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The map label for this gene is phoR [H]

Identifier: 52784923

GI number: 52784923

Start: 1156626

End: 1157993

Strand: Reverse

Name: phoR [H]

Synonym: BLi01151

Alternate gene names: 52784923

Gene position: 1157993-1156626 (Counterclockwise)

Preceding gene: 52784924

Following gene: 52784922

Centisome position: 27.42

GC content: 47.37

Gene sequence:

>1368_bases
ATGAAAAAGATTTCATTTGAGCTCGCAGGTTCATTTTTCGTTTTAATCCTTTTCATCGAAGCCGTCCTTTTTGCCGCGCT
GTATACAACGATTGTCAACACGAGAATAAACGAAGAAATAAGCGCGCTTCAACTAAGAGGCAACAGCCACAGAGACGTCC
TCGAAAAGCATTTTGACAAAAGGACGATAGACCACGTCACCCTGATGGAGACTGAAGCCCGGACAAACGTGATCATCACG
GACCAAAACAGACGCGTATTGGCGCAGTCTGCCCCGGGAGACATGACGGAACACCTTCATTTCGAAGAACAGAACATCCC
GAGGAACGGGACCGCTTTATCTTCCCATTGGAATACATCAAAGTACATTTGTACGATCAGTCCGATCATGAACGGACGGG
AAACGGCCGGCTACGTCTTCATGTATTTGGAGACCTCCTCGATAAAAGCCTTGGTGGCAAGCATTACGAAGCGGTTTTTC
CTCAGCTTCGGCTTAACCGGCGTCTTAACGGTCGCAGCTATTCTTTGGTTCAGCCGTGTTTTAGCGAAGCCGATTATTAA
ACTGAAGGAGGCAACCGAAAGCATCAAAAACGGTCAAGCTTCGATTCCGCTTGATATCAAAAGGAATGATGAACTCGGAG
AGCTCGCCGCATCAATCGAAAGCCTTTCCTCAAATCTCAGCAGGCTTCAAAAAGAGCGAAACGATTTTCTGTCAAGCGTC
GCCCATGAGCTGCGGACTCCGATCACATATATAAAAGGCTACACAGATGTCGCGATGAGAGATAAGCTCGAACCGCAAGC
CAGAAATCAGTACTTGTCGATCATCAAAGAGGAAGCGGACAATTTAAACACCCTTGTTGACGATTTATTTTTGCTGACAA
AACTGAAACAGCCCGGATTTCAAATCAATAAGAAACAGGTTCACCTTTACACATTCGTGAAAAAAGAAATTCAGAAAGCG
GCGGTCGCTTTTTCGGAAAAGCGAATCAGCGTTTCGTTCGACATCCCGACGGATCTTTATGTCACAGTCGACGAGGTCCG
CTTTTCACAAGTGATCTCAAATTTGCTGAACAACGCCCGCCAATACTCCGATCCTGAATCAACAGCGGCCGTCACCGCAT
CAAAATTGGAGGACCAGGTCAAGATTACGGTAGCGGATGAAGGCTGCGGCATTCCGGAAGAAGAACGGGATTATATATTT
GAGCGCTTTTACCGGATCGATAAATCGAGGTCCAGACAAACCGGCGGTACCGGGCTGGGTCTGGCCATCGTGAAAGAAAT
CGTCGAGCTTCATGGCGGTCAGATTGCAGCGAAAAACAGAACCCCGAAAGGAAGCGAATTTATCATCACGCTGCCTTCCG
ATGTGTAA

Upstream 100 bases:

>100_bases
ATTTGCGGCACCGATTGAAAAAAGCGGGCTTTCCGGTTGAAGACCATCTCCGGACCGTCTACGGCGTCGGCTACAAATGG
ACAAGCAAAGGAACCGGAGC

Downstream 100 bases:

>100_bases
CAATGTCGAGATGTCTGCACCAGTTTTGCACATTTCCCGGGTATACTACTCAGTAATCTGAACCAAAAAGGGGGAAAACA
CAATGAAATTGAGATTCGGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKKISFELAGSFFVLILFIEAVLFAALYTTIVNTRINEEISALQLRGNSHRDVLEKHFDKRTIDHVTLMETEARTNVIIT
DQNRRVLAQSAPGDMTEHLHFEEQNIPRNGTALSSHWNTSKYICTISPIMNGRETAGYVFMYLETSSIKALVASITKRFF
LSFGLTGVLTVAAILWFSRVLAKPIIKLKEATESIKNGQASIPLDIKRNDELGELAASIESLSSNLSRLQKERNDFLSSV
AHELRTPITYIKGYTDVAMRDKLEPQARNQYLSIIKEEADNLNTLVDDLFLLTKLKQPGFQINKKQVHLYTFVKKEIQKA
AVAFSEKRISVSFDIPTDLYVTVDEVRFSQVISNLLNNARQYSDPESTAAVTASKLEDQVKITVADEGCGIPEEERDYIF
ERFYRIDKSRSRQTGGTGLGLAIVKEIVELHGGQIAAKNRTPKGSEFIITLPSDV

Sequences:

