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The map label for this gene is pepP [H]

Identifier: 52143522

GI number: 52143522

Start: 1809889

End: 1811169

Strand: Direct

Name: pepP [H]

Synonym: BCZK1712

Alternate gene names: 52143522

Gene position: 1809889-1811169 (Clockwise)

Preceding gene: 52143526

Following gene: 52143521

Centisome position: 34.14

GC content: 31.69

Gene sequence:

>1281_bases
ATGAAATCAACATTTTTTGCTCAAAATAGAGAACGACTAGTAAACACATTACCAGATGAATCTATTACTATTTTATTTGC
TGGACAAGCACCTCATATGTCAGCGGATGCACATTATAAATTTGTGCCGAATCGAAATTTTTACTATGTAACAGGAATCG
ATGAACCAAATGTTATTTTCATGTTGAAAAAGTTTGAAAATAGTGTAGAAGAAATACTTTTCATTGAAAAGTCAGATCCA
GTAATGGAAAAATGGGTTGGTAAAACAGTTTCTAACGAAGAAGCAGAGAAAATTTCAGGTATAAAAAAAGTTATATATTT
AGATAGCTTTGAAAAAACAATGTCAAATATACTTTTTACAGAAAATGTGAAACATCTATATTTAGATTTAGAGTGTCGTG
AGTGGAAAGGTACGGAGACAAAAACATTAGCATTTGCTAAACATGTAAGAGAACAATATCCACACGTAACAATTGGTAAT
GTATATCCGAACATTTGTGAATTGCGAGTATTTAAAACAGATGAAGAGATTGAAATTATTAAAGAAGCAATTGCTGTAAC
GAAAGACGGTATTTACAACGTACTTAAGCATGCAAAAGCAGACATGATGGAATATGAATTAGAAGCTCAGTTTGATTTCA
CACTGAAGTCATCTGGCATTAAGCATCATGCGTTCAATACAATTTTGGCAAGTGGGAAAAATGCTACAGTTCTTCATTAT
GAAGATAATGATGCACAAATTCAAAATGGTGATTTAGTATTACTAGATTTAGGTGCTCAAAAAGACTACTATAACGCTGA
TATTAGTTATACATTCCCGGCAAATGGAACATTCTCTAGTCGCCAAAAACAAATTTATAATATTGTATTAAAAGCATTAA
AAGAAACAACAGAGATTATTAAGCCAGGTTTGAAGTTCGCTACATTAAATGAGCATGCTAAAAAAGTACTCGCAGAAGGG
TGTAAAGCAGTTGGTTTAATTCAAGAAGATGAGGAACTGTCTAAATACTATTATCATGGAGTCAGCCATTTTCTTGGTTT
AGATACGCATGATGTAGGTACATACAAAGATAGAGTTTTAGAAGAAGGTATGGTTATTACAATTGAACCTGGTCTTTATA
TTGAAGAAGAATCAATTGGCATTCGTATTGAAGATGATATTCTTGTAACGAAAGACGGACATGAAAACTTGTCAAAAGAT
ATCATTAGAGAAGTTGAAGAGATTGAAGAGTTTATGAGAGAAAATAATGTGAATGTAAAACAAGATGAGGTTGTTATGTA
A

Upstream 100 bases:

>100_bases
CTATGAGCACTATTAATTGACGAAAAATTATAACAATAATAAAATGAATTGATTAGATAATTAGTTTTTGAATCATACAT
AGAAAGCTAGGGGGATTATT

Downstream 100 bases:

>100_bases
TGAGTTTCTATTGTAAAGCGCTTAAAGATAAGTCTATATTTATACATTGCTAATGTTTCCTCAGCGTTTTCAATTTGAAG
TAACAAAGTCGAAGTATAAT

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKSTFFAQNRERLVNTLPDESITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPNVIFMLKKFENSVEEILFIEKSDP
VMEKWVGKTVSNEEAEKISGIKKVIYLDSFEKTMSNILFTENVKHLYLDLECREWKGTETKTLAFAKHVREQYPHVTIGN
VYPNICELRVFKTDEEIEIIKEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHY
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLKALKETTEIIKPGLKFATLNEHAKKVLAEG
CKAVGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVLEEGMVITIEPGLYIEEESIGIRIEDDILVTKDGHENLSKD
IIREVEEIEEFMRENNVNVKQDEVVM

Sequences:

>Translated_426_residues
MKSTFFAQNRERLVNTLPDESITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPNVIFMLKKFENSVEEILFIEKSDP
VMEKWVGKTVSNEEAEKISGIKKVIYLDSFEKTMSNILFTENVKHLYLDLECREWKGTETKTLAFAKHVREQYPHVTIGN
VYPNICELRVFKTDEEIEIIKEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHY
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLKALKETTEIIKPGLKFATLNEHAKKVLAEG
CKAVGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVLEEGMVITIEPGLYIEEESIGIRIEDDILVTKDGHENLSKD
IIREVEEIEEFMRENNVNVKQDEVVM
>Mature_426_residues
MKSTFFAQNRERLVNTLPDESITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPNVIFMLKKFENSVEEILFIEKSDP
VMEKWVGKTVSNEEAEKISGIKKVIYLDSFEKTMSNILFTENVKHLYLDLECREWKGTETKTLAFAKHVREQYPHVTIGN
VYPNICELRVFKTDEEIEIIKEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHY
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLKALKETTEIIKPGLKFATLNEHAKKVLAEG
CKAVGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVLEEGMVITIEPGLYIEEESIGIRIEDDILVTKDGHENLSKD
IIREVEEIEEFMRENNVNVKQDEVVM

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=422, Percent_Identity=28.6729857819905, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI149589008, Length=472, Percent_Identity=28.1779661016949, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI260593665, Length=305, Percent_Identity=32.7868852459016, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI260593663, Length=471, Percent_Identity=25.4777070063694, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI264681563, Length=256, Percent_Identity=28.90625, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789275, Length=437, Percent_Identity=31.5789473684211, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1788728, Length=237, Percent_Identity=30.379746835443, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1790282, Length=291, Percent_Identity=23.3676975945017, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17508215, Length=468, Percent_Identity=30.1282051282051, Blast_Score=188, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71989583, Length=265, Percent_Identity=27.1698113207547, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320922, Length=452, Percent_Identity=27.212389380531, Blast_Score=162, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6321118, Length=435, Percent_Identity=27.816091954023, Blast_Score=156, Evalue=5e-39,
Organism=Drosophila melanogaster, GI21357079, Length=478, Percent_Identity=30.5439330543933, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI19920384, Length=419, Percent_Identity=27.6849642004773, Blast_Score=172, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 48839; Mature: 48839

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTFFAQNRERLVNTLPDESITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPNVIF
CCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCEEEEEECCCCCEEE
MLKKFENSVEEILFIEKSDPVMEKWVGKTVSNEEAEKISGIKKVIYLDSFEKTMSNILFT
EEHHHHCCHHHEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHEEEECHHHHHHHHHEEE
ENVKHLYLDLECREWKGTETKTLAFAKHVREQYPHVTIGNVYPNICELRVFKTDEEIEII
CCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCHHHHHH
KEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHY
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCHHHHHHHHCCCCCEEEEEE
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLKALKETTEII
ECCCCEEECCCEEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KPGLKFATLNEHAKKVLAEGCKAVGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVL
CCCCEEEEHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EEGMVITIEPGLYIEEESIGIRIEDDILVTKDGHENLSKDIIREVEEIEEFMRENNVNVK
HCCEEEEECCCCEEECCCCEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
QDEVVM
CCCCCC
>Mature Secondary Structure
MKSTFFAQNRERLVNTLPDESITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPNVIF
CCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCEEEEEECCCCCEEE
MLKKFENSVEEILFIEKSDPVMEKWVGKTVSNEEAEKISGIKKVIYLDSFEKTMSNILFT
EEHHHHCCHHHEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHEEEECHHHHHHHHHEEE
ENVKHLYLDLECREWKGTETKTLAFAKHVREQYPHVTIGNVYPNICELRVFKTDEEIEII
CCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCHHHHHH
KEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHY
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCHHHHHHHHCCCCCEEEEEE
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLKALKETTEII
ECCCCEEECCCEEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KPGLKFATLNEHAKKVLAEGCKAVGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVL
CCCCEEEEHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EEGMVITIEPGLYIEEESIGIRIEDDILVTKDGHENLSKDIIREVEEIEEFMRENNVNVK
HCCEEEEECCCCEEECCCCEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
QDEVVM
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]