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The map label for this gene is uxaA [H]

Identifier: 52787203

GI number: 52787203

Start: 3351359

End: 3352849

Strand: Reverse

Name: uxaA [H]

Synonym: BLi03512

Alternate gene names: 52787203

Gene position: 3352849-3351359 (Counterclockwise)

Preceding gene: 52787204

Following gene: 52787202

Centisome position: 79.4

GC content: 48.02

Gene sequence:

>1491_bases
ATGAAAGACTGCTTGATGATCAATCCTCAAGATAATGTCGGCATTGCGTTAAGAGAATTGCAGACCGGTGAAACGGTCAC
TGTCGGAGAACGAACCATCGTGATCAAGGAACCGATTTTGAAAGGCCATAAGTTTGCTTTAAAAGACATCGCTGAAAATG
AAAACGTCATCAAATACGGCTTTCCGATCGGGCACGCCACTGAAATGATTCAGACGGGAGAGTGGGTGCACACGAAAAAT
GTGAAAACGAATTTGGGCGGTGTCGAAGAATACAGCTACAAGCCGAAGTTTACGGAAAACCGCTATCAAAAAGAACCGCT
TACATTTAAAGGCTTTAAACGAAAAGACGGAAAAACCGGGATCAGAAACGAGCTATGGATCGTCCCGACTGTCGGCTGTG
TAAATGGCATTGCAGAGCTGATCATCAAAGAATTTAAGGCTGAGGTCGGCTCCATCGCCCCTTTTGAAAGCGTTCACGTA
TTAAAGCATCAGTACGGCTGTTCACAGCTTGGCGACGATCATATCAACACGAGAACGATTTTGGCGAATGCCGTCAACCA
CCCGAATGCAGGCGGTGTCCTTGTGCTGGGGCTCGGCTGTGAAAACAACAGCATTCACGAATTCCGCGAAGCGCTCGGCG
ATTACGATCACAGCCGGGTCAAGTTTCTGCTTTCCCAAGAGGTATCAAACGAAGTCACGGAAGGCGTCAAACTGTTAAAG
GAAATTTATAAGCATGCAAAAGGTGACCACCGCGAAGATGTTCCGCTTTCTGAACTGAAAATCGGTTTGAAGTGCGGCGG
ATCTGATGGATTTTCCGGCATTACCGCGAACCCGCTGCTCGGCCGGCTCTCCGATTTTCTGATCGCCCAAGGGGGAACGG
CGGTGTTGACAGAAGTGCCTGAAATGTTTGGGGCAGAAACGCTATTGATGGAGCGGGCTGAAAATGAGGAAGTGTTTCAT
AAAATTGTCCGCTTAATCAACGATTTTAAACAGTACTTTATCGATCACAGGCAGCCCGTCTATGAAAACCCGTCTCCGGG
AAACAAAGCGGGCGGCATTACGACATTGGAAGATAAATCGCTCGGCTGTACGCAAAAAGCCGGCACTTCAAAGGTGGCGG
ATGTCCTTGAATACGGGGACGTTTTGAAAAAGAAAGGGCTGAACCTGCTGAGTGCTCCGGGAAATGACCTTGTTGCTTCA
TCCGCACTGGCCGCTGCAGGGTGTCAAATCGTTTTATTTACGACAGGACGGGGAACTCCTTTTGGCACCTTTGTGCCGAC
GATGAAAATTTCGACAAATACGGCGATTTATGAGGCAAAGCGCCATTGGATCGATTTTAATGCGGGAAAGGTGCTCGAAG
ACCGATCAGAAGATGACGTTTTGAAGGAGCTGACAGCGTATTTGATCGAAGTCGCAAGCGGCAGGCAGCTGAACAATGAG
ATAAACGATTTCAGGGAGCTTGCGATATTTAAAACAGGCGTCACATTATAA

Upstream 100 bases:

>100_bases
ACAAGACGGCTGAATATTTAAGGGACATGAAACAAACGGGAATGAGGAAGGCGCTGGAAAAAATGATGAAAAGCCAAATG
GCTGAGCTGGGGGACATGTA

Downstream 100 bases:

>100_bases
AGGGGGCGGTAACGTGAGTCTGCAGAAAATAAAAGAAGAGATTGTAAAGAAGCTGAAGGTTCCGGTATTTCCGAATCGCT
CATTTGATGTCACATCGTTT

Product: UxaA

Products: NA

Alternate protein names: Altronic acid hydratase [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MKDCLMINPQDNVGIALRELQTGETVTVGERTIVIKEPILKGHKFALKDIAENENVIKYGFPIGHATEMIQTGEWVHTKN
VKTNLGGVEEYSYKPKFTENRYQKEPLTFKGFKRKDGKTGIRNELWIVPTVGCVNGIAELIIKEFKAEVGSIAPFESVHV
LKHQYGCSQLGDDHINTRTILANAVNHPNAGGVLVLGLGCENNSIHEFREALGDYDHSRVKFLLSQEVSNEVTEGVKLLK
EIYKHAKGDHREDVPLSELKIGLKCGGSDGFSGITANPLLGRLSDFLIAQGGTAVLTEVPEMFGAETLLMERAENEEVFH
KIVRLINDFKQYFIDHRQPVYENPSPGNKAGGITTLEDKSLGCTQKAGTSKVADVLEYGDVLKKKGLNLLSAPGNDLVAS
SALAAAGCQIVLFTTGRGTPFGTFVPTMKISTNTAIYEAKRHWIDFNAGKVLEDRSEDDVLKELTAYLIEVASGRQLNNE
INDFRELAIFKTGVTL

Sequences:

>Translated_496_residues
MKDCLMINPQDNVGIALRELQTGETVTVGERTIVIKEPILKGHKFALKDIAENENVIKYGFPIGHATEMIQTGEWVHTKN
VKTNLGGVEEYSYKPKFTENRYQKEPLTFKGFKRKDGKTGIRNELWIVPTVGCVNGIAELIIKEFKAEVGSIAPFESVHV
LKHQYGCSQLGDDHINTRTILANAVNHPNAGGVLVLGLGCENNSIHEFREALGDYDHSRVKFLLSQEVSNEVTEGVKLLK
EIYKHAKGDHREDVPLSELKIGLKCGGSDGFSGITANPLLGRLSDFLIAQGGTAVLTEVPEMFGAETLLMERAENEEVFH
KIVRLINDFKQYFIDHRQPVYENPSPGNKAGGITTLEDKSLGCTQKAGTSKVADVLEYGDVLKKKGLNLLSAPGNDLVAS
SALAAAGCQIVLFTTGRGTPFGTFVPTMKISTNTAIYEAKRHWIDFNAGKVLEDRSEDDVLKELTAYLIEVASGRQLNNE
INDFRELAIFKTGVTL
>Mature_496_residues
MKDCLMINPQDNVGIALRELQTGETVTVGERTIVIKEPILKGHKFALKDIAENENVIKYGFPIGHATEMIQTGEWVHTKN
VKTNLGGVEEYSYKPKFTENRYQKEPLTFKGFKRKDGKTGIRNELWIVPTVGCVNGIAELIIKEFKAEVGSIAPFESVHV
LKHQYGCSQLGDDHINTRTILANAVNHPNAGGVLVLGLGCENNSIHEFREALGDYDHSRVKFLLSQEVSNEVTEGVKLLK
EIYKHAKGDHREDVPLSELKIGLKCGGSDGFSGITANPLLGRLSDFLIAQGGTAVLTEVPEMFGAETLLMERAENEEVFH
KIVRLINDFKQYFIDHRQPVYENPSPGNKAGGITTLEDKSLGCTQKAGTSKVADVLEYGDVLKKKGLNLLSAPGNDLVAS
SALAAAGCQIVLFTTGRGTPFGTFVPTMKISTNTAIYEAKRHWIDFNAGKVLEDRSEDDVLKELTAYLIEVASGRQLNNE
INDFRELAIFKTGVTL

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789475, Length=492, Percent_Identity=57.520325203252, Blast_Score=599, Evalue=1e-172,
Organism=Escherichia coli, GI1789516, Length=500, Percent_Identity=32.8, Blast_Score=228, Evalue=5e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.7 [H]

Molecular weight: Translated: 54588; Mature: 54588

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDCLMINPQDNVGIALRELQTGETVTVGERTIVIKEPILKGHKFALKDIAENENVIKYG
CCCCEEECCCCCCCEEEEEECCCCEEEECCEEEEEECCCCCCCHHHHHHHHCCCCEEEEC
FPIGHATEMIQTGEWVHTKNVKTNLGGVEEYSYKPKFTENRYQKEPLTFKGFKRKDGKTG
CCCCHHHHHHHCCCEEEECCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
IRNELWIVPTVGCVNGIAELIIKEFKAEVGSIAPFESVHVLKHQYGCSQLGDDHINTRTI
CCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHCCCCCCCHHHH
LANAVNHPNAGGVLVLGLGCENNSIHEFREALGDYDHSRVKFLLSQEVSNEVTEGVKLLK
HHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EIYKHAKGDHREDVPLSELKIGLKCGGSDGFSGITANPLLGRLSDFLIAQGGTAVLTEVP
HHHHHCCCCCCCCCCHHHEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHH
EMFGAETLLMERAENEEVFHKIVRLINDFKQYFIDHRQPVYENPSPGNKAGGITTLEDKS
HHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCC
LGCTQKAGTSKVADVLEYGDVLKKKGLNLLSAPGNDLVASSALAAAGCQIVLFTTGRGTP
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHCCCEEEEEECCCCCC
FGTFVPTMKISTNTAIYEAKRHWIDFNAGKVLEDRSEDDVLKELTAYLIEVASGRQLNNE
CCCCCCEEEECCCHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
INDFRELAIFKTGVTL
HHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKDCLMINPQDNVGIALRELQTGETVTVGERTIVIKEPILKGHKFALKDIAENENVIKYG
CCCCEEECCCCCCCEEEEEECCCCEEEECCEEEEEECCCCCCCHHHHHHHHCCCCEEEEC
FPIGHATEMIQTGEWVHTKNVKTNLGGVEEYSYKPKFTENRYQKEPLTFKGFKRKDGKTG
CCCCHHHHHHHCCCEEEECCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
IRNELWIVPTVGCVNGIAELIIKEFKAEVGSIAPFESVHVLKHQYGCSQLGDDHINTRTI
CCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHCCCCCCCHHHH
LANAVNHPNAGGVLVLGLGCENNSIHEFREALGDYDHSRVKFLLSQEVSNEVTEGVKLLK
HHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EIYKHAKGDHREDVPLSELKIGLKCGGSDGFSGITANPLLGRLSDFLIAQGGTAVLTEVP
HHHHHCCCCCCCCCCHHHEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHH
EMFGAETLLMERAENEEVFHKIVRLINDFKQYFIDHRQPVYENPSPGNKAGGITTLEDKS
HHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCC
LGCTQKAGTSKVADVLEYGDVLKKKGLNLLSAPGNDLVASSALAAAGCQIVLFTTGRGTP
CCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHCCCEEEEEECCCCCC
FGTFVPTMKISTNTAIYEAKRHWIDFNAGKVLEDRSEDDVLKELTAYLIEVASGRQLNNE
CCCCCCEEEECCCHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
INDFRELAIFKTGVTL
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377 [H]