTTYGQNVYEQHGLKEMEVTDEVFRSKHSKVFDEAENRM
HTIKAVMAATLGDLD

Sequences:

>Translated_335_residues
MNQTINLKGRSYLAEKDFSEEEILYLLDLAQKLKEKKAQGIRHRYLEGKNIALLFEKPSTRTRCAFTTACIDLGAHPEYL
GKDDIQLGKKESIEDTAKVLGRMFDGIEFRGFEHEKVISLAEHSGVPVWNGLTDLWHPTQMLADFMTVKEHTGRVKGVKL
TYIGDGRNNVANSLLIGGAKVGMDVRICSPQELFPDQDIVKMAEAFAEESGGKITVTSDTDKAVSGADVLYTDVWVSMGE
EDKFAERIKLLKPYQVNMDLVKKTGNDNVIFLHCLPAFHDLHTTYGQNVYEQHGLKEMEVTDEVFRSKHSKVFDEAENRM
HTIKAVMAATLGDLD
>Mature_335_residues
MNQTINLKGRSYLAEKDFSEEEILYLLDLAQKLKEKKAQGIRHRYLEGKNIALLFEKPSTRTRCAFTTACIDLGAHPEYL
GKDDIQLGKKESIEDTAKVLGRMFDGIEFRGFEHEKVISLAEHSGVPVWNGLTDLWHPTQMLADFMTVKEHTGRVKGVKL
TYIGDGRNNVANSLLIGGAKVGMDVRICSPQELFPDQDIVKMAEAFAEESGGKITVTSDTDKAVSGADVLYTDVWVSMGE
EDKFAERIKLLKPYQVNMDLVKKTGNDNVIFLHCLPAFHDLHTTYGQNVYEQHGLKEMEVTDEVFRSKHSKVFDEAENRM
HTIKAVMAATLGDLD

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=334, Percent_Identity=41.3173652694611, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI18105007, Length=339, Percent_Identity=23.3038348082596, Blast_Score=78, Evalue=9e-15,
Organism=Escherichia coli, GI1790703, Length=326, Percent_Identity=55.2147239263804, Blast_Score=351, Evalue=3e-98,
Organism=Escherichia coli, GI1786469, Length=334, Percent_Identity=53.8922155688623, Blast_Score=347, Evalue=7e-97,
Organism=Escherichia coli, GI48994908, Length=372, Percent_Identity=25.2688172043011, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI2367364, Length=327, Percent_Identity=28.7461773700306, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193204318, Length=165, Percent_Identity=30.9090909090909, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322373, Length=335, Percent_Identity=37.0149253731343, Blast_Score=198, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6322331, Length=284, Percent_Identity=27.8169014084507, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24642586, Length=232, Percent_Identity=29.3103448275862, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): OTCC_BACLD (O86132)

Other databases:

- EMBL:   Y17554
- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_081236.1
- RefSeq:   YP_093670.1
- ProteinModelPortal:   O86132
- SMR:   O86132
- STRING:   O86132
- EnsemblBacteria:   EBBACT00000054849
- EnsemblBacteria:   EBBACT00000062225
- GeneID:   3029078
- GeneID:   3099318
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi04164
- KEGG:   bli:BL01914
- NMPDR:   fig|279010.5.peg.2954
- eggNOG:   COG0078
- GeneTree:   EBGT00050000002562
- HOGENOM:   HBG579429
- OMA:   NHETVES
- ProtClustDB:   PRK02102
- BioCyc:   BLIC279010-1:BLI04164-MONOMER
- BioCyc:   BLIC279010:BL01914-MONOMER
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 37659; Mature: 37659

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 110-110 BINDING 137-137

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQTINLKGRSYLAEKDFSEEEILYLLDLAQKLKEKKAQGIRHRYLEGKNIALLFEKPST
CCCEEECCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
RTRCAFTTACIDLGAHPEYLGKDDIQLGKKESIEDTAKVLGRMFDGIEFRGFEHEKVISL
CCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
AEHSGVPVWNGLTDLWHPTQMLADFMTVKEHTGRVKGVKLTYIGDGRNNVANSLLIGGAK
HHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHEECCCE
VGMDVRICSPQELFPDQDIVKMAEAFAEESGGKITVTSDTDKAVSGADVLYTDVWVSMGE
ECCEEEECCCHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHEEEHHHHHCCC
EDKFAERIKLLKPYQVNMDLVKKTGNDNVIFLHCLPAFHDLHTTYGQNVYEQHGLKEMEV
CHHHHHHHHHCCCEECCHHHHEECCCCCEEEEEECHHHHHHHHHHCCCHHHHCCCCHHHH
TDEVFRSKHSKVFDEAENRMHTIKAVMAATLGDLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNQTINLKGRSYLAEKDFSEEEILYLLDLAQKLKEKKAQGIRHRYLEGKNIALLFEKPST
CCCEEECCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
RTRCAFTTACIDLGAHPEYLGKDDIQLGKKESIEDTAKVLGRMFDGIEFRGFEHEKVISL
CCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHH
AEHSGVPVWNGLTDLWHPTQMLADFMTVKEHTGRVKGVKLTYIGDGRNNVANSLLIGGAK
HHHCCCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHEECCCE
VGMDVRICSPQELFPDQDIVKMAEAFAEESGGKITVTSDTDKAVSGADVLYTDVWVSMGE
ECCEEEECCCHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHEEEHHHHHCCC
EDKFAERIKLLKPYQVNMDLVKKTGNDNVIFLHCLPAFHDLHTTYGQNVYEQHGLKEMEV
CHHHHHHHHHCCCEECCHHHHEECCCCCEEEEEECHHHHHHHHHHCCCHHHHCCCCHHHH
TDEVFRSKHSKVFDEAENRMHTIKAVMAATLGDLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9851988