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The map label for this gene is mmgC [H]

Identifier: 52143125

GI number: 52143125

Start: 2234553

End: 2236262

Strand: Direct

Name: mmgC [H]

Synonym: BCZK2114

Alternate gene names: 52143125

Gene position: 2234553-2236262 (Clockwise)

Preceding gene: 52143124

Following gene: 52143122

Centisome position: 42.15

GC content: 35.73

Gene sequence:

>1710_bases
ATGGAGAAAACGAAGTTACCGTGGGATGAATTTTTTTCACTTAATAAAGATGTGAATCATGCTTTCTTTACGCCAGAAGA
TTTTTCAGGAGATGAAGATTTAATTGCAAAAACGACAGAACAATTCGTTAAACAAGAAATTGTTCCACAAATGGAGAATA
TTGAACAACATAACTATAAAGTTTCCCGTCAATTGTTTGAGAAAGCTGGAGAACTTGGATTATTAAGTATCGAGGTCCCA
GAAGAATATGGCGGATTCGAATTAGGAAAGGCAGTTTCAGGGCTTGTAGCAGAAAAAATGGGATATGCTGGTGCATTTAG
CGTTTCATTTAATATACATGCTGGTGTAGGTACATTGCCTTACATATATTACGGAACGAAAGAACAAAAAGAAAAATATT
TGCCAAAAATTGCGTCAGGAGAATGGATTGGTGCTTATGCTTTAACTGAGCCAAATGCCGGTTCTGATGCATTAAGCGCA
AAAACGAGCGCAGTATTGAATGAAGATGGTACTGCTTGGAAGTTAAATGGTGAGAAGCAGTGGATTACAAATGCTCATAT
GGCAGATGTATACGTTGTTTTTGCGAAGACAAATAAAGGAATGACAGCGTTTATTGTCGAAAGAACATGTGAAGGTGTAT
CCATTGGACTAGAAGAAAAGAAAATGGGGATTAAAGGTTCTTCAACGGCTACGCTTATTTTAGAAGATGTTGTCATACCT
GCTGAAAATGTTTTAGGGGAAGTTGGGAAAGGGCATCACGTAGCTCTTAATATTCTTAACTTCGCTAGACTAAAGCTTGC
TTTTGGAAATATTGGAACAGCAAAACAAGCAATTGGATTGTCGGTTCAATATGGAAAAGAGCGAAAACAGTTCCAAACGG
AATTAGTAGATTTTACGATGATTCAAGAGAAAATTGCAAATATGATTATTGCTACATATGGAGCAGAAAGTGCAGCTTAT
CGTACAGCAGGTGTAATTGATGAAGCAATTCATGAGAGTGATGAGGATCTTATGAAGAAAATGTCTCAATTTGCTATTGA
ATGTGCACTGAATAAAGTAAATGCTTCTGAAACACTTGGTCATATCGTAGATGAAGCTGTACAAATTCATGGTGGTTACG
GTTATATGCAAGAATACGAGGTAGAACGATTATATCGTGATGCTAGAATTAGTCGTATTTTTGAAGGAACGAATGAAATT
AATAGATTAACCGTTGCCAAAATGTTAATGAAGCAAATGGAACAAATTGAAGATACTGAAGTAGAGATTGATATAGCAAA
TGTCGAGCGAAACCATCGTTACATTTTATTAGCGAAAAAATTGTTGAAACAATCTTTGAAAACGCTCTCTAAAACTCCAG
GGTTAAAAATTGATCAAGAGCAAGAATATTCACGTGTATTATCTAATATGTTAACGGATGTTTACGTCATGGAATCAGCA
TTTTTACGTACGAGTAAAGCAATTAGTAAAAATGGTGAAGGGAAAGAGCGTACGAAACAAATGATAACTGACGTTATTTG
TGAAGAAGGCTATCGTAAAGTAGAAGAAGCGGCGATTTCTATACTTTCAGCGGCTGTTACAGAAGAACAAGATAGGCACG
TAATTTTAGCTGAAATCCGTCAATTATTAGTACCTTTATACACGAACGTATTTACGAAAAAGAGAGAAATTGCGAAAGCT
ATTATAAATCGCGGAAAGTATATTGTGTAA

Upstream 100 bases:

>100_bases
TGAAAATTCATCGCCTTCTGTTTTCAAAAATAAGATATTCCACTCATCGTAGACGTGCATAAGTAGTAGCAAGTAAGGCC
GAAATGATAGGGGGATTCAG

Downstream 100 bases:

>100_bases
ATAGGGGGAAAGCGATATGAAAAAGATTGGTTTTATCGGTTTAGGTAACATGGGTCTTCCAATGTCTAAAAATTTAGTTA
AATCAAATTACACAGTATAT

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MEKTKLPWDEFFSLNKDVNHAFFTPEDFSGDEDLIAKTTEQFVKQEIVPQMENIEQHNYKVSRQLFEKAGELGLLSIEVP
EEYGGFELGKAVSGLVAEKMGYAGAFSVSFNIHAGVGTLPYIYYGTKEQKEKYLPKIASGEWIGAYALTEPNAGSDALSA
KTSAVLNEDGTAWKLNGEKQWITNAHMADVYVVFAKTNKGMTAFIVERTCEGVSIGLEEKKMGIKGSSTATLILEDVVIP
AENVLGEVGKGHHVALNILNFARLKLAFGNIGTAKQAIGLSVQYGKERKQFQTELVDFTMIQEKIANMIIATYGAESAAY
RTAGVIDEAIHESDEDLMKKMSQFAIECALNKVNASETLGHIVDEAVQIHGGYGYMQEYEVERLYRDARISRIFEGTNEI
NRLTVAKMLMKQMEQIEDTEVEIDIANVERNHRYILLAKKLLKQSLKTLSKTPGLKIDQEQEYSRVLSNMLTDVYVMESA
FLRTSKAISKNGEGKERTKQMITDVICEEGYRKVEEAAISILSAAVTEEQDRHVILAEIRQLLVPLYTNVFTKKREIAKA
IINRGKYIV

Sequences:

>Translated_569_residues
MEKTKLPWDEFFSLNKDVNHAFFTPEDFSGDEDLIAKTTEQFVKQEIVPQMENIEQHNYKVSRQLFEKAGELGLLSIEVP
EEYGGFELGKAVSGLVAEKMGYAGAFSVSFNIHAGVGTLPYIYYGTKEQKEKYLPKIASGEWIGAYALTEPNAGSDALSA
KTSAVLNEDGTAWKLNGEKQWITNAHMADVYVVFAKTNKGMTAFIVERTCEGVSIGLEEKKMGIKGSSTATLILEDVVIP
AENVLGEVGKGHHVALNILNFARLKLAFGNIGTAKQAIGLSVQYGKERKQFQTELVDFTMIQEKIANMIIATYGAESAAY
RTAGVIDEAIHESDEDLMKKMSQFAIECALNKVNASETLGHIVDEAVQIHGGYGYMQEYEVERLYRDARISRIFEGTNEI
NRLTVAKMLMKQMEQIEDTEVEIDIANVERNHRYILLAKKLLKQSLKTLSKTPGLKIDQEQEYSRVLSNMLTDVYVMESA
FLRTSKAISKNGEGKERTKQMITDVICEEGYRKVEEAAISILSAAVTEEQDRHVILAEIRQLLVPLYTNVFTKKREIAKA
IINRGKYIV
>Mature_569_residues
MEKTKLPWDEFFSLNKDVNHAFFTPEDFSGDEDLIAKTTEQFVKQEIVPQMENIEQHNYKVSRQLFEKAGELGLLSIEVP
EEYGGFELGKAVSGLVAEKMGYAGAFSVSFNIHAGVGTLPYIYYGTKEQKEKYLPKIASGEWIGAYALTEPNAGSDALSA
KTSAVLNEDGTAWKLNGEKQWITNAHMADVYVVFAKTNKGMTAFIVERTCEGVSIGLEEKKMGIKGSSTATLILEDVVIP
AENVLGEVGKGHHVALNILNFARLKLAFGNIGTAKQAIGLSVQYGKERKQFQTELVDFTMIQEKIANMIIATYGAESAAY
RTAGVIDEAIHESDEDLMKKMSQFAIECALNKVNASETLGHIVDEAVQIHGGYGYMQEYEVERLYRDARISRIFEGTNEI
NRLTVAKMLMKQMEQIEDTEVEIDIANVERNHRYILLAKKLLKQSLKTLSKTPGLKIDQEQEYSRVLSNMLTDVYVMESA
FLRTSKAISKNGEGKERTKQMITDVICEEGYRKVEEAAISILSAAVTEEQDRHVILAEIRQLLVPLYTNVFTKKREIAKA
IINRGKYIV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=516, Percent_Identity=35.6589147286822, Blast_Score=283, Evalue=4e-76,
Organism=Homo sapiens, GI76496475, Length=583, Percent_Identity=32.4185248713551, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI4557235, Length=583, Percent_Identity=32.4185248713551, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI4557233, Length=402, Percent_Identity=36.81592039801, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI226958412, Length=401, Percent_Identity=34.1645885286783, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI226958414, Length=377, Percent_Identity=35.0132625994695, Blast_Score=212, Evalue=9e-55,
Organism=Homo sapiens, GI4501859, Length=403, Percent_Identity=32.0099255583127, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI4501857, Length=390, Percent_Identity=33.5897435897436, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI187960098, Length=391, Percent_Identity=34.2710997442455, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI4557231, Length=391, Percent_Identity=34.2710997442455, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI7656849, Length=381, Percent_Identity=29.9212598425197, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI4503943, Length=393, Percent_Identity=30.7888040712468, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI7669494, Length=376, Percent_Identity=31.1170212765957, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI48976061, Length=421, Percent_Identity=25.41567695962, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI211971008, Length=421, Percent_Identity=25.41567695962, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI38505218, Length=410, Percent_Identity=24.6341463414634, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1786223, Length=373, Percent_Identity=28.1501340482574, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI87081958, Length=394, Percent_Identity=27.1573604060914, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI87082384, Length=319, Percent_Identity=26.3322884012539, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI87081702, Length=378, Percent_Identity=24.0740740740741, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71985184, Length=356, Percent_Identity=40.7303370786517, Blast_Score=250, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17538396, Length=390, Percent_Identity=32.8205128205128, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17508101, Length=399, Percent_Identity=33.3333333333333, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17569725, Length=398, Percent_Identity=31.6582914572864, Blast_Score=201, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17506239, Length=407, Percent_Identity=32.9238329238329, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71985192, Length=282, Percent_Identity=40.4255319148936, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17533517, Length=388, Percent_Identity=30.1546391752577, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17534899, Length=384, Percent_Identity=31.7708333333333, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17570075, Length=413, Percent_Identity=30.5084745762712, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17534353, Length=397, Percent_Identity=27.9596977329975, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI71990804, Length=277, Percent_Identity=33.9350180505415, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI32563615, Length=238, Percent_Identity=37.3949579831933, Blast_Score=148, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17551932, Length=393, Percent_Identity=25.9541984732824, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71982178, Length=287, Percent_Identity=32.404181184669, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=25.6, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17531909, Length=250, Percent_Identity=27.6, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17540912, Length=473, Percent_Identity=24.9471458773784, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI86563383, Length=299, Percent_Identity=24.7491638795987, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI86563381, Length=299, Percent_Identity=24.7491638795987, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562446, Length=370, Percent_Identity=27.5675675675676, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6321233, Length=360, Percent_Identity=23.6111111111111, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI281363737, Length=347, Percent_Identity=42.3631123919308, Blast_Score=253, Evalue=3e-67,
Organism=Drosophila melanogaster, GI21356377, Length=389, Percent_Identity=35.2185089974293, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI21355753, Length=412, Percent_Identity=33.7378640776699, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24660351, Length=400, Percent_Identity=33.25, Blast_Score=212, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24646207, Length=395, Percent_Identity=32.9113924050633, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24666513, Length=393, Percent_Identity=32.0610687022901, Blast_Score=198, Evalue=1e-50,
Organism=Drosophila melanogaster, GI19920834, Length=358, Percent_Identity=30.7262569832402, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24652780, Length=320, Percent_Identity=25.3125, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 63646; Mature: 63646

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTKLPWDEFFSLNKDVNHAFFTPEDFSGDEDLIAKTTEQFVKQEIVPQMENIEQHNYK
CCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSRQLFEKAGELGLLSIEVPEEYGGFELGKAVSGLVAEKMGYAGAFSVSFNIHAGVGTLP
HHHHHHHHCCCEEEEEEECCHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCC
YIYYGTKEQKEKYLPKIASGEWIGAYALTEPNAGSDALSAKTSAVLNEDGTAWKLNGEKQ
EEEECCHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCC
WITNAHMADVYVVFAKTNKGMTAFIVERTCEGVSIGLEEKKMGIKGSSTATLILEDVVIP
CCCCCCEEEEEEEEEECCCCCEEEEEECCCCCCEECCHHHHCCCCCCCCEEEEEHHHHCC
AENVLGEVGKGHHVALNILNFARLKLAFGNIGTAKQAIGLSVQYGKERKQFQTELVDFTM
HHHHHHHCCCCCEEEEHHHHHHHHHEEECCCCCHHHHHCCEECCCHHHHHHHHHHHHHHH
IQEKIANMIIATYGAESAAYRTAGVIDEAIHESDEDLMKKMSQFAIECALNKVNASETLG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHH
HIVDEAVQIHGGYGYMQEYEVERLYRDARISRIFEGTNEINRLTVAKMLMKQMEQIEDTE
HHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCE
VEIDIANVERNHRYILLAKKLLKQSLKTLSKTPGLKIDQEQEYSRVLSNMLTDVYVMESA
EEEEEECCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FLRTSKAISKNGEGKERTKQMITDVICEEGYRKVEEAAISILSAAVTEEQDRHVILAEIR
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHH
QLLVPLYTNVFTKKREIAKAIINRGKYIV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEKTKLPWDEFFSLNKDVNHAFFTPEDFSGDEDLIAKTTEQFVKQEIVPQMENIEQHNYK
CCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSRQLFEKAGELGLLSIEVPEEYGGFELGKAVSGLVAEKMGYAGAFSVSFNIHAGVGTLP
HHHHHHHHCCCEEEEEEECCHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCC
YIYYGTKEQKEKYLPKIASGEWIGAYALTEPNAGSDALSAKTSAVLNEDGTAWKLNGEKQ
EEEECCHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCC
WITNAHMADVYVVFAKTNKGMTAFIVERTCEGVSIGLEEKKMGIKGSSTATLILEDVVIP
CCCCCCEEEEEEEEEECCCCCEEEEEECCCCCCEECCHHHHCCCCCCCCEEEEEHHHHCC
AENVLGEVGKGHHVALNILNFARLKLAFGNIGTAKQAIGLSVQYGKERKQFQTELVDFTM
HHHHHHHCCCCCEEEEHHHHHHHHHEEECCCCCHHHHHCCEECCCHHHHHHHHHHHHHHH
IQEKIANMIIATYGAESAAYRTAGVIDEAIHESDEDLMKKMSQFAIECALNKVNASETLG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHH
HIVDEAVQIHGGYGYMQEYEVERLYRDARISRIFEGTNEINRLTVAKMLMKQMEQIEDTE
HHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCE
VEIDIANVERNHRYILLAKKLLKQSLKTLSKTPGLKIDQEQEYSRVLSNMLTDVYVMESA
EEEEEECCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FLRTSKAISKNGEGKERTKQMITDVICEEGYRKVEEAAISILSAAVTEEQDRHVILAEIR
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHH
QLLVPLYTNVFTKKREIAKAIINRGKYIV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]