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The map label for this gene is glxI [H]

Identifier: 52140348

GI number: 52140348

Start: 5001558

End: 5001938

Strand: Direct

Name: glxI [H]

Synonym: BCZK4912

Alternate gene names: 52140348

Gene position: 5001558-5001938 (Clockwise)

Preceding gene: 52140349

Following gene: 52140346

Centisome position: 94.35

GC content: 34.38

Gene sequence:

>381_bases
ATGATTAATCAAATTGGACAAATTATGTTATATGTAAATAATCAAGATAAAGCCGTACAATTTTGGACTGAGACAGTAGG
GTTCCAAATTATTGCAGAAGAAAATAATGGACAAGGATTTCGCTGGATTGAAATTGCGCCAGCAAAAGAAGCAGGAACAA
GCATCGTCCTTCACGATAAAGCGTTAATTGCAAAGATGCAACCTGAATTAAACTTAGGTACTCCTTCACTTATGTTCTTC
TCTAACAACTTAGATCAACTATATAAAGATCTTTCTGAGAAAAACGTTACTGTTGGACAAGTTGTAGAATTACCTACTGG
CAGAGCATTTAACTTTGCTGATAATGAAAACAATTACTTTGCGGTAATGGAACGCAAATAA

Upstream 100 bases:

>100_bases
ATGGGCGAAGATCGTACTTCGAAAAAATCACGAAAAAGTATGCAAACCATATCTTTGATATAATAGAATTTCATACAAGA
AAAGAAAGTAGGATACACCT

Downstream 100 bases:

>100_bases
AAAAGAAGCTATCCGAAAAAGTCGGATAGCTTCTTTCATTTTAAGAAACTTATTCTGCATTCGTTTCCCTATGTTGTATA
TGGCTCGTGATCCAAGCAAT

Product: lactoylglutathione lyase (glyoxalase I)

Products: glutathione; methylglyoxal

Alternate protein names: NA

Number of amino acids: Translated: 126; Mature: 126

Protein sequence:

>126_residues
MINQIGQIMLYVNNQDKAVQFWTETVGFQIIAEENNGQGFRWIEIAPAKEAGTSIVLHDKALIAKMQPELNLGTPSLMFF
SNNLDQLYKDLSEKNVTVGQVVELPTGRAFNFADNENNYFAVMERK

Sequences:

>Translated_126_residues
MINQIGQIMLYVNNQDKAVQFWTETVGFQIIAEENNGQGFRWIEIAPAKEAGTSIVLHDKALIAKMQPELNLGTPSLMFF
SNNLDQLYKDLSEKNVTVGQVVELPTGRAFNFADNENNYFAVMERK
>Mature_126_residues
MINQIGQIMLYVNNQDKAVQFWTETVGFQIIAEENNGQGFRWIEIAPAKEAGTSIVLHDKALIAKMQPELNLGTPSLMFF
SNNLDQLYKDLSEKNVTVGQVVELPTGRAFNFADNENNYFAVMERK

Specific function: Unknown

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 4.4.1.5

Molecular weight: Translated: 14272; Mature: 14272

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINQIGQIMLYVNNQDKAVQFWTETVGFQIIAEENNGQGFRWIEIAPAKEAGTSIVLHDK
CCCCCCEEEEEECCCCCEEEEEEECCCEEEEEECCCCCCEEEEEECCCCCCCCEEEEECC
ALIAKMQPELNLGTPSLMFFSNNLDQLYKDLSEKNVTVGQVVELPTGRAFNFADNENNYF
EEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHCCCEEHEEEECCCCCEEEECCCCCCEE
AVMERK
EEEECC
>Mature Secondary Structure
MINQIGQIMLYVNNQDKAVQFWTETVGFQIIAEENNGQGFRWIEIAPAKEAGTSIVLHDK
CCCCCCEEEEEECCCCCEEEEEEECCCEEEEEECCCCCCEEEEEECCCCCCCCEEEEECC
ALIAKMQPELNLGTPSLMFFSNNLDQLYKDLSEKNVTVGQVVELPTGRAFNFADNENNYF
EEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHCCCEEHEEEECCCCCEEEECCCCCCEE
AVMERK
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-S-lactoylglutathione

Specific reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]