| Definition | Bacillus licheniformis ATCC 14580, complete genome. |
|---|---|
| Accession | NC_006322 |
| Length | 4,222,645 |
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The map label for this gene is yjmF [H]
Identifier: 52785125
GI number: 52785125
Start: 1348174
End: 1349022
Strand: Direct
Name: yjmF [H]
Synonym: BLi01357
Alternate gene names: 52785125
Gene position: 1348174-1349022 (Clockwise)
Preceding gene: 52785124
Following gene: 52785126
Centisome position: 31.93
GC content: 51.0
Gene sequence:
>849_bases ATGCTTGAAATCCATGAAAATTTAGCGGGGAAAACTGCGGTCATCACAGGCGGCAGCGGGGTGCTTTGCGGTGCGATGGC GAGAGAGCTCGGCCGGCAGGGTATGAATGTTGCCATTCTTAATCGAACCGTTGAAAAAGGGGAACTCGTGGCCGAAGCTG TCCGAAAAGCCGGCGGCGCAGCGATTGCAGTTGAGTGTGATGTCATCAGCCAACGGAGCGTTGAACAGGCGAAACGCGTT GTGGCCGACCGATTCGGCGGCTGTGATCTATTGGTGAACGGAGCCGGCGGCAATCACCCCAATGGCACGACATCAGATGA AACATTCAACTCCGAGCACATCTTCCAGGACAACATCAAGACGTTATTTGATCTGAACTGCGATGATGTCGGTTCTGTTC TCAATTTAAACTTCCTCGGTTCTTTCATTCCAACACAGCAATTTGCAAAAATGATGCTGAATCAAAAAGGGGCGTCCGTG ATCAATATTTCTTCAATGAGCGCTCAAACCCCGATGACGAAAGTGCCTGCATACAGCGCGGCGAAAGCGGGCATCGACAA TTTTACGAAATGGCTGGCCGTCTATCTGGCCGAAACGGGAATCAGGGTCAACGCCATTGCCCCGGGATTTTTCCTAACCA ATCAAAATGAAAGGCTTCTTCTTGATCAAAACGGCGAATTTACAGATAGAGCAAAGAAGATCATCTCTCACACCCCGATG AGGCGTTTCGGCAAACCGGAAGATTTGCTGGGGACGCTGCTTTGGCTGGCGGATGAGAAGATGTCCGGATTTGTTACCGG CATAACAGTGCCGGTAGATGGCGGATTTACGGCTTATGCCGGTGTCTAA
Upstream 100 bases:
>100_bases AGTGCAGGCCCGGCTACGGTCTGTATGACAGGGCGCTCGGTATCATGTATTTATGGGGCATATGGGATTCGCTCAATAGA GAAAAACAGGAGGCTTCAAA
Downstream 100 bases:
>100_bases AAACACGATAAAGGGGAGGCCGGTACATGAAGCAGATTGTGTGTGAAAAGCCTTATCGTTTTAAAATGACGGATGTGAAA ATGCCGGAACTAAAGGATGG
Product: D-mannonate oxidoreductase
Products: D-Gluconate; Nicotinamide adenine dinucleotide phosphate [C]
Alternate protein names: NA
Number of amino acids: Translated: 282; Mature: 282
Protein sequence:
>282_residues MLEIHENLAGKTAVITGGSGVLCGAMARELGRQGMNVAILNRTVEKGELVAEAVRKAGGAAIAVECDVISQRSVEQAKRV VADRFGGCDLLVNGAGGNHPNGTTSDETFNSEHIFQDNIKTLFDLNCDDVGSVLNLNFLGSFIPTQQFAKMMLNQKGASV INISSMSAQTPMTKVPAYSAAKAGIDNFTKWLAVYLAETGIRVNAIAPGFFLTNQNERLLLDQNGEFTDRAKKIISHTPM RRFGKPEDLLGTLLWLADEKMSGFVTGITVPVDGGFTAYAGV
Sequences:
>Translated_282_residues MLEIHENLAGKTAVITGGSGVLCGAMARELGRQGMNVAILNRTVEKGELVAEAVRKAGGAAIAVECDVISQRSVEQAKRV VADRFGGCDLLVNGAGGNHPNGTTSDETFNSEHIFQDNIKTLFDLNCDDVGSVLNLNFLGSFIPTQQFAKMMLNQKGASV INISSMSAQTPMTKVPAYSAAKAGIDNFTKWLAVYLAETGIRVNAIAPGFFLTNQNERLLLDQNGEFTDRAKKIISHTPM RRFGKPEDLLGTLLWLADEKMSGFVTGITVPVDGGFTAYAGV >Mature_282_residues MLEIHENLAGKTAVITGGSGVLCGAMARELGRQGMNVAILNRTVEKGELVAEAVRKAGGAAIAVECDVISQRSVEQAKRV VADRFGGCDLLVNGAGGNHPNGTTSDETFNSEHIFQDNIKTLFDLNCDDVGSVLNLNFLGSFIPTQQFAKMMLNQKGASV INISSMSAQTPMTKVPAYSAAKAGIDNFTKWLAVYLAETGIRVNAIAPGFFLTNQNERLLLDQNGEFTDRAKKIISHTPM RRFGKPEDLLGTLLWLADEKMSGFVTGITVPVDGGFTAYAGV
Specific function: Catalyzes A Reversible Reduction Of 5-Ketoglutanate To Form D-Gluconate. Dependent On Nadp, Almost Inactive With NAD. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI40254992, Length=266, Percent_Identity=27.0676691729323, Blast_Score=98, Evalue=7e-21, Organism=Homo sapiens, GI32483357, Length=274, Percent_Identity=29.9270072992701, Blast_Score=94, Evalue=2e-19, Organism=Homo sapiens, GI19923817, Length=278, Percent_Identity=28.0575539568345, Blast_Score=92, Evalue=6e-19, Organism=Homo sapiens, GI31542939, Length=278, Percent_Identity=28.0575539568345, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI5031737, Length=267, Percent_Identity=27.7153558052434, Blast_Score=82, Evalue=4e-16, Organism=Homo sapiens, GI15277342, Length=164, Percent_Identity=33.5365853658537, Blast_Score=82, Evalue=8e-16, Organism=Homo sapiens, GI59889578, Length=232, Percent_Identity=30.1724137931034, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI10190704, Length=274, Percent_Identity=25.9124087591241, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI7705925, Length=277, Percent_Identity=24.5487364620939, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI33667109, Length=207, Percent_Identity=28.9855072463768, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI109715829, Length=259, Percent_Identity=27.7992277992278, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI4758504, Length=215, Percent_Identity=32.5581395348837, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI126723750, Length=271, Percent_Identity=26.1992619926199, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI4503301, Length=271, Percent_Identity=28.0442804428044, Blast_Score=66, Evalue=4e-11, Organism=Homo sapiens, GI224922801, Length=183, Percent_Identity=27.8688524590164, Blast_Score=65, Evalue=5e-11, Organism=Escherichia coli, GI1790717, Length=272, Percent_Identity=29.7794117647059, Blast_Score=114, Evalue=7e-27, Organism=Escherichia coli, GI1789208, Length=274, Percent_Identity=32.8467153284672, Blast_Score=110, Evalue=1e-25, Organism=Escherichia coli, GI87082160, Length=270, Percent_Identity=30, Blast_Score=110, Evalue=1e-25, Organism=Escherichia coli, GI1787905, Length=268, Percent_Identity=27.6119402985075, Blast_Score=100, Evalue=2e-22, Organism=Escherichia coli, GI87082100, Length=279, Percent_Identity=30.8243727598566, Blast_Score=96, Evalue=3e-21, Organism=Escherichia coli, GI1789378, Length=271, Percent_Identity=28.4132841328413, Blast_Score=92, Evalue=4e-20, Organism=Escherichia coli, GI1788459, Length=273, Percent_Identity=28.2051282051282, Blast_Score=92, Evalue=5e-20, Organism=Escherichia coli, GI2367175, Length=269, Percent_Identity=27.5092936802974, Blast_Score=87, Evalue=2e-18, Organism=Escherichia coli, GI1787335, Length=271, Percent_Identity=28.0442804428044, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI1789057, Length=273, Percent_Identity=28.9377289377289, Blast_Score=82, Evalue=4e-17, Organism=Escherichia coli, GI2367365, Length=270, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=7e-14, Organism=Escherichia coli, GI1786812, Length=279, Percent_Identity=24.7311827956989, Blast_Score=67, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17562990, Length=284, Percent_Identity=28.5211267605634, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17538486, Length=278, Percent_Identity=29.136690647482, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17560150, Length=284, Percent_Identity=28.5211267605634, Blast_Score=100, Evalue=7e-22, Organism=Caenorhabditis elegans, GI17559104, Length=281, Percent_Identity=28.4697508896797, Blast_Score=100, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17562906, Length=284, Percent_Identity=26.4084507042254, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17560332, Length=273, Percent_Identity=30.03663003663, Blast_Score=98, Evalue=6e-21, Organism=Caenorhabditis elegans, GI17563726, Length=281, Percent_Identity=27.0462633451957, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17560220, Length=289, Percent_Identity=28.3737024221453, Blast_Score=94, Evalue=7e-20, Organism=Caenorhabditis elegans, GI17562910, Length=285, Percent_Identity=28.0701754385965, Blast_Score=94, Evalue=8e-20, Organism=Caenorhabditis elegans, GI17562904, Length=285, Percent_Identity=28.7719298245614, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI25147288, Length=273, Percent_Identity=30.4029304029304, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17562908, Length=282, Percent_Identity=25.886524822695, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI193204405, Length=287, Percent_Identity=27.5261324041812, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17536025, Length=271, Percent_Identity=28.7822878228782, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17538480, Length=275, Percent_Identity=26.5454545454545, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17565030, Length=280, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17560676, Length=271, Percent_Identity=25.830258302583, Blast_Score=88, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17531453, Length=277, Percent_Identity=24.9097472924188, Blast_Score=87, Evalue=8e-18, Organism=Caenorhabditis elegans, GI72000259, Length=285, Percent_Identity=26.3157894736842, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI17561272, Length=272, Percent_Identity=29.4117647058824, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17551412, Length=288, Percent_Identity=25.6944444444444, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17555706, Length=273, Percent_Identity=27.8388278388278, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI71994604, Length=268, Percent_Identity=28.3582089552239, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17536651, Length=271, Percent_Identity=26.9372693726937, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI115534694, Length=143, Percent_Identity=32.1678321678322, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI71994600, Length=271, Percent_Identity=26.9372693726937, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17544670, Length=276, Percent_Identity=23.1884057971014, Blast_Score=75, Evalue=5e-14, Organism=Caenorhabditis elegans, GI17561402, Length=275, Percent_Identity=26.5454545454545, Blast_Score=74, Evalue=7e-14, Organism=Caenorhabditis elegans, GI193207185, Length=147, Percent_Identity=31.2925170068027, Blast_Score=67, Evalue=1e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=273, Percent_Identity=29.3040293040293, Blast_Score=90, Evalue=5e-19, Organism=Drosophila melanogaster, GI23397609, Length=274, Percent_Identity=29.5620437956204, Blast_Score=113, Evalue=2e-25, Organism=Drosophila melanogaster, GI21357041, Length=275, Percent_Identity=30.1818181818182, Blast_Score=100, Evalue=1e-21, Organism=Drosophila melanogaster, GI24644337, Length=273, Percent_Identity=30.4029304029304, Blast_Score=100, Evalue=2e-21, Organism=Drosophila melanogaster, GI28571526, Length=268, Percent_Identity=27.6119402985075, Blast_Score=97, Evalue=1e-20, Organism=Drosophila melanogaster, GI24639444, Length=273, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=4e-19, Organism=Drosophila melanogaster, GI24644339, Length=276, Percent_Identity=28.2608695652174, Blast_Score=92, Evalue=5e-19, Organism=Drosophila melanogaster, GI21355319, Length=275, Percent_Identity=25.8181818181818, Blast_Score=89, Evalue=4e-18, Organism=Drosophila melanogaster, GI17737361, Length=207, Percent_Identity=32.8502415458937, Blast_Score=80, Evalue=2e-15, Organism=Drosophila melanogaster, GI24665243, Length=231, Percent_Identity=29.4372294372294, Blast_Score=75, Evalue=3e-14, Organism=Drosophila melanogaster, GI221331218, Length=231, Percent_Identity=29.4372294372294, Blast_Score=75, Evalue=4e-14, Organism=Drosophila melanogaster, GI24584748, Length=222, Percent_Identity=28.8288288288288, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI161076933, Length=222, Percent_Identity=28.8288288288288, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI24643142, Length=275, Percent_Identity=28, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI24665247, Length=232, Percent_Identity=29.3103448275862, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI221331216, Length=232, Percent_Identity=29.3103448275862, Blast_Score=72, Evalue=6e-13, Organism=Drosophila melanogaster, GI28574402, Length=237, Percent_Identity=27.0042194092827, Blast_Score=71, Evalue=1e-12, Organism=Drosophila melanogaster, GI24584744, Length=237, Percent_Identity=27.0042194092827, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI24640442, Length=211, Percent_Identity=25.5924170616114, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI21355631, Length=193, Percent_Identity=27.4611398963731, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI21357673, Length=211, Percent_Identity=27.0142180094787, Blast_Score=65, Evalue=6e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.69 [C]
Molecular weight: Translated: 30145; Mature: 30145
Theoretical pI: Translated: 6.13; Mature: 6.13
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 4.6 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 3.2 %Met (Mature Protein) 4.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLEIHENLAGKTAVITGGSGVLCGAMARELGRQGMNVAILNRTVEKGELVAEAVRKAGGA CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCE AIAVECDVISQRSVEQAKRVVADRFGGCDLLVNGAGGNHPNGTTSDETFNSEHIFQDNIK EEEEEECHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEHHCCH TLFDLNCDDVGSVLNLNFLGSFIPTQQFAKMMLNQKGASVINISSMSAQTPMTKVPAYSA HEEECCCHHHHHEEEHHHHHHHCCHHHHHHHHHCCCCCCEEEECCCCCCCCCHHCCCCHH AKAGIDNFTKWLAVYLAETGIRVNAIAPGFFLTNQNERLLLDQNGEFTDRAKKIISHTPM HHHCHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCCEEEEECCCCHHHHHHHHHHCCCH RRFGKPEDLLGTLLWLADEKMSGFVTGITVPVDGGFTAYAGV HHCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCEEEECCC >Mature Secondary Structure MLEIHENLAGKTAVITGGSGVLCGAMARELGRQGMNVAILNRTVEKGELVAEAVRKAGGA CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCE AIAVECDVISQRSVEQAKRVVADRFGGCDLLVNGAGGNHPNGTTSDETFNSEHIFQDNIK EEEEEECHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEHHCCH TLFDLNCDDVGSVLNLNFLGSFIPTQQFAKMMLNQKGASVINISSMSAQTPMTKVPAYSA HEEECCCHHHHHEEEHHHHHHHCCHHHHHHHHHCCCCCCEEEECCCCCCCCCHHCCCCHH AKAGIDNFTKWLAVYLAETGIRVNAIAPGFFLTNQNERLLLDQNGEFTDRAKKIISHTPM HHHCHHHHHHHHHHHHHHCCEEEEEECCCEEEECCCCEEEEECCCCHHHHHHHHHHCCCH RRFGKPEDLLGTLLWLADEKMSGFVTGITVPVDGGFTAYAGV HHCCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCCEEEECCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NAD+; NADH; NADP+; NADPH [C]
Metal ions: Mn2+ [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 20 {D-gluconate}} 0.006 {NADPH}} 0.9 {5-keto-D-gluconate}} 0.02 {NADP+}} [C]
Substrates: 5-Dehydro-D-gluconate; H+; Nicotinamide adenine dinucleotide phosphate - reduced [C]
Specific reaction: 5-Dehydro-D-gluconate + H+ + Nicotinamide adenine dinucleotide phosphate - reduced <==> D-Gluconate + Nicotinamide adenine dinucleotide phosphate [C]
General reaction: Redox reaction [C]
Inhibitor: Cd2+; Cs2+; Cu2+; Divalent metal ions; Hg2+; Ni2+; p-Chloromercuribenzoate; Sn2+; Sulfhydryl reagents [C]
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9579062; 9384377 [H]