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The map label for this gene is hemE

Identifier: 52144241

GI number: 52144241

Start: 1091887

End: 1092933

Strand: Direct

Name: hemE

Synonym: BCZK0986

Alternate gene names: 52144241

Gene position: 1091887-1092933 (Clockwise)

Preceding gene: 52144243

Following gene: 52144240

Centisome position: 20.6

GC content: 39.35

Gene sequence:

>1047_bases
TTGGTAAGAACTATAAATGAGACATTTTTAAAAGCATGTAGGGGGGAACGTACTGATTATGTACCAGCATGGTATATGCG
TCAGGCAGGTCGTTCGCAGCCGGAATATAGAAAGATAAAAGAAAAGTATTCTTTATTTGAAATTACACATAATCCAGAGT
TATGTGCTTACGTTACAAAACTACCAGTTGATCAATATAACGTAGACGCAGCAATTCTTTATAAAGATATTATGTCACCA
CTACCTGCAATTGGTGTGGATGTAGAAATTAAATCAGGTATTGGCCCAGTTATTGATAATCCAATCCGTTCTTTACAAGA
CGTAGAAAAACTAGGGGAAATCAATCCAGAAGATGACGTACCGTACATATTAGATACAATTCGTTTATTAACGACTGAAA
TGCTAGACGTACCGTTAATCGGTTTTTCAGGAGCTCCATTTACGTTAGCGAGCTATATGATTGAAGGCGGTCCATCTCGT
AACTACCATAATACGAAAGCGTTTATGTATGCAGAGCCGAAAGCTTGGTTTGCTTTAATGGATAAGCTAGCAGATATGGT
TATTACATATTTAAAAGCGCAAATTAACGCAGGAGCAAAAGCAGTTCAAATTTTCGATTCTTGGGTTGGAACAGTAAATG
TAGCAGATTACCGCGTATTTATTAAACCAGCAATGGAGCGTATTTTTGCAGAAGTTCGCACGATGGGTGTACCGATGATT
ATGCACGGCGTAGGAGCTGCACACTTAGTGAATGAGTGGCACGACTTACCGCTTGATGTAGTCGGTTTAGACTGGCGTTT
ACCAATTGAAGAAGCACGTGCACGCGGCGTCCACAAGGCGGTACAAGGGAATATGGATCCGTCATTCTTACTTGCGCCAT
GGTCTGTTATTGAAGAACATGTAAAAGGTATTTTAGATCAAGGGATGAAGCAACCAGGTTATATCTTTAACTTAGGTCAC
GGTGTATTCCCAGAAGTAAATCCAGATACATTAAAACGTTTAACTACATTTATTCACGAATACTCTAAAGGGCAGTTAGC
GAAGTAA

Upstream 100 bases:

>100_bases
GTACATAATATTATGCATTTTGTTTTTACAAGCTGTATAGTAAAAAAAGATAAATATCGAACGTATTCGAAGCATTGTGG
TAAGGAAGGGAGCTAGGGTC

Downstream 100 bases:

>100_bases
AGGAGCATTGCTGTATGAAAAAGAAAATTGGTTTGCTTGTAATGGCATACGGAACGCCATATAAAGAAGAAGATATTGAA
CGTTACTATACACATATTCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSP
LPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSR
NYHNTKAFMYAEPKAWFALMDKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMI
MHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGH
GVFPEVNPDTLKRLTTFIHEYSKGQLAK

Sequences:

>Translated_348_residues
MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSP
LPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSR
NYHNTKAFMYAEPKAWFALMDKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMI
MHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGH
GVFPEVNPDTLKRLTTFIHEYSKGQLAK
>Mature_348_residues
MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTKLPVDQYNVDAAILYKDIMSP
LPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDVPYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSR
NYHNTKAFMYAEPKAWFALMDKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMI
MHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEHVKGILDQGMKQPGYIFNLGH
GVFPEVNPDTLKRLTTFIHEYSKGQLAK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=350, Percent_Identity=36.2857142857143, Blast_Score=219, Evalue=4e-57,
Organism=Escherichia coli, GI2367337, Length=350, Percent_Identity=40, Blast_Score=247, Evalue=9e-67,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=32.4786324786325, Blast_Score=190, Evalue=4e-49,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=33.4302325581395, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=33.4302325581395, Blast_Score=205, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_BACAH (A0RAS3)

Other databases:

- EMBL:   CP000485
- RefSeq:   YP_893823.1
- ProteinModelPortal:   A0RAS3
- SMR:   A0RAS3
- STRING:   A0RAS3
- EnsemblBacteria:   EBBACT00000070144
- GeneID:   4545660
- GenomeReviews:   CP000485_GR
- KEGG:   btl:BALH_0950
- eggNOG:   COG0407
- GeneTree:   EBGT00050000000611
- HOGENOM:   HBG628392
- ProtClustDB:   PRK00115
- BioCyc:   BTHU412694:BALH_0950-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39213; Mature: 39213

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 46-46 BINDING 76-76 BINDING 152-152 BINDING 207-207 BINDING 320-320

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTK
CCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHEEEECCCHHHHHHHH
LPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDV
CCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCHHCHHHHHHHHHHHHHCCCCCCCC
PYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALM
CHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHH
DKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMI
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHH
MHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEH
HHHCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHH
VKGILDQGMKQPGYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQLAK
HHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVRTINETFLKACRGERTDYVPAWYMRQAGRSQPEYRKIKEKYSLFEITHNPELCAYVTK
CCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHEEEECCCHHHHHHHH
LPVDQYNVDAAILYKDIMSPLPAIGVDVEIKSGIGPVIDNPIRSLQDVEKLGEINPEDDV
CCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCCCHHCHHHHHHHHHHHHHCCCCCCCC
PYILDTIRLLTTEMLDVPLIGFSGAPFTLASYMIEGGPSRNYHNTKAFMYAEPKAWFALM
CHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHH
DKLADMVITYLKAQINAGAKAVQIFDSWVGTVNVADYRVFIKPAMERIFAEVRTMGVPMI
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHH
MHGVGAAHLVNEWHDLPLDVVGLDWRLPIEEARARGVHKAVQGNMDPSFLLAPWSVIEEH
HHHCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHH
VKGILDQGMKQPGYIFNLGHGVFPEVNPDTLKRLTTFIHEYSKGQLAK
HHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA