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The map label for this gene is pepA [H]

Identifier: 52140603

GI number: 52140603

Start: 4751013

End: 4752497

Strand: Reverse

Name: pepA [H]

Synonym: BCZK4653

Alternate gene names: 52140603

Gene position: 4752497-4751013 (Counterclockwise)

Preceding gene: 52140602

Following gene: 52140605

Centisome position: 89.65

GC content: 40.07

Gene sequence:

>1485_bases
ATGTTCCAAGTACAAAAAGAATTAGCAAGCCATGAAGCGGTGGTTGTTGCTTTATTTGAAGAAGAGAAAACGAGTAGCTT
TGTACAAGAACTGGACAAAGCGTTTGAAGGACAATTACAAGTTTTATTAGAAGAGAAAGAACTTTCTACGAAGAAGAAAG
CTATTTCAAAAGTACATAGTTTAGGAAAAACAGATGTGAAACGTTATTATTTCGTTGGTTTAGGTAAGAAAGAATCTTAT
ACGACAGAAACATTACGTTCGGCTCTTGGTAAGACGTTTAAAACACTGCAAGCAGCAAAAGTACAAGATGCAGCAATCTT
ACTTGATTCTTTCGTAACAGAGAAATTAGACGCGATTGATGTCGCTCATATTGCGGCAGAAGTACAAGGCCTTGGTACAT
ATGAGTTACAAACGTATAAATCAGATAAAAAGGATCGTGTAGAGTTAGAGAAGTTTACGGCTATTACAGCGGAAGATGCA
CAGGAAATTGAAGCGGCATTAACAGTTGGCTACGTACATGGACGTGCAACAAATTCAGCTCGTACACTTGTAAATATGCC
GCCAAACGTATTAACAGCAACAAAGCTTGCTGAGTATGCTGTTGAGTTAGCGGAAAAGTATGATATGGATTATAAAGTTC
TTGAGAAAGAGGAGATGGAAGAGCTTGGTATGGGTGCATTACTTGCAGTAAACCAAGGTAGTGTAGAGCCACCAAAAATG
ATCGCTCTTATTTATAAAGGAAAAGAAGAGTGGACAGATGTTATTGGATTCGTTGGAAAAGGAATCACATATGATACAGG
TGGTTATTCTTTAAAACCACGTGAAGGTATGGTCGGTATGAAAGGTGATATGGGCGGTGCAGCTGCTGTATTAGGTGCGA
TGGAAATTATTGGTGAACTTCGCCCAGAGCAAAATGTGATCGCTGTTATTCCATCAACAGATAACGTTGTAAGTGGTACA
GCATTTAAGCCAGACGATGTAATCACATCTATGAGCGGAAAAACAATTGAAGTATTAAATACAGATGCAGAAGGTCGCTT
AGCATTAGCTGACGGTATTACGTATGCGAAAAAATTAGGTGCAAACTATCTCATTGATGTGGCGACATTAACAGGTGGTG
TAATTGTTGCACTTGGAAATCATACGACAGGTGCGATGACAAACAATGAAGAGTTGTTTGAGCAAGTGCTAGAGGCATCT
ATGGAAACAGATGAATCAATTTGGCAATTACCGATTTTTGATCGTGATAAAGAGCGCGTGAGAAACAGTAAGTTTGCTGA
TTTAAATAACTCACCAGGCCGCGAAGGACATGCGGTTATGGCAGGTACATTCCTAGGTGAATTCGCTGAAGATACACCTT
GGGTACACTTAGACATCGCTGGAACATCTGAATCATCAGGAGCGCATGATTTAGGACCAGCTGGAGCAACAGGTGCGATG
GTACGTACACTTGCAACACTTGTTGAACGTTTCGGCGAAGAATAA

Upstream 100 bases:

>100_bases
ATAGGGACTAGATAGAATATAACAGAAGTTAGAATTGTCGCATTTTATCGAAAATAAAGTTATAATAAAGGTAGAGTAGA
GAAATTTAGGGGGTCTGAAC

Downstream 100 bases:

>100_bases
GATTATAAGAGAAGGCTGTTCCTACATTTTGGAACAGCCTTTTTATTGATATATGTGGTGTTACGGCTGATGTAATTTCA
CTTTATAAAGAAATTGTATA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MFQVQKELASHEAVVVALFEEEKTSSFVQELDKAFEGQLQVLLEEKELSTKKKAISKVHSLGKTDVKRYYFVGLGKKESY
TTETLRSALGKTFKTLQAAKVQDAAILLDSFVTEKLDAIDVAHIAAEVQGLGTYELQTYKSDKKDRVELEKFTAITAEDA
QEIEAALTVGYVHGRATNSARTLVNMPPNVLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSVEPPKM
IALIYKGKEEWTDVIGFVGKGITYDTGGYSLKPREGMVGMKGDMGGAAAVLGAMEIIGELRPEQNVIAVIPSTDNVVSGT
AFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLGANYLIDVATLTGGVIVALGNHTTGAMTNNEELFEQVLEAS
METDESIWQLPIFDRDKERVRNSKFADLNNSPGREGHAVMAGTFLGEFAEDTPWVHLDIAGTSESSGAHDLGPAGATGAM
VRTLATLVERFGEE

Sequences:

>Translated_494_residues
MFQVQKELASHEAVVVALFEEEKTSSFVQELDKAFEGQLQVLLEEKELSTKKKAISKVHSLGKTDVKRYYFVGLGKKESY
TTETLRSALGKTFKTLQAAKVQDAAILLDSFVTEKLDAIDVAHIAAEVQGLGTYELQTYKSDKKDRVELEKFTAITAEDA
QEIEAALTVGYVHGRATNSARTLVNMPPNVLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSVEPPKM
IALIYKGKEEWTDVIGFVGKGITYDTGGYSLKPREGMVGMKGDMGGAAAVLGAMEIIGELRPEQNVIAVIPSTDNVVSGT
AFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLGANYLIDVATLTGGVIVALGNHTTGAMTNNEELFEQVLEAS
METDESIWQLPIFDRDKERVRNSKFADLNNSPGREGHAVMAGTFLGEFAEDTPWVHLDIAGTSESSGAHDLGPAGATGAM
VRTLATLVERFGEE
>Mature_494_residues
MFQVQKELASHEAVVVALFEEEKTSSFVQELDKAFEGQLQVLLEEKELSTKKKAISKVHSLGKTDVKRYYFVGLGKKESY
TTETLRSALGKTFKTLQAAKVQDAAILLDSFVTEKLDAIDVAHIAAEVQGLGTYELQTYKSDKKDRVELEKFTAITAEDA
QEIEAALTVGYVHGRATNSARTLVNMPPNVLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSVEPPKM
IALIYKGKEEWTDVIGFVGKGITYDTGGYSLKPREGMVGMKGDMGGAAAVLGAMEIIGELRPEQNVIAVIPSTDNVVSGT
AFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLGANYLIDVATLTGGVIVALGNHTTGAMTNNEELFEQVLEAS
METDESIWQLPIFDRDKERVRNSKFADLNNSPGREGHAVMAGTFLGEFAEDTPWVHLDIAGTSESSGAHDLGPAGATGAM
VRTLATLVERFGEE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=494, Percent_Identity=33.4008097165992, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI47155554, Length=345, Percent_Identity=33.6231884057971, Blast_Score=159, Evalue=6e-39,
Organism=Escherichia coli, GI1790710, Length=487, Percent_Identity=37.9876796714579, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI87082123, Length=390, Percent_Identity=34.6153846153846, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=295, Percent_Identity=36.271186440678, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17565172, Length=147, Percent_Identity=42.8571428571429, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24661038, Length=361, Percent_Identity=34.0720221606648, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI21355725, Length=393, Percent_Identity=33.587786259542, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI20129969, Length=469, Percent_Identity=27.7185501066098, Blast_Score=175, Evalue=7e-44,
Organism=Drosophila melanogaster, GI21355645, Length=500, Percent_Identity=28.6, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24662223, Length=500, Percent_Identity=28.6, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI161077148, Length=472, Percent_Identity=27.1186440677966, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI20130057, Length=472, Percent_Identity=27.1186440677966, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24662227, Length=381, Percent_Identity=28.3464566929134, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI21357381, Length=294, Percent_Identity=36.0544217687075, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI221379063, Length=294, Percent_Identity=36.0544217687075, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI221379062, Length=294, Percent_Identity=36.0544217687075, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI19922386, Length=463, Percent_Identity=27.8617710583153, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI20129963, Length=363, Percent_Identity=28.9256198347107, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24646701, Length=324, Percent_Identity=29.9382716049383, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24646703, Length=324, Percent_Identity=29.9382716049383, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI21358201, Length=324, Percent_Identity=29.9382716049383, Blast_Score=108, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53514; Mature: 53514

