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The map label for this gene is kynU [H]

Identifier: 52142752

GI number: 52142752

Start: 2621787

End: 2623073

Strand: Reverse

Name: kynU [H]

Synonym: BCZK2488

Alternate gene names: 52142752

Gene position: 2623073-2621787 (Counterclockwise)

Preceding gene: 52142750

Following gene: 52142753

Centisome position: 49.48

GC content: 36.13

Gene sequence:

>1287_bases
ATGTATAAAGAACCATTTCAACCAACTTATGAGTATGCGCTTGAATGTGATAAACATGATGAACTGAAAGATTTTCAAAC
TGAATTTTATAAAAAAGAAGGAACAATATATTTAGATGGAAACTCATTAGGGCTACTTTCAAAAAGAGCAGAGAAATCAT
TACTTACTTTGCTAGATTCATGGAAAGAATATGGCATTGACGGCTGGACCGAGGGTGAGCATCCGTGGTTTTTCCTTTCG
GAGAAATTAGGTGAATTGACTGCACCTCTTATTGGAGCTTTACCAGAAGAAACTATTGTAACCGGTTCCACGACGACGAA
TATTCATCAAGTAATCGCAACTTTCTATGAGCCGAAAGGAATTCGGACAAAAATTCTTGCTGATGAATTAACATTTCCGT
CAGATATATATGCACTTCAAAGTCAAATTCGTTTAAAGGGTCTAGATCCAGATGAGCATTTAGTACGAGTGAAGAGCCGA
GACGGTAGAACACTTTCTGAAGATGATATTATTCAAGCAATGACAGATGACATCGCGTTAATTTTGTTGCCTTCTGTACT
ATATAGAAGTGGACAAATTCTTGATATGAAACGTTTAACAGCGGAAGCACATAAGCGTGGTATTCATATTGGGTTCGATT
TATGTCACTCAATCGGTTCTATTCCGCATCATTTCAAAGAGTGGGATGTTGATTTCGCGATTTGGTGTAATTATAAATAC
TTAAATGCGGGACCTGGTGGTGTTGCAGGGCTTTATGTAAATAAAAAGCATTTTAATAGACCTCCTGGATTATCAGGTTG
GTTTAGTTCTAGAAAAGATAAGCAGTTTGATATGGAACATACATTAACAGCTGCTGATCATGCAGGTGCTTATCAAATTG
GTACACCACACGTATTAAGTACTGCACCTTTAATCGGTTCTCTTGAAATATTTAAAGATGCTGGTATAGAACGTTTACGC
GAAAAATCATTACATATTACAAGATACATGCTTAATTTGATTGATCATGAATTAAAAGATTTCGGATTTACAATTGGAAA
TCCATTTGAGGATGAAAAACGAGGCGGGCATATTTATTTAGAGCATGCAGAAGCAGCACGTATATGTAAAGCGTTAAAAG
CAAATGGAGTAATTCCAGATTTTAGAGCGCCAAATGGAGTGAGACTTGCGCCAGTTGCTTTATATAATACGTACGAAGAA
GTATGGCAGTCTGTTATGATTTTAAAGAAAATTATGAAAGATGAAGAGTATAAGCAATTTGAAAATAAGCGAGAGGTTGT
GGCATAA

Upstream 100 bases:

>100_bases
TGTATAAAGTCAACTGACATAATATCATTGACGTTATATCAACTAAGGTGATATATTTCAATTAGTTAGAATAAAAAGAA
AATTAAGAGAAGGTGACACC

Downstream 100 bases:

>100_bases
GTATGAAAACATCAGAGTGGATTGATATTTCACAACCGCTAAATAATGATATTGCTACTTGGCCAGGGGATACACCATTC
TCGTATGAAGTTTCATGGTC

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLLTLLDSWKEYGIDGWTEGEHPWFFLS
EKLGELTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKGIRTKILADELTFPSDIYALQSQIRLKGLDPDEHLVRVKSR
DGRTLSEDDIIQAMTDDIALILLPSVLYRSGQILDMKRLTAEAHKRGIHIGFDLCHSIGSIPHHFKEWDVDFAIWCNYKY
LNAGPGGVAGLYVNKKHFNRPPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHVLSTAPLIGSLEIFKDAGIERLR
EKSLHITRYMLNLIDHELKDFGFTIGNPFEDEKRGGHIYLEHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEE
VWQSVMILKKIMKDEEYKQFENKREVVA

Sequences:

>Translated_428_residues
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLLTLLDSWKEYGIDGWTEGEHPWFFLS
EKLGELTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKGIRTKILADELTFPSDIYALQSQIRLKGLDPDEHLVRVKSR
DGRTLSEDDIIQAMTDDIALILLPSVLYRSGQILDMKRLTAEAHKRGIHIGFDLCHSIGSIPHHFKEWDVDFAIWCNYKY
LNAGPGGVAGLYVNKKHFNRPPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHVLSTAPLIGSLEIFKDAGIERLR
EKSLHITRYMLNLIDHELKDFGFTIGNPFEDEKRGGHIYLEHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEE
VWQSVMILKKIMKDEEYKQFENKREVVA
>Mature_428_residues
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLLTLLDSWKEYGIDGWTEGEHPWFFLS
EKLGELTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKGIRTKILADELTFPSDIYALQSQIRLKGLDPDEHLVRVKSR
DGRTLSEDDIIQAMTDDIALILLPSVLYRSGQILDMKRLTAEAHKRGIHIGFDLCHSIGSIPHHFKEWDVDFAIWCNYKY
LNAGPGGVAGLYVNKKHFNRPPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHVLSTAPLIGSLEIFKDAGIERLR
EKSLHITRYMLNLIDHELKDFGFTIGNPFEDEKRGGHIYLEHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEE
VWQSVMILKKIMKDEEYKQFENKREVVA

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=443, Percent_Identity=34.9887133182844, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI74101437, Length=285, Percent_Identity=35.7894736842105, Blast_Score=163, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17550466, Length=391, Percent_Identity=35.5498721227622, Blast_Score=259, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6323261, Length=450, Percent_Identity=35.1111111111111, Blast_Score=245, Evalue=9e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 48707; Mature: 48707

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLLTLLDS
CCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
WKEYGIDGWTEGEHPWFFLSEKLGELTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKG
HHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCC
IRTKILADELTFPSDIYALQSQIRLKGLDPDEHLVRVKSRDGRTLSEDDIIQAMTDDIAL
CEEEEEHHHCCCCHHHHHHHHHHEECCCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHH
ILLPSVLYRSGQILDMKRLTAEAHKRGIHIGFDLCHSIGSIPHHFKEWDVDFAIWCNYKY
HHHHHHHHCCCCEEHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHCCCCEEEEEEEEE
LNAGPGGVAGLYVNKKHFNRPPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHVLS
EECCCCCEEEEEEEHHHCCCCCCCCCHHCCCCCCCCCHHHHHHHHCCCCCEECCCCCHHC
TAPLIGSLEIFKDAGIERLREKSLHITRYMLNLIDHELKDFGFTIGNPFEDEKRGGHIYL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
EHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEEVWQSVMILKKIMKDEEYKQF
ECHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ENKREVVA
HHHHCCCC
>Mature Secondary Structure
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLLTLLDS
CCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
WKEYGIDGWTEGEHPWFFLSEKLGELTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKG
HHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCC
IRTKILADELTFPSDIYALQSQIRLKGLDPDEHLVRVKSRDGRTLSEDDIIQAMTDDIAL
CEEEEEHHHCCCCHHHHHHHHHHEECCCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHH
ILLPSVLYRSGQILDMKRLTAEAHKRGIHIGFDLCHSIGSIPHHFKEWDVDFAIWCNYKY
HHHHHHHHCCCCEEHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHCCCCEEEEEEEEE
LNAGPGGVAGLYVNKKHFNRPPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHVLS
EECCCCCEEEEEEEHHHCCCCCCCCCHHCCCCCCCCCHHHHHHHHCCCCCEECCCCCHHC
TAPLIGSLEIFKDAGIERLREKSLHITRYMLNLIDHELKDFGFTIGNPFEDEKRGGHIYL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEE
EHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEEVWQSVMILKKIMKDEEYKQF
ECHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ENKREVVA
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA