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The map label for this gene is uxuA

Identifier: 52785124

GI number: 52785124

Start: 1347101

End: 1348198

Strand: Direct

Name: uxuA

Synonym: BLi01356

Alternate gene names: 52785124

Gene position: 1347101-1348198 (Clockwise)

Preceding gene: 52785123

Following gene: 52785125

Centisome position: 31.9

GC content: 49.36

Gene sequence:

>1098_bases
ATGAAAATGGTTTTCAGATGGTATGGAGAAGGAAACGACTCCGTCACCCTTGAGCAGATCAGGCAGATTCCCGGTGTGGA
GGGAATCGTTTGGGCGCTTCATCATCAGCCGCCGGGTGAAGAGTGGCCATTGGAAGAAATTTTAGAAGTGAAGCGGCAGT
GTGAACAGCACGGTTTTCACATTGAAGTTGTTGAAAGCGTTAACATCCATGAGGATATAAAGCTTGGGCTGCCGACGAGA
GATCTGTATATTGAAAAATACAAGCGAACGATTGAAAATTTGGCCAAAGCCGGCGTAAAAGTGATCTGCTATAATTTTAT
GCCTGTATTTGACTGGCTGCGGACCGATTTGTACAAAAAGGCTCCAGACGGTTCCACCGCTTTGTTCTATGAGCACGCAA
AGGTGCACACAATCGACCCTTTTGCGCTTGTCGATCAAATCGCCAAGCATCCCGAATTCACGATGCCCGGCTGGGAACCG
GAGCGGCTTGAGCATCTGACAAGGCTGTTTGAAGCCTATCAAAATGTGACGGAGGAGGATCTGTGGAGCCATCTTCACTA
TTTTCTTGAACGCATCATTCCAACCGCCGCACGCTGCGGAATCAAAATGGCGATCCATCCCGATGATCCGCCGTGGCCGG
TTTTCGGACTCCCGCGCATCATGACTTCAGGAGAAAGCATCGGGCGGCTGCTACAGCTTGTCGATCATCCGGCGAATGGC
GTGACACTGTGCAGCGGTTCATTGGGCGCCAACCCCGAAAATGATATTTCCGCCATGATCCATGCGTATGCCGACCGGAT
TCCATTTGCCCATATCCGAAACGTCAAAGTCTACGAAAACGGCGATTTTATCGAAACATCGCACAGAACAAAAGATGGCA
CAGTTGACATTTGCGGGATTGTCAAAGCCTATCATGAAACAGGTTTTTCAGGCTATGTGCGTCCGGATCACGGCCGCCAC
ATTTGGGATGAAAAGTGCAGGCCCGGCTACGGTCTGTATGACAGGGCGCTCGGTATCATGTATTTATGGGGCATATGGGA
TTCGCTCAATAGAGAAAAACAGGAGGCTTCAAAATGCTTGAAATCCATGAAAATTTAG

Upstream 100 bases:

>100_bases
CTTTTATGGAAATAGAAGAGGCGTTGAAAAAAGCGAAAAACTGTCCCCATCAGGTCACAAAGATCATTTTATCTTATTGA
ATCGGTGAGGAGGAAGTGTG

Downstream 100 bases:

>100_bases
CGGGGAAAACTGCGGTCATCACAGGCGGCAGCGGGGTGCTTTGCGGTGCGATGGCGAGAGAGCTCGGCCGGCAGGGTATG
AATGTTGCCATTCTTAATCG

Product: mannonate dehydratase

Products: NA

Alternate protein names: D-mannonate hydrolase 1

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MKMVFRWYGEGNDSVTLEQIRQIPGVEGIVWALHHQPPGEEWPLEEILEVKRQCEQHGFHIEVVESVNIHEDIKLGLPTR
DLYIEKYKRTIENLAKAGVKVICYNFMPVFDWLRTDLYKKAPDGSTALFYEHAKVHTIDPFALVDQIAKHPEFTMPGWEP
ERLEHLTRLFEAYQNVTEEDLWSHLHYFLERIIPTAARCGIKMAIHPDDPPWPVFGLPRIMTSGESIGRLLQLVDHPANG
VTLCSGSLGANPENDISAMIHAYADRIPFAHIRNVKVYENGDFIETSHRTKDGTVDICGIVKAYHETGFSGYVRPDHGRH
IWDEKCRPGYGLYDRALGIMYLWGIWDSLNREKQEASKCLKSMKI

Sequences:

>Translated_365_residues
MKMVFRWYGEGNDSVTLEQIRQIPGVEGIVWALHHQPPGEEWPLEEILEVKRQCEQHGFHIEVVESVNIHEDIKLGLPTR
DLYIEKYKRTIENLAKAGVKVICYNFMPVFDWLRTDLYKKAPDGSTALFYEHAKVHTIDPFALVDQIAKHPEFTMPGWEP
ERLEHLTRLFEAYQNVTEEDLWSHLHYFLERIIPTAARCGIKMAIHPDDPPWPVFGLPRIMTSGESIGRLLQLVDHPANG
VTLCSGSLGANPENDISAMIHAYADRIPFAHIRNVKVYENGDFIETSHRTKDGTVDICGIVKAYHETGFSGYVRPDHGRH
IWDEKCRPGYGLYDRALGIMYLWGIWDSLNREKQEASKCLKSMKI
>Mature_365_residues
MKMVFRWYGEGNDSVTLEQIRQIPGVEGIVWALHHQPPGEEWPLEEILEVKRQCEQHGFHIEVVESVNIHEDIKLGLPTR
DLYIEKYKRTIENLAKAGVKVICYNFMPVFDWLRTDLYKKAPDGSTALFYEHAKVHTIDPFALVDQIAKHPEFTMPGWEP
ERLEHLTRLFEAYQNVTEEDLWSHLHYFLERIIPTAARCGIKMAIHPDDPPWPVFGLPRIMTSGESIGRLLQLVDHPANG
VTLCSGSLGANPENDISAMIHAYADRIPFAHIRNVKVYENGDFIETSHRTKDGTVDICGIVKAYHETGFSGYVRPDHGRH
IWDEKCRPGYGLYDRALGIMYLWGIWDSLNREKQEASKCLKSMKI

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1312

COG function: function code G; D-mannonate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannonate dehydratase family

Homologues:

Organism=Escherichia coli, GI1790778, Length=393, Percent_Identity=36.8956743002545, Blast_Score=231, Evalue=7e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXUA1_BACLD (Q65L04)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_078545.1
- RefSeq:   YP_090953.1
- ProteinModelPortal:   Q65L04
- SMR:   Q65L04
- STRING:   Q65L04
- EnsemblBacteria:   EBBACT00000054805
- EnsemblBacteria:   EBBACT00000061259
- GeneID:   3030383
- GeneID:   3101581
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi01356
- KEGG:   bli:BL03802
- NMPDR:   fig|279010.5.peg.716
- eggNOG:   COG1312
- GeneTree:   EBGT00050000001836
- HOGENOM:   HBG585927
- OMA:   GIVWALH
- ProtClustDB:   PRK03906
- BioCyc:   BLIC279010-1:BLI01356-MONOMER
- BioCyc:   BLIC279010:BL03802-MONOMER
- HAMAP:   MF_00106
- InterPro:   IPR004628
- InterPro:   IPR013022
- Gene3D:   G3DSA:3.20.20.150
- PIRSF:   PIRSF016049
- TIGRFAMs:   TIGR00695

Pfam domain/function: PF03786 UxuA; SSF51658 Xyl_isomerase-like_TIM-brl

EC number: =4.2.1.8

Molecular weight: Translated: 42015; Mature: 42015

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMVFRWYGEGNDSVTLEQIRQIPGVEGIVWALHHQPPGEEWPLEEILEVKRQCEQHGFH
CCEEEEEECCCCCCEEHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCE
IEVVESVNIHEDIKLGLPTRDLYIEKYKRTIENLAKAGVKVICYNFMPVFDWLRTDLYKK
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHC
APDGSTALFYEHAKVHTIDPFALVDQIAKHPEFTMPGWEPERLEHLTRLFEAYQNVTEED
CCCCCEEEEEECCEEEECCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHH
LWSHLHYFLERIIPTAARCGIKMAIHPDDPPWPVFGLPRIMTSGESIGRLLQLVDHPANG
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHCCHHHHHHHHHHHCCCCC
VTLCSGSLGANPENDISAMIHAYADRIPFAHIRNVKVYENGDFIETSHRTKDGTVDICGI
EEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHCCEEEEECCCEEECCCCCCCCCCHHHHH
VKAYHETGFSGYVRPDHGRHIWDEKCRPGYGLYDRALGIMYLWGIWDSLNREKQEASKCL
HHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
KSMKI
HHCCC
>Mature Secondary Structure
MKMVFRWYGEGNDSVTLEQIRQIPGVEGIVWALHHQPPGEEWPLEEILEVKRQCEQHGFH
CCEEEEEECCCCCCEEHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCE
IEVVESVNIHEDIKLGLPTRDLYIEKYKRTIENLAKAGVKVICYNFMPVFDWLRTDLYKK
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHC
APDGSTALFYEHAKVHTIDPFALVDQIAKHPEFTMPGWEPERLEHLTRLFEAYQNVTEED
CCCCCEEEEEECCEEEECCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHH
LWSHLHYFLERIIPTAARCGIKMAIHPDDPPWPVFGLPRIMTSGESIGRLLQLVDHPANG
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHCCHHHHHHHHHHHCCCCC
VTLCSGSLGANPENDISAMIHAYADRIPFAHIRNVKVYENGDFIETSHRTKDGTVDICGI
EEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHCCEEEEECCCEEECCCCCCCCCCHHHHH
VKAYHETGFSGYVRPDHGRHIWDEKCRPGYGLYDRALGIMYLWGIWDSLNREKQEASKCL
HHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
KSMKI
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA