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The map label for this gene is pbp3 [H]

Identifier: 52143215

GI number: 52143215

Start: 2144518

End: 2146503

Strand: Direct

Name: pbp3 [H]

Synonym: BCZK2022

Alternate gene names: 52143215

Gene position: 2144518-2146503 (Clockwise)

Preceding gene: 52143216

Following gene: 52143214

Centisome position: 40.46

GC content: 35.7

Gene sequence:

>1986_bases
TTGAGAAAAATATGGGGGATTCTTTTTCTTTGCCTAACATTCATGTTAGTCGGATGTGGTAAAGAAGAAAAACCGCAAGA
AGCATTTGATACATATGCAAAAGCATGGAATAAACAAAAATTTGCAGAAATGTATGATCAATTATCAGAAAAGGCAAAAA
AAGATATTTCAAAGAAAGAATTCACTGAGAAATATGAAAAAATTTATTCTGGCATTGAAGTGAAAAACTTAAAAGTGGAA
GCAGGAGAAGTAAAGGAAGATAAAAAAGATGAAGGTCCTATTCCTTTTAAAGTAAGCATGGATACAGTGGGTGGAAAAAT
CAATTTTGGCCATGAAGCAAAAATGGTGAAAGAAAAAGATGGAGATAAAGAATCTTGGAAAGTAGATTGGACTCCTGACT
TTATCTTCCCAGGTATGACGAAAGATAGTAAAGTGCGTATGCAAACGACAGAGCCGAAGCGCGGAGAAATATATGACCGT
AACGGTAAATATCTTGCGGTAAATGGTAAAGCTTCTGAAATCGGATTGATTCCTGAAAAATTAGGGGATACAGCTCCGCA
AACGAAAGAAACGGTAGCGAAGTTATTAAATATGTCTGTCGAAGAAATTGATCAAAAACTAGCAGCTAAATGGGTAAAAC
CAAATTACCTTGTACCAATTGGAATATTGCCTGAAGGAGCAACACAAAATACGTACATAGATTTACCTGGTGTTGCAACA
AAGCCAGTAAATGTTCGCTCATATCCATTAGGAGAAGAAGCCGCACATCTTACTGGCTATATTGGAAAAGTGAATGCTGA
AGATTTAAAAACGTTACAAAAGAAAGGTTATCAAGCAGATGATCCAGTAGGTAAAGCTGGTTTAGAGCAAGTACTGGAAG
AAAAGCTACGCGGTAAAAAAGGTGGTCGTGTCTTCGTAGAAGATGCACAAGGAAAAGAAATTAAAAATTTAGCAAAAACA
GATGCTGTTGATGGAGAAAATGTAACTTTAACGATTGACAGTGCAGTTCAAAGCGAAATTTATAATGAAATGAAAAATGA
GGTAGGATCAAGTGCAGCAATTAATCCAAAGACTGGAGAAACACTTGCACTTGTGAGCACACCAGCTTATAACCCAAATA
CCCTTACAAGAGGGGCGTCAAAAGCGCAACGTGATGCGGTAAATAATGATCCGAAAAAACCGATGACGAATCGATTTACA
CAATTATCAGTTCCAGGTTCTGTATTTAAGCCTATTACAGGTGCAATTGGTCTTGAAACGAAAACAATTGATCCAAAAGA
AGAGTTGAAAATTGAAGGATTGAAATGGACAAAAGATTCTTCTTGGGGTAATTATTATGTAACACGTGTAAAAGATGCAA
ATCCGATTGATTTTGATAAGGCGATGAAATACTCGGATAATATTTATTTCGCACAAGAAGCTTTGAAAATCGGAAAAGAT
AAATTTATGAGTGAAGCGAAAAAATTCGGATTTGATGAGAAGTTACCAATTGAATATGGATTCCCAGCTTCTAAAATCGC
AAATGATAGTATTAAAAATGATATTCAAATGGCAGACACAGGTTATGGACAAGGGCAAGTATTAATGACGCCACTACATC
TAGCATTAACATACGCACCAATTGTTAATGACGGAAACATACCTTCTCCATACATTATTAAAACGGATAAGCAACCAAAA
GTTTGGAAAGAGAATGTCATTTCAAAAGGCAATCAGGATATATTAAAAACTGCTATGACGAAAGTAATTAATGATCCAGA
TGGTACAGGGAAAATTGCTAAAATTGATGGTATGACGCTTGCTGGAAAAACAGGTACAGCAGAATTAAAAGTATCAAAAG
AGGCCGAAGGAAAAGAACTAGGCTGGTTCGCTGCATTTGATTTAAATTCACCAGATATGGTCATTACCATGATGATTGAA
GATGTAAAGGGTAGAGGCGGAAGTAATATCCCGGCTGAAAAAGTAAAACATGTATTTCAAAAATAA

Upstream 100 bases:

>100_bases
TTGGTTTATAGATGAGATTCGATAGTGCTATAATGAAAGGTAGCATGTGAAAATGCTAAAATTTTCAAGAGTATTAAGAT
AGTAAGAGGAGGAGAATCGA

Downstream 100 bases:

>100_bases
TATGTAATAAAAGACTGGCTCTATAATTTGTAGAGCTAGTCTTTTTATATGAAGAAATTCTTGATATTTGTATACTTAAT
TTTAAGGAAACAAAATAAAT

Product: penicillin-binding protein 3

Products: NA

Alternate protein names: PBP 3; PSPB20; Penicillin-binding protein C [H]

Number of amino acids: Translated: 661; Mature: 661

Protein sequence:

>661_residues
MRKIWGILFLCLTFMLVGCGKEEKPQEAFDTYAKAWNKQKFAEMYDQLSEKAKKDISKKEFTEKYEKIYSGIEVKNLKVE
AGEVKEDKKDEGPIPFKVSMDTVGGKINFGHEAKMVKEKDGDKESWKVDWTPDFIFPGMTKDSKVRMQTTEPKRGEIYDR
NGKYLAVNGKASEIGLIPEKLGDTAPQTKETVAKLLNMSVEEIDQKLAAKWVKPNYLVPIGILPEGATQNTYIDLPGVAT
KPVNVRSYPLGEEAAHLTGYIGKVNAEDLKTLQKKGYQADDPVGKAGLEQVLEEKLRGKKGGRVFVEDAQGKEIKNLAKT
DAVDGENVTLTIDSAVQSEIYNEMKNEVGSSAAINPKTGETLALVSTPAYNPNTLTRGASKAQRDAVNNDPKKPMTNRFT
QLSVPGSVFKPITGAIGLETKTIDPKEELKIEGLKWTKDSSWGNYYVTRVKDANPIDFDKAMKYSDNIYFAQEALKIGKD
KFMSEAKKFGFDEKLPIEYGFPASKIANDSIKNDIQMADTGYGQGQVLMTPLHLALTYAPIVNDGNIPSPYIIKTDKQPK
VWKENVISKGNQDILKTAMTKVINDPDGTGKIAKIDGMTLAGKTGTAELKVSKEAEGKELGWFAAFDLNSPDMVITMMIE
DVKGRGGSNIPAEKVKHVFQK

Sequences:

