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The map label for this gene is plsC [H]

Identifier: 52143213

GI number: 52143213

Start: 2147493

End: 2148212

Strand: Direct

Name: plsC [H]

Synonym: BCZK2024

Alternate gene names: 52143213

Gene position: 2147493-2148212 (Clockwise)

Preceding gene: 52143214

Following gene: 52143212

Centisome position: 40.51

GC content: 35.28

Gene sequence:

>720_bases
ATGATTCAAACGTTTTTTAAAATCTTTTATTTAATTTTAATCGTAATTGCGATTACACCAAGAATGTGGCGTCTGAAAAG
ACAAGTAAATACAATGTCGCCACAAGAAAAAGATAATGCTGTGTACAAAACGACAAATTGGTTTGGTAAGAAAATGGTAC
GTATAGCTGGGGGAACAGTAGAAGTTAAAGGACTTGAAAATGTTCCGAAAGACAAGCCGGTACTAGTTGTAAGTAATCAC
CAGAGTAATATGGATATCCCTGTTTTACTAGGTTATTTAAATAAACCAATTGGCTTCGTTTCAAAGGCAGAGATTAAAAA
GTTCCCAGTTGTACCAACTTGGATGGAACTTATGAATTGTGTATTTATGGATCGTAGCGATCGTCGTCAATCACTTCAAG
CGATTAAAGATGGAATTGAATTATTAAAGAATGGACATTCTATCGTAATTTTCCCTGAAGGGACAAGAAGTAAGGGTGGC
GAAGTTGGAGAGTTTAAAGCTGGTAGTTTTCATCTTGCAGTAAAGTCAGGTGTAGCAATTTTACCTGTAACCTTAGATGG
GACATATAAAATGTTTGAAGCAAATGGAAACCGTATGAAATCAGCTCATGCAACAGTAACCATTTCAAAGCCGATTACAC
CTGAAGAATATGCGAATATGGATATTAAAGAATTAACAAAGCATACACAGGAAGTTATCGCATCACAGTTACATAAGTAA

Upstream 100 bases:

>100_bases
TAAAAATGTCCAAACACTTGTTGTTTGGACATTTTTTCTTCTTTTTCCTTCGTTTGTCTAGTATAATGAAGGTCGGAATG
ATAATAGGTGGGGGTTCTGT

Downstream 100 bases:

>100_bases
TAAAAAAGGTTTCAGCTTACAGTAAGCTGAAACCTTTTTTATTATGCTGTAGGTAAGACGTAAAAGAGTACACAGAAGAA
CATCATTGCACTACCACCTA

Product: 1-acyl-sn-glycerol-3-phosphate acyltransferase

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MIQTFFKIFYLILIVIAITPRMWRLKRQVNTMSPQEKDNAVYKTTNWFGKKMVRIAGGTVEVKGLENVPKDKPVLVVSNH
QSNMDIPVLLGYLNKPIGFVSKAEIKKFPVVPTWMELMNCVFMDRSDRRQSLQAIKDGIELLKNGHSIVIFPEGTRSKGG
EVGEFKAGSFHLAVKSGVAILPVTLDGTYKMFEANGNRMKSAHATVTISKPITPEEYANMDIKELTKHTQEVIASQLHK

Sequences:

>Translated_239_residues
MIQTFFKIFYLILIVIAITPRMWRLKRQVNTMSPQEKDNAVYKTTNWFGKKMVRIAGGTVEVKGLENVPKDKPVLVVSNH
QSNMDIPVLLGYLNKPIGFVSKAEIKKFPVVPTWMELMNCVFMDRSDRRQSLQAIKDGIELLKNGHSIVIFPEGTRSKGG
EVGEFKAGSFHLAVKSGVAILPVTLDGTYKMFEANGNRMKSAHATVTISKPITPEEYANMDIKELTKHTQEVIASQLHK
>Mature_239_residues
MIQTFFKIFYLILIVIAITPRMWRLKRQVNTMSPQEKDNAVYKTTNWFGKKMVRIAGGTVEVKGLENVPKDKPVLVVSNH
QSNMDIPVLLGYLNKPIGFVSKAEIKKFPVVPTWMELMNCVFMDRSDRRQSLQAIKDGIELLKNGHSIVIFPEGTRSKGG
EVGEFKAGSFHLAVKSGVAILPVTLDGTYKMFEANGNRMKSAHATVTISKPITPEEYANMDIKELTKHTQEVIASQLHK

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position [H]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI5453718, Length=178, Percent_Identity=27.5280898876405, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI15100175, Length=178, Percent_Identity=27.5280898876405, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI6041665, Length=181, Percent_Identity=26.5193370165746, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1789395, Length=194, Percent_Identity=27.8350515463918, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17564032, Length=185, Percent_Identity=24.3243243243243, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320151, Length=202, Percent_Identity=31.6831683168317, Blast_Score=93, Evalue=5e-20,
Organism=Drosophila melanogaster, GI281364648, Length=242, Percent_Identity=29.7520661157025, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24582856, Length=242, Percent_Identity=29.7520661157025, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24582854, Length=242, Percent_Identity=29.7520661157025, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24641614, Length=206, Percent_Identity=25.7281553398058, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641612, Length=206, Percent_Identity=25.7281553398058, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR004552 [H]

Pfam domain/function: PF01553 Acyltransferase [H]

EC number: =2.3.1.51 [H]

Molecular weight: Translated: 26891; Mature: 26891

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQTFFKIFYLILIVIAITPRMWRLKRQVNTMSPQEKDNAVYKTTNWFGKKMVRIAGGTV
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHEEEEECCEE
EVKGLENVPKDKPVLVVSNHQSNMDIPVLLGYLNKPIGFVSKAEIKKFPVVPTWMELMNC
EECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHH
VFMDRSDRRQSLQAIKDGIELLKNGHSIVIFPEGTRSKGGEVGEFKAGSFHLAVKSGVAI
HHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCEE
LPVTLDGTYKMFEANGNRMKSAHATVTISKPITPEEYANMDIKELTKHTQEVIASQLHK
EEEEECCCEEEEECCCCEEECCEEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIQTFFKIFYLILIVIAITPRMWRLKRQVNTMSPQEKDNAVYKTTNWFGKKMVRIAGGTV
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHEEEEECCEE
EVKGLENVPKDKPVLVVSNHQSNMDIPVLLGYLNKPIGFVSKAEIKKFPVVPTWMELMNC
EECCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHH
VFMDRSDRRQSLQAIKDGIELLKNGHSIVIFPEGTRSKGGEVGEFKAGSFHLAVKSGVAI
HHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCEE
LPVTLDGTYKMFEANGNRMKSAHATVTISKPITPEEYANMDIKELTKHTQEVIASQLHK
EEEEECCCEEEEECCCCEEECCEEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7569993; 8253680 [H]