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The map label for this gene is nprE [H]

Identifier: 52142776

GI number: 52142776

Start: 2599187

End: 2600890

Strand: Reverse

Name: nprE [H]

Synonym: BCZK2464

Alternate gene names: 52142776

Gene position: 2600890-2599187 (Counterclockwise)

Preceding gene: 52142775

Following gene: 52142777

Centisome position: 49.06

GC content: 35.27

Gene sequence:

>1704_bases
ATGAAAAACAAAAAGACGTTAACTAAGGTAGCATTAACAACAGGTTTAGCTTTAACAGCAGTAGCACCATACGGAGTAGG
TCATGCAGAGGAAACAGATCAACTACAAGTTCAAATTCAGGAGGAATCATTCCGTTCTGGTGAACTTACACAACCGTCAC
AAAAGGCACCAGAGAATGTAGTAAAAGATGCTCTTAAGGAGAAAACAGAACAAGCCCTTTCTTCAAAACAAGTCAATGGA
GAAACTGGAGTAGATTACAAAGTTCTTCAAAAACGTGATTCATATGATGGGACTACACTTGTACGTATACAGCAAACATA
TGAAGGAAAAGAAGTATATGGCCATCAATTAACTGCACACGTAGATAATAACGGTGTTATTAAAAGTGTTTCAGGTGATA
GCGCGCAAAATTTAAAACAAGAAGAATTGAAAAAACCTATCAATCTATCAAAAGATGAAGCACAACAATATATTTATACG
AAGTACGGGAACGATATCAATTTTATTTCTGAGCCAGAAGTTAAGGAAGTTATTTTTGTTGATGAAAATAATGGCCAAGC
TAGCAATGCGTACCAGGTTACATTTGAAGCTGCCACGCCAAACTATGTTTCTGGAACATATTTAGTAAATGCACAAAATG
GTGATATGTTAAAAAATATGGTACAAGAATCTAACTTAAAAGCAAGTGAAAAACTAGTTGGAGCCTTAAAGAAAAGTAAA
AAAAGCAGTCTTACATCATTAACGGGCACTGGAAAAGATGATTTAGGTATCTCTCGTTCATTTGGTATCTCTAAACAAAG
TAATGGCAAATATGCTCTGGCTGATTATACAAGAGGGCAAGGGATTGAAACATATGATGTGAATTACAGAGATATTACGA
AAGAAGAAAGCTATTATCCTGGTACATTAGCAACTAGTACTTCAACAACATTTAACGATCCAAAAGCAGTAAGTGCTCAT
TACTTAGCAACAAAAGTTTTTGATTTTTATAAAGATAAATACAATCGTAATAGCTTTGATAATAAGGGACAAAAGGTAGT
TTCAGTTGTACATGCTTGGGATTCTGGAGATACGAATGATCCGAAAAATTGGCAGAATGCGTTAAGTGCTAATAATGGTA
GTATGCTTGTATATGGGGATCCTATCGTCAAAGCATATGATGTAGCTGGGCATGAATTTACACATGCTGTTACTTCTAGT
GAATCTAATCTTGAATATTACGGTGAGTCTGGTGCGATTAATGAGGCACTATCTGATATTATGGGAACATCTATTGAGAA
ATACGTAAATAATGGAAGCTTTAACTGGACGATGGGAGAACAAACTGGATCTGTCTTCCGTGATATGGAAAACCCAGCTT
CTGTTCCATCTTCACTTGGAGTACCTTATCCAGATGATTACAGTGAATTTAATGATTTTAACGGATGGGATCAAGGTGGC
GTTCATTTTAATTCAAGCATTATTAATAAAGTTGCGTATCTCATCGCAAAAGGCGGAACTCATAACGGTGTAACTGTTAA
AGGAATTGGTGAAGATAAAATGTTTGATATTTTCTATTACGCCAATACAGATGAGTTAAACATGACTTCTAATTTCAAAG
AATTGAGATCAGCATGTATTCGAGTGGCAACTAATAAATATGGTGCAAATTCAGCTGAAGTTCAAGCAGTACAAAAGGCA
TTTGATGCAGCAAAAATTAAGTAA

Upstream 100 bases:

>100_bases
CATAATGTTACATAAATTGTGTATTTTCCCTTTTTTTCGACAGGAACAGGCAGTATACTTTGTACAAGCTTTCTATTTCA
AAATTATACGAGGTGAAAAA

Downstream 100 bases:

>100_bases
GTTAGAAATATAGTTCTTATTCATATATTATTACATTATGAAAAACAGCTAATGTCGTTTTAAGGATATTAGCTGTTTTT
TCATACCAATGTATTTGAAA

Product: extracellular neutral metalloprotease, bacillolysin

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MKNKKTLTKVALTTGLALTAVAPYGVGHAEETDQLQVQIQEESFRSGELTQPSQKAPENVVKDALKEKTEQALSSKQVNG
ETGVDYKVLQKRDSYDGTTLVRIQQTYEGKEVYGHQLTAHVDNNGVIKSVSGDSAQNLKQEELKKPINLSKDEAQQYIYT
KYGNDINFISEPEVKEVIFVDENNGQASNAYQVTFEAATPNYVSGTYLVNAQNGDMLKNMVQESNLKASEKLVGALKKSK
KSSLTSLTGTGKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATSTSTTFNDPKAVSAH
YLATKVFDFYKDKYNRNSFDNKGQKVVSVVHAWDSGDTNDPKNWQNALSANNGSMLVYGDPIVKAYDVAGHEFTHAVTSS
ESNLEYYGESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTGSVFRDMENPASVPSSLGVPYPDDYSEFNDFNGWDQGG
VHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKELRSACIRVATNKYGANSAEVQAVQKA
FDAAKIK

Sequences:

>Translated_567_residues
MKNKKTLTKVALTTGLALTAVAPYGVGHAEETDQLQVQIQEESFRSGELTQPSQKAPENVVKDALKEKTEQALSSKQVNG
ETGVDYKVLQKRDSYDGTTLVRIQQTYEGKEVYGHQLTAHVDNNGVIKSVSGDSAQNLKQEELKKPINLSKDEAQQYIYT
KYGNDINFISEPEVKEVIFVDENNGQASNAYQVTFEAATPNYVSGTYLVNAQNGDMLKNMVQESNLKASEKLVGALKKSK
KSSLTSLTGTGKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATSTSTTFNDPKAVSAH
YLATKVFDFYKDKYNRNSFDNKGQKVVSVVHAWDSGDTNDPKNWQNALSANNGSMLVYGDPIVKAYDVAGHEFTHAVTSS
ESNLEYYGESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTGSVFRDMENPASVPSSLGVPYPDDYSEFNDFNGWDQGG
VHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKELRSACIRVATNKYGANSAEVQAVQKA
FDAAKIK
>Mature_567_residues
MKNKKTLTKVALTTGLALTAVAPYGVGHAEETDQLQVQIQEESFRSGELTQPSQKAPENVVKDALKEKTEQALSSKQVNG
ETGVDYKVLQKRDSYDGTTLVRIQQTYEGKEVYGHQLTAHVDNNGVIKSVSGDSAQNLKQEELKKPINLSKDEAQQYIYT
KYGNDINFISEPEVKEVIFVDENNGQASNAYQVTFEAATPNYVSGTYLVNAQNGDMLKNMVQESNLKASEKLVGALKKSK
KSSLTSLTGTGKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYPGTLATSTSTTFNDPKAVSAH
YLATKVFDFYKDKYNRNSFDNKGQKVVSVVHAWDSGDTNDPKNWQNALSANNGSMLVYGDPIVKAYDVAGHEFTHAVTSS
ESNLEYYGESGAINEALSDIMGTSIEKYVNNGSFNWTMGEQTGSVFRDMENPASVPSSLGVPYPDDYSEFNDFNGWDQGG
VHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKELRSACIRVATNKYGANSAEVQAVQKA
FDAAKIK