>Translated_455_residues
MKKISFELAGSFFVLILFIEAVLFAALYTTIVNTRINEEISALQLRGNSHRDVLEKHFDKRTIDHVTLMETEARTNVIIT
DQNRRVLAQSAPGDMTEHLHFEEQNIPRNGTALSSHWNTSKYICTISPIMNGRETAGYVFMYLETSSIKALVASITKRFF
LSFGLTGVLTVAAILWFSRVLAKPIIKLKEATESIKNGQASIPLDIKRNDELGELAASIESLSSNLSRLQKERNDFLSSV
AHELRTPITYIKGYTDVAMRDKLEPQARNQYLSIIKEEADNLNTLVDDLFLLTKLKQPGFQINKKQVHLYTFVKKEIQKA
AVAFSEKRISVSFDIPTDLYVTVDEVRFSQVISNLLNNARQYSDPESTAAVTASKLEDQVKITVADEGCGIPEEERDYIF
ERFYRIDKSRSRQTGGTGLGLAIVKEIVELHGGQIAAKNRTPKGSEFIITLPSDV
>Mature_455_residues
MKKISFELAGSFFVLILFIEAVLFAALYTTIVNTRINEEISALQLRGNSHRDVLEKHFDKRTIDHVTLMETEARTNVIIT
DQNRRVLAQSAPGDMTEHLHFEEQNIPRNGTALSSHWNTSKYICTISPIMNGRETAGYVFMYLETSSIKALVASITKRFF
LSFGLTGVLTVAAILWFSRVLAKPIIKLKEATESIKNGQASIPLDIKRNDELGELAASIESLSSNLSRLQKERNDFLSSV
AHELRTPITYIKGYTDVAMRDKLEPQARNQYLSIIKEEADNLNTLVDDLFLLTKLKQPGFQINKKQVHLYTFVKKEIQKA
AVAFSEKRISVSFDIPTDLYVTVDEVRFSQVISNLLNNARQYSDPESTAAVTASKLEDQVKITVADEGCGIPEEERDYIF
ERFYRIDKSRSRQTGGTGLGLAIVKEIVELHGGQIAAKNRTPKGSEFIITLPSDV

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=31.4079422382672, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1786600, Length=278, Percent_Identity=29.4964028776978, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1786783, Length=349, Percent_Identity=24.6418338108883, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1786912, Length=223, Percent_Identity=32.7354260089686, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1790346, Length=276, Percent_Identity=30.0724637681159, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1789149, Length=221, Percent_Identity=28.9592760180996, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1787894, Length=287, Percent_Identity=26.4808362369338, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=29.1304347826087, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1790861, Length=329, Percent_Identity=23.1003039513678, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=32.8767123287671, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI48994928, Length=229, Percent_Identity=27.0742358078603, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI145693157, Length=254, Percent_Identity=27.1653543307087, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=27.9475982532751, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87082128, Length=289, Percent_Identity=24.2214532871972, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788279, Length=295, Percent_Identity=27.4576271186441, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI87081816, Length=340, Percent_Identity=23.2352941176471, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789808, Length=269, Percent_Identity=23.7918215613383, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789403, Length=383, Percent_Identity=26.6318537859008, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1787374, Length=310, Percent_Identity=23.8709677419355, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790551, Length=290, Percent_Identity=25.5172413793103, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790300, Length=233, Percent_Identity=27.4678111587983, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786837, Length=114, Percent_Identity=34.2105263157895, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51188; Mature: 51188

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKISFELAGSFFVLILFIEAVLFAALYTTIVNTRINEEISALQLRGNSHRDVLEKHFDK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEECCCCHHHHHHHHHHH
RTIDHVTLMETEARTNVIITDQNRRVLAQSAPGDMTEHLHFEEQNIPRNGTALSSHWNTS
HHHCCEEEEEECCCCEEEEECCCCEEEECCCCCCHHHHCCCCCCCCCCCCCEECCCCCCC
KYICTISPIMNGRETAGYVFMYLETSSIKALVASITKRFFLSFGLTGVLTVAAILWFSRV
EEEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
LAKPIIKLKEATESIKNGQASIPLDIKRNDELGELAASIESLSSNLSRLQKERNDFLSSV
HHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHELRTPITYIKGYTDVAMRDKLEPQARNQYLSIIKEEADNLNTLVDDLFLLTKLKQPGF
HHHHHCCHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QINKKQVHLYTFVKKEIQKAAVAFSEKRISVSFDIPTDLYVTVDEVRFSQVISNLLNNAR
CCCCCEEHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHH
QYSDPESTAAVTASKLEDQVKITVADEGCGIPEEERDYIFERFYRIDKSRSRQTGGTGLG
HCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHH
LAIVKEIVELHGGQIAAKNRTPKGSEFIITLPSDV
HHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MKKISFELAGSFFVLILFIEAVLFAALYTTIVNTRINEEISALQLRGNSHRDVLEKHFDK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEECCCCHHHHHHHHHHH
RTIDHVTLMETEARTNVIITDQNRRVLAQSAPGDMTEHLHFEEQNIPRNGTALSSHWNTS
HHHCCEEEEEECCCCEEEEECCCCEEEECCCCCCHHHHCCCCCCCCCCCCCEECCCCCCC
KYICTISPIMNGRETAGYVFMYLETSSIKALVASITKRFFLSFGLTGVLTVAAILWFSRV
EEEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
LAKPIIKLKEATESIKNGQASIPLDIKRNDELGELAASIESLSSNLSRLQKERNDFLSSV
HHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHELRTPITYIKGYTDVAMRDKLEPQARNQYLSIIKEEADNLNTLVDDLFLLTKLKQPGF
HHHHHCCHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QINKKQVHLYTFVKKEIQKAAVAFSEKRISVSFDIPTDLYVTVDEVRFSQVISNLLNNAR
CCCCCEEHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHH
QYSDPESTAAVTASKLEDQVKITVADEGCGIPEEERDYIFERFYRIDKSRSRQTGGTGLG
HCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHH
LAIVKEIVELHGGQIAAKNRTPKGSEFIITLPSDV
HHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]