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The map label for this gene is glcD [H]

Identifier: 52144038

GI number: 52144038

Start: 1291546

End: 1292958

Strand: Reverse

Name: glcD [H]

Synonym: BCZK1190

Alternate gene names: 52144038

Gene position: 1292958-1291546 (Counterclockwise)

Preceding gene: 52144039

Following gene: 52144040

Centisome position: 24.39

GC content: 40.13

Gene sequence:

>1413_bases
ATGTTAGAAAAACAAATTATTGATTCATTCGTATCCATTGTTGGCGAAGATAATGTGGATACATCCAATATGGGGCGTTT
AACGTATAGTTATGATGCCACTCCAAACTTCCAAGCAATGCCTGATGCAGTCATTGCTCCTCGTAATACAAATGAAGTAG
CTGAAGTGTTAAAAGTATGTAACACTCACAAAATTCCTGTATATGTTCGTGGTTCCGGGACGAACCTTTGCGCAGGAACA
TGTCCACTTGAAGGCGGTATCGTCCTTATCTTCCGACATATGAATAACATTTTAGAAATTGATGAAGAAAATTTAACAAT
TACTGTACAAGCTGGTGTTATTACGCTTGATATTATTAAAGCGGTGGAAGAAAAAGGTTTATTTTATCCACCAGATCCAA
GCTCAATGAAAATTTCTACAATTGGCGGTAACATTAATGAAAACTCGGGTGGATTACGTGGATTAAAATATGGCGTAACA
CGTGATTATGTGATGGGGCTTGAACTTGTCTTACCAAATGGTGATATTATTCGTACCGGTGGTAAATTAGCCAAAGATGT
AGCTGGTTACGATTTAACTCGTTTATTTATCGGTTCTGAAGGGACTCTTGGCGTCGTAACAGAAGCAATATTAAAACTTG
TCCCTATGCCTGAAACGAAGAAAACGATGCTTGCACTATATGAAGATATTAACGAAGCTGCACGTGCTGTTTCTTCTATT
ATTGCAAATAAAATCATTCCAGCGACACTTGAGTTTTTAGACCAGCCGACAATTGAAGTAGTAGAAGAGTTTGCTCAAAT
CGGTTTACCAACTGACGTAAAAGCAATTTTATTAATTGAGCAAGACGGTCCGCCTGAAGTTGTTAATCGAGATATTGAAA
AAATGGCTAACGTTTGTCGTTCCATGAATGCAGTTGATGTTCGCGTCGCAAAAGATGAAGCGGAAGCAGATGCGCTTCGA
ACAGCTCGCCGTAGTGCACTGTCAGCACTGGCAAGATTAAAGCCTACTACAATATTAGAAGATGCAACGGTACCACGCTC
ACAGATTGCTCCGATGGTTGAAGCTATTAATGCCATTGCCAAAAAATATAATATTCCTATTTGTACGTTTGGGCATGCTG
GCGATGGCAACCTACACCCAACTTGTATGACAGATGCTCGCAACGAAGAAGAAATGCACCGAGCTGAACAAGCTTTTGCT
GAAATATTTGCGAAAGCAATCGAACTTGGTGGCACAATCACTGGTGAACATGGTGTTGGTGCGATGAAAGCTCCGTATTT
AGAAATGAAGTTAGGTAAAGAAGGTATTGCCGCTATGCAAGGAATTAAACACGCCTTCGATCCAAATAACATTATGAATC
CAGGAAAGATGTTCGCGAAGGACACTCGTAAAAGAGTGGTGGTTGAGCGATGA

Upstream 100 bases:

>100_bases
ATAGAAAGAATCCCCCGACTTTTTTATCATTATAATGAAAGCACTGTGACAACGTTTTTTATTATGACTAATTACGTTAA
CAGTTTGAGGGGGATTTCCA

Downstream 100 bases:

>100_bases
CAACATTAAATAAAGAAAACATTCAAAAAGAATTTAAAGAACGATTAAGTGAAAATGAACTACTAAACTGTATGCGATGC
GGTTTCTGTTTACCAACTTG

Product: (S)-2-hydroxy-acid oxidase, subunit D

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MLEKQIIDSFVSIVGEDNVDTSNMGRLTYSYDATPNFQAMPDAVIAPRNTNEVAEVLKVCNTHKIPVYVRGSGTNLCAGT
CPLEGGIVLIFRHMNNILEIDEENLTITVQAGVITLDIIKAVEEKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT
RDYVMGLELVLPNGDIIRTGGKLAKDVAGYDLTRLFIGSEGTLGVVTEAILKLVPMPETKKTMLALYEDINEAARAVSSI
IANKIIPATLEFLDQPTIEVVEEFAQIGLPTDVKAILLIEQDGPPEVVNRDIEKMANVCRSMNAVDVRVAKDEAEADALR
TARRSALSALARLKPTTILEDATVPRSQIAPMVEAINAIAKKYNIPICTFGHAGDGNLHPTCMTDARNEEEMHRAEQAFA
EIFAKAIELGGTITGEHGVGAMKAPYLEMKLGKEGIAAMQGIKHAFDPNNIMNPGKMFAKDTRKRVVVER

Sequences:

>Translated_470_residues
MLEKQIIDSFVSIVGEDNVDTSNMGRLTYSYDATPNFQAMPDAVIAPRNTNEVAEVLKVCNTHKIPVYVRGSGTNLCAGT
CPLEGGIVLIFRHMNNILEIDEENLTITVQAGVITLDIIKAVEEKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT
RDYVMGLELVLPNGDIIRTGGKLAKDVAGYDLTRLFIGSEGTLGVVTEAILKLVPMPETKKTMLALYEDINEAARAVSSI
IANKIIPATLEFLDQPTIEVVEEFAQIGLPTDVKAILLIEQDGPPEVVNRDIEKMANVCRSMNAVDVRVAKDEAEADALR
TARRSALSALARLKPTTILEDATVPRSQIAPMVEAINAIAKKYNIPICTFGHAGDGNLHPTCMTDARNEEEMHRAEQAFA
EIFAKAIELGGTITGEHGVGAMKAPYLEMKLGKEGIAAMQGIKHAFDPNNIMNPGKMFAKDTRKRVVVER
>Mature_470_residues
MLEKQIIDSFVSIVGEDNVDTSNMGRLTYSYDATPNFQAMPDAVIAPRNTNEVAEVLKVCNTHKIPVYVRGSGTNLCAGT
CPLEGGIVLIFRHMNNILEIDEENLTITVQAGVITLDIIKAVEEKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT
RDYVMGLELVLPNGDIIRTGGKLAKDVAGYDLTRLFIGSEGTLGVVTEAILKLVPMPETKKTMLALYEDINEAARAVSSI
IANKIIPATLEFLDQPTIEVVEEFAQIGLPTDVKAILLIEQDGPPEVVNRDIEKMANVCRSMNAVDVRVAKDEAEADALR
TARRSALSALARLKPTTILEDATVPRSQIAPMVEAINAIAKKYNIPICTFGHAGDGNLHPTCMTDARNEEEMHRAEQAFA
EIFAKAIELGGTITGEHGVGAMKAPYLEMKLGKEGIAAMQGIKHAFDPNNIMNPGKMFAKDTRKRVVVER

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=467, Percent_Identity=30.8351177730193, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI37595754, Length=490, Percent_Identity=29.3877551020408, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI119964728, Length=432, Percent_Identity=28.2407407407407, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI4501993, Length=228, Percent_Identity=28.9473684210526, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1789351, Length=430, Percent_Identity=38.1395348837209, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI1787977, Length=512, Percent_Identity=27.5390625, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI48994907, Length=484, Percent_Identity=25.8264462809917, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI48994914, Length=177, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71992373, Length=467, Percent_Identity=32.762312633833, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI71992381, Length=467, Percent_Identity=32.3340471092077, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71992392, Length=384, Percent_Identity=32.5520833333333, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17534361, Length=465, Percent_Identity=29.0322580645161, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17556096, Length=219, Percent_Identity=28.7671232876712, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6320027, Length=445, Percent_Identity=31.0112359550562, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6320764, Length=474, Percent_Identity=28.6919831223629, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6320023, Length=453, Percent_Identity=28.476821192053, Blast_Score=174, Evalue=4e-44,
Organism=Drosophila melanogaster, GI18921117, Length=425, Percent_Identity=29.4117647058824, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24639277, Length=425, Percent_Identity=29.4117647058824, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24639275, Length=425, Percent_Identity=29.4117647058824, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24653753, Length=255, Percent_Identity=27.843137254902, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 50976; Mature: 50976

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKQIIDSFVSIVGEDNVDTSNMGRLTYSYDATPNFQAMPDAVIAPRNTNEVAEVLKVC
CCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCEECCCCHHHHHHHHHHH
NTHKIPVYVRGSGTNLCAGTCPLEGGIVLIFRHMNNILEIDEENLTITVQAGVITLDIIK
CCCCCEEEEECCCCCEEEECCCCCCCEEEEEEHHHHHEEECCCCEEEEEECCEEHHHHHH
AVEEKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVTRDYVMGLELVLPNGDIIRTG
HHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEECCCCHHHHEEEEEEECCCCEEECC
GKLAKDVAGYDLTRLFIGSEGTLGVVTEAILKLVPMPETKKTMLALYEDINEAARAVSSI
CHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
IANKIIPATLEFLDQPTIEVVEEFAQIGLPTDVKAILLIEQDGPPEVVNRDIEKMANVCR
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
SMNAVDVRVAKDEAEADALRTARRSALSALARLKPTTILEDATVPRSQIAPMVEAINAIA
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHH
KKYNIPICTFGHAGDGNLHPTCMTDARNEEEMHRAEQAFAEIFAKAIELGGTITGEHGVG
HHCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCC
AMKAPYLEMKLGKEGIAAMQGIKHAFDPNNIMNPGKMFAKDTRKRVVVER
CCCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLEKQIIDSFVSIVGEDNVDTSNMGRLTYSYDATPNFQAMPDAVIAPRNTNEVAEVLKVC
CCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCEECCCCHHHHHHHHHHH
NTHKIPVYVRGSGTNLCAGTCPLEGGIVLIFRHMNNILEIDEENLTITVQAGVITLDIIK
CCCCCEEEEECCCCCEEEECCCCCCCEEEEEEHHHHHEEECCCCEEEEEECCEEHHHHHH
AVEEKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVTRDYVMGLELVLPNGDIIRTG
HHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEECCCCHHHHEEEEEEECCCCEEECC
GKLAKDVAGYDLTRLFIGSEGTLGVVTEAILKLVPMPETKKTMLALYEDINEAARAVSSI
CHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
IANKIIPATLEFLDQPTIEVVEEFAQIGLPTDVKAILLIEQDGPPEVVNRDIEKMANVCR
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
SMNAVDVRVAKDEAEADALRTARRSALSALARLKPTTILEDATVPRSQIAPMVEAINAIA
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHH
KKYNIPICTFGHAGDGNLHPTCMTDARNEEEMHRAEQAFAEIFAKAIELGGTITGEHGVG
HHCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCC
AMKAPYLEMKLGKEGIAAMQGIKHAFDPNNIMNPGKMFAKDTRKRVVVER
CCCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]