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The map label for this gene is ytpA [H]

Identifier: 52786915

GI number: 52786915

Start: 3073672

End: 3074451

Strand: Reverse

Name: ytpA [H]

Synonym: BLi03191

Alternate gene names: 52786915

Gene position: 3074451-3073672 (Counterclockwise)

Preceding gene: 52786919

Following gene: 52786914

Centisome position: 72.81

GC content: 48.21

Gene sequence:

>780_bases
ATGTGGTGCATGGAAGCGGAAAGACCTGTTGCTACAATCGTCGTCATTCACGGTGCATGTGAGCATCACGGGCGGTATAA
ATGGCTGTCCGAAATGTGGCGTTCATCCGGCTTTAATGTCGTGATGGGGGATTTGCCCGGCCAGGGCACTTCGACAAGAG
AAAGAGGACATATACGCTCTTTTCAAGAATATATTGATGAAGTGGACAAATGGGTCGCCAGGGCGAAAGCATTTGAACTG
CCTGTGTTTATGCTCGGGCACAGCATGGGCGGCCTGATTGCGATCGAATGGTTTAAGCAGCAGCAAAGCGGCATTGCCGG
TCTCATTTTATCATCCCCTTGTCTCGGGCTGCAATTAAAGCCGAACAAATTTCTGGACTTGATTTCCAAGGGGCTCAACG
TTTTGGCGCCGTCTATGCGGTTTGAATCCGGGATCACGCCTGATAAAGCGACGAGAAACAAAGAAGTCATCGAAATGGAC
ATCAACGATTCATTATATATCACAAAAGTTTCTGTCAGATGGTATCAAGAAATGTTAAAAGCGTTGAAAAGCGCGATGGA
GCCGACGGACGCCTTTCTCAACATCCCGCTCTTTGTCATGCAGGCGGGCACCGACTGGCTTGTCGACAAAAAAATGGTCG
TCAAGTGGTTTAACCAGCTTGCTTCCCACAATAAGACGTACAGGGAATGGGATGGCTTGTACCACGAAATTTTCAATGAG
CCTGAACGGGAAGACGTTTTTAAAGCGGCCAGAGCGTTTGCGGAGCAGTATATAACATAA

Upstream 100 bases:

>100_bases
GGCGATAAACGCCGTTTCATGAATAACGGGTTCCGTTTTTTTATAAGGGTAGATCATAGGTTTCATCCTTTCATTTATAA
AATTGTGTGAGGTGGTCAGC

Downstream 100 bases:

>100_bases
TGGAGGTGCATTCTTTGGCAGTACCGGAGCATCCTTTTGGATTAATGGCTAAAGTATACAGAGAGGTTTTTCCCCTTGTT
CATCAGGAATTGGACAAGTG

Product: YtpA

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MWCMEAERPVATIVVIHGACEHHGRYKWLSEMWRSSGFNVVMGDLPGQGTSTRERGHIRSFQEYIDEVDKWVARAKAFEL
PVFMLGHSMGGLIAIEWFKQQQSGIAGLILSSPCLGLQLKPNKFLDLISKGLNVLAPSMRFESGITPDKATRNKEVIEMD
INDSLYITKVSVRWYQEMLKALKSAMEPTDAFLNIPLFVMQAGTDWLVDKKMVVKWFNQLASHNKTYREWDGLYHEIFNE
PEREDVFKAARAFAEQYIT

Sequences:

>Translated_259_residues
MWCMEAERPVATIVVIHGACEHHGRYKWLSEMWRSSGFNVVMGDLPGQGTSTRERGHIRSFQEYIDEVDKWVARAKAFEL
PVFMLGHSMGGLIAIEWFKQQQSGIAGLILSSPCLGLQLKPNKFLDLISKGLNVLAPSMRFESGITPDKATRNKEVIEMD
INDSLYITKVSVRWYQEMLKALKSAMEPTDAFLNIPLFVMQAGTDWLVDKKMVVKWFNQLASHNKTYREWDGLYHEIFNE
PEREDVFKAARAFAEQYIT
>Mature_259_residues
MWCMEAERPVATIVVIHGACEHHGRYKWLSEMWRSSGFNVVMGDLPGQGTSTRERGHIRSFQEYIDEVDKWVARAKAFEL
PVFMLGHSMGGLIAIEWFKQQQSGIAGLILSSPCLGLQLKPNKFLDLISKGLNVLAPSMRFESGITPDKATRNKEVIEMD
INDSLYITKVSVRWYQEMLKALKSAMEPTDAFLNIPLFVMQAGTDWLVDKKMVVKWFNQLASHNKTYREWDGLYHEIFNE
PEREDVFKAARAFAEQYIT

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=239, Percent_Identity=32.6359832635983, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI6005786, Length=239, Percent_Identity=32.6359832635983, Blast_Score=98, Evalue=9e-21,
Organism=Escherichia coli, GI1787678, Length=249, Percent_Identity=22.0883534136546, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 29756; Mature: 29756

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWCMEAERPVATIVVIHGACEHHGRYKWLSEMWRSSGFNVVMGDLPGQGTSTRERGHIRS
CCCCCCCCCEEEEEEEECCHHHCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHH
FQEYIDEVDKWVARAKAFELPVFMLGHSMGGLIAIEWFKQQQSGIAGLILSSPCLGLQLK
HHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEHHHHHHHHHCCCEEEEECCCCCCEEEC
PNKFLDLISKGLNVLAPSMRFESGITPDKATRNKEVIEMDINDSLYITKVSVRWYQEMLK
CHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEEHHHHHHHHHH
ALKSAMEPTDAFLNIPLFVMQAGTDWLVDKKMVVKWFNQLASHNKTYREWDGLYHEIFNE
HHHHHCCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
PEREDVFKAARAFAEQYIT
CCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MWCMEAERPVATIVVIHGACEHHGRYKWLSEMWRSSGFNVVMGDLPGQGTSTRERGHIRS
CCCCCCCCCEEEEEEEECCHHHCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHH
FQEYIDEVDKWVARAKAFELPVFMLGHSMGGLIAIEWFKQQQSGIAGLILSSPCLGLQLK
HHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEHHHHHHHHHCCCEEEEECCCCCCEEEC
PNKFLDLISKGLNVLAPSMRFESGITPDKATRNKEVIEMDINDSLYITKVSVRWYQEMLK
CHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEEECCCCEEEEEEHHHHHHHHHH
ALKSAMEPTDAFLNIPLFVMQAGTDWLVDKKMVVKWFNQLASHNKTYREWDGLYHEIFNE
HHHHHCCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
PEREDVFKAARAFAEQYIT
CCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]