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The map label for this gene is hom [H]

Identifier: 52787106

GI number: 52787106

Start: 3260194

End: 3261495

Strand: Reverse

Name: hom [H]

Synonym: BLi03414

Alternate gene names: 52787106

Gene position: 3261495-3260194 (Counterclockwise)

Preceding gene: 52787107

Following gene: 52787105

Centisome position: 77.24

GC content: 48.77

Gene sequence:

>1302_bases
TTGAAGGCGATACGAGTGGGGCTGCTAGGATTAGGAACAGTCGGGAGCGGTGTGGTGAAGATTATTCAGGATCACCAGGA
TAAGCTGACACACCAAGTCGGATGCCCTGTTACGATTCAAAAAGTTCTTGTAAAAGATAAAGATAAGAAGAGGGATGTCG
AGCTTTCCAAAGACGTTCTGACGACTGAAGCCTATGATGTCATTCAAGATCCAGAAGTAGATGTCATTATCGAGGTCATC
GGGGGGATCGAGGAGACGAGACGCTATTTGCTTGACGCGCTTCAGGCGAAGAAACACGTCGTGACAGCGAATAAAGATTT
GATCGCCCTCTATGGATCGGAACTGACGGCTGCCGCGAAAGAAAACGGCTGCGACCTTTATTTTGAAGCGAGCGTCGCCG
GCGGAATTCCGATTTTGCGAAGCCTTGAAGACGGGCTGGCTTCAGACCGGATTACGAAGATGATGGGCATCGTCAATGGA
ACGACCAACTTTATTTTAACGAAGATGAACAAAGAAAACGCGCCTTATGACGAGGTGCTGAAAGAAGCGCAGGAGCTCGG
CTTCGCAGAAGCAGACCCGACAGCTGATGTTGAAGGTCTTGATGCCGCGAGAAAGATGGCGATTTTGGCCAGGCTCGGTT
TCTCAATGAATGTCGACCTTGACGATGTCAAAGTGAAAGGCATTTCCCAAGTGTCTGATGAAGACATCAATTTCAGCAAA
CGGCTCGGCTATACGATGAAGCTGATCGGCATCGCTCAGCGCGACGGACAAAAAGTCGAAGTGAGCGTCCAGCCGACATT
GCTGCCGGAGCATCATCCGCTGTCTTCCGTCCATAATGAATTCAATGCGGTTTACGTATACGGCGAAGCCGTAGGGGAAA
CGATGTTTTACGGACCTGGCGCCGGAAGCATGCCGACTGCAACCGCCGTCGTGTCAGATTTGGTCTCCGTCATGAAAAAC
ATGCGTCTTGGCGTGAACGGCAGCAGCTTTGTCGATCCGCAGTTTGAAAAGAAGATAAAGGCGCCGTCTGAAATCTTTGC
CCAGCAGTTTTTAAGAATTCATGTCAAAGACCAGGTTGGTTCGTTTTCGAAAATCACATCGATTTTTTCAGAAAGAGGCG
TCAGCTTTGAAAAGATCCTTCAGCTTCCGATTAAAGGCCATGACGACCTGGCTGAGATTGTCATTGTGACACATCATACG
TCAGAAGAGGATTTTACGGATATCCTGCAAAAGCTGAACGATCTTGAGGTTGTTCATCAGGTGAAAAGCACTTATCGAGT
AGAAGGGAACGGTTGGAGCTAA

Upstream 100 bases:

>100_bases
AAGAATCCCCCATTATAATGTTTGTAACTTAAATGTCTGCGTTGTGTTTACAAATGTCCTTTCAGAGAGGACGGACAAGA
GAGAGAAAGGTGGAATTTCA

Downstream 100 bases:

>100_bases
TGTGGAAAGGACTCATCCATCAATATAAAGAATATTTGCCAGTAACGGACAAAACACCGGAATTGACGCTGAACGAGGGA
AATACCCCGCTTATTTATCT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MKAIRVGLLGLGTVGSGVVKIIQDHQDKLTHQVGCPVTIQKVLVKDKDKKRDVELSKDVLTTEAYDVIQDPEVDVIIEVI
GGIEETRRYLLDALQAKKHVVTANKDLIALYGSELTAAAKENGCDLYFEASVAGGIPILRSLEDGLASDRITKMMGIVNG
TTNFILTKMNKENAPYDEVLKEAQELGFAEADPTADVEGLDAARKMAILARLGFSMNVDLDDVKVKGISQVSDEDINFSK
RLGYTMKLIGIAQRDGQKVEVSVQPTLLPEHHPLSSVHNEFNAVYVYGEAVGETMFYGPGAGSMPTATAVVSDLVSVMKN
MRLGVNGSSFVDPQFEKKIKAPSEIFAQQFLRIHVKDQVGSFSKITSIFSERGVSFEKILQLPIKGHDDLAEIVIVTHHT
SEEDFTDILQKLNDLEVVHQVKSTYRVEGNGWS

Sequences:

>Translated_433_residues
MKAIRVGLLGLGTVGSGVVKIIQDHQDKLTHQVGCPVTIQKVLVKDKDKKRDVELSKDVLTTEAYDVIQDPEVDVIIEVI
GGIEETRRYLLDALQAKKHVVTANKDLIALYGSELTAAAKENGCDLYFEASVAGGIPILRSLEDGLASDRITKMMGIVNG
TTNFILTKMNKENAPYDEVLKEAQELGFAEADPTADVEGLDAARKMAILARLGFSMNVDLDDVKVKGISQVSDEDINFSK
RLGYTMKLIGIAQRDGQKVEVSVQPTLLPEHHPLSSVHNEFNAVYVYGEAVGETMFYGPGAGSMPTATAVVSDLVSVMKN
MRLGVNGSSFVDPQFEKKIKAPSEIFAQQFLRIHVKDQVGSFSKITSIFSERGVSFEKILQLPIKGHDDLAEIVIVTHHT
SEEDFTDILQKLNDLEVVHQVKSTYRVEGNGWS
>Mature_433_residues
MKAIRVGLLGLGTVGSGVVKIIQDHQDKLTHQVGCPVTIQKVLVKDKDKKRDVELSKDVLTTEAYDVIQDPEVDVIIEVI
GGIEETRRYLLDALQAKKHVVTANKDLIALYGSELTAAAKENGCDLYFEASVAGGIPILRSLEDGLASDRITKMMGIVNG
TTNFILTKMNKENAPYDEVLKEAQELGFAEADPTADVEGLDAARKMAILARLGFSMNVDLDDVKVKGISQVSDEDINFSK
RLGYTMKLIGIAQRDGQKVEVSVQPTLLPEHHPLSSVHNEFNAVYVYGEAVGETMFYGPGAGSMPTATAVVSDLVSVMKN
MRLGVNGSSFVDPQFEKKIKAPSEIFAQQFLRIHVKDQVGSFSKITSIFSERGVSFEKILQLPIKGHDDLAEIVIVTHHT
SEEDFTDILQKLNDLEVVHQVKSTYRVEGNGWS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=261, Percent_Identity=27.9693486590038, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790376, Length=368, Percent_Identity=24.7282608695652, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322599, Length=96, Percent_Identity=36.4583333333333, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47474; Mature: 47474

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIRVGLLGLGTVGSGVVKIIQDHQDKLTHQVGCPVTIQKVLVKDKDKKRDVELSKDVL
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHH
TTEAYDVIQDPEVDVIIEVIGGIEETRRYLLDALQAKKHVVTANKDLIALYGSELTAAAK
HHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCHHHHHH
ENGCDLYFEASVAGGIPILRSLEDGLASDRITKMMGIVNGTTNFILTKMNKENAPYDEVL
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHH
KEAQELGFAEADPTADVEGLDAARKMAILARLGFSMNVDLDDVKVKGISQVSDEDINFSK
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCEECCCHHCCCCCCCHHH
RLGYTMKLIGIAQRDGQKVEVSVQPTLLPEHHPLSSVHNEFNAVYVYGEAVGETMFYGPG
HCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHCCCCEEEEEECHHCCEEEECCC
AGSMPTATAVVSDLVSVMKNMRLGVNGSSFVDPQFEKKIKAPSEIFAQQFLRIHVKDQVG
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHEEEHHHCC
SFSKITSIFSERGVSFEKILQLPIKGHDDLAEIVIVTHHTSEEDFTDILQKLNDLEVVHQ
CHHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
VKSTYRVEGNGWS
HHHHEEECCCCCC
>Mature Secondary Structure
MKAIRVGLLGLGTVGSGVVKIIQDHQDKLTHQVGCPVTIQKVLVKDKDKKRDVELSKDVL
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHH
TTEAYDVIQDPEVDVIIEVIGGIEETRRYLLDALQAKKHVVTANKDLIALYGSELTAAAK
HHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHEEECCCCEEEEECCCHHHHHH
ENGCDLYFEASVAGGIPILRSLEDGLASDRITKMMGIVNGTTNFILTKMNKENAPYDEVL
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHH
KEAQELGFAEADPTADVEGLDAARKMAILARLGFSMNVDLDDVKVKGISQVSDEDINFSK
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCEECCCHHCCCCCCCHHH
RLGYTMKLIGIAQRDGQKVEVSVQPTLLPEHHPLSSVHNEFNAVYVYGEAVGETMFYGPG
HCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHCCCCEEEEEECHHCCEEEECCC
AGSMPTATAVVSDLVSVMKNMRLGVNGSSFVDPQFEKKIKAPSEIFAQQFLRIHVKDQVG
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHEEEHHHCC
SFSKITSIFSERGVSFEKILQLPIKGHDDLAEIVIVTHHTSEEDFTDILQKLNDLEVVHQ
CHHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
VKSTYRVEGNGWS
HHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]