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The map label for this gene is uxaB [H]

Identifier: 52787204

GI number: 52787204

Start: 3352849

End: 3354318

Strand: Reverse

Name: uxaB [H]

Synonym: BLi03513

Alternate gene names: 52787204

Gene position: 3354318-3352849 (Counterclockwise)

Preceding gene: 52787205

Following gene: 52787203

Centisome position: 79.44

GC content: 49.66

Gene sequence:

>1470_bases
ATGGAGAGGCTGTCCAAACGGATAAGGTCTAAGCCGAGCCGCCCCGAACGGATTTTGCAAATCGGGGAAGGTAACTTTAT
GAGGGGGTTTATTGACTGGCAGATTCATAGATTGAATGAAGAAACCGATTTTAACGGCAGTGCCGTCGTCGTGCCTCCGC
GCCGCGGTTCAGTAACGGCCTTTCAAGAACAGGATGGGCTTTACACGCTTTATCTTGAAGGTTTCCGGGAAGGACGGGAG
GTTCGCGATTCTGCTGTCATTACATCAATCAGCAGAGTCGTCAGCAGCTATGAGCATTATGATGAATTTATGGAGCTGGC
CGATCTGCCGGATTTGCGGTTTGTATTTTCAAATACGACAGAGGCCGGCATCATTTATATCGAGGAAGACCGTCTGTCCG
ACCGTCCGCAGAAAAGCTATCCAGGGAAGCTGACTGCACTTTTATACAGACGATACATGACTTTTCAAGGAAGCAGGGAA
AAAGGTCTGGTGATCCTCCCGTGTGAGCTGCTTGAGGATAACGGGAAAATACTGAAAGACATTGTGCTGCGCTATACAAA
CGCGTGGGCGCTTGAACAAGGGTTCATCGATTGGCTTGAAGAGGCAAACGTGTTCTGCAATACGCTTGTGGACAGGATCG
TACCGGGATTCCCGAAAGAAAATGCACACCGGCTTGAAGAGGCGGCCGGCTATCACGATTCCTTGATGGTGAAGGCGGAG
CCGTATCATTTGTTCGTGATTGAAGGGCCGAAATGGCTTCGAGACGAGCTTCCGCTTCATGAGGCCGGTCTGAATGTCGA
GTTTGTCCAGGATGTGACGCCGTACAGGATAAGAAAAGTGAGAATTTTAAACGGCGCCCATACCGCGATGACGCCGGTCG
CTTATTTGGCAGGCCTTGAGACGGTTCGCGAAGCGGCTGAAGACGAGCTTATCGGCTCATTTGTGAAAGAGCTGATCCAG
CGGGAGGTGCTCGAGACGATCGATATGCCCGATAGCGAGCTTGACAACTACGTGGAAGAGATTCTCGACCGCTTTAAAAA
CCCGTTTATCCGTCACAAGCTGATCGATATTTCCTTAAATTCCTTTGCAAAATTCAAAGTCAGAAATTTGCCCGTCTTAA
TGGAATATGCGGAACGAACAGGCAAACTTCCGGCTCGAACCGTATTTGCTTTAAGCGCCTTAATTTATTTTTACCGAGGC
CAACGGGATGGGGATGATGGGGCCATTCCGCTGTCTGACGACGATGAGGTGCTGGCTTTCCTCAAACGGCTCTGGACGGA
AGAGACAGACGTTTCGAACATCGCATTCCATGTTCTTGGGTTTGAAAAAGTGTGGGGGCAAAATCTGAACGACATGCCCG
GATTGACGGACAAGACGGCTGAATATTTAAGGGACATGAAACAAACGGGAATGAGGAAGGCGCTGGAAAAAATGATGAAA
AGCCAAATGGCTGAGCTGGGGGACATGTAA

Upstream 100 bases:

>100_bases
CACGGAGCTGATCATTCGCAATTCAGTTAAGCATCTATAGCATCATTTTTTTGATGCGCTGTAAAATGTGAACGTGTGCA
GAAATGAGGAGGGGATTGAA

Downstream 100 bases:

>100_bases
TGAAAGACTGCTTGATGATCAATCCTCAAGATAATGTCGGCATTGCGTTAAGAGAATTGCAGACCGGTGAAACGGTCACT
GTCGGAGAACGAACCATCGT

Product: altronate oxidoreductase

Products: NA

Alternate protein names: Tagaturonate dehydrogenase; Tagaturonate reductase [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MERLSKRIRSKPSRPERILQIGEGNFMRGFIDWQIHRLNEETDFNGSAVVVPPRRGSVTAFQEQDGLYTLYLEGFREGRE
VRDSAVITSISRVVSSYEHYDEFMELADLPDLRFVFSNTTEAGIIYIEEDRLSDRPQKSYPGKLTALLYRRYMTFQGSRE
KGLVILPCELLEDNGKILKDIVLRYTNAWALEQGFIDWLEEANVFCNTLVDRIVPGFPKENAHRLEEAAGYHDSLMVKAE
PYHLFVIEGPKWLRDELPLHEAGLNVEFVQDVTPYRIRKVRILNGAHTAMTPVAYLAGLETVREAAEDELIGSFVKELIQ
REVLETIDMPDSELDNYVEEILDRFKNPFIRHKLIDISLNSFAKFKVRNLPVLMEYAERTGKLPARTVFALSALIYFYRG
QRDGDDGAIPLSDDDEVLAFLKRLWTEETDVSNIAFHVLGFEKVWGQNLNDMPGLTDKTAEYLRDMKQTGMRKALEKMMK
SQMAELGDM

Sequences:

>Translated_489_residues
MERLSKRIRSKPSRPERILQIGEGNFMRGFIDWQIHRLNEETDFNGSAVVVPPRRGSVTAFQEQDGLYTLYLEGFREGRE
VRDSAVITSISRVVSSYEHYDEFMELADLPDLRFVFSNTTEAGIIYIEEDRLSDRPQKSYPGKLTALLYRRYMTFQGSRE
KGLVILPCELLEDNGKILKDIVLRYTNAWALEQGFIDWLEEANVFCNTLVDRIVPGFPKENAHRLEEAAGYHDSLMVKAE
PYHLFVIEGPKWLRDELPLHEAGLNVEFVQDVTPYRIRKVRILNGAHTAMTPVAYLAGLETVREAAEDELIGSFVKELIQ
REVLETIDMPDSELDNYVEEILDRFKNPFIRHKLIDISLNSFAKFKVRNLPVLMEYAERTGKLPARTVFALSALIYFYRG
QRDGDDGAIPLSDDDEVLAFLKRLWTEETDVSNIAFHVLGFEKVWGQNLNDMPGLTDKTAEYLRDMKQTGMRKALEKMMK
SQMAELGDM
>Mature_489_residues
MERLSKRIRSKPSRPERILQIGEGNFMRGFIDWQIHRLNEETDFNGSAVVVPPRRGSVTAFQEQDGLYTLYLEGFREGRE
VRDSAVITSISRVVSSYEHYDEFMELADLPDLRFVFSNTTEAGIIYIEEDRLSDRPQKSYPGKLTALLYRRYMTFQGSRE
KGLVILPCELLEDNGKILKDIVLRYTNAWALEQGFIDWLEEANVFCNTLVDRIVPGFPKENAHRLEEAAGYHDSLMVKAE
PYHLFVIEGPKWLRDELPLHEAGLNVEFVQDVTPYRIRKVRILNGAHTAMTPVAYLAGLETVREAAEDELIGSFVKELIQ
REVLETIDMPDSELDNYVEEILDRFKNPFIRHKLIDISLNSFAKFKVRNLPVLMEYAERTGKLPARTVFALSALIYFYRG
QRDGDDGAIPLSDDDEVLAFLKRLWTEETDVSNIAFHVLGFEKVWGQNLNDMPGLTDKTAEYLRDMKQTGMRKALEKMMK
SQMAELGDM

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxaB subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994885, Length=485, Percent_Identity=46.5979381443299, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1787823, Length=484, Percent_Identity=22.9338842975207, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1790779, Length=382, Percent_Identity=26.1780104712042, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788497, Length=353, Percent_Identity=25.7790368271955, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324401, Length=378, Percent_Identity=26.1904761904762, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320765, Length=378, Percent_Identity=26.1904761904762, Blast_Score=118, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.58 [H]

Molecular weight: Translated: 56373; Mature: 56373

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERLSKRIRSKPSRPERILQIGEGNFMRGFIDWQIHRLNEETDFNGSAVVVPPRRGSVTA
CHHHHHHHHCCCCCCHHHHEECCCCEEEEEEEEEEEECCCCCCCCCCEEEECCCCCCEEE
FQEQDGLYTLYLEGFREGREVRDSAVITSISRVVSSYEHYDEFMELADLPDLRFVFSNTT
EECCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
EAGIIYIEEDRLSDRPQKSYPGKLTALLYRRYMTFQGSREKGLVILPCELLEDNGKILKD
CCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHCCCCHHHHH
IVLRYTNAWALEQGFIDWLEEANVFCNTLVDRIVPGFPKENAHRLEEAAGYHDSLMVKAE
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEEC
PYHLFVIEGPKWLRDELPLHEAGLNVEFVQDVTPYRIRKVRILNGAHTAMTPVAYLAGLE
CEEEEEECCCHHHHHCCCHHHCCCCEEECCCCCCHHEEEEEEECCCHHHHHHHHHHHHHH
TVREAAEDELIGSFVKELIQREVLETIDMPDSELDNYVEEILDRFKNPFIRHKLIDISLN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHEEEEEECC
SFAKFKVRNLPVLMEYAERTGKLPARTVFALSALIYFYRGQRDGDDGAIPLSDDDEVLAF
CHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
LKRLWTEETDVSNIAFHVLGFEKVWGQNLNDMPGLTDKTAEYLRDMKQTGMRKALEKMMK
HHHHCCCCCCHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SQMAELGDM
HHHHHHCCC
>Mature Secondary Structure
MERLSKRIRSKPSRPERILQIGEGNFMRGFIDWQIHRLNEETDFNGSAVVVPPRRGSVTA
CHHHHHHHHCCCCCCHHHHEECCCCEEEEEEEEEEEECCCCCCCCCCEEEECCCCCCEEE
FQEQDGLYTLYLEGFREGREVRDSAVITSISRVVSSYEHYDEFMELADLPDLRFVFSNTT
EECCCCEEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
EAGIIYIEEDRLSDRPQKSYPGKLTALLYRRYMTFQGSREKGLVILPCELLEDNGKILKD
CCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHCCCCHHHHH
IVLRYTNAWALEQGFIDWLEEANVFCNTLVDRIVPGFPKENAHRLEEAAGYHDSLMVKAE
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEEC
PYHLFVIEGPKWLRDELPLHEAGLNVEFVQDVTPYRIRKVRILNGAHTAMTPVAYLAGLE
CEEEEEECCCHHHHHCCCHHHCCCCEEECCCCCCHHEEEEEEECCCHHHHHHHHHHHHHH
TVREAAEDELIGSFVKELIQREVLETIDMPDSELDNYVEEILDRFKNPFIRHKLIDISLN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHEEEEEECC
SFAKFKVRNLPVLMEYAERTGKLPARTVFALSALIYFYRGQRDGDDGAIPLSDDDEVLAF
CHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
LKRLWTEETDVSNIAFHVLGFEKVWGQNLNDMPGLTDKTAEYLRDMKQTGMRKALEKMMK
HHHHCCCCCCHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SQMAELGDM
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377 [H]