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The map label for this gene is hutU [H]

Identifier: 52141893

GI number: 52141893

Start: 3486659

End: 3488317

Strand: Reverse

Name: hutU [H]

Synonym: BCZK3353

Alternate gene names: 52141893

Gene position: 3488317-3486659 (Counterclockwise)

Preceding gene: 52141894

Following gene: 52141892

Centisome position: 65.81

GC content: 41.77

Gene sequence:

>1659_bases
ATGGAAAAAGTACAACAAACAATTCGCGCGCCAAGAGGTACTGAGTTACAAACGAAAGGGTGGGTACAAGAAGCTGCACT
TCGTATGTTAATGAATAATTTAGATCCTGAAGTTGCTGAAAAACCAGAAGAATTAGTTGTATATGGCGGAATTGGCCGTG
CAGCTCGTAACTGGGAAAGTTATCAGGCGATTGTAGATTCACTAAAAACGTTAGAAAGCGATGAAACTTTACTTGTTCAA
TCAGGAAAACCAGTTGCTATTTTTAAATCACATGAAGATGCGCCTCGCGTTCTTTTAGCGAACTCAAACTTAGTACCGAA
GTGGGCGAACTGGGATCACTTCCGTGAACTAGAGAAAAAAGGTCTTATGATGTACGGACAAATGACGGCAGGTAGCTGGA
TTTACATCGGAACACAAGGTATTTTACAAGGAACTTATGAAACGTTTGGTGAAGCGGCACGTCAACATTTCGGTGGTTCA
TTAAAAGGCACATTAACACTTACTGCTGGTTTAGGTGGTATGGGTGGTGCACAACCTCTTGCTGTAACGATGAACGGCGG
TGTTGTTATTGCTATTGATGTTGATAAGCGCAGCATCGATCGTCGTATTGAAAAGAGATACTGTGATATGTATACAGAAT
CATTAGAAGAAGCGTTAGCGGTTGCGAACGAGTATAAAGAGAAGAAAGAACCAATTTCTATTGGTTTATTAGGAAATGCG
GCAGAAATTTTACCAGAACTAGTGAAGCGCAATATTACGCCAGACTTGGTTACAGATCAAACATCTGCTCATGATCCATT
AAACGGTTATATTCCAGTAGGCTACACGTTAGAAGAAGCAGCAAAACTTCGTGAAGAAGATCCAGAACGCTACGTACAAT
TATCAAAAGAAAGCATGACAAAACATGTGGAAGCAATGCTTGCTATGCAAGAAAAAGGCGCAATTACATTTGATTACGGA
AATAACATTCGCCAAGTTGCTTTTGATGAGGGTTTGAAAAATGCATTCGATTTCCCAGGGTTCGTTCCAGCATTTATCCG
TCCATTATTCTGCGAAGGAAAAGGACCATTCCGCTGGGTAGCACTTTCTGGTGACCCAGAAGATATTTATAAAACAGACG
AAGTAATTTTACGTGAGTTCGCGGATAATGAGCATTTATGTAACTGGATTCGTATGGCACGTCAGCAAGTTGAATTCCAA
GGCCTTCCATCACGTATTTGTTGGCTTGGTTACGGTGAGCGTGCGAAATTTGGTCGCATCATTAATGAAATGGTTGCAAA
TGGTGAATTATCAGCACCAATTGTTATCGGTCGTGACCATTTAGATTGCGGATCAGTAGCGTCTCCAAACCGTGAAACAG
AAGCGATGAAAGACGGTAGTGATGCAGTAGCTGACTGGCCAATCTTAAATGCATTAATTAACAGTGTAAACGGTGCAAGT
TGGGTATCTGTTCACCACGGTGGTGGCGTTGGTATGGGGTATTCACTTCATGCGGGAATGGTTATCGTTGCAGATGGAAC
AGAAGCAGCAGCAAAACGTATTGAGCGCGTATTAACTTCTGATCCTGGTATGGGAGTTGTTCGTCACGTTGATGCAGGGT
ATGACTTAGCTGTGGAAACTGCGAAAGAAAAAGGCGTTAACATTCCAATGATGAAATAA

Upstream 100 bases:

>100_bases
ATATTGAAAATATTACGCATTGGTTAAAAACGAATTATTCGATAAAAGAAAGATTAGATGTAAACGCAGCACTATAAAAT
GAGAAAAGGGAGAGATTGAA

Downstream 100 bases:

>100_bases
GGAGGAGAAAACATGCTGGACACTTTACTAATCAATATCGGTCAATTACTAACAATGGATCAAGAAGATGGCTTGTTAAG
ACGGGAAGCGATGAACACGC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MEKVQQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWESYQAIVDSLKTLESDETLLVQ
SGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKKGLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGS
LKGTLTLTAGLGGMGGAQPLAVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALAVANEYKEKKEPISIGLLGNA
AEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMTKHVEAMLAMQEKGAITFDYG
NNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQ
GLPSRICWLGYGERAKFGRIINEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGAS
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVETAKEKGVNIPMMK

Sequences:

>Translated_552_residues
MEKVQQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWESYQAIVDSLKTLESDETLLVQ
SGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKKGLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGS
LKGTLTLTAGLGGMGGAQPLAVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALAVANEYKEKKEPISIGLLGNA
AEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMTKHVEAMLAMQEKGAITFDYG
NNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQ
GLPSRICWLGYGERAKFGRIINEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGAS
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVETAKEKGVNIPMMK
>Mature_552_residues
MEKVQQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWESYQAIVDSLKTLESDETLLVQ
SGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKKGLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGS
LKGTLTLTAGLGGMGGAQPLAVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALAVANEYKEKKEPISIGLLGNA
AEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMTKHVEAMLAMQEKGAITFDYG
NNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQ
GLPSRICWLGYGERAKFGRIINEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGAS
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVETAKEKGVNIPMMK

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=563, Percent_Identity=35.5239786856128, Blast_Score=329, Evalue=4e-90,
Organism=Homo sapiens, GI260306182, Length=623, Percent_Identity=32.7447833065811, Blast_Score=300, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI71997891, Length=551, Percent_Identity=35.5716878402904, Blast_Score=339, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60763; Mature: 60763

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVQQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWES
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCHHHHCHHH
YQAIVDSLKTLESDETLLVQSGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKK
HHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHC
GLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGSLKGTLTLTAGLGGMGGAQPL
CCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCE
AVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALAVANEYKEKKEPISIGLLGNA
EEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCH
AEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMT
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCEEHHHHHHHHHCCHHHHHHHHHHHHH
KHVEAMLAMQEKGAITFDYGNNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWV
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHEECCCCCEEEE
ALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQGLPSRICWLGYGERAKFGRI
EECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHH
INEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGAS
HHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCE
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVET
EEEEECCCCCCCCEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEH
AKEKGVNIPMMK
HHHCCCCCCCCC
>Mature Secondary Structure
MEKVQQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWES
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCHHHHCHHH
YQAIVDSLKTLESDETLLVQSGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKK
HHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHC
GLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGSLKGTLTLTAGLGGMGGAQPL
CCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCE
AVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALAVANEYKEKKEPISIGLLGNA
EEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCH
AEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMT
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCEEHHHHHHHHHCCHHHHHHHHHHHHH
KHVEAMLAMQEKGAITFDYGNNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWV
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHEECCCCCEEEE
ALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQGLPSRICWLGYGERAKFGRI
EECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHH
INEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDAVADWPILNALINSVNGAS
HHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCE
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVET
EEEEECCCCCCCCEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEH
AKEKGVNIPMMK
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA