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The map label for this gene is manB [H]

Identifier: 52140605

GI number: 52140605

Start: 4748457

End: 4750181

Strand: Reverse

Name: manB [H]

Synonym: BCZK4651

Alternate gene names: 52140605

Gene position: 4750181-4748457 (Counterclockwise)

Preceding gene: 52140603

Following gene: 52140606

Centisome position: 89.61

GC content: 38.67

Gene sequence:

>1725_bases
ATGAACTGGAAACAAGAATTTAGTCGCTGGCTTTCATATGCAGAGTTAGACGCAGAACTAAAAGAACAGTTAGAAAACAT
GAAGCAAGATGAGAAAAAAATCGAGGACAGCTTTTATAAAAATCTAGAATTTGGCACAGGTGGTATGCGTGGTGAACTTG
GTGCTGGTACGAACCGTTTGAACGTATATACAGTTCGTAAAGCAACACAAGGATTAGCGAAGTTTATTGAAAAGTTAGGT
GAAGAAGCGAAGAAGCGCGGTGTTGTTGTAGCGTATGATTCTCGTCATAAATCACCTGAGTTCGCAATGGAAGTAGCAGC
TACACTTGGTGCACACGGTATTACAACATATGTGTTTGAAAGTTTACGCCCAACGCCAGTGCTTTCTTTCGCAGTTCGTC
ATTTACATACAGTGAGTGGAATCGTTCTTACGGCAAGTCATAATCCGCCTGAATATAACGGTTATAAAGTATACGGTGAA
GATGGTGGGCAGTTGCCTCCAAAAGAAGCTGATGAATTAATTAGCTACGTAAACGCAGTAGAAGATGAATTAACAGTTGA
AGTTGCTGATGTAGAGCAATTAAAAGCTGACGGTTTATTACATATAATTGGACAAGAAGTAGATGATGCATATGCTGCAG
AATTGAACAATGTCATTATTAATAAAGAAATGGTACAAAAGGTTGGGAAAGACTTAAAAATCGTCTTCACACCACTACAT
GGAACATCAAATCTTTCTGTACGCCGTGGCTTAGCAGAAGTTGGATTTACAGATGTAACAGTTGTAAAAGAGCAAGAGTT
ACCAGATCCGAACTTCTCTACAGTAAAATCACCGAACCCAGAAGAGCATGCAGCGTTTGAGTATGCAATTCGTGACGGTG
AGAAAGTAGGCGCAGATGTGTTAATCGCAACAGATCCTGACGCAGACCGCCTTGGTGTGGCAGTTCGTAACCACGATGGT
GAGTTCCAAGTATTAACTGGTAACCAAACAGGTGCATTAATGCTTGATTACTTATTGTCTCAAAAGAAAGAAAACGGAAC
GCTTCCAGAGAACGGTGTTGTATTAAAAACAATCGTAACATCTGAGATTGGCCGTACAATCGCGAAAGCATATGGTTTAG
ATACAGTCGATACGTTAACTGGATTTAAATTTATCGGTGAGAAAATTAAACAGTATGAAGAAAGCGGCCAATACGAATTC
CAATTCGGTTATGAGGAAAGCTATGGTTATTTAATCCGTCCATTCTGCCGTGATAAAGATGCAGTACAATCTGTTCTATT
TGCATGTGAAGTAGCTGCATACTACAAATCACAAGGTAAAACGTTATACGATGGTCTATTAGAAGTATTTGAGAAGTACG
GCTTCTTCCGTGAAGATCTTGTATCGTTAACGCTAAAAGGAAAAGATGGAGCGGAAAAAATTCAAGAAATGATGGCAACA
TTCCGTGAAAATCCTCCGAAAGAAGTAGCTGGCTTAACAGTTGTAGCAGTTGAAGACTATAAAGCGAGCATCATTACATC
TTTACAAGATGGACATAAAGAAGAGATTCACTTACCGAAATCAAATGTGTTAAAATATCAATTAGAAGATGGTTCTTGGT
TCTGCCTACGTCCATCTGGAACTGAACCGAAGATCAAGTTCTACTTCGGTGTTCAAGATAATTCTTTACAAAATAGTGAA
CAAAAGTTACTTACTATTAAAGAAGATATTATGAATCGTTTATAA

Upstream 100 bases:

>100_bases
AAATATTCCTAGTAAAATCCTGTTAGATTGTAAAAAATATTGAGATACAGGTTGTTTTTTTCATATAATAAAGGTATGAC
AAGCGAGAGGAGATAGAAAT

Downstream 100 bases:

>100_bases
TATAAAGTAATTTTAAGTAGTAGGAAACAAAAGGGAGCGAAACCTCCCTTTTGTTCTATGTAAGGAAATAATCGTTATTG
ATTCTGACAGAAGAGAGGGT

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MNWKQEFSRWLSYAELDAELKEQLENMKQDEKKIEDSFYKNLEFGTGGMRGELGAGTNRLNVYTVRKATQGLAKFIEKLG
EEAKKRGVVVAYDSRHKSPEFAMEVAATLGAHGITTYVFESLRPTPVLSFAVRHLHTVSGIVLTASHNPPEYNGYKVYGE
DGGQLPPKEADELISYVNAVEDELTVEVADVEQLKADGLLHIIGQEVDDAYAAELNNVIINKEMVQKVGKDLKIVFTPLH
GTSNLSVRRGLAEVGFTDVTVVKEQELPDPNFSTVKSPNPEEHAAFEYAIRDGEKVGADVLIATDPDADRLGVAVRNHDG
EFQVLTGNQTGALMLDYLLSQKKENGTLPENGVVLKTIVTSEIGRTIAKAYGLDTVDTLTGFKFIGEKIKQYEESGQYEF
QFGYEESYGYLIRPFCRDKDAVQSVLFACEVAAYYKSQGKTLYDGLLEVFEKYGFFREDLVSLTLKGKDGAEKIQEMMAT
FRENPPKEVAGLTVVAVEDYKASIITSLQDGHKEEIHLPKSNVLKYQLEDGSWFCLRPSGTEPKIKFYFGVQDNSLQNSE
QKLLTIKEDIMNRL

Sequences:

>Translated_574_residues
MNWKQEFSRWLSYAELDAELKEQLENMKQDEKKIEDSFYKNLEFGTGGMRGELGAGTNRLNVYTVRKATQGLAKFIEKLG
EEAKKRGVVVAYDSRHKSPEFAMEVAATLGAHGITTYVFESLRPTPVLSFAVRHLHTVSGIVLTASHNPPEYNGYKVYGE
DGGQLPPKEADELISYVNAVEDELTVEVADVEQLKADGLLHIIGQEVDDAYAAELNNVIINKEMVQKVGKDLKIVFTPLH
GTSNLSVRRGLAEVGFTDVTVVKEQELPDPNFSTVKSPNPEEHAAFEYAIRDGEKVGADVLIATDPDADRLGVAVRNHDG
EFQVLTGNQTGALMLDYLLSQKKENGTLPENGVVLKTIVTSEIGRTIAKAYGLDTVDTLTGFKFIGEKIKQYEESGQYEF
QFGYEESYGYLIRPFCRDKDAVQSVLFACEVAAYYKSQGKTLYDGLLEVFEKYGFFREDLVSLTLKGKDGAEKIQEMMAT
FRENPPKEVAGLTVVAVEDYKASIITSLQDGHKEEIHLPKSNVLKYQLEDGSWFCLRPSGTEPKIKFYFGVQDNSLQNSE
QKLLTIKEDIMNRL
>Mature_574_residues
MNWKQEFSRWLSYAELDAELKEQLENMKQDEKKIEDSFYKNLEFGTGGMRGELGAGTNRLNVYTVRKATQGLAKFIEKLG
EEAKKRGVVVAYDSRHKSPEFAMEVAATLGAHGITTYVFESLRPTPVLSFAVRHLHTVSGIVLTASHNPPEYNGYKVYGE
DGGQLPPKEADELISYVNAVEDELTVEVADVEQLKADGLLHIIGQEVDDAYAAELNNVIINKEMVQKVGKDLKIVFTPLH
GTSNLSVRRGLAEVGFTDVTVVKEQELPDPNFSTVKSPNPEEHAAFEYAIRDGEKVGADVLIATDPDADRLGVAVRNHDG
EFQVLTGNQTGALMLDYLLSQKKENGTLPENGVVLKTIVTSEIGRTIAKAYGLDTVDTLTGFKFIGEKIKQYEESGQYEF
QFGYEESYGYLIRPFCRDKDAVQSVLFACEVAAYYKSQGKTLYDGLLEVFEKYGFFREDLVSLTLKGKDGAEKIQEMMAT
FRENPPKEVAGLTVVAVEDYKASIITSLQDGHKEEIHLPKSNVLKYQLEDGSWFCLRPSGTEPKIKFYFGVQDNSLQNSE
QKLLTIKEDIMNRL

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI31377548, Length=561, Percent_Identity=34.7593582887701, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI63055049, Length=564, Percent_Identity=31.3829787234043, Blast_Score=277, Evalue=2e-74,
Organism=Escherichia coli, GI1786904, Length=564, Percent_Identity=25.531914893617, Blast_Score=90, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71993870, Length=586, Percent_Identity=30.8873720136519, Blast_Score=250, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI71993878, Length=346, Percent_Identity=30.635838150289, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323934, Length=567, Percent_Identity=31.3932980599647, Blast_Score=207, Evalue=4e-54,
Organism=Drosophila melanogaster, GI20129809, Length=558, Percent_Identity=27.9569892473118, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24651977, Length=487, Percent_Identity=28.3367556468172, Blast_Score=213, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24653722, Length=558, Percent_Identity=26.8817204301075, Blast_Score=202, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 64137; Mature: 64137

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWKQEFSRWLSYAELDAELKEQLENMKQDEKKIEDSFYKNLEFGTGGMRGELGAGTNRL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
NVYTVRKATQGLAKFIEKLGEEAKKRGVVVAYDSRHKSPEFAMEVAATLGAHGITTYVFE
EEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHH
SLRPTPVLSFAVRHLHTVSGIVLTASHNPPEYNGYKVYGEDGGQLPPKEADELISYVNAV
HCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHH
EDELTVEVADVEQLKADGLLHIIGQEVDDAYAAELNNVIINKEMVQKVGKDLKIVFTPLH
HHHHEEEEHHHHHHHHCCEEEECCCCCCHHHHHHHHHHEECHHHHHHCCCCEEEEEEECC
GTSNLSVRRGLAEVGFTDVTVVKEQELPDPNFSTVKSPNPEEHAAFEYAIRDGEKVGADV
CCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEE
LIATDPDADRLGVAVRNHDGEFQVLTGNQTGALMLDYLLSQKKENGTLPENGVVLKTIVT
EEEECCCCHHHEEEEECCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEHHHH
SEIGRTIAKAYGLDTVDTLTGFKFIGEKIKQYEESGQYEFQFGYEESYGYLIRPFCRDKD
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEHHCCCHH
AVQSVLFACEVAAYYKSQGKTLYDGLLEVFEKYGFFREDLVSLTLKGKDGAEKIQEMMAT
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHEEEEECCCCHHHHHHHHHHH
FRENPPKEVAGLTVVAVEDYKASIITSLQDGHKEEIHLPKSNVLKYQLEDGSWFCLRPSG
HHCCCCHHHHCEEEEEECCHHHHHHHHHHCCCCCEECCCCCCEEEEEECCCCEEEECCCC
TEPKIKFYFGVQDNSLQNSEQKLLTIKEDIMNRL
CCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNWKQEFSRWLSYAELDAELKEQLENMKQDEKKIEDSFYKNLEFGTGGMRGELGAGTNRL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
NVYTVRKATQGLAKFIEKLGEEAKKRGVVVAYDSRHKSPEFAMEVAATLGAHGITTYVFE
EEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHH
SLRPTPVLSFAVRHLHTVSGIVLTASHNPPEYNGYKVYGEDGGQLPPKEADELISYVNAV
HCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHH
EDELTVEVADVEQLKADGLLHIIGQEVDDAYAAELNNVIINKEMVQKVGKDLKIVFTPLH
HHHHEEEEHHHHHHHHCCEEEECCCCCCHHHHHHHHHHEECHHHHHHCCCCEEEEEEECC
GTSNLSVRRGLAEVGFTDVTVVKEQELPDPNFSTVKSPNPEEHAAFEYAIRDGEKVGADV
CCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEE
LIATDPDADRLGVAVRNHDGEFQVLTGNQTGALMLDYLLSQKKENGTLPENGVVLKTIVT
EEEECCCCHHHEEEEECCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCEEEEHHHH
SEIGRTIAKAYGLDTVDTLTGFKFIGEKIKQYEESGQYEFQFGYEESYGYLIRPFCRDKD
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEHHCCCHH
AVQSVLFACEVAAYYKSQGKTLYDGLLEVFEKYGFFREDLVSLTLKGKDGAEKIQEMMAT
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHEEEEECCCCHHHHHHHHHHH
FRENPPKEVAGLTVVAVEDYKASIITSLQDGHKEEIHLPKSNVLKYQLEDGSWFCLRPSG
HHCCCCHHHHCEEEEEECCHHHHHHHHHHCCCCCEECCCCCCEEEEEECCCCEEEECCCC
TEPKIKFYFGVQDNSLQNSEQKLLTIKEDIMNRL
CCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]