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The map label for this gene is pcp [H]

Identifier: 52142437

GI number: 52142437

Start: 2920861

End: 2921508

Strand: Reverse

Name: pcp [H]

Synonym: BCZK2805

Alternate gene names: 52142437

Gene position: 2921508-2920861 (Counterclockwise)

Preceding gene: 52142438

Following gene: 52142436

Centisome position: 55.11

GC content: 39.81

Gene sequence:

>648_bases
ATGAAAACAGTATTATTAACAGGATTTGATCCGTTCGGCGGAGAAAGTATCAATCCAGCTTGGGAAGTCGCAAAAAGTTT
GCATGAAAAAACAATCAGAGAATACAAGATTATTAGTAAACAAGTCCCAACTGTATTTCATAAATCAATACAAGTTTTAA
AAGAATATATAGATGAACTAAATCCAGAAATAATTATATGTATCGGACAGGCTGGGGGCAGACCAGATATTACGATAGAG
CGTGTCGCAATTAATATTGATGATGCAAGAATTGCTGACAATGAAGGGAACCAGCCGGTAGATGTACCAGTCGTAGAAGA
AGGATCAGCTGCTTATTGGTCTACACTTCCGATGAAAGCAATTGTAAAAAGACTACAGGCAGAGGGCATACCGGCTTCCG
TTTCACAAACAGCAGGTACATTCGTTTGTAATCACTTATTCTATGGTCTCATGCATGAACTAGAGAAACAGGATCAGAAA
ATAAAAGGCGGGTTTGTTCATATACCGTTTTTACCAGAACAAGCGAGTAAGTATCCAGGGCAATCGAGTATGTCTCTTTC
TACTATTCGTAAAGGGATAGAGTTGGCGGTTGAGGTAACGACGACCGTTGAGGTGGATATTGTAGAGGTTGGTGGCACGA
CGCATTAA

Upstream 100 bases:

>100_bases
GTTATTAAAGCACAGGTACCAATTGCTCTTTCCATTTTCATTATTAATATGTTTATTATGTACGGCCTTGTATATCGTTT
CTAATTAGGAGGATAAAACT

Downstream 100 bases:

>100_bases
GTAGAATGAATTGTACGACACCTCCTGTAAACAACTGATATAATATAGTATAGGAAAATACATAGAGGTGATTTTTGTGC
AACAATTTGAAGAAGTACGT

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIREYKIISKQVPTVFHKSIQVLKEYIDELNPEIIICIGQAGGRPDITIE
RVAINIDDARIADNEGNQPVDVPVVEEGSAAYWSTLPMKAIVKRLQAEGIPASVSQTAGTFVCNHLFYGLMHELEKQDQK
IKGGFVHIPFLPEQASKYPGQSSMSLSTIRKGIELAVEVTTTVEVDIVEVGGTTH

Sequences:

>Translated_215_residues
MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIREYKIISKQVPTVFHKSIQVLKEYIDELNPEIIICIGQAGGRPDITIE
RVAINIDDARIADNEGNQPVDVPVVEEGSAAYWSTLPMKAIVKRLQAEGIPASVSQTAGTFVCNHLFYGLMHELEKQDQK
IKGGFVHIPFLPEQASKYPGQSSMSLSTIRKGIELAVEVTTTVEVDIVEVGGTTH
>Mature_215_residues
MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIREYKIISKQVPTVFHKSIQVLKEYIDELNPEIIICIGQAGGRPDITIE
RVAINIDDARIADNEGNQPVDVPVVEEGSAAYWSTLPMKAIVKRLQAEGIPASVSQTAGTFVCNHLFYGLMHELEKQDQK
IKGGFVHIPFLPEQASKYPGQSSMSLSTIRKGIELAVEVTTTVEVDIVEVGGTTH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline [H]

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family [H]

Homologues:

Organism=Homo sapiens, GI8923198, Length=189, Percent_Identity=24.3386243386243, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000816
- InterPro:   IPR016125 [H]

Pfam domain/function: PF01470 Peptidase_C15 [H]

EC number: =3.4.19.3 [H]

Molecular weight: Translated: 23598; Mature: 23598

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS01333 PYRASE_GLU ; PS01334 PYRASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIREYKIISKQVPTVFHKSIQVLKEYIDEL
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NPEIIICIGQAGGRPDITIERVAINIDDARIADNEGNQPVDVPVVEEGSAAYWSTLPMKA
CCEEEEEEECCCCCCCEEEEEEEEECCCCEECCCCCCCCCCCEEEECCCCCHHHHCCHHH
IVKRLQAEGIPASVSQTAGTFVCNHLFYGLMHELEKQDQKIKGGFVHIPFLPEQASKYPG
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHCCCC
QSSMSLSTIRKGIELAVEVTTTVEVDIVEVGGTTH
CCCCCHHHHHHCCEEEEEEEEEEEEEEEECCCCCC
>Mature Secondary Structure
MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIREYKIISKQVPTVFHKSIQVLKEYIDEL
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NPEIIICIGQAGGRPDITIERVAINIDDARIADNEGNQPVDVPVVEEGSAAYWSTLPMKA
CCEEEEEEECCCCCCCEEEEEEEEECCCCEECCCCCCCCCCCEEEECCCCCHHHHCCHHH
IVKRLQAEGIPASVSQTAGTFVCNHLFYGLMHELEKQDQKIKGGFVHIPFLPEQASKYPG
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHCCCC
QSSMSLSTIRKGIELAVEVTTTVEVDIVEVGGTTH
CCCCCHHHHHHCCEEEEEEEEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA