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The map label for this gene is kbl [H]

Identifier: 52785682

GI number: 52785682

Start: 1884035

End: 1885210

Strand: Direct

Name: kbl [H]

Synonym: BLi01924

Alternate gene names: 52785682

Gene position: 1884035-1885210 (Clockwise)

Preceding gene: 52785681

Following gene: 52785683

Centisome position: 44.62

GC content: 48.38

Gene sequence:

>1176_bases
ATGAAAGAATTCAATTTTTTAGCTTCCGAGCTTAATACAATGAAAGAAAACGGAACTTTTCAAGAGCTGCCGATCATCGA
ATCAATGCAAGGATCAACCGTCAAAATGAAAGGAAAAGACATTATACAGCTTTCATCCAATAACTATCTCGGGCTGACGT
CTCATCCGCGCCTCCAAAAAGCGGCCGAAGAGGCGGTCAAACGGTACGGAGCTGGAACCGGATCGGTCCGTACAATAGCC
GGAACATTCACCATGCATGATGAGCTCGAAAAGAAGCTTGCTTCATTTAAAAACACTGAAGCGGCACTCGTATTCCAGTC
CGGATTTACCGCAAATCAAGGCATTCTTTCAAGCATTCTCACCAAAGATGATCTTGTTATCTCAGACGAATTAAACCATG
CTTCCATCATTGACGGCATCAGACTCACCAAAGCGGGCAAAAAAGTATATCAGCATGCGGACATGGAAGATTTAGAAAAG
ATTTTGAAAAAGTCGATGAACTACAGAATGCGCCTTATCGTTACAGACGGCGTGTTTTCGATGGACGGAGACATCGCGCC
GCTGCCCGAAATCGTCCGGCTCGCTGAACAGTATGACGCATTTGTCATGGTCGACGACGCGCACGCGTCCGGCGTTCTCG
GCGAAAACGGGCGCGGAACGGTTCACCATTTCGGGCTGGACGGGAAGGTTCACATTCAAGTCGGCACACTCAGCAAGGCG
ATCGGCGTATTAGGAGGCTATGCGGCCGGATCCAAGGTGCTGATCGACTACTTAAAGCATAAAGGAAGACCGTTTCTCTT
CAGTACTTCCCATCCGCCGGCCGTCACTGCGGCATGCATTGAAGCGGTCAATGTGCTGATGGAGGAACCTTCATTGATTA
AAAAGCTTTGGGACAATACCGCGTACTTCAAAAAAGAGCTTGAAAAAATCGGCCTTCCGCTGATTAAGAGCGAAACGCCG
ATTACGCCGATTTTGATCGGTGATGAAGCTGAGGCATGCCGCTTCTCAAACACGCTTTTTGAGCTCGGTTTATTTGCCCA
GGCCATTGTATTTCCGACCGTCCCGAAAGGCAAAGCGCGGATCAGAACGATCATGACCGCCCAGCATTCGAAAGAAGAGC
TCGATAAAGCGCTTGAAATCATTCAAACCGGCGCTAAAAAAGCGGGTCTGCTTTAA

Upstream 100 bases:

>100_bases
TCACCGTTTCCCGATGGAAGAGTTTGAAAAAGGCTTTGAACTGATGAGAAAAGGGCAATGCGGCAAAGTCGTACTGATAC
CGTAGAAAGGAGAGATTAAT

Downstream 100 bases:

>100_bases
ACTCATCGATTTCTTTTTGAACAAAGCAAATAACCATTGATAATCATTTTCAGTTAGTGTACAATGATGGGTTCTGGGTT
GTGCTGACAACCGAGAACCT

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MKEFNFLASELNTMKENGTFQELPIIESMQGSTVKMKGKDIIQLSSNNYLGLTSHPRLQKAAEEAVKRYGAGTGSVRTIA
GTFTMHDELEKKLASFKNTEAALVFQSGFTANQGILSSILTKDDLVISDELNHASIIDGIRLTKAGKKVYQHADMEDLEK
ILKKSMNYRMRLIVTDGVFSMDGDIAPLPEIVRLAEQYDAFVMVDDAHASGVLGENGRGTVHHFGLDGKVHIQVGTLSKA
IGVLGGYAAGSKVLIDYLKHKGRPFLFSTSHPPAVTAACIEAVNVLMEEPSLIKKLWDNTAYFKKELEKIGLPLIKSETP
ITPILIGDEAEACRFSNTLFELGLFAQAIVFPTVPKGKARIRTIMTAQHSKEELDKALEIIQTGAKKAGLL

Sequences:

>Translated_391_residues
MKEFNFLASELNTMKENGTFQELPIIESMQGSTVKMKGKDIIQLSSNNYLGLTSHPRLQKAAEEAVKRYGAGTGSVRTIA
GTFTMHDELEKKLASFKNTEAALVFQSGFTANQGILSSILTKDDLVISDELNHASIIDGIRLTKAGKKVYQHADMEDLEK
ILKKSMNYRMRLIVTDGVFSMDGDIAPLPEIVRLAEQYDAFVMVDDAHASGVLGENGRGTVHHFGLDGKVHIQVGTLSKA
IGVLGGYAAGSKVLIDYLKHKGRPFLFSTSHPPAVTAACIEAVNVLMEEPSLIKKLWDNTAYFKKELEKIGLPLIKSETP
ITPILIGDEAEACRFSNTLFELGLFAQAIVFPTVPKGKARIRTIMTAQHSKEELDKALEIIQTGAKKAGLL
>Mature_391_residues
MKEFNFLASELNTMKENGTFQELPIIESMQGSTVKMKGKDIIQLSSNNYLGLTSHPRLQKAAEEAVKRYGAGTGSVRTIA
GTFTMHDELEKKLASFKNTEAALVFQSGFTANQGILSSILTKDDLVISDELNHASIIDGIRLTKAGKKVYQHADMEDLEK
ILKKSMNYRMRLIVTDGVFSMDGDIAPLPEIVRLAEQYDAFVMVDDAHASGVLGENGRGTVHHFGLDGKVHIQVGTLSKA
IGVLGGYAAGSKVLIDYLKHKGRPFLFSTSHPPAVTAACIEAVNVLMEEPSLIKKLWDNTAYFKKELEKIGLPLIKSETP
ITPILIGDEAEACRFSNTLFELGLFAQAIVFPTVPKGKARIRTIMTAQHSKEELDKALEIIQTGAKKAGLL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=378, Percent_Identity=42.8571428571429, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI284448556, Length=404, Percent_Identity=40.0990099009901, Blast_Score=315, Evalue=3e-86,
Organism=Homo sapiens, GI4758668, Length=365, Percent_Identity=35.3424657534247, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI83977440, Length=364, Percent_Identity=35.4395604395604, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI83977442, Length=364, Percent_Identity=35.4395604395604, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI83977444, Length=364, Percent_Identity=35.4395604395604, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI119220554, Length=361, Percent_Identity=33.5180055401662, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI4502025, Length=357, Percent_Identity=33.8935574229692, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI40316939, Length=357, Percent_Identity=33.8935574229692, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI5454084, Length=375, Percent_Identity=29.8666666666667, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1790046, Length=392, Percent_Identity=41.8367346938776, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1786993, Length=345, Percent_Identity=34.2028985507246, Blast_Score=214, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI71994529, Length=390, Percent_Identity=43.8461538461538, Blast_Score=335, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI32566772, Length=373, Percent_Identity=30.2949061662198, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17560914, Length=423, Percent_Identity=29.5508274231678, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17560912, Length=362, Percent_Identity=31.2154696132597, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71982617, Length=382, Percent_Identity=26.7015706806283, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71982625, Length=382, Percent_Identity=26.7015706806283, Blast_Score=152, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6320438, Length=356, Percent_Identity=34.5505617977528, Blast_Score=206, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=31.7934782608696, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6323954, Length=280, Percent_Identity=27.8571428571429, Blast_Score=132, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24662918, Length=375, Percent_Identity=43.7333333333333, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI17137420, Length=342, Percent_Identity=36.8421052631579, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI17136286, Length=381, Percent_Identity=34.9081364829396, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24653280, Length=386, Percent_Identity=25.3886010362694, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24653276, Length=386, Percent_Identity=25.3886010362694, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24653278, Length=386, Percent_Identity=25.3886010362694, Blast_Score=155, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42765; Mature: 42765

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEFNFLASELNTMKENGTFQELPIIESMQGSTVKMKGKDIIQLSSNNYLGLTSHPRLQK
CCHHHHHHHHHHHHHHCCCEEECCCHHCCCCCEEEECCCEEEEECCCCEEECCCCHHHHH
AAEEAVKRYGAGTGSVRTIAGTFTMHDELEKKLASFKNTEAALVFQSGFTANQGILSSIL
HHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHH
TKDDLVISDELNHASIIDGIRLTKAGKKVYQHADMEDLEKILKKSMNYRMRLIVTDGVFS
CCCCEEEECCCCCHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEECCEEE
MDGDIAPLPEIVRLAEQYDAFVMVDDAHASGVLGENGRGTVHHFGLDGKVHIQVGTLSKA
CCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEECCCCEEEEEECCHHHH
IGVLGGYAAGSKVLIDYLKHKGRPFLFSTSHPPAVTAACIEAVNVLMEEPSLIKKLWDNT
HHHHCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCH
AYFKKELEKIGLPLIKSETPITPILIGDEAEACRFSNTLFELGLFAQAIVFPTVPKGKAR
HHHHHHHHHHCCCEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
IRTIMTAQHSKEELDKALEIIQTGAKKAGLL
HHHHHHHHCCHHHHHHHHHHHHHCCHHCCCC
>Mature Secondary Structure
MKEFNFLASELNTMKENGTFQELPIIESMQGSTVKMKGKDIIQLSSNNYLGLTSHPRLQK
CCHHHHHHHHHHHHHHCCCEEECCCHHCCCCCEEEECCCEEEEECCCCEEECCCCHHHHH
AAEEAVKRYGAGTGSVRTIAGTFTMHDELEKKLASFKNTEAALVFQSGFTANQGILSSIL
HHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHH
TKDDLVISDELNHASIIDGIRLTKAGKKVYQHADMEDLEKILKKSMNYRMRLIVTDGVFS
CCCCEEEECCCCCHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEECCEEE
MDGDIAPLPEIVRLAEQYDAFVMVDDAHASGVLGENGRGTVHHFGLDGKVHIQVGTLSKA
CCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEECCCCEEEEEECCHHHH
IGVLGGYAAGSKVLIDYLKHKGRPFLFSTSHPPAVTAACIEAVNVLMEEPSLIKKLWDNT
HHHHCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCH
AYFKKELEKIGLPLIKSETPITPILIGDEAEACRFSNTLFELGLFAQAIVFPTVPKGKAR
HHHHHHHHHHCCCEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
IRTIMTAQHSKEELDKALEIIQTGAKKAGLL
HHHHHHHHCCHHHHHHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]