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The map label for this gene is hisD [H]

Identifier: 52143939

GI number: 52143939

Start: 1385081

End: 1386370

Strand: Direct

Name: hisD [H]

Synonym: BCZK1291

Alternate gene names: 52143939

Gene position: 1385081-1386370 (Clockwise)

Preceding gene: 52143938

Following gene: 52143937

Centisome position: 26.13

GC content: 38.37

Gene sequence:

>1290_bases
ATGGAGATAGTTTGTGAGGATTTTCAAAAGGCGTTAACGAAAATAAAACTGTTACGAGAAAACGCTAATATAATAGAAGA
AACTGTTCAAAGAAGTGTCAGGGAAATCGTTCAGAATGTAAGAGAGAGTAGAGATGAGGCGTTATCTTTCTATACAAAAA
AGTTTGATGGTGTAGAGATTAAAGATGTTCGTGTAAGTGAAGAAGAAATAAAACAAGCGAGTATGTTTGTAGAGAGTTCA
TTTTTAGAAGCGTTACAAGAGGCGAAGAAAAACATTATTTCGTACCATGAAAAGCAAAAAAGACAATCGATGTTTGATTG
CACGAGTAAAGGCATCATAAGGGGACAAATCATTCGGCCGTTAGAAAATATAGGGGTATATGTGCCAGGCGGAACTGCTT
CGTACCCTTCGTCAGTATTAATGAATGTATTGCCAGCAAAGCTCGCGGGTGTGAAAAAGATTGTAATGGTAACACCGCCA
AGAGCAGGAGGAATTGATCCGCATATTTTAGTTGCTGCAAGCCTTGCAGGAGTAGATGAAATTTATATGATAGGTGGCGC
GCAAGCAATTGCTGCTTTAGCATACGGGACGGAATCGATTCCGAAAGTGGATAAAATAGTTGGACCAGGAAATTTGTACG
TCGCTCTAGCGAAACGAGAAGTATACGGAATAGTAAATATCGATATGATTGCTGGACCGTCAGAAATAGTAGTTATTGCT
GATGAAACTGGCAATGCAAAATATATTGCTGCTGATTTATTATCACAAGCAGAACATGATGAGAGAGCGACAGCAATTTG
TATTACAACGAATATAGAATTAGCAAAAGAAGTAGAAAAAGAGATAGAAAGGCAGTTAGAAACATTACCAAGAAGCGAAA
TTGCACGTGAATCAATAAATAGAAATGGAGCCATTTTTATCGTTCCTTCTATAGATGAGGCACTACAGTTATCGAATGAA
ATCGCTCCGGAACATTTAGAGTTACATATAAAAGAACCGATGAATGCTTTAGCTTATGTGAAACATGCAGGATCTATCTT
TCTTGGACCGTATGCACCAGAACCGCTCGGTGATTATTTAGCGGGACCGAATCACGTATTACCGACAAGTGGAACGGCAA
GGTTTTTCTCGCCGTTATCAGTCGATGATTTCGTGAAAAAATCAAGTTTTCTATCTTATACGGAGGAAGCATTAAGAGAT
GTAAAACATCATATTGTAGAACTTGCCAATAAAGAAGGGCTACATGCGCATGCGAGATCAATTCAAATAAGATTTGGGGA
GGAAGAATAA

Upstream 100 bases:

>100_bases
TTGTAAATAAGGCTGCCTTAAAAACTAAAAAAGACGAAATATTCAGTATTATAAATATGATGGAGCAAGAAATTTTGTCA
GGAAAATAGGGGGACTTGTA

Downstream 100 bases:

>100_bases
TGCGGGAGTTTAGTCAAATACGTGAGACGACAGAAACAAAAATAAAATTAAGTTTGCAGCTTGATGAAGGAAAGAACGTT
TCTGTACAAACGGGAGTTGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MEIVCEDFQKALTKIKLLRENANIIEETVQRSVREIVQNVRESRDEALSFYTKKFDGVEIKDVRVSEEEIKQASMFVESS
FLEALQEAKKNIISYHEKQKRQSMFDCTSKGIIRGQIIRPLENIGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPP
RAGGIDPHILVAASLAGVDEIYMIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVIA
DETGNAKYIAADLLSQAEHDERATAICITTNIELAKEVEKEIERQLETLPRSEIARESINRNGAIFIVPSIDEALQLSNE
IAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYLAGPNHVLPTSGTARFFSPLSVDDFVKKSSFLSYTEEALRD
VKHHIVELANKEGLHAHARSIQIRFGEEE

Sequences:

>Translated_429_residues
MEIVCEDFQKALTKIKLLRENANIIEETVQRSVREIVQNVRESRDEALSFYTKKFDGVEIKDVRVSEEEIKQASMFVESS
FLEALQEAKKNIISYHEKQKRQSMFDCTSKGIIRGQIIRPLENIGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPP
RAGGIDPHILVAASLAGVDEIYMIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVIA
DETGNAKYIAADLLSQAEHDERATAICITTNIELAKEVEKEIERQLETLPRSEIARESINRNGAIFIVPSIDEALQLSNE
IAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYLAGPNHVLPTSGTARFFSPLSVDDFVKKSSFLSYTEEALRD
VKHHIVELANKEGLHAHARSIQIRFGEEE
>Mature_429_residues
MEIVCEDFQKALTKIKLLRENANIIEETVQRSVREIVQNVRESRDEALSFYTKKFDGVEIKDVRVSEEEIKQASMFVESS
FLEALQEAKKNIISYHEKQKRQSMFDCTSKGIIRGQIIRPLENIGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPP
RAGGIDPHILVAASLAGVDEIYMIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVIA
DETGNAKYIAADLLSQAEHDERATAICITTNIELAKEVEKEIERQLETLPRSEIARESINRNGAIFIVPSIDEALQLSNE
IAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYLAGPNHVLPTSGTARFFSPLSVDDFVKKSSFLSYTEEALRD
VKHHIVELANKEGLHAHARSIQIRFGEEE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=412, Percent_Identity=40.7766990291262, Blast_Score=312, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6319819, Length=432, Percent_Identity=37.7314814814815, Blast_Score=283, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47272; Mature: 47272

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIVCEDFQKALTKIKLLRENANIIEETVQRSVREIVQNVRESRDEALSFYTKKFDGVEI
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
KDVRVSEEEIKQASMFVESSFLEALQEAKKNIISYHEKQKRQSMFDCTSKGIIRGQIIRP
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCC
LENIGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPPRAGGIDPHILVAASLAGVDE
HHHCCEEECCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHCCCCC
IYMIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVIA
EEEECCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEECEEEEEEEEEEECCCCEEEEEE
DETGNAKYIAADLLSQAEHDERATAICITTNIELAKEVEKEIERQLETLPRSEIARESIN
ECCCCCEEHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
RNGAIFIVPSIDEALQLSNEIAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYL
CCCCEEEEECCHHHHHHHHCCCCCHHEEEHHHHHHHHHHHHHCCCEEECCCCCCCHHHHH
AGPNHVLPTSGTARFFSPLSVDDFVKKSSFLSYTEEALRDVKHHIVELANKEGLHAHARS
CCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECEE
IQIRFGEEE
EEEEECCCC
>Mature Secondary Structure
MEIVCEDFQKALTKIKLLRENANIIEETVQRSVREIVQNVRESRDEALSFYTKKFDGVEI
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
KDVRVSEEEIKQASMFVESSFLEALQEAKKNIISYHEKQKRQSMFDCTSKGIIRGQIIRP
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCC
LENIGVYVPGGTASYPSSVLMNVLPAKLAGVKKIVMVTPPRAGGIDPHILVAASLAGVDE
HHHCCEEECCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHCCCCC
IYMIGGAQAIAALAYGTESIPKVDKIVGPGNLYVALAKREVYGIVNIDMIAGPSEIVVIA
EEEECCHHHHHHHHHCCCCCCCHHHHCCCCCEEEEEEECEEEEEEEEEEECCCCEEEEEE
DETGNAKYIAADLLSQAEHDERATAICITTNIELAKEVEKEIERQLETLPRSEIARESIN
ECCCCCEEHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHC
RNGAIFIVPSIDEALQLSNEIAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYL
CCCCEEEEECCHHHHHHHHCCCCCHHEEEHHHHHHHHHHHHHCCCEEECCCCCCCHHHHH
AGPNHVLPTSGTARFFSPLSVDDFVKKSSFLSYTEEALRDVKHHIVELANKEGLHAHARS
CCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECEE
IQIRFGEEE
EEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]