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The map label for this gene is hemH [H]

Identifier: 52787792

GI number: 52787792

Start: 3936922

End: 3937875

Strand: Direct

Name: hemH [H]

Synonym: BLi04115

Alternate gene names: 52787792

Gene position: 3936922-3937875 (Clockwise)

Preceding gene: 52787791

Following gene: 52787804

Centisome position: 93.23

GC content: 49.48

Gene sequence:

>954_bases
ATGGAACGAAAAAAAGTCGGCCTGTTAGTCATGGCATACGGAACCCCTTATCAGGAAGAAGATATCATTCCGTATTACAC
GCATATCCGTCATGGAAAACGACCGTCCGATGATATGATTGAAGACTTGAAAAAACGCTACAAGCATATCGGCGGAATCT
CTCCGCTCGCGAAAATTACGCTCGCTCAGGCAAAAGAGCTGGAAAAAACGTTGAACGAGCGCCAAGATAAAGTCGAATAC
GTGATGTATCTCGGCTTAAAACACATCTCTCCGTTTATCGAGGATGCGGTTGAACAAATGAAAAAAGACCAAATTGAAGA
GGCCGTTTCCGTCGTCTTAGCTCCCCACTATTCCACCTTCAGCACCGAAGTATACAATCGGCGCGCCAAACAGGCCGCAG
CAGCAATCGGCGGACCACGGATCGCATCGATTGACGAGTGGTATCAGGAAGAAGGCTTTATTCGCTATTGGTCTGAAGAA
ATCGGCAGCATTTTAAACGACATGTCTGAAAAAGAGCGGGAAAAAGCGGCCGTCATATTCTCAGCACACAGCCTGCCGGA
AAAAATCAGGGAGCATGGCGATCCTTACCCGGATCAGCTCGAGAAAACAGCACAACTAATCGGAGAACGGCTGTCATTTG
ACCAGATCGCCGTAGGCTGGCAAAGCGAGGGCAACACGCCCGATCCTTGGCTCGGCCCGGACGTCCAAGACTTAACAAAG
GAACTGTATGAAGAAGGCTTCCGGTCATTCATTTACGCACCAGTCGGTTTTGTATCTGACCACCTGGAAGTTCTGTATGA
CAACGACTATGAGTGCAAAGTGGTTACGGACGAGCTTGGCGCAAGCTATCACCGTCCGCCTATGCCGAACACTGATCCGC
GGTTCATCGATACGCTTGCTTCAGTCGTGGAGCGAACATACAACAGCACAGAACAGGAGAAAGCGGAGCTGTAA

Upstream 100 bases:

>100_bases
TGCGGCAGCACAATTGACGAACTTTAAAGTGAACTCGCATTTTCTAGGAATCTATGGAATCTGTACAACATGCCAAGAAC
AGCAGCAGAGGTGAAGACAT

Downstream 100 bases:

>100_bases
ATCGAGCTCCGCTTTTTGCTGCAATGTTATGACGTGACAATATCCCGCTTTTGAAAAACCCAAAAGGAGACAGCCAGAAA
AAGAATAAAATAAACAGCAA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MERKKVGLLVMAYGTPYQEEDIIPYYTHIRHGKRPSDDMIEDLKKRYKHIGGISPLAKITLAQAKELEKTLNERQDKVEY
VMYLGLKHISPFIEDAVEQMKKDQIEEAVSVVLAPHYSTFSTEVYNRRAKQAAAAIGGPRIASIDEWYQEEGFIRYWSEE
IGSILNDMSEKEREKAAVIFSAHSLPEKIREHGDPYPDQLEKTAQLIGERLSFDQIAVGWQSEGNTPDPWLGPDVQDLTK
ELYEEGFRSFIYAPVGFVSDHLEVLYDNDYECKVVTDELGASYHRPPMPNTDPRFIDTLASVVERTYNSTEQEKAEL

Sequences:

>Translated_317_residues
MERKKVGLLVMAYGTPYQEEDIIPYYTHIRHGKRPSDDMIEDLKKRYKHIGGISPLAKITLAQAKELEKTLNERQDKVEY
VMYLGLKHISPFIEDAVEQMKKDQIEEAVSVVLAPHYSTFSTEVYNRRAKQAAAAIGGPRIASIDEWYQEEGFIRYWSEE
IGSILNDMSEKEREKAAVIFSAHSLPEKIREHGDPYPDQLEKTAQLIGERLSFDQIAVGWQSEGNTPDPWLGPDVQDLTK
ELYEEGFRSFIYAPVGFVSDHLEVLYDNDYECKVVTDELGASYHRPPMPNTDPRFIDTLASVVERTYNSTEQEKAEL
>Mature_317_residues
MERKKVGLLVMAYGTPYQEEDIIPYYTHIRHGKRPSDDMIEDLKKRYKHIGGISPLAKITLAQAKELEKTLNERQDKVEY
VMYLGLKHISPFIEDAVEQMKKDQIEEAVSVVLAPHYSTFSTEVYNRRAKQAAAAIGGPRIASIDEWYQEEGFIRYWSEE
IGSILNDMSEKEREKAAVIFSAHSLPEKIREHGDPYPDQLEKTAQLIGERLSFDQIAVGWQSEGNTPDPWLGPDVQDLTK
ELYEEGFRSFIYAPVGFVSDHLEVLYDNDYECKVVTDELGASYHRPPMPNTDPRFIDTLASVVERTYNSTEQEKAEL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=287, Percent_Identity=30.3135888501742, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI60499021, Length=287, Percent_Identity=30.3135888501742, Blast_Score=142, Evalue=5e-34,
Organism=Escherichia coli, GI1786681, Length=224, Percent_Identity=24.1071428571429, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324750, Length=330, Percent_Identity=26.969696969697, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17864156, Length=325, Percent_Identity=27.0769230769231, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI45552018, Length=163, Percent_Identity=33.1288343558282, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24651774, Length=260, Percent_Identity=24.6153846153846, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 36385; Mature: 36385

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERKKVGLLVMAYGTPYQEEDIIPYYTHIRHGKRPSDDMIEDLKKRYKHIGGISPLAKIT
CCCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
LAQAKELEKTLNERQDKVEYVMYLGLKHISPFIEDAVEQMKKDQIEEAVSVVLAPHYSTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
STEVYNRRAKQAAAAIGGPRIASIDEWYQEEGFIRYWSEEIGSILNDMSEKEREKAAVIF
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAHSLPEKIREHGDPYPDQLEKTAQLIGERLSFDQIAVGWQSEGNTPDPWLGPDVQDLTK
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHEECCCCCCCCCCCCCCCCHHHHHH
ELYEEGFRSFIYAPVGFVSDHLEVLYDNDYECKVVTDELGASYHRPPMPNTDPRFIDTLA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCCCCCCCCCCCHHHHHHHH
SVVERTYNSTEQEKAEL
HHHHHHHCCCHHHHCCC
>Mature Secondary Structure
MERKKVGLLVMAYGTPYQEEDIIPYYTHIRHGKRPSDDMIEDLKKRYKHIGGISPLAKIT
CCCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
LAQAKELEKTLNERQDKVEYVMYLGLKHISPFIEDAVEQMKKDQIEEAVSVVLAPHYSTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
STEVYNRRAKQAAAAIGGPRIASIDEWYQEEGFIRYWSEEIGSILNDMSEKEREKAAVIF
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAHSLPEKIREHGDPYPDQLEKTAQLIGERLSFDQIAVGWQSEGNTPDPWLGPDVQDLTK
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHEECCCCCCCCCCCCCCCCHHHHHH
ELYEEGFRSFIYAPVGFVSDHLEVLYDNDYECKVVTDELGASYHRPPMPNTDPRFIDTLA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCCCCCCCCCCCHHHHHHHH
SVVERTYNSTEQEKAEL
HHHHHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA