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The map label for this gene is dapA [H]

Identifier: 52785661

GI number: 52785661

Start: 1861229

End: 1862098

Strand: Direct

Name: dapA [H]

Synonym: BLi01902

Alternate gene names: 52785661

Gene position: 1861229-1862098 (Clockwise)

Preceding gene: 52785660

Following gene: 52785662

Centisome position: 44.08

GC content: 51.38

Gene sequence:

>870_bases
ATGAACTTCGGAAATATCGCAACCGCGATGGTTACGCCCTTTGACAAAAATGAAAATATCGATTTTCAAAAACTGTCAAA
GCTGATCGATTATTTACTAAACAATGGGACGGATTCCCTGGTCGTTGCCGGAACAACCGGAGAATCGCCGACGCTTTCCG
AAGAAGAAAAGGTAGCGCTCATTCAATACTCTGTCAAGGAAGCGGCAGGCCGTGCCCCAATCATCGCCGGCACGGGAAGC
AACAACACGAAGGCGTCGATCAAGCTGACGAAAAAAGCTGAAGAAGCCGGCGCTGACGCTGTCATGCTCGTCACTCCGTA
CTACAACAAGCCTTCTCAGGAAGGCATGTACCGCCATTTCAGAGCGATTGCGGAGGAAACATCGCTGCCTGTCATGCTTT
ATAATGTGCCGGGAAGAACGGCTGCTTCGCTCGCACCAGAGACGACAATCCGCCTTGCGGAGATCCCGAATATTATCGCC
ATTAAAGAAGCGAGCGGCGACCTAGATGCGATAACAAAAATCGTAGCCGAAACCCCTGAGGACTTTGCAGTTTATTCAGG
AGATGACAGCCTGACACTGCCGGCGCTGTCCGTGGGAGCGAGAGGAATCGTTTCCGTTGCATCACACATCATCGGACCGG
AAATGCAGGAAATGATCAAACATTATACCGAGGGGAACACGGCTCAGGCTGCTTTGATCCATCAAAAGCTGCTTCCGCTG
ATGAAAGGGCTTTTTGCCGCACCGAACCCGTCTCCATTAAAGACGGCTCTTCAGCTGAAGGGTCTTGACGTCGGGTCCGT
CCGGCTCCCTTTGATTCCGCTAAATGAAGATGAACGACTCCGTTTAAGCAGCCTGATGAACGGCCTGTAA

Upstream 100 bases:

>100_bases
GCTCGTGCACGAGAAAAATATGGCGACGGCCGTAAATGCGCTGCATGAAGTGTTTGAACTGTCAAAATAAATATGATTGA
ATCATGATGAGGTGAAAAAA

Downstream 100 bases:

>100_bases
AAAACAATACGGACGAAAACGGTCATTCTCTTTTGGAGGGGATGACCGTTTGTCATATACATAATGGTTCTTGTTTTCTA
AATTTAGATTCAGGTATAAT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS; Vegetative protein 81; VEG81 [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MNFGNIATAMVTPFDKNENIDFQKLSKLIDYLLNNGTDSLVVAGTTGESPTLSEEEKVALIQYSVKEAAGRAPIIAGTGS
NNTKASIKLTKKAEEAGADAVMLVTPYYNKPSQEGMYRHFRAIAEETSLPVMLYNVPGRTAASLAPETTIRLAEIPNIIA
IKEASGDLDAITKIVAETPEDFAVYSGDDSLTLPALSVGARGIVSVASHIIGPEMQEMIKHYTEGNTAQAALIHQKLLPL
MKGLFAAPNPSPLKTALQLKGLDVGSVRLPLIPLNEDERLRLSSLMNGL

Sequences:

>Translated_289_residues
MNFGNIATAMVTPFDKNENIDFQKLSKLIDYLLNNGTDSLVVAGTTGESPTLSEEEKVALIQYSVKEAAGRAPIIAGTGS
NNTKASIKLTKKAEEAGADAVMLVTPYYNKPSQEGMYRHFRAIAEETSLPVMLYNVPGRTAASLAPETTIRLAEIPNIIA
IKEASGDLDAITKIVAETPEDFAVYSGDDSLTLPALSVGARGIVSVASHIIGPEMQEMIKHYTEGNTAQAALIHQKLLPL
MKGLFAAPNPSPLKTALQLKGLDVGSVRLPLIPLNEDERLRLSSLMNGL
>Mature_289_residues
MNFGNIATAMVTPFDKNENIDFQKLSKLIDYLLNNGTDSLVVAGTTGESPTLSEEEKVALIQYSVKEAAGRAPIIAGTGS
NNTKASIKLTKKAEEAGADAVMLVTPYYNKPSQEGMYRHFRAIAEETSLPVMLYNVPGRTAASLAPETTIRLAEIPNIIA
IKEASGDLDAITKIVAETPEDFAVYSGDDSLTLPALSVGARGIVSVASHIIGPEMQEMIKHYTEGNTAQAALIHQKLLPL
MKGLFAAPNPSPLKTALQLKGLDVGSVRLPLIPLNEDERLRLSSLMNGL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=297, Percent_Identity=27.2727272727273, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI13540533, Length=277, Percent_Identity=25.9927797833935, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1788823, Length=278, Percent_Identity=44.2446043165468, Blast_Score=249, Evalue=1e-67,
Organism=Escherichia coli, GI87082415, Length=277, Percent_Identity=32.4909747292419, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786463, Length=285, Percent_Identity=32.9824561403509, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1789620, Length=279, Percent_Identity=31.5412186379928, Blast_Score=134, Evalue=8e-33,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 30917; Mature: 30917

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFGNIATAMVTPFDKNENIDFQKLSKLIDYLLNNGTDSLVVAGTTGESPTLSEEEKVAL
CCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCEEE
IQYSVKEAAGRAPIIAGTGSNNTKASIKLTKKAEEAGADAVMLVTPYYNKPSQEGMYRHF
EEEEHHHHCCCCCEEEECCCCCCEEEEEEEECHHHCCCCEEEEEECCCCCCCHHHHHHHH
RAIAEETSLPVMLYNVPGRTAASLAPETTIRLAEIPNIIAIKEASGDLDAITKIVAETPE
HHHHHHCCCCEEEEECCCCCHHHCCCCCEEEHHHCCCEEEEECCCCCHHHHHHHHHCCCC
DFAVYSGDDSLTLPALSVGARGIVSVASHIIGPEMQEMIKHYTEGNTAQAALIHQKLLPL
CCEEECCCCCEECCHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
MKGLFAAPNPSPLKTALQLKGLDVGSVRLPLIPLNEDERLRLSSLMNGL
HHHHHCCCCCCHHHHHHEECCCCCCCEEEEEEECCCCCHHHHHHHHCCC
>Mature Secondary Structure
MNFGNIATAMVTPFDKNENIDFQKLSKLIDYLLNNGTDSLVVAGTTGESPTLSEEEKVAL
CCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCEEE
IQYSVKEAAGRAPIIAGTGSNNTKASIKLTKKAEEAGADAVMLVTPYYNKPSQEGMYRHF
EEEEHHHHCCCCCEEEECCCCCCEEEEEEEECHHHCCCCEEEEEECCCCCCCHHHHHHHH
RAIAEETSLPVMLYNVPGRTAASLAPETTIRLAEIPNIIAIKEASGDLDAITKIVAETPE
HHHHHHCCCCEEEEECCCCCHHHCCCCCEEEHHHCCCEEEEECCCCCHHHHHHHHHCCCC
DFAVYSGDDSLTLPALSVGARGIVSVASHIIGPEMQEMIKHYTEGNTAQAALIHQKLLPL
CCEEECCCCCEECCHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
MKGLFAAPNPSPLKTALQLKGLDVGSVRLPLIPLNEDERLRLSSLMNGL
HHHHHCCCCCCHHHHHHEECCCCCCCEEEEEEECCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8098035; 9384377; 9298659 [H]