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The map label for this gene is hemY [H]

Identifier: 52784866

GI number: 52784866

Start: 1093070

End: 1094482

Strand: Direct

Name: hemY [H]

Synonym: BLi01094

Alternate gene names: 52784866

Gene position: 1093070-1094482 (Clockwise)

Preceding gene: 52784865

Following gene: 52784867

Centisome position: 25.89

GC content: 51.73

Gene sequence:

>1413_bases
ATGAGTGGAGAACGCAGGCAGATTGTCATCATCGGCGGCGGTATTACCGGGTTGGCCGCCGCCTTCTACTTGGAGAAGGA
AATCAAAAAGAATGATCTCCCGGCCGAAGTCACGCTTGTTGAAGCAAGCCCGAGACTGGGCGGAAAGATGCAGACGGTAC
ACAAAGACGGCTATGTGATTGAACGGGGTCCGGATTCATTTTTGGAACGGAAACAAAGCGCACCTCAGCTCGTGAAGGAT
CTCGGACTGGAGCATTTGCTTGTGAACAATGCGACTGGCCAGTCTTATGTGCTTGTCAGCGAAACGCTCTATCCGATTCC
GGAAGGAGCCGTGATGGGGGTGCCGACAAAAATCGGTCCTTTTCTGACAACCGGCTTGTTTTCCTTGCCGGGGAAGTTGA
GAGCCGGAATGGATTTGGTGCTTCCAGCAAGCAAGCCGCAGGAAGACCAATCGCTCGGAGAATTTTTCAGAAGGCGCGTC
GGCGGTGAAGTGGTGGAGAACCTGATCGAACCGCTTTTGTCAGGCATTTATGCCGGGGACATCGACCGTCTCAGTCTGAT
GTCGACTTTCCCGCAGTTCTATCAGACAGAGCAGAAGTACAGAAGCTTGATCATCGGGATGAAAAAATCGCGCGGCGCCC
AGAGCGTCGGAAAGCCTGCAAACAAAAAGAAAGGCCAGTTCCAGACGGTGAAAACCGGCCTGCAGACGATAGTTGAAGAA
TTGGAAAAGCAGCTCGGCATCACAAAGGTTTATAAAGGCACAAAGGTCGTCAGCATTGAGCGTGCGGGCTCGGCTTACAG
CATGAAGCTTGACAACGGCAAGGTGCTTCACGCCGATTCGGCCGTGGTCACCGCTCCTCATAAAGCAGCTGCCGCGATGT
TTCAAAAAGAGGATTGGCTGAAGGGTTTAGAGGATATGGTGTCAACATCTGTCGCCAATGTGGCGCTCGGATTTCCGGAA
GAAGCCGTCCAAATGGAGCATCAAGGCACGGGCTTTGTCATTTCAAGAAACAGCGATTTTTCCATTACGGCGTGTACCTG
GACAAACAAAAAATGGCCGAGCACAACGCCTGAAGGAAAAGTCCTGCTAAGGGCTTATGTAGGGAAAGCCGGCGATGAGT
CCGTTGTCGAACAGTCTGATAACGAAATGGTGAAAATCGTCCTCGACGATTTAAAACGGATTATGAAGATCGACGGCGAA
CCGGAAATGACCTGCATCACAAGATGGCATGAAGCGATGCCGCAATACCATGTCGGCCATAAGAAAAGAATTAAAGAAAT
CAGGGAAGGCTTGGAAGCGTCCTATCCGGGTGTTTTCATTACGGGGGCCTCATTTGAAGGGGTCGGCATCCCTGATTGCA
TCGACCAAGGCAAGCAGGCCGTCGCCGATGTACTCTCGCACCTTTTCGAATAA

Upstream 100 bases:

>100_bases
CAGACCTGAAATGCCTAACGCTAAACATGAGTTTATCGATGCTTTAGCGGATGTTGTATTAAAACAATTGGAGAAAGAAC
AGTAAAGAAGGCGATTGTAA

Downstream 100 bases:

>100_bases
AGAAGAGCAAAAAAAGCTGACCGAAACCATTCGGCGGCTTTTTTTATTTTCACTCTTTTTACAGCTTTCATCATTTTAAA
GTTTGTTTATGGAAAAGATA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSGERRQIVIIGGGITGLAAAFYLEKEIKKNDLPAEVTLVEASPRLGGKMQTVHKDGYVIERGPDSFLERKQSAPQLVKD
LGLEHLLVNNATGQSYVLVSETLYPIPEGAVMGVPTKIGPFLTTGLFSLPGKLRAGMDLVLPASKPQEDQSLGEFFRRRV
GGEVVENLIEPLLSGIYAGDIDRLSLMSTFPQFYQTEQKYRSLIIGMKKSRGAQSVGKPANKKKGQFQTVKTGLQTIVEE
LEKQLGITKVYKGTKVVSIERAGSAYSMKLDNGKVLHADSAVVTAPHKAAAAMFQKEDWLKGLEDMVSTSVANVALGFPE
EAVQMEHQGTGFVISRNSDFSITACTWTNKKWPSTTPEGKVLLRAYVGKAGDESVVEQSDNEMVKIVLDDLKRIMKIDGE
PEMTCITRWHEAMPQYHVGHKKRIKEIREGLEASYPGVFITGASFEGVGIPDCIDQGKQAVADVLSHLFE

Sequences:

>Translated_470_residues
MSGERRQIVIIGGGITGLAAAFYLEKEIKKNDLPAEVTLVEASPRLGGKMQTVHKDGYVIERGPDSFLERKQSAPQLVKD
LGLEHLLVNNATGQSYVLVSETLYPIPEGAVMGVPTKIGPFLTTGLFSLPGKLRAGMDLVLPASKPQEDQSLGEFFRRRV
GGEVVENLIEPLLSGIYAGDIDRLSLMSTFPQFYQTEQKYRSLIIGMKKSRGAQSVGKPANKKKGQFQTVKTGLQTIVEE
LEKQLGITKVYKGTKVVSIERAGSAYSMKLDNGKVLHADSAVVTAPHKAAAAMFQKEDWLKGLEDMVSTSVANVALGFPE
EAVQMEHQGTGFVISRNSDFSITACTWTNKKWPSTTPEGKVLLRAYVGKAGDESVVEQSDNEMVKIVLDDLKRIMKIDGE
PEMTCITRWHEAMPQYHVGHKKRIKEIREGLEASYPGVFITGASFEGVGIPDCIDQGKQAVADVLSHLFE
>Mature_469_residues
SGERRQIVIIGGGITGLAAAFYLEKEIKKNDLPAEVTLVEASPRLGGKMQTVHKDGYVIERGPDSFLERKQSAPQLVKDL
GLEHLLVNNATGQSYVLVSETLYPIPEGAVMGVPTKIGPFLTTGLFSLPGKLRAGMDLVLPASKPQEDQSLGEFFRRRVG
GEVVENLIEPLLSGIYAGDIDRLSLMSTFPQFYQTEQKYRSLIIGMKKSRGAQSVGKPANKKKGQFQTVKTGLQTIVEEL
EKQLGITKVYKGTKVVSIERAGSAYSMKLDNGKVLHADSAVVTAPHKAAAAMFQKEDWLKGLEDMVSTSVANVALGFPEE
AVQMEHQGTGFVISRNSDFSITACTWTNKKWPSTTPEGKVLLRAYVGKAGDESVVEQSDNEMVKIVLDDLKRIMKIDGEP
EMTCITRWHEAMPQYHVGHKKRIKEIREGLEASYPGVFITGASFEGVGIPDCIDQGKQAVADVLSHLFE

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=489, Percent_Identity=26.9938650306748, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4506001, Length=489, Percent_Identity=26.9938650306748, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24649745, Length=466, Percent_Identity=23.8197424892704, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 51457; Mature: 51326

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGERRQIVIIGGGITGLAAAFYLEKEIKKNDLPAEVTLVEASPRLGGKMQTVHKDGYVI
CCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECCCEEE
ERGPDSFLERKQSAPQLVKDLGLEHLLVNNATGQSYVLVSETLYPIPEGAVMGVPTKIGP
ECCCHHHHHHHHCHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCCCCEECCCCHHHH
FLTTGLFSLPGKLRAGMDLVLPASKPQEDQSLGEFFRRRVGGEVVENLIEPLLSGIYAGD
HHHHHHHHCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCC
IDRLSLMSTFPQFYQTEQKYRSLIIGMKKSRGAQSVGKPANKKKGQFQTVKTGLQTIVEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHH
LEKQLGITKVYKGTKVVSIERAGSAYSMKLDNGKVLHADSAVVTAPHKAAAAMFQKEDWL
HHHHCCCHHEECCCEEEEEECCCCEEEEEECCCEEEECCCCEEECCHHHHHHHHHHHHHH
KGLEDMVSTSVANVALGFPEEAVQMEHQGTGFVISRNSDFSITACTWTNKKWPSTTPEGK
HHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCCC
VLLRAYVGKAGDESVVEQSDNEMVKIVLDDLKRIMKIDGEPEMTCITRWHEAMPQYHVGH
EEHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCH
KKRIKEIREGLEASYPGVFITGASFEGVGIPDCIDQGKQAVADVLSHLFE
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGERRQIVIIGGGITGLAAAFYLEKEIKKNDLPAEVTLVEASPRLGGKMQTVHKDGYVI
CCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEECCCEEE
ERGPDSFLERKQSAPQLVKDLGLEHLLVNNATGQSYVLVSETLYPIPEGAVMGVPTKIGP
ECCCHHHHHHHHCHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCCCCEECCCCHHHH
FLTTGLFSLPGKLRAGMDLVLPASKPQEDQSLGEFFRRRVGGEVVENLIEPLLSGIYAGD
HHHHHHHHCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCC
IDRLSLMSTFPQFYQTEQKYRSLIIGMKKSRGAQSVGKPANKKKGQFQTVKTGLQTIVEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHH
LEKQLGITKVYKGTKVVSIERAGSAYSMKLDNGKVLHADSAVVTAPHKAAAAMFQKEDWL
HHHHCCCHHEECCCEEEEEECCCCEEEEEECCCEEEECCCCEEECCHHHHHHHHHHHHHH
KGLEDMVSTSVANVALGFPEEAVQMEHQGTGFVISRNSDFSITACTWTNKKWPSTTPEGK
HHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCCC
VLLRAYVGKAGDESVVEQSDNEMVKIVLDDLKRIMKIDGEPEMTCITRWHEAMPQYHVGH
EEHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCH
KKRIKEIREGLEASYPGVFITGASFEGVGIPDCIDQGKQAVADVLSHLFE
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]