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The map label for this gene is hisB [H]

Identifier: 52143937

GI number: 52143937

Start: 1386370

End: 1386954

Strand: Direct

Name: hisB [H]

Synonym: BCZK1292

Alternate gene names: 52143937

Gene position: 1386370-1386954 (Clockwise)

Preceding gene: 52143939

Following gene: 52143936

Centisome position: 26.15

GC content: 38.46

Gene sequence:

>585_bases
ATGCGGGAGTTTAGTCAAATACGTGAGACGACAGAAACAAAAATAAAATTAAGTTTGCAGCTTGATGAAGGAAAGAACGT
TTCTGTACAAACGGGAGTTGGTTTTTTTGATCATATGCTAACTTTATTTGCAAGGCATGGAAGATTCGGTTTGCAAGTGG
AGGCGGAAGGCGATGTATTCGTTGATGCGCATCATACAGTTGAAGATGTTGGGATTGTACTCGGAAATTGTTTAAAAGAA
GCATTGCAAAATAAAGAGGGGATTAACCGTTACGGCTCGGCATATGTGCCGATGGACGAATCTTTAGGGTTTGTCGCAAT
TGATATTAGTGGGCGCTCATATATTGTATTTCAAGGAGAATTAACGAATCCGAAACTTGGGGATTTTGATACAGAACTAA
CAGAAGAATTTTTTAGAGCAGTTGCTCATGCCGCTAATATTACATTACATGCTCGTATTTTATATGGAAGCAATACACAT
CACAAAATTGAAGCATTATTTAAAGCGTTTGGTAGAGCGCTTAGAGAAGCAGTCGAAAGAAATGCCCACATTACTGGTGT
AAATTCAACGAAAGGGATGTTGTAA

Upstream 100 bases:

>100_bases
CATTAAGAGATGTAAAACATCATATTGTAGAACTTGCCAATAAAGAAGGGCTACATGCGCATGCGAGATCAATTCAAATA
AGATTTGGGGAGGAAGAATA

Downstream 100 bases:

>100_bases
TTGATTGCCATTATAGATTATGGAATGGGAAATATTCGTAGTGTAGAACAAGCATTAAAATACATTGGAGCAGCGTACAT
CGTAACGAGTGATAAAGAAG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MREFSQIRETTETKIKLSLQLDEGKNVSVQTGVGFFDHMLTLFARHGRFGLQVEAEGDVFVDAHHTVEDVGIVLGNCLKE
ALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGELTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTH
HKIEALFKAFGRALREAVERNAHITGVNSTKGML

Sequences:

>Translated_194_residues
MREFSQIRETTETKIKLSLQLDEGKNVSVQTGVGFFDHMLTLFARHGRFGLQVEAEGDVFVDAHHTVEDVGIVLGNCLKE
ALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGELTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTH
HKIEALFKAFGRALREAVERNAHITGVNSTKGML
>Mature_194_residues
MREFSQIRETTETKIKLSLQLDEGKNVSVQTGVGFFDHMLTLFARHGRFGLQVEAEGDVFVDAHHTVEDVGIVLGNCLKE
ALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGELTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTH
HKIEALFKAFGRALREAVERNAHITGVNSTKGML

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=188, Percent_Identity=45.2127659574468, Blast_Score=173, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6324776, Length=175, Percent_Identity=42.8571428571429, Blast_Score=151, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21570; Mature: 21570

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREFSQIRETTETKIKLSLQLDEGKNVSVQTGVGFFDHMLTLFARHGRFGLQVEAEGDVF
CCCHHHHHHCCCEEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCEE
VDAHHTVEDVGIVLGNCLKEALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGE
EECCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCEECCCCCCCCEEEEEECCCEEEEEECC
LTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTHHKIEALFKAFGRALREAVER
CCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
NAHITGVNSTKGML
CCEEEECCCCCCCC
>Mature Secondary Structure
MREFSQIRETTETKIKLSLQLDEGKNVSVQTGVGFFDHMLTLFARHGRFGLQVEAEGDVF
CCCHHHHHHCCCEEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCEE
VDAHHTVEDVGIVLGNCLKEALQNKEGINRYGSAYVPMDESLGFVAIDISGRSYIVFQGE
EECCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCEECCCCCCCCEEEEEECCCEEEEEECC
LTNPKLGDFDTELTEEFFRAVAHAANITLHARILYGSNTHHKIEALFKAFGRALREAVER
CCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
NAHITGVNSTKGML
CCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA