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The map label for this gene is vanR [H]

Identifier: 52784924

GI number: 52784924

Start: 1157990

End: 1158664

Strand: Reverse

Name: vanR [H]

Synonym: BLi01152

Alternate gene names: 52784924

Gene position: 1158664-1157990 (Counterclockwise)

Preceding gene: 52784925

Following gene: 52784923

Centisome position: 27.44

GC content: 47.41

Gene sequence:

>675_bases
TTGAACGTGCTGCTTGTCGATGATGAAAACCGGATGCTCGATCTGCTGGAGCTTTATTTAGAGCATTATTCGTGCACAAA
AGCCGCCACCGGAAAAGAAGCCCTGGACTTAATAAAAATGCGCAATTTCGATCTTGTCATCCTCGATATCATGATGCCTG
AAATGGACGGATGGACGGTTTGCAAAGAGATCCGAAGATTGACAAGCATTCCGGTTATCATGCTGACGGCAAAAAACGGG
CAGGATGATATTGTACGAGGCCTGAACTGCGGTGCAGACGATTATTTAACAAAGCCGTTCAGCGAAAAAGTGCTGCTTGC
CAAAATAGAAGCCGTCCTGCGCAGAACCCGCCGATTTCATGAAATCAGGTTCCGCGGTTTAATCTGGAATAAACAGCATC
ATACCCTGCATGTCAATCACCGTGAAATCAGCATTACGCCAAGTGAATTCGATCTGCTTGGAACACTCTTAGACCATATG
GATCAAGTGCTTTCGAGAGACCAATTGATTGAGAACATCTGGGGATTCAACTCTGATATCGAGCCCCGCACCATCGATTC
GCACATGAGAAATTTGCGGCACCGATTGAAAAAAGCGGGCTTTCCGGTTGAAGACCATCTCCGGACCGTCTACGGCGTCG
GCTACAAATGGACAAGCAAAGGAACCGGAGCATGA

Upstream 100 bases:

>100_bases
CAAAGAGGTGATTCAGTTCGTTCCGCCTTGATCAATATACCCTTATAGGGTATATTTTTAAAATAGCGGACTTATATTTT
GACTAAAGAGGTGCTAGACA

Downstream 100 bases:

>100_bases
AAAAGATTTCATTTGAGCTCGCAGGTTCATTTTTCGTTTTAATCCTTTTCATCGAAGCCGTCCTTTTTGCCGCGCTGTAT
ACAACGATTGTCAACACGAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MNVLLVDDENRMLDLLELYLEHYSCTKAATGKEALDLIKMRNFDLVILDIMMPEMDGWTVCKEIRRLTSIPVIMLTAKNG
QDDIVRGLNCGADDYLTKPFSEKVLLAKIEAVLRRTRRFHEIRFRGLIWNKQHHTLHVNHREISITPSEFDLLGTLLDHM
DQVLSRDQLIENIWGFNSDIEPRTIDSHMRNLRHRLKKAGFPVEDHLRTVYGVGYKWTSKGTGA

Sequences:

>Translated_224_residues
MNVLLVDDENRMLDLLELYLEHYSCTKAATGKEALDLIKMRNFDLVILDIMMPEMDGWTVCKEIRRLTSIPVIMLTAKNG
QDDIVRGLNCGADDYLTKPFSEKVLLAKIEAVLRRTRRFHEIRFRGLIWNKQHHTLHVNHREISITPSEFDLLGTLLDHM
DQVLSRDQLIENIWGFNSDIEPRTIDSHMRNLRHRLKKAGFPVEDHLRTVYGVGYKWTSKGTGA
>Mature_224_residues
MNVLLVDDENRMLDLLELYLEHYSCTKAATGKEALDLIKMRNFDLVILDIMMPEMDGWTVCKEIRRLTSIPVIMLTAKNG
QDDIVRGLNCGADDYLTKPFSEKVLLAKIEAVLRRTRRFHEIRFRGLIWNKQHHTLHVNHREISITPSEFDLLGTLLDHM
DQVLSRDQLIENIWGFNSDIEPRTIDSHMRNLRHRLKKAGFPVEDHLRTVYGVGYKWTSKGTGA

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=36, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=35.3982300884956, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=34.6846846846847, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1789809, Length=236, Percent_Identity=32.2033898305085, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=32.2869955156951, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=32.4324324324324, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=31.8181818181818, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=34.6320346320346, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=29.7777777777778, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=31.2217194570136, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=28.5087719298246, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.004329004329, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=29.0909090909091, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=25.2173913043478, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1790437, Length=157, Percent_Identity=31.2101910828025, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788550, Length=101, Percent_Identity=40.5940594059406, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=121, Percent_Identity=33.8842975206612, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=36.036036036036, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788905, Length=112, Percent_Identity=33.9285714285714, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1788713, Length=108, Percent_Identity=35.1851851851852, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI48994928, Length=116, Percent_Identity=38.7931034482759, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788192, Length=103, Percent_Identity=37.8640776699029, Blast_Score=60, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322000, Length=102, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26026; Mature: 26026

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVLLVDDENRMLDLLELYLEHYSCTKAATGKEALDLIKMRNFDLVILDIMMPEMDGWTV
CEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHH
CKEIRRLTSIPVIMLTAKNGQDDIVRGLNCGADDYLTKPFSEKVLLAKIEAVLRRTRRFH
HHHHHHHHCCCEEEEEECCCHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
EIRFRGLIWNKQHHTLHVNHREISITPSEFDLLGTLLDHMDQVLSRDQLIENIWGFNSDI
HHHHHHEEECCCCCEEEEECCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EPRTIDSHMRNLRHRLKKAGFPVEDHLRTVYGVGYKWTSKGTGA
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEECCCCCCC
>Mature Secondary Structure
MNVLLVDDENRMLDLLELYLEHYSCTKAATGKEALDLIKMRNFDLVILDIMMPEMDGWTV
CEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHH
CKEIRRLTSIPVIMLTAKNGQDDIVRGLNCGADDYLTKPFSEKVLLAKIEAVLRRTRRFH
HHHHHHHHCCCEEEEEECCCHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
EIRFRGLIWNKQHHTLHVNHREISITPSEFDLLGTLLDHMDQVLSRDQLIENIWGFNSDI
HHHHHHEEECCCCCEEEEECCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EPRTIDSHMRNLRHRLKKAGFPVEDHLRTVYGVGYKWTSKGTGA
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]