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 62328; Mature: 62328

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKKTLTKVALTTGLALTAVAPYGVGHAEETDQLQVQIQEESFRSGELTQPSQKAPENV
CCCCHHHHHHHHHHCHHHEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHCCHHHH
VKDALKEKTEQALSSKQVNGETGVDYKVLQKRDSYDGTTLVRIQQTYEGKEVYGHQLTAH
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCEEEEEEEECCCCCHHCCCEEEEE
VDNNGVIKSVSGDSAQNLKQEELKKPINLSKDEAQQYIYTKYGNDINFISEPEVKEVIFV
ECCCCEEEECCCCCHHHCCHHHHHCCCCCCHHHHHHEEEEECCCCCCCCCCCCCEEEEEE
DENNGQASNAYQVTFEAATPNYVSGTYLVNAQNGDMLKNMVQESNLKASEKLVGALKKSK
ECCCCCCCCEEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
KSSLTSLTGTGKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYP
HHHHHEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEECCHHCCCCCCCCCC
GTLATSTSTTFNDPKAVSAHYLATKVFDFYKDKYNRNSFDNKGQKVVSVVHAWDSGDTND
CEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEEECCCCCCCC
PKNWQNALSANNGSMLVYGDPIVKAYDVAGHEFTHAVTSSESNLEYYGESGAINEALSDI
CHHHHHHHCCCCCCEEEECCCCEEEEECCCCHHHHHHCCCCCCCEEECCCCCHHHHHHHH
MGTSIEKYVNNGSFNWTMGEQTGSVFRDMENPASVPSSLGVPYPDDYSEFNDFNGWDQGG
HHHHHHHHHCCCCEEEEECCCHHHHHHHCCCHHCCCHHCCCCCCCCHHHCCCCCCCCCCC
VHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKELRSACI
EEECHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCHHHHHHHHH
RVATNKYGANSAEVQAVQKAFDAAKIK
HHHHCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNKKTLTKVALTTGLALTAVAPYGVGHAEETDQLQVQIQEESFRSGELTQPSQKAPENV
CCCCHHHHHHHHHHCHHHEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHCCHHHH
VKDALKEKTEQALSSKQVNGETGVDYKVLQKRDSYDGTTLVRIQQTYEGKEVYGHQLTAH
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCEEEEEEEECCCCCHHCCCEEEEE
VDNNGVIKSVSGDSAQNLKQEELKKPINLSKDEAQQYIYTKYGNDINFISEPEVKEVIFV
ECCCCEEEECCCCCHHHCCHHHHHCCCCCCHHHHHHEEEEECCCCCCCCCCCCCEEEEEE
DENNGQASNAYQVTFEAATPNYVSGTYLVNAQNGDMLKNMVQESNLKASEKLVGALKKSK
ECCCCCCCCEEEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
KSSLTSLTGTGKDDLGISRSFGISKQSNGKYALADYTRGQGIETYDVNYRDITKEESYYP
HHHHHEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEECCHHCCCCCCCCCC
GTLATSTSTTFNDPKAVSAHYLATKVFDFYKDKYNRNSFDNKGQKVVSVVHAWDSGDTND
CEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEEECCCCCCCC
PKNWQNALSANNGSMLVYGDPIVKAYDVAGHEFTHAVTSSESNLEYYGESGAINEALSDI
CHHHHHHHCCCCCCEEEECCCCEEEEECCCCHHHHHHCCCCCCCEEECCCCCHHHHHHHH
MGTSIEKYVNNGSFNWTMGEQTGSVFRDMENPASVPSSLGVPYPDDYSEFNDFNGWDQGG
HHHHHHHHHCCCCEEEEECCCHHHHHHHCCCHHCCCHHCCCCCCCCHHHCCCCCCCCCCC
VHFNSSIINKVAYLIAKGGTHNGVTVKGIGEDKMFDIFYYANTDELNMTSNFKELRSACI
EEECHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCHHHHHHHHH
RVATNKYGANSAEVQAVQKAFDAAKIK
HHHHCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7764969 [H]