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The map label for this gene is gltP [H]

Identifier: 52786913

GI number: 52786913

Start: 3071287

End: 3072537

Strand: Direct

Name: gltP [H]

Synonym: BLi03189

Alternate gene names: 52786913

Gene position: 3071287-3072537 (Clockwise)

Preceding gene: 52786912

Following gene: 52786916

Centisome position: 72.73

GC content: 48.92

Gene sequence:

>1251_bases
TTGAAAAAATTTATCGCTTATCAAATTTTGATCGCACTCGCCATTGGAGCAGTTATCGGACATTTCTTCCCTGATTTCGG
AATGGCGCTGCGCCCCGTCGGAGACGGATTTATCCGTCTGATTAAAATGATCGTCGTTCCAATCGTTTTTTCTACAATTG
TCATCGGAGCGGCCGGAAGCGGAAGCATGAAAAAAATGGGCAGCCTCGGCATCAAGACGATTATTTGGTTTGAAGTGATT
ACGACGTTCGTGCTCGGACTCGGGCTGCTTTTGGCTAATGTGTTAAAGCCCGGCGTCGGCCTTGACCTTTCCCATTTGGC
CAAAAAGGATATCGACGAACTCTCGGGCTACACGGAAAAAGTGGTCGATATTAAACAAATGATCCTCGATATCATTCCTA
CCAACATCGTTGACGTCATGGCCAGAAATGATTTGCTCGCCGTGATCTTCTTTGCGATATTGTTCGGCGTTGCAGCTGCC
GGGATCGGCAAAGCCTCGGAACCTGTCATGAAGTTTTTTGAATCTGTTGCCAACATCATGTTCAAGCTGACGCAGATGGT
GATGGTCACAGCGCCTATCGGCGTGCTTGCTCTTATGGCCGCATCCGTCGGGCAATACGGCATCGAGCTCCTGCTTCCTA
TGTTAAAATTAGTCGGCACTGTTTTTCTCGGACTGTTTCTCGTTCTTTTTGTTTTATTTCCGATCGTCGGTCTTGTTTTT
AAAATTAAATACTTCGAAGTCCTGAAAATGATTTGGGATTTGTTTCTGATCGCGTTCTCCACGACGAGCACAGAAACAGT
CTTGCCGCAGCTGATGGACCGCATGGAGAAATACGGCTGCCCAAAACGGGTCGTTTCCTTCGTGGTTCCTTCAGGCTTAT
CTCTGAATTGCGACGGCTCCAGCCTATATTTATCGGTCGCCTGTATCTTTTTGGCGCAGGCTTTCAATATAGACATGAGC
ATTTCCCAGCAATTGCTCATGATGCTCGTGCTAGTGATGACAAGCAAAGGGATCGCCGCCGTGCCATCTGGCTCGCTCGT
CGTCCTTCTGGCTACCGCCAACGCAGTCGGCCTTCCCGCTGAAGGAGTCGCGATTATCGCGGGAGTGGACCGCGTGATGG
ACATGGCGCGAACAGGCGTGAACGTGCCGGGTCATGCTGTCGCCTGCATCGTTGTTTCTAAATGGGAAAAAAGCTTCCGG
TATAATAAGCGCTTTGTGCTTGAAAAACAATACCGGACGGAAAGCTTATAA

Upstream 100 bases:

>100_bases
AGATTTCGGAATTTTCTAAAAAACACCAAATAATGGAGGTGGTTTCACTCTTTGTCGCGAAATTATTGAAAACTCATGGA
AAATACGGAGGGATTTCGCT

Downstream 100 bases:

>100_bases
ACGGCAAAAGCTCAAGCCGATAAACGGTTTGAGCTTTTCTTTACGAGCTTTTCATCCACGGCATTTTTTGAATTTTGCGG
TATGCCCTGCCGTTAATATA

Product: hypothetical protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKKFIAYQILIALAIGAVIGHFFPDFGMALRPVGDGFIRLIKMIVVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVI
TTFVLGLGLLLANVLKPGVGLDLSHLAKKDIDELSGYTEKVVDIKQMILDIIPTNIVDVMARNDLLAVIFFAILFGVAAA
GIGKASEPVMKFFESVANIMFKLTQMVMVTAPIGVLALMAASVGQYGIELLLPMLKLVGTVFLGLFLVLFVLFPIVGLVF
KIKYFEVLKMIWDLFLIAFSTTSTETVLPQLMDRMEKYGCPKRVVSFVVPSGLSLNCDGSSLYLSVACIFLAQAFNIDMS
ISQQLLMMLVLVMTSKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAVACIVVSKWEKSFR
YNKRFVLEKQYRTESL

Sequences:

>Translated_416_residues
MKKFIAYQILIALAIGAVIGHFFPDFGMALRPVGDGFIRLIKMIVVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVI
TTFVLGLGLLLANVLKPGVGLDLSHLAKKDIDELSGYTEKVVDIKQMILDIIPTNIVDVMARNDLLAVIFFAILFGVAAA
GIGKASEPVMKFFESVANIMFKLTQMVMVTAPIGVLALMAASVGQYGIELLLPMLKLVGTVFLGLFLVLFVLFPIVGLVF
KIKYFEVLKMIWDLFLIAFSTTSTETVLPQLMDRMEKYGCPKRVVSFVVPSGLSLNCDGSSLYLSVACIFLAQAFNIDMS
ISQQLLMMLVLVMTSKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAVACIVVSKWEKSFR
YNKRFVLEKQYRTESL
>Mature_416_residues
MKKFIAYQILIALAIGAVIGHFFPDFGMALRPVGDGFIRLIKMIVVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVI
TTFVLGLGLLLANVLKPGVGLDLSHLAKKDIDELSGYTEKVVDIKQMILDIIPTNIVDVMARNDLLAVIFFAILFGVAAA
GIGKASEPVMKFFESVANIMFKLTQMVMVTAPIGVLALMAASVGQYGIELLLPMLKLVGTVFLGLFLVLFVLFPIVGLVF
KIKYFEVLKMIWDLFLIAFSTTSTETVLPQLMDRMEKYGCPKRVVSFVVPSGLSLNCDGSSLYLSVACIFLAQAFNIDMS
ISQQLLMMLVLVMTSKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAVACIVVSKWEKSFR
YNKRFVLEKQYRTESL

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=392, Percent_Identity=27.0408163265306, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI40254478, Length=464, Percent_Identity=26.2931034482759, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI66773030, Length=419, Percent_Identity=25.7756563245823, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI169790839, Length=459, Percent_Identity=23.3115468409586, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI4827012, Length=266, Percent_Identity=27.8195488721804, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI194239697, Length=423, Percent_Identity=24.113475177305, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI223468566, Length=251, Percent_Identity=28.2868525896414, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI223468564, Length=250, Percent_Identity=28.4, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI5032093, Length=379, Percent_Identity=25.3298153034301, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI262359914, Length=379, Percent_Identity=22.6912928759894, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI301601644, Length=173, Percent_Identity=30.0578034682081, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1790514, Length=423, Percent_Identity=45.8628841607565, Blast_Score=363, Evalue=1e-102,
Organism=Escherichia coli, GI1789947, Length=404, Percent_Identity=38.1188118811881, Blast_Score=304, Evalue=8e-84,
Organism=Escherichia coli, GI1788024, Length=407, Percent_Identity=26.5356265356265, Blast_Score=111, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17537407, Length=394, Percent_Identity=27.1573604060914, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71996953, Length=419, Percent_Identity=26.7303102625298, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71983106, Length=461, Percent_Identity=25.5965292841649, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI71983099, Length=417, Percent_Identity=26.1390887290168, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI193206505, Length=448, Percent_Identity=26.7857142857143, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI193206654, Length=414, Percent_Identity=24.6376811594203, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17541374, Length=406, Percent_Identity=25.1231527093596, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24583025, Length=400, Percent_Identity=24.25, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI17137668, Length=400, Percent_Identity=24.25, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24583023, Length=400, Percent_Identity=24.25, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI281360481, Length=439, Percent_Identity=25.0569476082005, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281360483, Length=440, Percent_Identity=25, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17137666, Length=440, Percent_Identity=25, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45023; Mature: 45023

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHEEHHHHCCCC
>Mature Secondary Structure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CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHEEHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7751298; 9384377 [H]