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The map label for this gene is hemH [H]

Identifier: 52784865

GI number: 52784865

Start: 1092116

End: 1093054

Strand: Direct

Name: hemH [H]

Synonym: BLi01093

Alternate gene names: 52784865

Gene position: 1092116-1093054 (Clockwise)

Preceding gene: 52784864

Following gene: 52784866

Centisome position: 25.86

GC content: 47.71

Gene sequence:

>939_bases
TTGGGTAAAAAGAAAATGGGGCTTCTTGTCATGGCATATGGGACGCCGTACAAAGAGGAAGACATTGAACGTTATTATAC
ACATATCAGAAGAGGCAGAAAGCCTGAGCCTGACATGCTTCAGGACTTAAAAGACCGCTATAAGGCGATCGGAGGAATTT
CTCCGCTTGCAAAGATCACGCAGGAGCAGACGAAGCAGCTGGAAAAACGCTTAAACGAGCTTCAGGATGATGTGGTGTTC
AAGGCATATATCGGTCTCAAACATATCGAACCTTTCATTGAGGATGCCGTTCGGGAGATGCATAAAGACGGGATTACAGA
AGCCGTCAGCATCGTGCTCGCGCCCCATTTCTCCACCTTTAGCGTACAGTCGTACAACAAGCGGGCGAAAGACGAGGCTG
AAAAGCTCGGCGAATTGTCGATCACATCGATCAACAGCTGGTATGATGAGCCGAAATTTATCGCTTATTGGGCGGATCAG
GTGAGAAAAATCTATGACGAAATGCCTTCGGAAGAGAGGGAAAACGCCGTCTTGATTGTATCGGCGCACAGCCTTCCCGA
AAAAATCGTCGAAATGGGTGATCCGTATCCTGAACAGCTTAAAGAATCAGCGAAGCTGATTGCCGAAGCGGCGGGAGTAA
AAGATTACGCCGTCGGCTGGCAAAGCGAAGGAAACACCCCTGATCCGTGGCTGGGACCGGATGTTCAGGATTTGACGCGC
GACTTGTCAGAGCAAAAAGGGTACAGCGCTTTTGTTTATGCTCCCGTCGGCTTTGTAGCCGACCATTTGGAAGTCCTTTA
TGACAATGACTATGAGTGCAAAGTCGTCACGGACGATATCGGAGCAAGCTATTACAGACCTGAAATGCCTAACGCTAAAC
ATGAGTTTATCGATGCTTTAGCGGATGTTGTATTAAAACAATTGGAGAAAGAACAGTAA

Upstream 100 bases:

>100_bases
TCAAAAAAATCGAGCCTGATCACATGAGCATTTCAGTTGGTCTTTTCAATATAAACTGTCAAAATACGTATAGATCATGA
TCTTTAAAGAGGTGTTCACG

Downstream 100 bases:

>100_bases
AGAAGGCGATTGTAAATGAGTGGAGAACGCAGGCAGATTGTCATCATCGGCGGCGGTATTACCGGGTTGGCCGCCGCCTT
CTACTTGGAGAAGGAAATCA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MGKKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPDMLQDLKDRYKAIGGISPLAKITQEQTKQLEKRLNELQDDVVF
KAYIGLKHIEPFIEDAVREMHKDGITEAVSIVLAPHFSTFSVQSYNKRAKDEAEKLGELSITSINSWYDEPKFIAYWADQ
VRKIYDEMPSEERENAVLIVSAHSLPEKIVEMGDPYPEQLKESAKLIAEAAGVKDYAVGWQSEGNTPDPWLGPDVQDLTR
DLSEQKGYSAFVYAPVGFVADHLEVLYDNDYECKVVTDDIGASYYRPEMPNAKHEFIDALADVVLKQLEKEQ

Sequences:

>Translated_312_residues
MGKKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPDMLQDLKDRYKAIGGISPLAKITQEQTKQLEKRLNELQDDVVF
KAYIGLKHIEPFIEDAVREMHKDGITEAVSIVLAPHFSTFSVQSYNKRAKDEAEKLGELSITSINSWYDEPKFIAYWADQ
VRKIYDEMPSEERENAVLIVSAHSLPEKIVEMGDPYPEQLKESAKLIAEAAGVKDYAVGWQSEGNTPDPWLGPDVQDLTR
DLSEQKGYSAFVYAPVGFVADHLEVLYDNDYECKVVTDDIGASYYRPEMPNAKHEFIDALADVVLKQLEKEQ
>Mature_311_residues
GKKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPDMLQDLKDRYKAIGGISPLAKITQEQTKQLEKRLNELQDDVVFK
AYIGLKHIEPFIEDAVREMHKDGITEAVSIVLAPHFSTFSVQSYNKRAKDEAEKLGELSITSINSWYDEPKFIAYWADQV
RKIYDEMPSEERENAVLIVSAHSLPEKIVEMGDPYPEQLKESAKLIAEAAGVKDYAVGWQSEGNTPDPWLGPDVQDLTRD
LSEQKGYSAFVYAPVGFVADHLEVLYDNDYECKVVTDDIGASYYRPEMPNAKHEFIDALADVVLKQLEKEQ

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=277, Percent_Identity=31.0469314079422, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI60499025, Length=277, Percent_Identity=31.0469314079422, Blast_Score=143, Evalue=2e-34,
Organism=Escherichia coli, GI1786681, Length=226, Percent_Identity=26.9911504424779, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324750, Length=295, Percent_Identity=27.7966101694915, Blast_Score=119, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17864156, Length=334, Percent_Identity=27.8443113772455, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45552018, Length=172, Percent_Identity=32.5581395348837, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24651774, Length=260, Percent_Identity=26.1538461538462, Blast_Score=95, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35648; Mature: 35516

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPDMLQDLKDRYKAIGGISPLAKIT
CCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
QEQTKQLEKRLNELQDDVVFKAYIGLKHIEPFIEDAVREMHKDGITEAVSIVLAPHFSTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCE
SVQSYNKRAKDEAEKLGELSITSINSWYDEPKFIAYWADQVRKIYDEMPSEERENAVLIV
EHHHHHHHHHHHHHHHCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
SAHSLPEKIVEMGDPYPEQLKESAKLIAEAAGVKDYAVGWQSEGNTPDPWLGPDVQDLTR
ECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCHHHHHH
DLSEQKGYSAFVYAPVGFVADHLEVLYDNDYECKVVTDDIGASYYRPEMPNAKHEFIDAL
HHHHHCCCCEEEECHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHH
ADVVLKQLEKEQ
HHHHHHHHHCCC
>Mature Secondary Structure 
GKKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPDMLQDLKDRYKAIGGISPLAKIT
CCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
QEQTKQLEKRLNELQDDVVFKAYIGLKHIEPFIEDAVREMHKDGITEAVSIVLAPHFSTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCE
SVQSYNKRAKDEAEKLGELSITSINSWYDEPKFIAYWADQVRKIYDEMPSEERENAVLIV
EHHHHHHHHHHHHHHHCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
SAHSLPEKIVEMGDPYPEQLKESAKLIAEAAGVKDYAVGWQSEGNTPDPWLGPDVQDLTR
ECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCHHHHHH
DLSEQKGYSAFVYAPVGFVADHLEVLYDNDYECKVVTDDIGASYYRPEMPNAKHEFIDAL
HHHHHCCCCEEEECHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHH
ADVVLKQLEKEQ
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 9384565; 10704318; 9141132 [H]