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The map label for this gene is rocD [H]

Identifier: 52784242

GI number: 52784242

Start: 421253

End: 422455

Strand: Direct

Name: rocD [H]

Synonym: BLi00422

Alternate gene names: 52784242

Gene position: 421253-422455 (Clockwise)

Preceding gene: 52784237

Following gene: 52784243

Centisome position: 9.98

GC content: 51.12

Gene sequence:

>1203_bases
ATGACGGTTCTATCAAAGTCCGAGAAAATTATGAAGCAAACCGCACATTTTGGCGCGAATAACTATCATCCTCTGCCGAT
CGTGATTTCTGAAGCGGAAGGCGCGTGGGTGAAAGATCCGGAAGGCAACCGATACATGGATATGCTGAGCGCTTATTCCG
CAGTGAATCAAGGGCACAGGCACCCGAAAATCATCCAGGCGTTAAAAGATCAGGCAGACAAAATCACCCTGACTTCGAGA
GCTTTTCACAATGACCAGCTTGGTCCTTTTTATGAAAAGGTCGCTTCATTAACGGGGAAGGACATGGTTCTGCCGATGAA
CACCGGTGCGGAAGCGGTTGAGTCCGCAGTTAAAGCAGCGCGGCGCTGGGCTTATGATGTAAAAGGCGTTCCGGACAATC
AGGCGGAAATTATCGCATGTGAAGGCAATTTTCACGGCCGGACGATGCTGGCTGTGTCGCTATCTTCAGAAGAAGAGTAT
AAACGCGGTTTCGGACCGATGCTTCCCGGCATCAAGCTGATTCCATACGGGGATCTGGAAGCGCTGAAACAGGCGATCAC
ACCGAATACAGCCGCTTTTTTAATTGAGCCGATTCAAGGTGAAGCGGGAATTGTCATTCCGCCGGAAGGCTTTTTGAAGC
AGGCTGCTGAAGTCTGCAAAGAGCGCAATGTCTTGTTTATCGCCGATGAAATACAGTCAGGGCTTGCACGTACAGGGAAA
ATGTTCGCCTCTGATTGGGAGGACGTCACACCGGATATGTACATTTTAGGTAAAGCGCTCGGAGGCGGCGTGTTCCCGAT
ATCGTGCATTGCAGCAAACCGGGATGTGCTTGGCGTGTTTAATCCGGGCTCACACGGATCGACCTTTGGAGGGAACCCGC
TTGCATGCGCCGTATCGATCGCAGCTCTTGAAGTGCTGGAAGACGAGCGGCTCGCTGAACGGTCGCTGGAGCTTGGGGAA
TACTTTAAAGAAAAGCTCTCGCAAATTGATAATCCTAAAATCAAAGAAGTGCGCGGCAGGGGGCTGTTCATCGGGGTAGA
GCTGACCGAGGCGGCGCGTCCGTATTGCGAGCGCCTGAAAGAAGAAGGGCTGCTCTGCAAAGAAACGCATGAGACGGTAA
TTCGCTTTGCACCTCCTCTTGTCATTTCTCATGAGGATCTGGATTGGGCGATTGAAAAGATTACCCGTGTTTTGTCGAAG
TAA

Upstream 100 bases:

>100_bases
TTGCGGTATTAAGAGTTGGCACGATACTTGCATATAAGATAGTGTGAAACAAAATACGACATCTGGCATGTATGTCCAAA
AATAAGAAGGAGGAATCAGA

Downstream 100 bases:

>100_bases
AGCGAACGGCTGAACAATAAGGGGATTGTTCAGCCCGTTTTTTCGCTGTCTGTGCGAAGTTTGTCAAAAATTGAAATATC
AGGAAAATGTTCAGAAGATT

Product: ornithine--oxo-acid transaminase

Products: NA

Alternate protein names: OAT; Ornithine--oxo-acid aminotransferase [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MTVLSKSEKIMKQTAHFGANNYHPLPIVISEAEGAWVKDPEGNRYMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSR
AFHNDQLGPFYEKVASLTGKDMVLPMNTGAEAVESAVKAARRWAYDVKGVPDNQAEIIACEGNFHGRTMLAVSLSSEEEY
KRGFGPMLPGIKLIPYGDLEALKQAITPNTAAFLIEPIQGEAGIVIPPEGFLKQAAEVCKERNVLFIADEIQSGLARTGK
MFASDWEDVTPDMYILGKALGGGVFPISCIAANRDVLGVFNPGSHGSTFGGNPLACAVSIAALEVLEDERLAERSLELGE
YFKEKLSQIDNPKIKEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHETVIRFAPPLVISHEDLDWAIEKITRVLSK

Sequences:

>Translated_400_residues
MTVLSKSEKIMKQTAHFGANNYHPLPIVISEAEGAWVKDPEGNRYMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSR
AFHNDQLGPFYEKVASLTGKDMVLPMNTGAEAVESAVKAARRWAYDVKGVPDNQAEIIACEGNFHGRTMLAVSLSSEEEY
KRGFGPMLPGIKLIPYGDLEALKQAITPNTAAFLIEPIQGEAGIVIPPEGFLKQAAEVCKERNVLFIADEIQSGLARTGK
MFASDWEDVTPDMYILGKALGGGVFPISCIAANRDVLGVFNPGSHGSTFGGNPLACAVSIAALEVLEDERLAERSLELGE
YFKEKLSQIDNPKIKEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHETVIRFAPPLVISHEDLDWAIEKITRVLSK
>Mature_399_residues
TVLSKSEKIMKQTAHFGANNYHPLPIVISEAEGAWVKDPEGNRYMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRA
FHNDQLGPFYEKVASLTGKDMVLPMNTGAEAVESAVKAARRWAYDVKGVPDNQAEIIACEGNFHGRTMLAVSLSSEEEYK
RGFGPMLPGIKLIPYGDLEALKQAITPNTAAFLIEPIQGEAGIVIPPEGFLKQAAEVCKERNVLFIADEIQSGLARTGKM
FASDWEDVTPDMYILGKALGGGVFPISCIAANRDVLGVFNPGSHGSTFGGNPLACAVSIAALEVLEDERLAERSLELGEY
FKEKLSQIDNPKIKEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHETVIRFAPPLVISHEDLDWAIEKITRVLSK

Specific function: Catalyzes the interconversion of ornithine to glutamate semialdehyde. Controls arginine catabolism [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=397, Percent_Identity=50.1259445843829, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI284507298, Length=298, Percent_Identity=49.6644295302013, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI13994255, Length=436, Percent_Identity=29.3577981651376, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI24119277, Length=418, Percent_Identity=28.4688995215311, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI37574042, Length=417, Percent_Identity=26.8585131894484, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI226442705, Length=417, Percent_Identity=26.1390887290168, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI226442709, Length=385, Percent_Identity=26.7532467532467, Blast_Score=145, Evalue=9e-35,
Organism=Escherichia coli, GI1789759, Length=385, Percent_Identity=35.5844155844156, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI145693181, Length=381, Percent_Identity=33.0708661417323, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1788044, Length=379, Percent_Identity=34.0369393139842, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1787560, Length=407, Percent_Identity=33.9066339066339, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1789016, Length=412, Percent_Identity=30.8252427184466, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1786991, Length=405, Percent_Identity=28.3950617283951, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786349, Length=415, Percent_Identity=27.4698795180723, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=396, Percent_Identity=49.7474747474747, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI25144274, Length=275, Percent_Identity=45.8181818181818, Blast_Score=262, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI71981843, Length=174, Percent_Identity=52.8735632183908, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI32564660, Length=442, Percent_Identity=30.7692307692308, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71992977, Length=461, Percent_Identity=26.4642082429501, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17541228, Length=421, Percent_Identity=24.2280285035629, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323470, Length=414, Percent_Identity=48.3091787439614, Blast_Score=388, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6324432, Length=392, Percent_Identity=30.1020408163265, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324386, Length=425, Percent_Identity=26.1176470588235, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321456, Length=370, Percent_Identity=24.0540540540541, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21357415, Length=397, Percent_Identity=50.8816120906801, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI161085790, Length=430, Percent_Identity=30.2325581395349, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI28574759, Length=436, Percent_Identity=29.5871559633028, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21356575, Length=437, Percent_Identity=26.3157894736842, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.13 [H]

Molecular weight: Translated: 43868; Mature: 43737

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLSKSEKIMKQTAHFGANNYHPLPIVISEAEGAWVKDPEGNRYMDMLSAYSAVNQGHR
CCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEECCCCCHHHHHHHHHHHHHCCCC
HPKIIQALKDQADKITLTSRAFHNDQLGPFYEKVASLTGKDMVLPMNTGAEAVESAVKAA
CHHHHHHHHCCCCEEEEEHHCCCCCCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHH
RRWAYDVKGVPDNQAEIIACEGNFHGRTMLAVSLSSEEEYKRGFGPMLPGIKLIPYGDLE
HHHHCCCCCCCCCCCEEEEECCCCCCEEEEEEEECCHHHHHHCCCCCCCCCEEECCCCHH
ALKQAITPNTAAFLIEPIQGEAGIVIPPEGFLKQAAEVCKERNVLFIADEIQSGLARTGK
HHHHHHCCCCEEEEEEECCCCCCEEECCHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHH
MFASDWEDVTPDMYILGKALGGGVFPISCIAANRDVLGVFNPGSHGSTFGGNPLACAVSI
HHHCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHH
AALEVLEDERLAERSLELGEYFKEKLSQIDNPKIKEVRGRGLFIGVELTEAARPYCERLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEEEEEHHHHHHHHHHHH
EEGLLCKETHETVIRFAPPLVISHEDLDWAIEKITRVLSK
HCCCEEHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVLSKSEKIMKQTAHFGANNYHPLPIVISEAEGAWVKDPEGNRYMDMLSAYSAVNQGHR
CCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEECCCCCHHHHHHHHHHHHHCCCC
HPKIIQALKDQADKITLTSRAFHNDQLGPFYEKVASLTGKDMVLPMNTGAEAVESAVKAA
CHHHHHHHHCCCCEEEEEHHCCCCCCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHH
RRWAYDVKGVPDNQAEIIACEGNFHGRTMLAVSLSSEEEYKRGFGPMLPGIKLIPYGDLE
HHHHCCCCCCCCCCCEEEEECCCCCCEEEEEEEECCHHHHHHCCCCCCCCCEEECCCCHH
ALKQAITPNTAAFLIEPIQGEAGIVIPPEGFLKQAAEVCKERNVLFIADEIQSGLARTGK
HHHHHHCCCCEEEEEEECCCCCCEEECCHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHH
MFASDWEDVTPDMYILGKALGGGVFPISCIAANRDVLGVFNPGSHGSTFGGNPLACAVSI
HHHCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHH
AALEVLEDERLAERSLELGEYFKEKLSQIDNPKIKEVRGRGLFIGVELTEAARPYCERLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEEEEEHHHHHHHHHHHH
EEGLLCKETHETVIRFAPPLVISHEDLDWAIEKITRVLSK
HCCCEEHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7540694; 9384377; 8113162 [H]