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The map label for this gene is gltT [H]

Identifier: 52143915

GI number: 52143915

Start: 1408158

End: 1409429

Strand: Direct

Name: gltT [H]

Synonym: BCZK1314

Alternate gene names: 52143915

Gene position: 1408158-1409429 (Clockwise)

Preceding gene: 52143917

Following gene: 52143913

Centisome position: 26.56

GC content: 36.24

Gene sequence:

>1272_bases
ATGAAAAGAATAGGACTTGCATGGCAAATATTAATTGGTCTTGCGCTAGGTATTGCAGTTGGGGCGATTTTCTTTGGCAA
TCCGGCAGTGGTGAGCTATTTACAACCAATTGGTGATATTTTCATCCGATTAATTAAAATGATCGTTGTACCGATTGTTG
TAGCAAGTATTGTTGTTGGGGTTGCTGGTGTTGGCGATGTTAAAAAATTAGGCCGACTAGGCGGGAAAACAATTATTTAC
TTCGAAATTATTACAACACTTGCAATTATTGTCGGTCTATTAATTGCTAATATTTTCCAACCGGGAAAAGGCGTAAATAT
GGAGCAGTTAACAAAGACAGACATTTCGAAATATACACATACGACAGAGCAAGTACAAAGTCATTCATTTGCAGATACAT
TTGTAAATATTGTTCCAACGAACATTATGAAGTCATTAGCTGACGGAGATATGCTTGCTATTATCTTCTTCTCAGTATTA
TTTGGTTTAGGTGTAGCAGCAATTGGTGAAAGAGGAAGACCGGTTCTTCAATTTTTCCAAGGTGTAGCTGATGCAATGTT
TTACGTAACGAACCAAGTTATGAAATTTGCACCATTTGGTGTGTTCGCATTGATTGGTGTTACAGTATCTACATTCGGTT
TAGCTTCATTAATTCCGTTAGGGAAATTATTAATTGTAGTATACGGGGCAATGATTTTCTTCGTTGTAGTTGTCTTAGGA
CTTACAGCGAAAATATTTGGAATTAACATTTTCCAATTCTTTAAAATTTTAAAAGACGAACTGATCTTAGCGTATTCAAC
AGCAAGTTCAGAAACAGTTTTACCGAAAATTATGGAGAAAATGGAGAAGTTCGGTTGTCCGAAAGCAATTACATCTTTCG
TTATTCCGACAGGTTATTCATTTAACTTAGATGGATCAACTTTATATCAAGCAATTGCAGCTATTTTCTTAGCGCAAATG
TACGGTATTGATTTATCTATTACAGAACAAATTACATTATTACTTGTATTAATGGTTACATCAAAAGGTATCGCAGGTGT
ACCGGGCGTATCATTCGTTGTATTATTAGCGACACTTGGTACAGTAGGTATTCCAGCTGAAGGCTTAGCCTTCATCGCCG
GTATTGACCGTATTTTAGATATGGCTCGTACAGCAGTTAACGTTGTAGGTAACTCTTTAGCAGCTGTAGTTATGTCTAAG
TGGGAAGGTCAATATGACGCTGAAAAAGGACAAGCTTATTTGAAAGAAATTTCTAATAAGCAAGCAGCTTAA

Upstream 100 bases:

>100_bases
GTAGTGAATTGTCGAATAATATGTAATACTCTTAATTTCAAGTTTTATAGAGATAGAATGAAAGGTAGAGTGACACATCG
AAGAGGGGGTTACAACAAGT

Downstream 100 bases:

>100_bases
TTATAATTTGAAAAAAGCTCTCACATAATATGTGAGGGCTTTTCTATATAGAAGGGAAGCGGACGTAATGAAACGTAAAT
ATGGTGACGGTTCTTCGTGG

Product: proton/sodium-glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKRIGLAWQILIGLALGIAVGAIFFGNPAVVSYLQPIGDIFIRLIKMIVVPIVVASIVVGVAGVGDVKKLGRLGGKTIIY
FEIITTLAIIVGLLIANIFQPGKGVNMEQLTKTDISKYTHTTEQVQSHSFADTFVNIVPTNIMKSLADGDMLAIIFFSVL
FGLGVAAIGERGRPVLQFFQGVADAMFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLG
LTAKIFGINIFQFFKILKDELILAYSTASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDGSTLYQAIAAIFLAQM
YGIDLSITEQITLLLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPAEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSK
WEGQYDAEKGQAYLKEISNKQAA

Sequences:

>Translated_423_residues
MKRIGLAWQILIGLALGIAVGAIFFGNPAVVSYLQPIGDIFIRLIKMIVVPIVVASIVVGVAGVGDVKKLGRLGGKTIIY
FEIITTLAIIVGLLIANIFQPGKGVNMEQLTKTDISKYTHTTEQVQSHSFADTFVNIVPTNIMKSLADGDMLAIIFFSVL
FGLGVAAIGERGRPVLQFFQGVADAMFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLG
LTAKIFGINIFQFFKILKDELILAYSTASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDGSTLYQAIAAIFLAQM
YGIDLSITEQITLLLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPAEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSK
WEGQYDAEKGQAYLKEISNKQAA
>Mature_423_residues
MKRIGLAWQILIGLALGIAVGAIFFGNPAVVSYLQPIGDIFIRLIKMIVVPIVVASIVVGVAGVGDVKKLGRLGGKTIIY
FEIITTLAIIVGLLIANIFQPGKGVNMEQLTKTDISKYTHTTEQVQSHSFADTFVNIVPTNIMKSLADGDMLAIIFFSVL
FGLGVAAIGERGRPVLQFFQGVADAMFYVTNQVMKFAPFGVFALIGVTVSTFGLASLIPLGKLLIVVYGAMIFFVVVVLG
LTAKIFGINIFQFFKILKDELILAYSTASSETVLPKIMEKMEKFGCPKAITSFVIPTGYSFNLDGSTLYQAIAAIFLAQM
YGIDLSITEQITLLLVLMVTSKGIAGVPGVSFVVLLATLGTVGIPAEGLAFIAGIDRILDMARTAVNVVGNSLAAVVMSK
WEGQYDAEKGQAYLKEISNKQAA

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=425, Percent_Identity=27.2941176470588, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI40254478, Length=478, Percent_Identity=26.9874476987448, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI4827012, Length=454, Percent_Identity=27.5330396475771, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI169790839, Length=451, Percent_Identity=28.159645232816, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI194239697, Length=442, Percent_Identity=27.8280542986425, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI66773030, Length=410, Percent_Identity=28.0487804878049, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI5032093, Length=433, Percent_Identity=25.8660508083141, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI223468564, Length=276, Percent_Identity=26.8115942028986, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI223468566, Length=276, Percent_Identity=26.8115942028986, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI262359914, Length=374, Percent_Identity=26.4705882352941, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI301601644, Length=185, Percent_Identity=30.8108108108108, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1790514, Length=430, Percent_Identity=62.3255813953488, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1789947, Length=418, Percent_Identity=39.2344497607655, Blast_Score=334, Evalue=8e-93,
Organism=Escherichia coli, GI1788024, Length=413, Percent_Identity=27.1186440677966, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789473, Length=256, Percent_Identity=23.828125, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17537407, Length=424, Percent_Identity=29.2452830188679, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71996953, Length=439, Percent_Identity=28.7015945330296, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI193206505, Length=417, Percent_Identity=28.7769784172662, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71983099, Length=473, Percent_Identity=25.5813953488372, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71983106, Length=450, Percent_Identity=26, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17541374, Length=402, Percent_Identity=25.8706467661692, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI193206654, Length=430, Percent_Identity=23.4883720930233, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24583025, Length=406, Percent_Identity=25.615763546798, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI17137668, Length=406, Percent_Identity=25.615763546798, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24583023, Length=406, Percent_Identity=25.615763546798, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI281360481, Length=443, Percent_Identity=25.0564334085779, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281360483, Length=443, Percent_Identity=25.0564334085779, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17137666, Length=443, Percent_Identity=25.0564334085779, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45203; Mature: 45203

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1359385 [H]