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The map label for this gene is hemH [H]

Identifier: 52144240

GI number: 52144240

Start: 1092948

End: 1093883

Strand: Direct

Name: hemH [H]

Synonym: BCZK0987

Alternate gene names: 52144240

Gene position: 1092948-1093883 (Clockwise)

Preceding gene: 52144241

Following gene: 52144239

Centisome position: 20.62

GC content: 38.68

Gene sequence:

>936_bases
ATGAAAAAGAAAATTGGTTTGCTTGTAATGGCATACGGAACGCCATATAAAGAAGAAGATATTGAACGTTACTATACACA
TATTCGCAGAGGAAGAAAGCCAAGCCCTGAAATGCTAGAAGATTTAACAGAGCGTTACCGTGCAATTGGTGGTATTTCTC
CTTTAGCTACTATTACATTAGAGCAAGCTAAGAAGTTAGAGAAGCGTTTAAATGAAGTGCAAGATGAAGTCGAGTACCAC
ATGTATCTTGGCTTAAAACATATTGAACCGTTCATTGAAGATGCAGTGAAAGAGATGCATAACGACGGTATACAAGATGC
AATTGCACTTGTTCTTGCGCCGCACTATTCTACGTTTAGCGTGAAATCATACGTTGGACGTGCACAAGAAGAAGCTGAGA
AACTTGGAAACTTAACTATTCATGGCATTGATAGCTGGTATAAAGAACCGAAATTTATCCAGTACTGGGTTGATGCAGTA
AAAGGTATATATAACGGTATGTCAGACGCAGAACGTGAAAAAGCAGTTTTAATCGTATCTGCTCACAGTTTACCAGAGAA
AATTATTGCAATGGGCGATCCATATCCAGATCAGTTAAATGAAACAGCGGACTATATTGCGCGCGGAGCTGAAGTAGCAA
ACTATGCAGTAGGCTGGCAAAGTGCAGGAAACACGCCAGATCCTTGGATTGGTCCAGATGTACAAGATTTAACGAGAGAA
TTAAATGAAAAGTACGGTTATACTTCATTCGTATACGCACCAGTTGGATTTGTTGCGGAACATTTAGAAGTTTTATATGA
CAACGACTTTGAGTGTAAAGTGGTAACAGATGAAATTGGCGCGAAATATTATCGTCCAGAAATGCCAAATGCATCGGACG
CATTTATTGACTCTTTAACAGATGTTGTAGTAAAGAAAAAAGAATCTGTAATGTAA

Upstream 100 bases:

>100_bases
GTGTATTCCCAGAAGTAAATCCAGATACATTAAAACGTTTAACTACATTTATTCACGAATACTCTAAAGGGCAGTTAGCG
AAGTAAAGGAGCATTGCTGT

Downstream 100 bases:

>100_bases
GAAGAAAGGGGGAGCCTGCTTGAGGAAAAAAGTTGTAATCATCGGCGGTGGCATCACAGGATTAACAACAATGTATCACT
TACAAAAAGATATTCGTGAC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 1; Protoheme ferro-lyase 1 [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITLEQAKKLEKRLNEVQDEVEYH
MYLGLKHIEPFIEDAVKEMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAV
KGIYNGMSDAEREKAVLIVSAHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
LNEKYGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASDAFIDSLTDVVVKKKESVM

Sequences:

>Translated_311_residues
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITLEQAKKLEKRLNEVQDEVEYH
MYLGLKHIEPFIEDAVKEMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAV
KGIYNGMSDAEREKAVLIVSAHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
LNEKYGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASDAFIDSLTDVVVKKKESVM
>Mature_311_residues
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITLEQAKKLEKRLNEVQDEVEYH
MYLGLKHIEPFIEDAVKEMHNDGIQDAIALVLAPHYSTFSVKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAV
KGIYNGMSDAEREKAVLIVSAHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
LNEKYGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASDAFIDSLTDVVVKKKESVM

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=269, Percent_Identity=30.8550185873606, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI60499025, Length=269, Percent_Identity=30.8550185873606, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324750, Length=282, Percent_Identity=27.3049645390071, Blast_Score=109, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17864156, Length=328, Percent_Identity=25.609756097561, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI45552018, Length=170, Percent_Identity=31.1764705882353, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24651774, Length=253, Percent_Identity=22.9249011857708, Blast_Score=81, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35330; Mature: 35330

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITL
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
EQAKKLEKRLNEVQDEVEYHMYLGLKHIEPFIEDAVKEMHNDGIQDAIALVLAPHYSTFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
VKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAVKGIYNGMSDAEREKAVLIVS
HHHHHHHHHHHHHHHCCEEEEECHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
AHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
CCCCCHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LNEKYGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASDAFIDSLT
HHHHCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCHHCCCCCCCCHHHHHHHHH
DVVVKKKESVM
HHHHHHHHCCC
>Mature Secondary Structure
MKKKIGLLVMAYGTPYKEEDIERYYTHIRRGRKPSPEMLEDLTERYRAIGGISPLATITL
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
EQAKKLEKRLNEVQDEVEYHMYLGLKHIEPFIEDAVKEMHNDGIQDAIALVLAPHYSTFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
VKSYVGRAQEEAEKLGNLTIHGIDSWYKEPKFIQYWVDAVKGIYNGMSDAEREKAVLIVS
HHHHHHHHHHHHHHHCCEEEEECHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
AHSLPEKIIAMGDPYPDQLNETADYIARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRE
CCCCCHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
LNEKYGYTSFVYAPVGFVAEHLEVLYDNDFECKVVTDEIGAKYYRPEMPNASDAFIDSLT
HHHHCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCHHCCCCCCCCHHHHHHHHH
DVVVKKKESVM
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]