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The map label for this gene is cobB [H]

Identifier: 52142436

GI number: 52142436

Start: 2920056

End: 2920793

Strand: Reverse

Name: cobB [H]

Synonym: BCZK2804

Alternate gene names: 52142436

Gene position: 2920793-2920056 (Counterclockwise)

Preceding gene: 52142437

Following gene: 52142440

Centisome position: 55.1

GC content: 35.23

Gene sequence:

>738_bases
GTGATTTTTGTGCAACAATTTGAAGAAGTACGTTTGATTTTAGAAAAAGCGAAGAAAATTACAGTATTAACAGGAGCTGG
TGCAAGTACGGAAAGTGGTATCCCAGATTTTCGTTCAGCAAATGGATTGTATGCTGATGCGAATGTGGAAATGTACTTAT
CAAGAGGGTACTATAACCGAAGTCCGAAAGAATTTTGGAAGCATTATAAAGAAATATTTCAAATCAATACGTTTCATCAA
TATAAGCCAAATCGTGGACATCGCTTTTTAGCAGAACTAGAAGAACAAGGGAAAGATATTACGATTTTAACGCAAAATAT
TGACGGTTTACATCAAGTAGGTGGTAGTAAACATGTTATTGATTTACATGGAACACTGCAAACAGCACATTGTCCGAAGT
GTAAAACGGGATATGATTTGCAGTATATGATTGATCATGAGGTGCCACGCTGTCAGAAGTGTAATTTCATTTTAAATCCA
GACGTTGTTTTATACGGAGATACATTGCCGCAATATCAAAATGCGGTCAAACGTTTATATGAAACAGATGTGCTTATCGT
TATGGGAACGTCATTAAAAGTACAACCTGTTGCTTCATTCCCAGAAATCGCAAAGAGAGAAGTAGGAGCAACAACCGTCT
TAGTAAATGAAGAGTTAACAGGACAAGAATATAACTTTGATTATGTTTTTCAAAATAAGATTGGTGAATTTGTTGAAGGA
TTGTCTTCAAGGAAATAA

Upstream 100 bases:

>100_bases
GATATTGTAGAGGTTGGTGGCACGACGCATTAAGTAGAATGAATTGTACGACACCTCCTGTAAACAACTGATATAATATA
GTATAGGAAAATACATAGAG

Downstream 100 bases:

>100_bases
GTTATCGAAAAAACTGAGGTATCCGCCTCAGTTTTTTATTTGAGTAATCGTTATACTAAGCAACGTGAAAACATGTCGAT
AATGTAGTAACAACATCTCT

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MIFVQQFEEVRLILEKAKKITVLTGAGASTESGIPDFRSANGLYADANVEMYLSRGYYNRSPKEFWKHYKEIFQINTFHQ
YKPNRGHRFLAELEEQGKDITILTQNIDGLHQVGGSKHVIDLHGTLQTAHCPKCKTGYDLQYMIDHEVPRCQKCNFILNP
DVVLYGDTLPQYQNAVKRLYETDVLIVMGTSLKVQPVASFPEIAKREVGATTVLVNEELTGQEYNFDYVFQNKIGEFVEG
LSSRK

Sequences:

>Translated_245_residues
MIFVQQFEEVRLILEKAKKITVLTGAGASTESGIPDFRSANGLYADANVEMYLSRGYYNRSPKEFWKHYKEIFQINTFHQ
YKPNRGHRFLAELEEQGKDITILTQNIDGLHQVGGSKHVIDLHGTLQTAHCPKCKTGYDLQYMIDHEVPRCQKCNFILNP
DVVLYGDTLPQYQNAVKRLYETDVLIVMGTSLKVQPVASFPEIAKREVGATTVLVNEELTGQEYNFDYVFQNKIGEFVEG
LSSRK
>Mature_245_residues
MIFVQQFEEVRLILEKAKKITVLTGAGASTESGIPDFRSANGLYADANVEMYLSRGYYNRSPKEFWKHYKEIFQINTFHQ
YKPNRGHRFLAELEEQGKDITILTQNIDGLHQVGGSKHVIDLHGTLQTAHCPKCKTGYDLQYMIDHEVPRCQKCNFILNP
DVVLYGDTLPQYQNAVKRLYETDVLIVMGTSLKVQPVASFPEIAKREVGATTVLVNEELTGQEYNFDYVFQNKIGEFVEG
LSSRK

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7657575, Length=234, Percent_Identity=37.6068376068376, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI13775602, Length=231, Percent_Identity=35.4978354978355, Blast_Score=134, Evalue=5e-32,
Organism=Homo sapiens, GI13775600, Length=231, Percent_Identity=35.4978354978355, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI6912660, Length=248, Percent_Identity=34.6774193548387, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI63054862, Length=213, Percent_Identity=36.6197183098592, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI6912664, Length=261, Percent_Identity=30.2681992337165, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI300795542, Length=248, Percent_Identity=31.0483870967742, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI13787215, Length=254, Percent_Identity=29.9212598425197, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI300797705, Length=203, Percent_Identity=34.4827586206897, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI215982798, Length=173, Percent_Identity=37.5722543352601, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI6912662, Length=226, Percent_Identity=30.9734513274336, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI300797577, Length=252, Percent_Identity=27.7777777777778, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI308199517, Length=230, Percent_Identity=33.9130434782609, Blast_Score=100, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17541892, Length=230, Percent_Identity=33.9130434782609, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17567771, Length=227, Percent_Identity=27.3127753303965, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71990482, Length=215, Percent_Identity=28.3720930232558, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71990487, Length=217, Percent_Identity=28.110599078341, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324599, Length=297, Percent_Identity=28.6195286195286, Blast_Score=104, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324504, Length=282, Percent_Identity=28.0141843971631, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325242, Length=234, Percent_Identity=30.3418803418803, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320163, Length=254, Percent_Identity=27.9527559055118, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320397, Length=231, Percent_Identity=26.8398268398268, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137536, Length=256, Percent_Identity=33.203125, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24648389, Length=222, Percent_Identity=34.2342342342342, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28571445, Length=186, Percent_Identity=30.1075268817204, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24645650, Length=253, Percent_Identity=22.9249011857708, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27976; Mature: 27976

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFVQQFEEVRLILEKAKKITVLTGAGASTESGIPDFRSANGLYADANVEMYLSRGYYNR
CCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCC
SPKEFWKHYKEIFQINTFHQYKPNRGHRFLAELEEQGKDITILTQNIDGLHQVGGSKHVI
CHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHCCCCCEEE
DLHGTLQTAHCPKCKTGYDLQYMIDHEVPRCQKCNFILNPDVVLYGDTLPQYQNAVKRLY
EECCCEECCCCCCCCCCCCEEEEECCCCCCCCCCCEEECCCEEEECCCCHHHHHHHHHHH
ETDVLIVMGTSLKVQPVASFPEIAKREVGATTVLVNEELTGQEYNFDYVFQNKIGEFVEG
HCCEEEEECCCEEEEECCCCHHHHHHHCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHH
LSSRK
HHCCC
>Mature Secondary Structure
MIFVQQFEEVRLILEKAKKITVLTGAGASTESGIPDFRSANGLYADANVEMYLSRGYYNR
CCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCC
SPKEFWKHYKEIFQINTFHQYKPNRGHRFLAELEEQGKDITILTQNIDGLHQVGGSKHVI
CHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHCCCCCEEE
DLHGTLQTAHCPKCKTGYDLQYMIDHEVPRCQKCNFILNPDVVLYGDTLPQYQNAVKRLY
EECCCEECCCCCCCCCCCCEEEEECCCCCCCCCCCEEECCCEEEECCCCHHHHHHHHHHH
ETDVLIVMGTSLKVQPVASFPEIAKREVGATTVLVNEELTGQEYNFDYVFQNKIGEFVEG
HCCEEEEECCCEEEEECCCCHHHHHHHCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHH
LSSRK
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721630 [H]