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The map label for this gene is ribA [H]

Identifier: 52141383

GI number: 52141383

Start: 3993612

End: 3994805

Strand: Direct

Name: ribA [H]

Synonym: BCZK3867

Alternate gene names: 52141383

Gene position: 3993612-3994805 (Clockwise)

Preceding gene: 52141382

Following gene: 52141380

Centisome position: 75.34

GC content: 40.28

Gene sequence:

>1194_bases
ATGTTTCATCGTATTGAAGAAGCTCTAGAAGATTTAAAACAAGGAAAAGTCGTTATCGTATGTGATGATGAAAACCGTGA
AAACGAAGGCGATTTTATCGCTTTAGCAGAGTATATTACGCCAGAAACAATTAACTTTATGATTACACATGGACGCGGTC
TCGTTTGTGTACCGATTACAGAAGGATACGCAGAACGTCTACAATTAGAACCAATGGTATCTCATAATACAGATTCGCAT
CATACTGCATTTACAGTGAGCATTGACCATGTTTCTACAACAACAGGCATTAGCGCTCACGAACGTGCAACTACGATACA
ACAATTGTTAAATCCTGCATCAAAAGGTGCTGATTTCAATCGACCTGGACATATCTTTCCATTAATCGCGAAAGAAGGCG
GTGTCCTGCGTCGTGCTGGTCATACAGAAGCTGCTGTCGATTTAGCACAGCTCTGCGGGGCAGAACCAGCTGGAGTCATT
TGCGAGATTATCAATGAGGACGGTGCGATGGCACGCGTCCCTGATTTACTACAGTGCGCAAAACAATTTGATATAAAAAT
GATTACAATAGAAGATTTAATTGCTTATCGCCGCCATCATGAAACACTTGTGACGAGAGAAGTGGAAATTACATTACCTA
CAGATTTCGGTACTTTTCAAGCAATTGGCTATTCTAACTCATTAGATACGAAAGAACATATTGCACTCGTAAAAGGTGAT
ATTTCAACAGGTGAGCCTGTACTTGTACGCGTTCATTCAGAGTGCTTAACAGGAGATGTATTTGGCTCGTGCCGCTGTGA
TTGCGGACCACAACTCCATGCTGCACTTGCACAAATTGAGCGTGAAGGAAAAGGCGTTCTTCTTTATATGAGACAAGAAG
GACGAGGCATTGGCCTTCTTAATAAGCTTCGCGCTTATAAGTTACAAGAAGAAGGCTTCGATACTGTAGAAGCAAATGAA
AAGCTTGGTTTTCCCGCTGACCTTCGTGATTACGGTATCGGCGCTCAAATATTAAAAGATTTAGGTTTACAACATTTACG
ATTATTAACGAATAATCCAAGAAAAATCGCTGGCTTACAAGGTTACGATTTAACAGTTACGGAGCGCGTACCGTTACAAA
TGCCAGCAAAAGAAGAGAATAAAACGTATTTACAAACGAAAGTAAACAAATTAGGACATTTACTAAACTTATAA

Upstream 100 bases:

>100_bases
TAAATATATCGAACGATTTATTACTAAGCCTGTAAAACGAACAGGTTCAATGACCGAAAACTTTTTACAAGAAAACGGAT
TTCTATAAGGGGGAAGCATT

Downstream 100 bases:

>100_bases
TTAAAGGAGAGATTTATTATGGTATTCGAAGGTCATTTAGTTGGTACAGGATTAAAAGTTGGGGTTGTTGTTGGACGTTT
TAATGAATTTATTACAAGTA

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MFHRIEEALEDLKQGKVVIVCDDENRENEGDFIALAEYITPETINFMITHGRGLVCVPITEGYAERLQLEPMVSHNTDSH
HTAFTVSIDHVSTTTGISAHERATTIQQLLNPASKGADFNRPGHIFPLIAKEGGVLRRAGHTEAAVDLAQLCGAEPAGVI
CEIINEDGAMARVPDLLQCAKQFDIKMITIEDLIAYRRHHETLVTREVEITLPTDFGTFQAIGYSNSLDTKEHIALVKGD
ISTGEPVLVRVHSECLTGDVFGSCRCDCGPQLHAALAQIEREGKGVLLYMRQEGRGIGLLNKLRAYKLQEEGFDTVEANE
KLGFPADLRDYGIGAQILKDLGLQHLRLLTNNPRKIAGLQGYDLTVTERVPLQMPAKEENKTYLQTKVNKLGHLLNL

Sequences:

>Translated_397_residues
MFHRIEEALEDLKQGKVVIVCDDENRENEGDFIALAEYITPETINFMITHGRGLVCVPITEGYAERLQLEPMVSHNTDSH
HTAFTVSIDHVSTTTGISAHERATTIQQLLNPASKGADFNRPGHIFPLIAKEGGVLRRAGHTEAAVDLAQLCGAEPAGVI
CEIINEDGAMARVPDLLQCAKQFDIKMITIEDLIAYRRHHETLVTREVEITLPTDFGTFQAIGYSNSLDTKEHIALVKGD
ISTGEPVLVRVHSECLTGDVFGSCRCDCGPQLHAALAQIEREGKGVLLYMRQEGRGIGLLNKLRAYKLQEEGFDTVEANE
KLGFPADLRDYGIGAQILKDLGLQHLRLLTNNPRKIAGLQGYDLTVTERVPLQMPAKEENKTYLQTKVNKLGHLLNL
>Mature_397_residues
MFHRIEEALEDLKQGKVVIVCDDENRENEGDFIALAEYITPETINFMITHGRGLVCVPITEGYAERLQLEPMVSHNTDSH
HTAFTVSIDHVSTTTGISAHERATTIQQLLNPASKGADFNRPGHIFPLIAKEGGVLRRAGHTEAAVDLAQLCGAEPAGVI
CEIINEDGAMARVPDLLQCAKQFDIKMITIEDLIAYRRHHETLVTREVEITLPTDFGTFQAIGYSNSLDTKEHIALVKGD
ISTGEPVLVRVHSECLTGDVFGSCRCDCGPQLHAALAQIEREGKGVLLYMRQEGRGIGLLNKLRAYKLQEEGFDTVEANE
KLGFPADLRDYGIGAQILKDLGLQHLRLLTNNPRKIAGLQGYDLTVTERVPLQMPAKEENKTYLQTKVNKLGHLLNL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=55.440414507772, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI1789420, Length=201, Percent_Identity=49.7512437810945, Blast_Score=207, Evalue=9e-55,
Organism=Saccharomyces cerevisiae, GI6320695, Length=208, Percent_Identity=44.7115384615385, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=45.6140350877193, Blast_Score=133, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 43878; Mature: 43878

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHRIEEALEDLKQGKVVIVCDDENRENEGDFIALAEYITPETINFMITHGRGLVCVPIT
CCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEECCCCEEEEECC
EGYAERLQLEPMVSHNTDSHHTAFTVSIDHVSTTTGISAHERATTIQQLLNPASKGADFN
CCHHHHEEECCHHCCCCCCCCEEEEEEEECEECCCCCCHHHHHHHHHHHHCHHHCCCCCC
RPGHIFPLIAKEGGVLRRAGHTEAAVDLAQLCGAEPAGVICEIINEDGAMARVPDLLQCA
CCCCEEEEEECCCCEEEECCCCHHHHHHHHHHCCCCCHHHHEEECCCCCCCCCHHHHHHH
KQFDIKMITIEDLIAYRRHHETLVTREVEITLPTDFGTFQAIGYSNSLDTKEHIALVKGD
HHCCEEEEEHHHHHHHHHHHHHEEEEEEEEEECCCCCCEEEECCCCCCCCCHHEEEEECC
ISTGEPVLVRVHSECLTGDVFGSCRCDCGPQLHAALAQIEREGKGVLLYMRQEGRGIGLL
CCCCCCEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHH
NKLRAYKLQEEGFDTVEANEKLGFPADLRDYGIGAQILKDLGLQHLRLLTNNPRKIAGLQ
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCHHHHHHHCCCCCEEECCC
GYDLTVTERVPLQMPAKEENKTYLQTKVNKLGHLLNL
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFHRIEEALEDLKQGKVVIVCDDENRENEGDFIALAEYITPETINFMITHGRGLVCVPIT
CCHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEECCCCEEEEECC
EGYAERLQLEPMVSHNTDSHHTAFTVSIDHVSTTTGISAHERATTIQQLLNPASKGADFN
CCHHHHEEECCHHCCCCCCCCEEEEEEEECEECCCCCCHHHHHHHHHHHHCHHHCCCCCC
RPGHIFPLIAKEGGVLRRAGHTEAAVDLAQLCGAEPAGVICEIINEDGAMARVPDLLQCA
CCCCEEEEEECCCCEEEECCCCHHHHHHHHHHCCCCCHHHHEEECCCCCCCCCHHHHHHH
KQFDIKMITIEDLIAYRRHHETLVTREVEITLPTDFGTFQAIGYSNSLDTKEHIALVKGD
HHCCEEEEEHHHHHHHHHHHHHEEEEEEEEEECCCCCCEEEECCCCCCCCCHHEEEEECC
ISTGEPVLVRVHSECLTGDVFGSCRCDCGPQLHAALAQIEREGKGVLLYMRQEGRGIGLL
CCCCCCEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCHH
NKLRAYKLQEEGFDTVEANEKLGFPADLRDYGIGAQILKDLGLQHLRLLTNNPRKIAGLQ
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCHHHHHHHCCCCCEEECCC
GYDLTVTERVPLQMPAKEENKTYLQTKVNKLGHLLNL
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA