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The map label for this gene is 52143098

Identifier: 52143098

GI number: 52143098

Start: 2266896

End: 2268089

Strand: Reverse

Name: 52143098

Synonym: BCZK2139

Alternate gene names: NA

Gene position: 2268089-2266896 (Counterclockwise)

Preceding gene: 52143099

Following gene: 52143101

Centisome position: 42.79

GC content: 37.19

Gene sequence:

>1194_bases
TTGAAAAACAAAATCATCGTTTTCCTATCTGTTTTGTCATTTATTATTGGTGGTTTCTTCTTTAACACAAATACTTCAAG
TGCTGAAACATCATCTACTGATTACGTTCCTAACCAATTGATCGTTAAGTTCAAACAAAATGCATCTTTAAGTAATGTGC
AATCTTTTCATAAGTCTGTTGGTGCTACTGTTTTATCTAAAGATGATAAGTTAGGTTTTGAAGTCGTTCAATTTTCGAAA
GGTACTGTAAAAGAAAAGATAAAAAGCTATAAAAACAATCCAGATGTGGAATATGCAGAGCCGAATTACTACGTTCACTC
CTTTTGGACTCCGAACGATCCATATTATAAAAATCAATATGGATTACAAAAAATTCAAGCTCCACTAGCTTGGGATAGTC
AACGAAGTGATTCTAGTGTAAAAGTAGCTATTATTGATACAGGAGTACAAGGTTCACACCCTGATTTATCTTCGAAAGTA
ATTTACGGGCATGATTATGTTGATAACGACAATGTTTCTGATGACGGTAATGGTCATGGTACACATTGCGCTGGAATTAC
TGGAGCACTTACGAATAACAGCGTCGGAATTGCTGGTGTTGCCCCACACACTTCAATTTATGCTGTCCGCGTATTAGATA
ATCAAGGAAGTGGGACTCTTGATGCTGTAGCGCAAGGTATTCGAGAAGCTGCTGATTCAGGTGCAAAAGTAATTAGTTTA
AGTTTAGGAGCTCCAAATGGTGGGACTGCATTACAACAAGCTGTTCAATATGCATGGAATAAAGGCTCTGTTATTGTTGC
GGCTGCTGGAAATGCTGGAAATACAAAAGCTAATTACCCTGCTTATTACAGCGAAGTAATTGCAGTTGCTTCTACAGATC
AATCAGATAGAAAATCTTCATTTTCTACTTATGGTAGCTGGGTAGATGTTGCAGCACCAGGTTCAAATATATATTCCACA
TATAAAGGAAGCACGTATCAATCATTAAGTGGTACATCTATGGCAACACCCCACGTTGCAGGAGTCGCTGCTCTTTTAGC
AAATCAAGGATATAGCAATACACAAATCCGCCAAATTATTGAGTCAACTTCTGATAAAATTAGTGGTACAGGTACGTACT
GGAAAAACGGTAGAGTCAATGCATATAAAGCGGTACAATACGCTAAGCAATTACAAGAAAAGAAAGCCTCTTAA

Upstream 100 bases:

>100_bases
TAAATGACATAAATCGTATGGTCTAACTATATAGTTGAAAAGGAATGCGACATTAAAGCGTCGCTGAAAAACTTATCCAA
GAAAAGGGAGGAAAAATCTT

Downstream 100 bases:

>100_bases
GAAATAAAGTGAAATTTTAATCTGTCGATCTATCATTCATGCAGGATAAAATAGAAGGAGAGACTTCTACGATGAAAGCC
TCTCCTTCTTACAAATAATA

Product: alkaline serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MKNKIIVFLSVLSFIIGGFFFNTNTSSAETSSTDYVPNQLIVKFKQNASLSNVQSFHKSVGATVLSKDDKLGFEVVQFSK
GTVKEKIKSYKNNPDVEYAEPNYYVHSFWTPNDPYYKNQYGLQKIQAPLAWDSQRSDSSVKVAIIDTGVQGSHPDLSSKV
IYGHDYVDNDNVSDDGNGHGTHCAGITGALTNNSVGIAGVAPHTSIYAVRVLDNQGSGTLDAVAQGIREAADSGAKVISL
SLGAPNGGTALQQAVQYAWNKGSVIVAAAGNAGNTKANYPAYYSEVIAVASTDQSDRKSSFSTYGSWVDVAAPGSNIYST
YKGSTYQSLSGTSMATPHVAGVAALLANQGYSNTQIRQIIESTSDKISGTGTYWKNGRVNAYKAVQYAKQLQEKKAS

Sequences:

>Translated_397_residues
MKNKIIVFLSVLSFIIGGFFFNTNTSSAETSSTDYVPNQLIVKFKQNASLSNVQSFHKSVGATVLSKDDKLGFEVVQFSK
GTVKEKIKSYKNNPDVEYAEPNYYVHSFWTPNDPYYKNQYGLQKIQAPLAWDSQRSDSSVKVAIIDTGVQGSHPDLSSKV
IYGHDYVDNDNVSDDGNGHGTHCAGITGALTNNSVGIAGVAPHTSIYAVRVLDNQGSGTLDAVAQGIREAADSGAKVISL
SLGAPNGGTALQQAVQYAWNKGSVIVAAAGNAGNTKANYPAYYSEVIAVASTDQSDRKSSFSTYGSWVDVAAPGSNIYST
YKGSTYQSLSGTSMATPHVAGVAALLANQGYSNTQIRQIIESTSDKISGTGTYWKNGRVNAYKAVQYAKQLQEKKAS
>Mature_397_residues
MKNKIIVFLSVLSFIIGGFFFNTNTSSAETSSTDYVPNQLIVKFKQNASLSNVQSFHKSVGATVLSKDDKLGFEVVQFSK
GTVKEKIKSYKNNPDVEYAEPNYYVHSFWTPNDPYYKNQYGLQKIQAPLAWDSQRSDSSVKVAIIDTGVQGSHPDLSSKV
IYGHDYVDNDNVSDDGNGHGTHCAGITGALTNNSVGIAGVAPHTSIYAVRVLDNQGSGTLDAVAQGIREAADSGAKVISL
SLGAPNGGTALQQAVQYAWNKGSVIVAAAGNAGNTKANYPAYYSEVIAVASTDQSDRKSSFSTYGSWVDVAAPGSNIYST
YKGSTYQSLSGTSMATPHVAGVAALLANQGYSNTQIRQIIESTSDKISGTGTYWKNGRVNAYKAVQYAKQLQEKKAS

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=265, Percent_Identity=30.188679245283, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI31317307, Length=273, Percent_Identity=31.1355311355311, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI20336190, Length=362, Percent_Identity=24.8618784530387, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI27894285, Length=362, Percent_Identity=24.8618784530387, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI20336188, Length=362, Percent_Identity=24.8618784530387, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI20336186, Length=362, Percent_Identity=24.8618784530387, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI20336180, Length=361, Percent_Identity=24.9307479224377, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI4505577, Length=362, Percent_Identity=24.8618784530387, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI20336184, Length=361, Percent_Identity=24.9307479224377, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI20336182, Length=361, Percent_Identity=24.9307479224377, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI299523015, Length=334, Percent_Identity=25.4491017964072, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI4505579, Length=300, Percent_Identity=25, Blast_Score=66, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71983555, Length=395, Percent_Identity=23.0379746835443, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25141268, Length=395, Percent_Identity=23.0379746835443, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71988308, Length=272, Percent_Identity=28.3088235294118, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320775, Length=380, Percent_Identity=30.7894736842105, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6324576, Length=214, Percent_Identity=40.6542056074766, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319893, Length=241, Percent_Identity=36.5145228215768, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45550681, Length=289, Percent_Identity=25.6055363321799, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24642494, Length=306, Percent_Identity=27.4509803921569, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642490, Length=306, Percent_Identity=27.4509803921569, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45555723, Length=306, Percent_Identity=27.4509803921569, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642492, Length=306, Percent_Identity=27.4509803921569, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281360987, Length=286, Percent_Identity=27.972027972028, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642488, Length=309, Percent_Identity=27.1844660194175, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24642484, Length=309, Percent_Identity=27.1844660194175, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24642486, Length=309, Percent_Identity=27.1844660194175, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: =3.4.21.66 [H]

Molecular weight: Translated: 42395; Mature: 42395

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00136 SUBTILASE_ASP ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKIIVFLSVLSFIIGGFFFNTNTSSAETSSTDYVPNQLIVKFKQNASLSNVQSFHKSV
CCCCEEEHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
GATVLSKDDKLGFEVVQFSKGTVKEKIKSYKNNPDVEYAEPNYYVHSFWTPNDPYYKNQY
CCEEECCCCCCCEEEEECCCCHHHHHHHHHCCCCCCEEECCCEEEEEEECCCCCCCCCCC
GLQKIQAPLAWDSQRSDSSVKVAIIDTGVQGSHPDLSSKVIYGHDYVDNDNVSDDGNGHG
CHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
THCAGITGALTNNSVGIAGVAPHTSIYAVRVLDNQGSGTLDAVAQGIREAADSGAKVISL
CEECCEEEEECCCCCEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEE
SLGAPNGGTALQQAVQYAWNKGSVIVAAAGNAGNTKANYPAYYSEVIAVASTDQSDRKSS
EECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHEEEEECCCCHHHHHH
FSTYGSWVDVAAPGSNIYSTYKGSTYQSLSGTSMATPHVAGVAALLANQGYSNTQIRQII
HHHCCCEEEEECCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
ESTSDKISGTGTYWKNGRVNAYKAVQYAKQLQEKKAS
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNKIIVFLSVLSFIIGGFFFNTNTSSAETSSTDYVPNQLIVKFKQNASLSNVQSFHKSV
CCCCEEEHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
GATVLSKDDKLGFEVVQFSKGTVKEKIKSYKNNPDVEYAEPNYYVHSFWTPNDPYYKNQY
CCEEECCCCCCCEEEEECCCCHHHHHHHHHCCCCCCEEECCCEEEEEEECCCCCCCCCCC
GLQKIQAPLAWDSQRSDSSVKVAIIDTGVQGSHPDLSSKVIYGHDYVDNDNVSDDGNGHG
CHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCC
THCAGITGALTNNSVGIAGVAPHTSIYAVRVLDNQGSGTLDAVAQGIREAADSGAKVISL
CEECCEEEEECCCCCEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEE
SLGAPNGGTALQQAVQYAWNKGSVIVAAAGNAGNTKANYPAYYSEVIAVASTDQSDRKSS
EECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHEEEEECCCCHHHHHH
FSTYGSWVDVAAPGSNIYSTYKGSTYQSLSGTSMATPHVAGVAALLANQGYSNTQIRQII
HHHCCCEEEEECCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
ESTSDKISGTGTYWKNGRVNAYKAVQYAKQLQEKKAS
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2647518; 2689655; 2196375; 1993669 [H]