>Translated_661_residues
MRKIWGILFLCLTFMLVGCGKEEKPQEAFDTYAKAWNKQKFAEMYDQLSEKAKKDISKKEFTEKYEKIYSGIEVKNLKVE
AGEVKEDKKDEGPIPFKVSMDTVGGKINFGHEAKMVKEKDGDKESWKVDWTPDFIFPGMTKDSKVRMQTTEPKRGEIYDR
NGKYLAVNGKASEIGLIPEKLGDTAPQTKETVAKLLNMSVEEIDQKLAAKWVKPNYLVPIGILPEGATQNTYIDLPGVAT
KPVNVRSYPLGEEAAHLTGYIGKVNAEDLKTLQKKGYQADDPVGKAGLEQVLEEKLRGKKGGRVFVEDAQGKEIKNLAKT
DAVDGENVTLTIDSAVQSEIYNEMKNEVGSSAAINPKTGETLALVSTPAYNPNTLTRGASKAQRDAVNNDPKKPMTNRFT
QLSVPGSVFKPITGAIGLETKTIDPKEELKIEGLKWTKDSSWGNYYVTRVKDANPIDFDKAMKYSDNIYFAQEALKIGKD
KFMSEAKKFGFDEKLPIEYGFPASKIANDSIKNDIQMADTGYGQGQVLMTPLHLALTYAPIVNDGNIPSPYIIKTDKQPK
VWKENVISKGNQDILKTAMTKVINDPDGTGKIAKIDGMTLAGKTGTAELKVSKEAEGKELGWFAAFDLNSPDMVITMMIE
DVKGRGGSNIPAEKVKHVFQK
>Mature_661_residues
MRKIWGILFLCLTFMLVGCGKEEKPQEAFDTYAKAWNKQKFAEMYDQLSEKAKKDISKKEFTEKYEKIYSGIEVKNLKVE
AGEVKEDKKDEGPIPFKVSMDTVGGKINFGHEAKMVKEKDGDKESWKVDWTPDFIFPGMTKDSKVRMQTTEPKRGEIYDR
NGKYLAVNGKASEIGLIPEKLGDTAPQTKETVAKLLNMSVEEIDQKLAAKWVKPNYLVPIGILPEGATQNTYIDLPGVAT
KPVNVRSYPLGEEAAHLTGYIGKVNAEDLKTLQKKGYQADDPVGKAGLEQVLEEKLRGKKGGRVFVEDAQGKEIKNLAKT
DAVDGENVTLTIDSAVQSEIYNEMKNEVGSSAAINPKTGETLALVSTPAYNPNTLTRGASKAQRDAVNNDPKKPMTNRFT
QLSVPGSVFKPITGAIGLETKTIDPKEELKIEGLKWTKDSSWGNYYVTRVKDANPIDFDKAMKYSDNIYFAQEALKIGKD
KFMSEAKKFGFDEKLPIEYGFPASKIANDSIKNDIQMADTGYGQGQVLMTPLHLALTYAPIVNDGNIPSPYIIKTDKQPK
VWKENVISKGNQDILKTAMTKVINDPDGTGKIAKIDGMTLAGKTGTAELKVSKEAEGKELGWFAAFDLNSPDMVITMMIE
DVKGRGGSNIPAEKVKHVFQK

Specific function: Cell Wall Formation; Pbp-2 Is Responsible For The Determination Of The Rod Shape Of The Cell. Its Synthesize Cross- Linked Peptidoglycan From The Lipid Intermediates. [C]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=548, Percent_Identity=26.6423357664234, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI1786272, Length=501, Percent_Identity=25.748502994012, Blast_Score=132, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR007887
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF05223 MecA_N; PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 73122; Mature: 73122

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIWGILFLCLTFMLVGCGKEEKPQEAFDTYAKAWNKQKFAEMYDQLSEKAKKDISKKE
CHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHH
FTEKYEKIYSGIEVKNLKVEAGEVKEDKKDEGPIPFKVSMDTVGGKINFGHEAKMVKEKD
HHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEECCCHHHHHHHCC
GDKESWKVDWTPDFIFPGMTKDSKVRMQTTEPKRGEIYDRNGKYLAVNGKASEIGLIPEK
CCCCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCCEEECCCCEEEECCCCCCCCCCHHH
LGDTAPQTKETVAKLLNMSVEEIDQKLAAKWVKPNYLVPIGILPEGATQNTYIDLPGVAT
HCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEECCCCCC
KPVNVRSYPLGEEAAHLTGYIGKVNAEDLKTLQKKGYQADDPVGKAGLEQVLEEKLRGKK
CCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCC
GGRVFVEDAQGKEIKNLAKTDAVDGENVTLTIDSAVQSEIYNEMKNEVGSSAAINPKTGE
CCEEEEECCCCCHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCC
TLALVSTPAYNPNTLTRGASKAQRDAVNNDPKKPMTNRFTQLSVPGSVFKPITGAIGLET
EEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHCCEEECCCCHHHHCCCCCCCCEE
KTIDPKEELKIEGLKWTKDSSWGNYYVTRVKDANPIDFDKAMKYSDNIYFAQEALKIGKD
CCCCCHHHCEECCEEECCCCCCCCEEEEEECCCCCCCHHHHHHHCCCEEEHHHHHHHHHH
KFMSEAKKFGFDEKLPIEYGFPASKIANDSIKNDIQMADTGYGQGQVLMTPLHLALTYAP
HHHHHHHHCCCCCCCCEECCCCHHHHCCHHHHCCCEECCCCCCCCCEEEEHHEEHHEEEE
IVNDGNIPSPYIIKTDKQPKVWKENVISKGNQDILKTAMTKVINDPDGTGKIAKIDGMTL
EECCCCCCCCEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEECCEEE
AGKTGTAELKVSKEAEGKELGWFAAFDLNSPDMVITMMIEDVKGRGGSNIPAEKVKHVFQ
ECCCCCEEEEEECCCCCCCCCEEEEEECCCCCEEEEEEEEHHCCCCCCCCCHHHHHHHHC
K
C
>Mature Secondary Structure
MRKIWGILFLCLTFMLVGCGKEEKPQEAFDTYAKAWNKQKFAEMYDQLSEKAKKDISKKE
CHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHH
FTEKYEKIYSGIEVKNLKVEAGEVKEDKKDEGPIPFKVSMDTVGGKINFGHEAKMVKEKD
HHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEECCCHHHHHHHCC
GDKESWKVDWTPDFIFPGMTKDSKVRMQTTEPKRGEIYDRNGKYLAVNGKASEIGLIPEK
CCCCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCCEEECCCCEEEECCCCCCCCCCHHH
LGDTAPQTKETVAKLLNMSVEEIDQKLAAKWVKPNYLVPIGILPEGATQNTYIDLPGVAT
HCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEECCCCCC
KPVNVRSYPLGEEAAHLTGYIGKVNAEDLKTLQKKGYQADDPVGKAGLEQVLEEKLRGKK
CCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCC
GGRVFVEDAQGKEIKNLAKTDAVDGENVTLTIDSAVQSEIYNEMKNEVGSSAAINPKTGE
CCEEEEECCCCCHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCC
TLALVSTPAYNPNTLTRGASKAQRDAVNNDPKKPMTNRFTQLSVPGSVFKPITGAIGLET
EEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHCCEEECCCCHHHHCCCCCCCCEE
KTIDPKEELKIEGLKWTKDSSWGNYYVTRVKDANPIDFDKAMKYSDNIYFAQEALKIGKD
CCCCCHHHCEECCEEECCCCCCCCEEEEEECCCCCCCHHHHHHHCCCEEEHHHHHHHHHH
KFMSEAKKFGFDEKLPIEYGFPASKIANDSIKNDIQMADTGYGQGQVLMTPLHLALTYAP
HHHHHHHHCCCCCCCCEECCCCHHHHCCHHHHCCCEECCCCCCCCCEEEEHHEEHHEEEE
IVNDGNIPSPYIIKTDKQPKVWKENVISKGNQDILKTAMTKVINDPDGTGKIAKIDGMTL
EECCCCCCCCEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEECCEEE
AGKTGTAELKVSKEAEGKELGWFAAFDLNSPDMVITMMIEDVKGRGGSNIPAEKVKHVFQ
ECCCCCEEEEEECCCCCCCCCEEEEEECCCCCEEEEEEEEHHCCCCCCCCCHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 3145906 [H]