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQVQKELASHEAVVVALFEEEKTSSFVQELDKAFEGQLQVLLEEKELSTKKKAISKVHS
CCCCHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHCCHHHHEEEHHHHHHHHHHHHHHHH
LGKTDVKRYYFVGLGKKESYTTETLRSALGKTFKTLQAAKVQDAAILLDSFVTEKLDAID
CCCHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAHIAAEVQGLGTYELQTYKSDKKDRVELEKFTAITAEDAQEIEAALTVGYVHGRATNSA
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHEECHHHHHHHHHHHHEEEEECCCCCCC
RTLVNMPPNVLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSVEPPKM
CEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHCCCCEEEEECCCCCCCCCE
IALIYKGKEEWTDVIGFVGKGITYDTGGYSLKPREGMVGMKGDMGGAAAVLGAMEIIGEL
EEEEECCCHHHHHHHHHHCCCCEECCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHC
RPEQNVIAVIPSTDNVVSGTAFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLG
CCCCCEEEEECCCCCEECCCCCCCHHHHHCCCCCEEEEEECCCCCCEEEHHCHHHHHHCC
ANYLIDVATLTGGVIVALGNHTTGAMTNNEELFEQVLEASMETDESIWQLPIFDRDKERV
CCCEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCHHHH
RNSKFADLNNSPGREGHAVMAGTFLGEFAEDTPWVHLDIAGTSESSGAHDLGPAGATGAM
CCCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHH
VRTLATLVERFGEE
HHHHHHHHHHHCCC
>Mature Secondary Structure
MFQVQKELASHEAVVVALFEEEKTSSFVQELDKAFEGQLQVLLEEKELSTKKKAISKVHS
CCCCHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHCCHHHHEEEHHHHHHHHHHHHHHHH
LGKTDVKRYYFVGLGKKESYTTETLRSALGKTFKTLQAAKVQDAAILLDSFVTEKLDAID
CCCHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAHIAAEVQGLGTYELQTYKSDKKDRVELEKFTAITAEDAQEIEAALTVGYVHGRATNSA
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHEECHHHHHHHHHHHHEEEEECCCCCCC
RTLVNMPPNVLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSVEPPKM
CEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHCCCCEEEEECCCCCCCCCE
IALIYKGKEEWTDVIGFVGKGITYDTGGYSLKPREGMVGMKGDMGGAAAVLGAMEIIGEL
EEEEECCCHHHHHHHHHHCCCCEECCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHC
RPEQNVIAVIPSTDNVVSGTAFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLG
CCCCCEEEEECCCCCEECCCCCCCHHHHHCCCCCEEEEEECCCCCCEEEHHCHHHHHHCC
ANYLIDVATLTGGVIVALGNHTTGAMTNNEELFEQVLEASMETDESIWQLPIFDRDKERV
CCCEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCHHHH
RNSKFADLNNSPGREGHAVMAGTFLGEFAEDTPWVHLDIAGTSESSGAHDLGPAGATGAM
CCCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHH
VRTLATLVERFGEE
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA